scholarly journals Epithelioid Myoepithelioma of the Parotid Gland: A Histopathological and Immunohistochemical Study

2018 ◽  
Vol 1 (2) ◽  
pp. 177-183 ◽  
Author(s):  
María Samar ◽  
Rodolfo Avila ◽  
Marta Furnes ◽  
Ismael Fonseca ◽  
Hugo Juri ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Periodic Acid ◽  
Periodic Acid Schiff ◽  
Rare Tumour ◽  
Salivary Gland Tumours ◽  
Diagnosis And Classification ◽  
Clear Cytoplasm ◽  
Mitotic Figures ◽  
Epithelial Myoepithelial Carcinoma

The diagnosis and classification of salivary gland tumours is complicated by the wide variety of histological types that exist. Many authors attribute this complexity to the myoepithelial component of these tumours. The objective of this study is to evaluate the histological and immunohistochemical properties of a parotid gland myoepithelioma, in order to further our understanding of the differential diagnosis of salivary gland tumours which contain myoepitheliocytes. Histological specimens were analyzed using haematoxylin and eosin (H&E), periodic acid Schiff (PAS), Cason, Alcian blue, toluidine blue, a-SMA, p63 and ki67. The tumour examined was completely encapsulated, with solid cellular regions delimitated by a stroma. The stroma consisted of wide acidophilic and PAS-positive hyaline septae with areas of metachromasia. The tumour cells contained clear cytoplasm and round nuclei with lax chromatin, although some had more elongated nuclei and occasional dense chromatin. Neither cellular atypia nor mitotic figures were observed. Immunostaining was positive for a-SMA and p63, while it was negative for ki67. The histological characteristics of the tumour analyzed were consistent with a benign myoepithelioma, a rare tumour which represents less than 1% of salivary gland neoplasias. Immunostaining confirmed the morphological diagnosis of myoepithelioma. The absence of cytological changes and mitosis and its encapsulation differentiate it from its malignant counterpart. In comparison to pleomorphic adenoma, the myoepithelioma does not demonstrate ductal differentiation or chondromyxoid stroma. Importantly, the epithelial-myoepithelial carcinoma does develop tubular structures not seen in myoepithelioma. p63, which may act as an oncogene, is expressed within the nuclei of myoepitheliocytes of normal salivary glands. Its expression is retained in tumour myoepitheliocytes and thus it may play a role in oncogenesis.

Ultrastructure of the Parotid Gland of the Nine-Banded Armadillo

1977 ◽  
Vol 35 ◽  
pp. 640-641
Author(s):  
J. R. Ruby
Keyword(s):  
Endoplasmic Reticulum ◽  
Parotid Gland ◽  
Periodic Acid ◽  
Acinar Cells ◽  
Duct System ◽  
Parotid Glands ◽  
Dasypus Novemcinctus ◽  
Anterior Portion ◽  
Periodic Acid Schiff ◽  
Thin Sections

Parotid glands were obtained from five adult (four male and one female) armadillos (Dasypus novemcinctus) which were perfusion-fixed. The glands were located in a position similar to that of most mammals. They extended interiorly to the anterior portion of the submandibular gland.In the light microscope, it was noted that the acini were relatively small and stained strongly positive with the periodic acid-Schiff (PAS) and alcian blue techniques, confirming the earlier results of Shackleford (1). Based on these qualities and other structural criteria, these cells have been classified as seromucous (2). The duct system was well developed. There were numerous intercalated ducts and intralobular striated ducts. The striated duct cells contained large amounts of PAS-positive substance.Thin sections revealed that the acinar cells were pyramidal in shape and contained a basally placed, slightly flattened nucleus (Fig. 1). The rough endoplasmic reticulum was also at the base of the cell.

Parotid tumours

2021 ◽  
pp. 175573802110160
Author(s):  
Edward Balai ◽  
Navdeep Bhamra ◽  
Karan Jolly
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Head And Neck Neoplasms ◽  
Secondary Care ◽  
Care Management ◽  
Clinical Anatomy ◽  
Salivary Gland Tumours ◽  
The Common ◽  
Parotid Tumours ◽  
Key Aspects

Salivary gland tumours are uncommon and account for just 6% of all head and neck neoplasms. Worldwide incidence varies, from 0.4 to 13.5 cases per 100 000 population. The parotid gland is by far the most commonly affected site, accounting for 80% of cases. The vast majority of these tumours are benign; only approximately 20–25% being malignant. This article considers the relevant clinical anatomy of the parotid gland, key aspects of assessment with history and examination, and when to refer to secondary care for further investigation. It will touch on the common benign and malignant parotid neoplasms and give an overview of secondary care management.

