scholarly journals Predicting with Confidence: A Case-Based Reasoning Framework for Predicting Survival in Breast Cancer

2021 ◽  
Vol 34 (1) ◽  
Author(s):  
Isabelle Bichindaritz ◽  
Christopher Bartlett ◽  
Guanghui Liu
Keyword(s):  
Breast Cancer ◽  
State Of The Art ◽  
Predictive Performance ◽  
Black Box ◽  
Optimal Number ◽  
Case Based Reasoning ◽  
Analysis Framework ◽  
Insight Into ◽  
Adaptation Phase ◽  
Case Based

There is usually a trade-off between predictive performance and transparency, where the reasoning process behind an algorithm is shielded behind a ”black-box.” In medical domains, experts being responsible for their decisions need to understand the reasons behind machine-generated recommendations. This paper presents a transparent case-based survival analysis framework that automatically retrieves an optimal number of solved survival cases and adapts them to predict the survival of a new case. With this methodology, retrieved and adapted survival cases lend an insight into which cases a prediction is based on. Our framework is capable of integrating DNA methylation, gene expression, and their combination in breast cancer. Additionally, we test our approach with and without feature selection and demonstrate the usefulness of the adaptation phase. We demonstrate that our framework performs at least as effectively as other state-of-the-art methods while affording greater explainability.

Insight into interface design of web-based case-based reasoning retrieval systems

2009 ◽  
Vol 36 (3) ◽  
pp. 7280-7287 ◽  
Author(s):  
Wu He ◽  
Feng-Kwei Wang ◽  
Tawnya Means ◽  
Li Da Xu
Keyword(s):  
Interface Design ◽  
Case Based Reasoning ◽  
Web Based ◽  
Retrieval Systems ◽  
Insight Into ◽  
Case Based

A novel case-based reasoning system for breast cancer diagnosis: considering the effects of external characteristics of cases Abstract (Preprint)

2021 ◽  
Author(s):  
Dongxiao Gu ◽  
Wang Zhao ◽  
Xuejie Yang ◽  
Kaixiang Su ◽  
Changyong Liang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Naive Bayes ◽  
Breast Cancer Diagnosis ◽  
Naïve Bayes ◽  
Case Based Reasoning ◽  
Reasoning System ◽  
System P ◽  
External Characteristics ◽  
Case Based

BACKGROUND Artificial intelligence can help physicians improve the accuracy of breast cancer diagnosis. However, the effectiveness of AI applications is limited by doctors’ adoption of the results recommended by the AI systems. A case-based reasoning system for breast cancer diagnosis (CBR-BCD) that considers the effects of external characteristics of cases (ECC) can not only provide doctors with more accurate results for auxiliary diagnosis, but also improve doctors’ trust in the results, so as to encourage doctors to adopt the results recommended by the system. OBJECTIVE The objective of our study is to develop a novel integrated case-based reasoning (CBR) framework based on Naive Bayes and K-Nearest Neighbor (KNN) algorithms considering the effects of external characteristics of cases (CBR-ECC) and a corresponding system named CBR-BCD to assist in diagnosis and promote adoption by doctors. METHODS We used a real-world data set from the Maputo Central Hospital in Mozambique and constructed the CBR-ECC model and corresponding CBR-BCD system. We performed data processing and obtained six internal features and three external features of the cases. We randomly divided the 1214 cases into a training group and a testing group. The performance of the model was evaluated by accuracy and the area under the receiver operating characteristic curve (AUC). RESULTS The system based on the CBR-ECC model was developed. In the first stage of this model, Naive Bayes showed the best performance, compared with KNN and J48 decision tree classifiers, with an accuracy rate of 95.87%. In the second stage, the accuracy of the KNN model with the optimal K value of 2 was 99.40%. In the third stage, after considering the external characteristics of the cases, the rankings of recommendation changed. Finally, we report the users’ evaluation of the novel CBR system in a real hospital scenario; we found that it is superior to the original system. CONCLUSIONS CBR-BCD not only enables accurate case recommendations to support health practitioners in diagnosing breast cancer and reducing diagnostic inaccuracies, but also facilitates the adoption of system-recommended results by physicians, which is valuable for clinicians to assist in diagnosis. It enables the early screening of breast cancer to improve the quality of breast cancer management and reduces the socioeconomic burden compared to traditional methods.

