scholarly journals Correlation of Radiation Dose and PSA Blood Level in the Radiotherapy of Prostate Cancer: A retrospective case series

2021 ◽  
Vol 11 (2) ◽  
pp. 38-43
Author(s):  
Ade Margaretha LT ◽  
Soehartati A. Gondhowiardjo
Keyword(s):  
Radiation Dose ◽  
Blood Level ◽  
External Beam Radiotherapy ◽  
Specific Antigen ◽  
Case Series ◽  
Prostate Adenocarcinoma ◽  
External Beam ◽  
Retrospective Case ◽  
Before And After ◽  
Study Population

Background: The objective of this study was to analyze the correlation of radiation dose and Prostate-Specific Antigen (PSA) blood level following radiation therapy in prostate cancer.Methods: The study population was serial of 13 patients with histologically proven T1b-T4, any N, M0 prostate adenocarcinoma, having any Gleason score with any PSA before and after complete EBRT (external beam radiotherapy), from January 2009 to December 2010 and evaluated for PSA decrease post-EBRT.Results: Out of 13 patients, one patient received 62 Gy, one patient received 72 Gy, and 11 patients received 80 Gy. PSA blood level was decreased (median 5.4, 9.43 and 25.27, respectively) in all patients.Conclusion: This case series results were consistent with the results of previous studies that a higher radiation dose will have a higher PSA decrease with a tolerable side effect.

scholarly journals The Effect of Traditional Single Growing Rod Technique on the Growth of Unsegmented Levels in Mixed-Type Congenital Scoliosis

2020 ◽  
pp. 219256822097208
Author(s):  
Tianhua Rong ◽  
Jianxiong Shen ◽  
Yipeng Wang ◽  
Zheng Li ◽  
Youxi Lin ◽  
...  
Keyword(s):  
Mixed Type ◽  
Case Series ◽  
Congenital Scoliosis ◽  
Concave Side ◽  
Convex Side ◽  
Retrospective Case ◽  
Growing Rod ◽  
Before And After ◽  
Spine Radiographs

Study Design: Retrospective case series. Objectives: To present outcomes concerning patients with early-onset mixed-type congenital scoliosis (EOMTCS) treated with the traditional single growing rod (TSGR), focusing on the growth of unsegmented levels (USLs). Methods: Patients with EOMTCS who underwent TSGR and had a minimum of 4 USLs, 4 distractions, and 3-year follow-up were enrolled. Spine radiographs before and after index surgery and at the latest follow-up were evaluated. The length of the concave and convex side of USLs and thoracic parameters were measured. The absolute value and percentage of growth were calculated. Results: Fourteen patients (mean age, 7.3 ± 2.8 years) were enrolled. The average follow-up duration was 4.9 ± 1.2 years, during which time 84 distractions and 8 final fusions were performed. The average number of USLs was 6.3 ± 2.2. The total and annual percent growth of concave side of USLs was significantly higher than convex side (32.2 ± 13.3% vs. 23.9 ± 9.5%, p = 0.007; 6.8 ± 2.7%/year vs. 5.1% ± 2.2%/year, p = 0.007, respectively). The concave-to-convex ratio of USLs increased from 58.6 ± 6.4 ± 7.6% at baseline to 68.8 ± 9.3% at the latest follow-up (p < 0.001). The Campbell’s space available for lung ratio increased from 74.9 ± 11.1% at baseline to 89.6 ± 7.0% at the latest follow-up (p < 0.001). Conclusions: In patients with EOMTCS, unilateral repetitive lengthening with TSGR can accelerate the growth of the concave side of USLs and improve the symmetry of the thorax.

Bony nasolacrimal duct dehiscence in functional endoscopic sinus surgery: radiological study and discussion of surgical implications

2015 ◽  
Vol 129 (S3) ◽  
pp. S35-S40 ◽  
Author(s):  
M J Ali ◽  
J Murphy ◽  
P J Wormald ◽  
A J Psaltis
Keyword(s):  
Computed Tomography ◽  
Endoscopic Sinus Surgery ◽  
Case Series ◽  
Nasolacrimal Duct ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Retrospective Case ◽  
Computed Tomography Images ◽  
Before And After ◽  
Surgically Induced

AbstractObjectives:To analyse the radiological features of the bony nasolacrimal duct before and after functional endoscopic sinus surgery, and document the incidence of surgically induced dehiscence.Methods:A retrospective case series analysis was conducted of 63 consecutive patients who underwent uncinectomy as a part of 118 functional endoscopic sinus surgical procedures. All patients underwent pre- and post-operative computed tomography scans. Axial computed tomography images at the level of maxillary sinus were evaluated for the presence of bony nasolacrimal duct dehiscence, osteitis and completeness of uncinectomy.Results:The rate of nasolacrimal duct dehiscence prior to surgery was 6.8 per cent (8 out of 118 cases). Nasolacrimal duct dehiscence as a consequence of surgery was observed in 3.3 per cent of cases (4 out of 118), with a further 4.2 per cent (5 out of 118) showing post-operative reactive bony change of the nasolacrimal duct in the absence of dehiscence.Conclusion:The incidence of nasolacrimal duct injury observed was much lower than that previously reported in the literature.