Intraluminal crystalloids in malignant salivary gland tumours

1987 ◽  
Vol 101 (11) ◽  
pp. 1175-1181 ◽  
Author(s):  
Jae Y. Ro ◽  
Bruce Mackay ◽  
John G. Batsakis ◽  
Joiner Cartwright
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Parotid Glands ◽  
Salivary Duct ◽  
X Ray ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas

AbstractThe ultrastructural, X-ray microanalytical, histochemical and immunocytochemi-cal features of intraluminal crystalloids found in adenocarcinomas of the parotid gland have been studied. The crystalloids, putatively derived from an abnormal crystalization of salivary duct proteins, are considerably different from the crystalloids found in normal parotid glands, pleomorphic adenomas, and sialocysts.

scholarly journals Canine Cutaneous Clear Cell Adnexal Carcinoma: Histopathology, Immunohistochemistry, and Biologic Behavior of 26 Cases

2005 ◽  
Vol 17 (5) ◽  
pp. 403-411 ◽  
Author(s):  
F. Y. Schulman ◽  
T. P. Lipscomb ◽  
T. J. Atkin
Keyword(s):  
Clear Cell ◽  
Regional Lymph Node ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Dermal Papilla ◽  
Low Grade ◽  
Periodic Acid Schiff ◽  
Regional Lymph Nodes ◽  
S 100 ◽  
Clear Cytoplasm

Thirty tumors including 27 distinctive cutaneous neoplasms and 3 metastatic tumors from 26 dogs were collected from diagnostic submissions to 3 laboratories. Characteristic histopathologic features included location in the subcutis or dermis (or both); lobular, nodular, and nest-like architecture; and a component of epithelioid cells with clear cytoplasm. Additional features present in most cases included follicular dermal papilla-like structures, low mitotic index, nuclear pleomorphism, necrosis, and mineralization. Cytoplasmic periodic acid Schiff—positivity, which was abolished by pretreatment with diastase, indicated the presence of glycogen in all cases. The oil red O stain did not demonstrate cytoplasmic lipid. Melanin granules, accentuated by the Fontana-Masson method, were observed infrequently. A sparsely cellular mucinous stroma and stromal cartilaginous differentiation were uncommon. By immunohistochemistry, neoplastic cells stained positively for cytokeratin (29 of 29), vimentin (28 of 28), S-100 protein (24 of 29), and melan A (8 of 12); results were negative for smooth muscle actin and calponin in all cases. Clinical follow-up information was obtained on all 26 dogs. One tumor recurred, 1 metastasized to a regional lymph node, and 1 metastasized to regional lymph nodes twice. In another case, possible pulmonary metastasis was noted radiographically. The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin. Similar canine cutaneous neoplasms have been reported as “clear-cell hidradenocarcinoma” and “follicular stem cell carcinoma.” The authors propose the designation “cutaneous clear cell adnexal carcinoma.”

scholarly journals Salivary gland tumours - a three years experience at King Edward Medical College, Lahore

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Asmaa Qureshi ◽  
Khalilur Rehman ◽  
Sohail Husain ◽  
Nasirul Hasan Khawaja ◽  
Ghulam Rasood Qureshi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Single Case ◽  
Malignant Neoplasms ◽  
Salivary Gland Tumours ◽  
Medical College ◽  
Common Location ◽  
Female Predominance

Salivary gland tumours make an important part of oral & maxillofacial pathology. Only few studies have been done in Pakistani population. The aim of this study was to describe morphological types of salivary gland tumours diagnosed at King Edward Medical College/ Mayo Hospital, Lahore during the years 1999-2001 and to compare their demographic data with those previously published. Material & Methods: This descriptive cross-sectional study was carried out at King Edward Medical College/ Mayo Hospital, Lahore. It reports 117 cases of salivary gland tumours diagnosed at Pathology Department during 1999-2001. Results: Of the 128 specimens of salivary glands, 117(91.4%) were confirmed as salivary neoplasms. Out of them, 62.7% were benign and 37.6% malignant and a slight female predominance (58.1%) was found. The most common location was the parotid gland (65.8%) followed by minor salivary glands (19.6%). Majority oft he t tumours was diagnosed during 3rd to 5 decades of life. Median age for benign tumours was 33 years (range 1-78) and a female predominance (58.9%) was seen again. Median age for malignant neoplasms was 45 years (range 9-70) with a female predilection ( 56.8%). However, 4 out o f 5 patients with Warthin`s tumour were men. Pleomorphic adenoma was the most frequent tumour (51.3%), followed by mucoepidermoid carcinoma (25.6%), adenoid cystic carcinoma (7.7)), Warthin`s tumour (4.3%) and monomorphic adenoma (2.6%). Two cases each of oncytoma & adenocarcinoma were recorded. Rare categories (single case each) of salivary tumours included lipoma, acinic cell carcinoma, basal cell adenoma, capillary haemangioma, metastatic carcinoma and non Hodgkin`s lymphoma. Conclusion: The principal site of salivary tumours was the parotid gland and females were most affected. Pleomorphic adenoma was the most frequent finding. The results of this study are comparable with other studies.

