scholarly journals Impact of sutherlandia frutescens on hepatic steatosis in high-fat fed rats

2018 ◽  
Author(s):  
◽  
Nhu Y. Nguyen
Keyword(s):  
Hepatic Steatosis ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Acid Oxidation ◽  
Evidence Based ◽  
Type Ii ◽  
High Fat ◽  
Beneficial Effects ◽  
Triglyceride Accumulation ◽  
Metabolic Conditions

Hepatic steatosis is closely associated with development of obesity and type II diabetes mellitus. Western medicine for these metabolic conditions is less accessible to many developing countries because of cost, availability and need for clinical monitoring. These impediments might be addressed by development of evidence-based phytotherapies, especially those that are currently used and for which evidence of safety and efficacy can be provided ... Overall, this study provides a better understanding of the beneficial effects of Sutherlandia on hepatic steatosis by showing that consumption of this plant extract reduced HFD-induced accumulation of hepatic triglycerides by a mechanism that may involve increased fatty acid oxidation. This medicinal plant, therefore, may be a promising phytotherapy for hepatic conditions involving excess triglyceride accumulation.

scholarly journals The Severity of Non-Alcoholic Fatty Liver in Type II Diabetes

2018 ◽  
Vol 15 (6) ◽  
pp. 37-42
Author(s):  
Ovidiu Paul Calapod ◽  
Andreea Maria Marin ◽  
Laura Carina Tribus ◽  
Carmen Fierbinţeanu-Braticevici
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Alcoholic Fatty Liver

AbstractNonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that affects up to one third of the adult population of industrialized countries. The pathophysiological spectrum includes the following entities that are clinically and histologically distinct: hepatic steatosis and steatohepatitis; their subsequent evolution can lead to cirrhosis and hepatocellular carcinoma.The increase of the prevalence of NAFLD during the last decade is caused by the epidemiological and pathophysiological association with type II diabetes and obesity, NAFLD being present in about 70-80% of patients with type II diabetes mellitus. It has long been thought that the relationship between type II diabetes mellitus and NAFLD is unidirectional, fatty liver being secondary to insulin resistance and type II diabetes mellitus, but recent studies show that hepatic steatosis may precede insulin resistance and diabetes mellitus, thus demonstrating abidirectional causal relationship between these two disorders. Weight loss through diet andexercise is effective in preventing and treating NAFLD in diabetic patients; also, drugs that causeweight loss need to be evaluated. Both anti-diabetic medication and statins play an important vrole in the prevention and treatment of NAFLD.

scholarly journals Anti-Diabetic Effects of Mori Folium Extract on High-Fat Diet and Streptozotocin-Induced Type II Diabetes Mellitus in Mice

2015 ◽  
Vol 30 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Tae-Oh Kwon ◽  
Ji-Won Choi ◽  
Hyun-Seo Lee ◽  
Byoung-Ok Cho ◽  
Hong-Hua Yin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
High Fat Diet ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
High Fat

scholarly journals A Combination of Human Embryonic Stem Cell-Derived Pancreatic Endoderm Transplant with LDHA-Repressing miRNA Can Attenuate High-Fat Diet Induced Type II Diabetes in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Yunya Chen ◽  
Xiujie Wang ◽  
Xinyu Shao
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
High Fat Diet ◽  
Type Ii Diabetes ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
High Fat ◽  
Diabetes In Mice

Type II diabetes mellitus (T2D) is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. The deficit and dysfunction of insulin secretingβ-cell are signature symptom for T2D. Additionally, in pancreaticβ-cell, a small group of genes which are abundantly expressed in most other tissues are highly selectively repressed. Lactate dehydrogenase A (LDHA) is one of such genes. Upregulation of LDHA is found in both human T2D and rodent T2D models. In this study, we identified a LDHA-suppressing microRNA (hsa-miR-590-3p) and used it together with human embryonic stem cell (hESC) derived pancreatic endoderm (PE) transplantation into a high-fat diet induced T2D mouse model. The procedure significantly improved glucose metabolism and other symptoms of T2D. Our findings support the potential T2D treatment using the combination of microRNA and hESC-differentiated PE cells.

scholarly journals Punica granatum L.-derived omega-5 nanoemulsion improves hepatic steatosis in mice fed a high fat diet by increasing fatty acid utilization in hepatocytes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
K. Zamora-López ◽  
L. G. Noriega ◽  
A. Estanes-Hernández ◽  
I. Escalona-Nández ◽  
S. Tobón-Cornejo ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Hepatic Steatosis ◽  
Fatty Acid Oxidation ◽  
High Fat Diet ◽  
Punica Granatum ◽  
Acid Oxidation ◽  
Punicic Acid ◽  
High Fat ◽  
Beneficial Effects ◽  
Potential Benefits

Abstract Pomegranate seed oil (PSO) is mainly composed of punicic acid (PA), a polyunsaturated fatty acid also known as omega-5 (ω-5), a potent antioxidant associated with a variety of metabolic and cellular beneficial effects. However, the potential benefits of a nanoemulsified version of ω-5 (PSOn) have not been evaluated in a pathological liver condition. Here, we examined whether PSOn had beneficial effects on C57BL/6N mice fed a high-fat diet (HFD), specifically on hepatic steatosis. We observed that PSOn supplementation decreased body weight and body fat mass in control mice, whereas glucose intolerance, insulin resistance, energy expenditure, and hepatic steatosis were improved in both control mice and in mice fed a HFD. Interestingly, PSOn increased fatty acid oxidation in primary hepatocytes and antioxidant gene expression. Altogether, our data indicate that PSOn effectively reduces some of the HFD-derived metabolic syndrome indicators by means of an increase in fatty acid oxidation within hepatocytes.

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