Simplifying decision trees: A survey

1997 ◽  
Vol 12 (01) ◽  
pp. 1-40 ◽  
Author(s):  
LEONARD A. BRESLOW ◽  
DAVID W. AHA
Keyword(s):  
Decision Trees ◽  
Data Structures ◽  
Classification Accuracy ◽  
Case Based Reasoning ◽  
Reasoning Systems ◽  
Tree Generation ◽  
Good Classification ◽  
Classification Tasks ◽  
Insight Into ◽  
Case Based

Induced decision trees are an extensively-researched solution to classification tasks. For many practical tasks, the trees produced by tree-generation algorithms are not comprehensible to users due to their size and complexity. Although many tree induction algorithms have been shown to produce simpler, more comprehensible trees (or data structures derived from trees) with good classification accuracy, tree simplification has usually been of secondary concern relative to accuracy, and no attempt has been made to survey the literature from the perspective of simplification. We present a framework that organizes the approaches to tree simplification and summarize and critique the approaches within this framework. The purpose of this survey is to provide researchers and practitioners with a concise overview of tree-simplification approaches and insight into their relative capabilities. In our final discussion, we briefly describe some empirical findings and discuss the application of tree induction algorithms to case retrieval in case-based reasoning systems.

scholarly journals Analysis of Explainers of Black Box Deep Neural Networks for Computer Vision: A Survey

2021 ◽  
Vol 3 (4) ◽  
pp. 966-989
Author(s):  
Vanessa Buhrmester ◽  
David Münch ◽  
Michael Arens
Keyword(s):  
Neural Networks ◽  
Computer Vision ◽  
Deep Neural Networks ◽  
State Of The Art ◽  
Black Box ◽  
Complex Data ◽  
Comprehensive Overview ◽  
Nonlinear Structure ◽  
Black Boxes ◽  
Insight Into

Deep Learning is a state-of-the-art technique to make inference on extensive or complex data. As a black box model due to their multilayer nonlinear structure, Deep Neural Networks are often criticized as being non-transparent and their predictions not traceable by humans. Furthermore, the models learn from artificially generated datasets, which often do not reflect reality. By basing decision-making algorithms on Deep Neural Networks, prejudice and unfairness may be promoted unknowingly due to a lack of transparency. Hence, several so-called explanators, or explainers, have been developed. Explainers try to give insight into the inner structure of machine learning black boxes by analyzing the connection between the input and output. In this survey, we present the mechanisms and properties of explaining systems for Deep Neural Networks for Computer Vision tasks. We give a comprehensive overview about the taxonomy of related studies and compare several survey papers that deal with explainability in general. We work out the drawbacks and gaps and summarize further research ideas.

A novel case-based reasoning system for breast cancer diagnosis: considering the effects of external characteristics of cases (Preprint)

2021 ◽  
Author(s):  
Dongxiao Gu ◽  
Wang Zhao ◽  
Xuejie Yang ◽  
Kaixiang Su ◽  
Changyong Liang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Naive Bayes ◽  
Breast Cancer Diagnosis ◽  
Naïve Bayes ◽  
Case Based Reasoning ◽  
Reasoning System ◽  
System P ◽  
External Characteristics ◽  
Case Based

