scholarly journals Synthesis of Anhydrous Dicalcium Phosphate for Precursor of Natural Ceramic Apatite Material

2020 ◽  
Vol 29 (2) ◽  
pp. 82
Author(s):  
Muhammad Syaifun Nizar ◽  
Rizky Berliana Wijayanti ◽  
Kristanto Wahyudi
Keyword(s):  
Dicalcium Phosphate

scholarly journals Effects of Soft Phosphate and Dicalcium Phosphate on Reproductive Performance and Egg Quality

1961 ◽  
Vol 40 (1) ◽  
pp. 74-80 ◽  
Author(s):  
T.A. Crowley ◽  
M.W. Pasvogel ◽  
A.R. Kemmerer ◽  
M.G. Vavich ◽  
A.A. Kurnick
Keyword(s):  
Reproductive Performance ◽  
Egg Quality ◽  
Dicalcium Phosphate

Predictive evaluation of multicomponent direct compress model tablets by integrating sphere UV-Vis spectroscopy and chemometrics

2021 ◽  
pp. 1-12
Author(s):  
Yuta Otsuka ◽  
Suvra Pal
Keyword(s):  
Regression Models ◽  
Process Analytical Technology ◽  
Compaction Pressure ◽  
Principal Component ◽  
Magnesium Stearate ◽  
Dicalcium Phosphate ◽  
Integrating Sphere ◽  
Pls Regression ◽  
Standard Normal Variate ◽  
Vis Spectroscopy

BACKGROUND: Control of the pharmaceutical manufacturing process and active pharmaceutical ingredients (API) is essential to product formulation and bioavailability. OBJECTIVE: The aim of this study is to predict tablet surface API concentration by chemometrics using integrating sphere UV-Vis spectroscopy, a non-destructive and contact-free measurement method. METHODS: Riboflavin, pyridoxine hydrochloride, dicalcium phosphate anhydrate, and magnesium stearate were mixed and ground with a mortar and pestle, and 100 mg samples were subjected to direct compression at a compaction pressure of 6 MPa at 7 mm diameter. The flat surface tablets were then analyzed by integrating sphere UV-Vis spectrometry. Standard normal variate (SNV) normalization and principal component analysis were applied to evaluate the measured spectral dataset. The spectral ranges were prepared at 300–800 nm and 500–700 nm with SNV normalization. Partial least squares (PLS) regression models were constructed to predict the API concentrations based on two previous datasets. RESULTS: The regression vector of constructed PLS regression models for each API was evaluated. API concentration prediction depends on riboflavin absorbance at 550 nm and the excipient dicalcium phosphate anhydrate. CONCLUSION: Integrating sphere UV-Vis spectrometry is a useful tool to process analytical technology.

scholarly journals Powder properties of binary mixtures of chloroquine phosphate with lactose and dicalcium phosphate

2010 ◽  
Vol 46 (3) ◽  
pp. 531-537
Author(s):  
Michael Ayodele Odeniyi ◽  
Collins Chidi Onyenaka ◽  
Oludele Adelanwa Itiola
Keyword(s):  
Binary Mixtures ◽  
Internal Flow ◽  
Optical Microscope ◽  
Volume Reduction ◽  
Dicalcium Phosphate ◽  
Flow Properties ◽  
Maximum Volume ◽  
Cohesive Properties ◽  
Particle Size And Shape ◽  
The Individual

A study was conducted on the packing and cohesive properties of chloroquine phosphate in binary mixtures with lactose and dicalcium phosphate powders. The maximum volume reduction due to packing as expressed by the Kawakita constant, a, and the angle of internal flow, θ, were the assessment parameters. The individual powders were characterized for their particle size and shape using an optical microscope. Binary mixtures of various proportions of chloroquine phosphate with lactose and dicalcium phosphate powders were prepared. The bulk and tapped densities, angles of repose and internal flow, as well as compressibility index of the materials were determined using appropriate parameters. The calculated and determined values of maximum volume reduction for the binary mixtures were found to differ significantly (P< 0.05), with the Kawakita plot being more reliable in determining the packing properties. Diluent type was found to influence the flow properties of the mixtures, with dicalcium phosphate giving predictable results while mixtures containing lactose were anomalous with respect to flow. The characterization of the packing and cohesive properties of the binary mixtures of chloroquine with lactose and dicalcium phosphate would be useful in the production of powders, tablets, capsules and other drug delivery systems containing these powders with desirable and predictable flow properties.

554. Titration curves of whey constituents

1954 ◽  
Vol 21 (2) ◽  
pp. 229-237 ◽  
Author(s):  
M. Boulet ◽  
Dyson Rose
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Dissociation Constants ◽  
Calcium Content ◽  
Dicalcium Phosphate ◽  
Milk Serum ◽  
Titration Curves

Titration curves of calcium-containing and calcium-free solutions resembling milk serum indicated that precipitation of calcium from such solutions was greatly impeded by citrate. In the absence of citrate, precipitation of tricalcium phosphate was complete at pH 6·0, but, in solutions containing citrate, precipitation of tricalcium phosphate occurred gradually throughout the titration and was not complete at pH 10.In some solutions precipitation of calcium phosphate ceased at about pH 9·7, even though the base added had been insufficient to neutralize tertiary hydrogen equivalent to the known calcium content. Precipitation of dicalcium phosphate must therefore have occurred.The observed stability of calcium in these solutions was much greater than that predicted from the accepted solubility and dissociation constants. It is therefore concluded that detailed studies of these constants, and of the factors controlling precipitation of dior tricalcium phosphate, are needed.

Sign in / Sign up

Export Citation Format

Share Document