scholarly journals Serum levels of selenium in patients with breast cancer before and after treatment of external beam radiotherapy

2011 ◽  
Vol 22 (5) ◽  
pp. 1109-1112 ◽  
Author(s):  
C.A.S. Franca ◽  
C.R. Nogueira ◽  
A. Ramalho ◽  
A.C.P. Carvalho ◽  
S.L. Vieira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
External Beam Radiotherapy ◽  
Serum Levels ◽  
External Beam ◽  
Before And After

Prostate-Specific Antigen Kinetics After Brachytherapy or External Beam Radiotherapy and Neoadjuvant Hormonal Therapy

Urology ◽  
2007 ◽  
Vol 69 (1) ◽  
pp. 129-133 ◽  
Author(s):  
Michael Pinkawa ◽  
Karin Fischedick ◽  
Marc D. Piroth ◽  
Bernd Gagel ◽  
Holger Borchers ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Hormonal Therapy ◽  
External Beam Radiotherapy ◽  
Specific Antigen ◽  
External Beam ◽  
Neoadjuvant Hormonal Therapy

Multi-institutional outcomes following LDR brachytherapy in patients with higher-risk prostate cancer.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 238-238
Author(s):  
Ruth Conroy ◽  
Peter Hoskin ◽  
David Bottomley ◽  
Paula Mandall ◽  
Ric Swindell ◽  
...  
Keyword(s):  
External Beam Radiotherapy ◽  
Dose Range ◽  
Univariate Analysis ◽  
Hormone Treatment ◽  
Prostate Adenocarcinoma ◽  
Treatment Modalities ◽  
External Beam ◽  
Adjuvant Hormone Therapy ◽  
Mount Vernon ◽  
Ldr Brachytherapy

238 Background: We report the outcomes for a cohort of men with higher risk prostate adenocarcinoma treated with LDR brachytherapy in a multi-institutional UK practice. Methods: 217 men treated between 2003-2007 with Iodine-125 brachytherapy at Christie, Leeds and Mount Vernon were identified from a multi-institutional database. Higher risk was defined as patients with ≥ 2 D’Amico intermediate risk factors (PSA 10-20, GS 7 or clinical T2c) or ≥1 high risk factor (PSA > 20, GS ≥ 8). Kaplan-Meier methods were used to estimate biochemical relapse free survival (BRFS) defined using both Phoenix and ASTRO definitions. A univariate analysis was performed to assess the significance of Gleason score, PSA, T-stage, pre- or post-implant dosimetry, and additional hormones on BRFS. Results: The median age was 65yrs (43–79yrs) with a median PSA follow up of 62months (14–102months). Median pre-implant doses (ranges) were: V150 59.6(43.7–89.8), V200 20.1(11.6–36). 75 patients had post-implant dosimetry, median dose (range) was: D90 132.8Gy (75-192Gy). No patients had external beam radiotherapy. 67 patients had additional hormone treatment, median duration 7 months (3 – 22 months). The 3 and 5 year BRFS as defined by Phoenix were 85.4% and 74.4% and as defined by ASTRO were 76.6% and 69.8%. On univariate analysis there were no statistically significant predictors of inferior outcome. Conclusions: Single modality LDR brachytherapy is a well established treatment for low risk prostate adenocarcinoma reporting excellent long term BRFS. Some authors have advocated the addition of external beam radiotherapy when treating higher risk disease. These results show that good BRFS can be obtained with LDR brachytherapy alone and no additional benefit has been shown by the addition of adjuvant hormone therapy. These results appear comparable with other treatment modalities available to these patients.

High-Dose-Rate Brachytherapy Boost and Conformal External Beam Radiotherapy for Primary or Recurrent Localized Prostate Adenocarcinoma

Brachytherapy ◽  
2013 ◽  
Vol 12 ◽  
pp. S71
Author(s):  
Luis Larrea ◽  
Enrique Lopez Munoz ◽  
Paola Antonini ◽  
Banos Maria Carmen ◽  
Maria Angeles Garcia ◽  
...  
Keyword(s):  
Dose Rate ◽  
External Beam Radiotherapy ◽  
Prostate Adenocarcinoma ◽  
High Dose Rate ◽  
High Dose ◽  
External Beam ◽  
High Dose Rate Brachytherapy ◽  
Brachytherapy Boost
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