BACKGROUND Artificial intelligence can help physicians improve the accuracy of breast cancer diagnosis. However, the effectiveness of AI applications is limited by doctors’ adoption of the results recommended by the AI systems. A case-based reasoning system for breast cancer diagnosis (CBR-BCD) that considers the effects of external characteristics of cases (ECC) can not only provide doctors with more accurate results for auxiliary diagnosis, but also improve doctors’ trust in the results, so as to encourage doctors to adopt the results recommended by the system. OBJECTIVE The objective of our study is to develop a novel integrated case-based reasoning (CBR) framework based on Naive Bayes and K-Nearest Neighbor (KNN) algorithms considering the effects of external characteristics of cases (CBR-ECC) and a corresponding system named CBR-BCD to assist in diagnosis and promote adoption by doctors. METHODS We used a real-world data set from the Maputo Central Hospital in Mozambique and constructed the CBR-ECC model and corresponding CBR-BCD system. We performed data processing and obtained six internal features and three external features of the cases. We randomly divided the 1214 cases into a training group and a testing group. The performance of the model was evaluated by accuracy and the area under the receiver operating characteristic curve (AUC). RESULTS The system based on the CBR-ECC model was developed. In the first stage of this model, Naive Bayes showed the best performance, compared with KNN and J48 decision tree classifiers, with an accuracy rate of 95.87%. In the second stage, the accuracy of the KNN model with the optimal K value of 2 was 99.40%. In the third stage, after considering the external characteristics of the cases, the rankings of recommendation changed. Finally, we report the users’ evaluation of the novel CBR system in a real hospital scenario; we found that it is superior to the original system. CONCLUSIONS CBR-BCD not only enables accurate case recommendations to support health practitioners in diagnosing breast cancer and reducing diagnostic inaccuracies, but also facilitates the adoption of system-recommended results by physicians, which is valuable for clinicians to assist in diagnosis. It enables the early screening of breast cancer to improve the quality of breast cancer management and reduces the socioeconomic burden compared to traditional methods.

DEVELOPING CASE-BASED REASONING FOR DISCOVERY OF BREAST CANCER

2003 ◽  
Vol 03 (03n04) ◽  
pp. 231-245 ◽  
Author(s):  
S. C. FOK ◽  
E. Y. K. NG ◽  
G. L. THIMM
Keyword(s):  
Breast Cancer ◽  
Medical Records ◽  
Breast Tumor ◽  
Genetic Factors ◽  
Medical Professionals ◽  
Case Based Reasoning ◽  
Screening Process ◽  
Preliminary Screening ◽  
Physiological Information ◽  
Case Based

The treatment of early development of breast tumor has a higher success rate. This paper presents a framework for the early discovery of breast cancer. The objective is to assist the general practitioners and specialists in the detection of breast tumor. The proposed detection process consists of a preliminary screening process and a prediction process. The preliminary screening process using thermography aims to complement the detailed screening operation using mammography. The prediction process using artificial intelligence techniques aims to use past records of other similar cases to enhance the forecast of breast cancer development. The paper discusses the issues and techniques for the implementation of the proposed framework. These include the preliminary screening process, the retrieval of the relevant cases, and the prediction of the risk of developing breast cancer based on the thermographs, environmental/social data, physiological information, genetic factors, and medical records. This work constitutes initial effort to lessen the burden of medical professionals and increase the chances of successful treatment for patients in the fight against breast cancer.

Case-based reasoning commentaries: introduction

2005 ◽  
Vol 20 (3) ◽  
pp. 201-202 ◽  
Author(s):  
DAVID W. AHA ◽  
CINDY MARLING ◽  
IAN WATSON
Keyword(s):  
New Zealand ◽  
Knowledge Engineering ◽  
State Of The Art ◽  
The State ◽  
Case Based Reasoning ◽  
Special Issue ◽  
Case Based

We are delighted to present this special issue of The Knowledge Engineering Review, as it marks a significant accomplishment of the case-based reasoning (CBR) community. Its 19 commentaries, written by 41 authors, represent a compendium on the state-of-the-art in CBR. These evolved from a 2003 workshop that was held at Waiheke Island and Queenstown, New Zealand and chaired by Alec Holt and Ian Watson. The workshop's delegates identified the primary topics of CBR research and application, selected representative influential publications for each topic, and were encouraged to co-author commentaries on each topic with other CBR experts who were unable to attend. These collaborations produced the articles you now see. While several reviews exist on CBR (e.g. Marir & Watson, 1994; López de Mántaras & Plaza, 1997; Lenz et al., 1998), few have been published recently or have similar historical and subject breadth.

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