Two malignant salivary gland tumours of different type in one patient

1994 ◽  
Vol 108 (9) ◽  
pp. 798-800 ◽  
Author(s):  
A. Hosni ◽  
C. Fisher ◽  
P. Rhŷ-Evans
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Histological Type ◽  
Salivary Gland Tumours ◽  
Adenoid Cystic ◽  
The Right ◽  
Left Parotid Gland

AbstractThe synchronous or metachronous occurrence of two tumours of the salivary glands in one patient is rare. These are mainly benign and of the same histological type. Here we report a 56-year-old man who developed a mucoepidermoid tumour of the left parotid gland four years after diagnosis of adenoid cystic carcinoma of the right submandibular gland. This combination of neoplasms has not to our knowledge been reported before.

scholarly journals Bilateral Basal Cell Adenocarcinoma of the Parotid Gland: In a Recipient of Kidney Transplant

2010 ◽  
Vol 3 ◽  
pp. CPath.S3303 ◽  
Author(s):  
Mari Markkanen-Leppänen ◽  
Antti A. Mäkitie ◽  
Fabricio Passador-Santos ◽  
Ilmo Leivo ◽  
Jaana Hagström
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Basal Cell ◽  
Continuous Administration ◽  
Cell Adenoma ◽  
Basal Cell Adenocarcinoma ◽  
Salivary Gland Tumours ◽  
Important Differential Diagnosis ◽  
Salivary Gland Malignancy

We report a rare case of bilateral basal cell adenocarcinoma (BcAC) of the parotid gland in a male patient 30 years after kidney transplantation and continuous administration of immunosuppressive therapy. BcAC is a salivary gland malignancy first recognized as a distinct neoplastic entity in WHO classification of salivary gland tumours in 1991. Over 90% of BcACs are detected in the parotid gland. The most important differential diagnosis is basal cell adenoma. Infiltrative growth is the distinguishing feature of BcAC. Administration of immunosuppressive medication to this patient for three decades may have contributed to development of this rare neoplasia. To our knowledge, similar cases of BcAC have not been reported previously.

Perinatal salivary gland tumours (Embryomas)

1988 ◽  
Vol 102 (11) ◽  
pp. 1007-1011 ◽  
Author(s):  
John G. Batsakis ◽  
Brune Mackay ◽  
A. Francine Ryka ◽  
Robert W. Seifert
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Major Salivary Gland ◽  
Review Of The Literature ◽  
Salivary Gland Tumours ◽  
Rare Tumors ◽  
Monomorphic Adenoma

AbstractEpithelial salivary gland tumours presenting in the first month of life (perinatal tumours) are exclusively of major salivary gland origin and predominantly of the parotid gland. Approximately 25 per cent of these rare tumors have been histologically and/or biologically malignant. Except for an occasional pleomorphic and monomorphic adenoma, the majority of the tumors are proliferations suggesting a tumorous arrest of maturation of the salivary gland anlage, hence their designation as embryomas. A case report of an embryoma of the parotid is presented, accompanied by a review of the literature.

scholarly journals A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis

2015 ◽  
Vol 16 (7) ◽  
pp. 603-606
Author(s):  
Felipe Perozzo Daltoe ◽  
Liliane Janete Grando ◽  
Maria Inês Meurer ◽  
Elena Riet Correa Rivero ◽  
Filipe Modolo
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Rare Case ◽  
Periodic Acid ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Immunohistochemical Analysis ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Periodic Acid Schiff

ABSTRACT Mucoepidermoid carcinoma ex pleomorphic adenoma (MCxPA) is a rare salivary gland tumor predominantly found in major salivary glands. A case of MCxPA involving the soft tissue and bone of the retromolar region of a 26-year-old man is presented. The histopathological features revealed a neoplasm with predominance of pleomorphic adenoma (PA) elements, and presence of mucoepidermoid carcinoma malignant epithelial cells in several areas. Histochemical and immunohistochemical studies were positive for periodic acid Schiff, alcian blue, cytokeratins 7, 13, 14, and 19, Bcl-2, c-erbB-2, FGF-2 and maspin in the malignant areas. The patient underwent a partial resection of the left side of the mandible with neck dissection and MCxPA diagnosis was confirmed. How to cite this article Daltoe FP, Grando LJ, Meurer MI, Rivero ERC, Modolo F. A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis. J Contemp Dent Pract 2015;16(7):603-606.

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