scholarly journals The Role Protein Sonic Hedgehog in Carcinoma Basal Cell

2020 ◽  
Vol 5 (1) ◽  
pp. 212-218
Author(s):  
Yulia Farida Yahya ◽  
Radema Maradom ◽  
Hari Darmawan ◽  
Theresia L. Toruan ◽  
Ika Kartika
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Significant Relationship ◽  
Hair Follicles ◽  
Chi Square ◽  
Gene Target ◽  
Paraffin Block ◽  
Chi Square Test ◽  
Histopathologic Features

A B S T R A C TIntroduction: Basal cell carcinoma (KSB) is a non-melanoma skin cancer (KKNM),which is most commonly found compared to other skin cancers. KSB originates fromstem cells in the bulk of hair follicles or inter-follicular epidermis, through the Sonichadgehog (SHH) activation pathway, an increase in Sonic hadgehog (SHH) proteinexpression, involving Patches protein (PTCH), smothened protein (SMO), in the formof increased protein transcription activation Glia (GLI) in the nucleus, binds to DNAto initiate tumor-aggressive growth and tissue. Objective: to determine therelationship between Sonic hadgehog (SHH) expression and non-aggressive andaggressive basal cell carcinoma. Methods: The study was carried out in anobservational laboratory with 35 primary KSB patients, the tissue was taken usingelliptic biopsy technique, made paraffin block specimens for histopathologicalexamination of the subtype of KSB consisting of 20 non-aggressive KSB patients,namely nodular and superficial KSB; 15 patients with aggressive KSB werepigmented KSB; Infiltrates KSB, micronodular KSB, metypical KSB (basosquamousKSB) and SHH immunohistochemical (CPI) examination using SHH antibodies, inthe Anatomy Pathology section, FK Unsri / RSMH Palembang. The characteristics ofKSB patients were recorded, namely sex, age, occupation based on the length ofexposure to BC, namely exposure <3 hours / day, exposure 3-6 hours / day,exposure ≥ 6 hours / day. The data were processed using the Statistical AnalysisSoftware Package (SPSS) version 20.0 (IBM Corporation), tested with Pearsoncorrelation test and chi square test and presented in the form of diagrams, andnarrative tables. Results: Pearson's test showed a significant correlation betweenthe clinical features of KSB and the histopathologic features of non-aggressive andaggressive types of KSB (p 0.020), there was a significant relationship between thesubtypes of histopathologic features of KSB with non-aggressive and aggressivetypes of KSB (p 0.000), there was a significant relationship between strong SHHexpression and BCC aggressive compared to non-aggressive KSB, p 0.000 (p <05α),and r = 732 Conclusion: There is a relationship between SHH expression and KSBaggressiveness. The increase in strong SHH expression shows the aggressiveness ofKSB, SHH expression can be used as a biological gene target both as a prognosticindicator and can be used as a target for treatment of aggressive KSB, especially inthe elderly.

scholarly journals Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia

2006 ◽  
Vol 26 (17) ◽  
pp. 6609-6622 ◽  
Author(s):  
Erica Nieuwenhuis ◽  
Jun Motoyama ◽  
Paul C. Barnfield ◽  
Yoshiaki Yoshikawa ◽  
Xiaoyun Zhang ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Genetic Disorder ◽  
Skin Lesions ◽  
Hair Follicles ◽  
Limb Bud ◽  
Epidermal Hyperplasia ◽  
Phenotypic Analysis ◽  
Developmental Abnormalities

ABSTRACT Hedgehog (Hh) signaling plays pivotal roles in tissue patterning and development in Drosophila melanogaster and vertebrates. The Patched1 (Ptc1) gene, encoding the Hh receptor, is mutated in nevoid basal cell carcinoma syndrome, a human genetic disorder associated with developmental abnormalities and increased incidences of basal cell carcinoma (BCC) and medulloblastoma (MB). Ptc1 mutations also occur in sporadic forms of BCC and MB. Mutational studies with mice have verified that Ptc1 is a tumor suppressor. We previously identified a second mammalian Patched gene, Ptc2, and demonstrated its distinct expression pattern during embryogenesis, suggesting a unique role in development. Most notably, Ptc2 is expressed in an overlapping pattern with Shh in the epidermal compartment of developing hair follicles and is highly expressed in the developing limb bud, cerebellum, and testis. Here, we describe the generation and phenotypic analysis of Ptc2 tm1/tm1 mice. Our molecular analysis suggests that Ptc2 tm1 likely represents a hypomorphic allele. Despite the dynamic expression of Ptc2 during embryogenesis, Ptc2 tm1/tm1 mice are viable, fertile, and apparently normal. Interestingly, adult Ptc2 tm1/tm1 male animals develop skin lesions consisting of alopecia, ulceration, and epidermal hyperplasia. While functional compensation by Ptc1 might account for the lack of a strong mutant phenotype in Ptc2-deficient mice, our results suggest that normal Ptc2 function is required for adult skin homeostasis.

A Monoclonal Antibody Established from the Immunization of Basal Cell Carcinoma (BCC) Tissues Reacts to the Intercellular Space of BCC and Hair Follicles

2002 ◽  
Vol 29 (11) ◽  
pp. 718-725 ◽  
Author(s):  
Satoshi Kore-eda ◽  
Norihisa Matsuyoshi ◽  
Masamichi Ueda ◽  
Yuji Horiguchi ◽  
Yoshiki Miyachi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Intercellular Space ◽  
Hair Follicles

Reproducible Histopathologic Features in Cases of Basal Cell Carcinoma With Neuroendocrine Expression

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jose A. Plaza ◽  
Llana Pootrakul ◽  
Shyam S. Raghavan ◽  
Martin Sangueza ◽  
Alejandro A. Gru
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histopathologic Features

scholarly journals The excision width in surgical treatment of basal cell carcinoma

2006 ◽  
Vol 53 (3) ◽  
pp. 53-57
Author(s):  
M. Jovanovic ◽  
D. Brasanac ◽  
L. Rasulic ◽  
M. Colic ◽  
M. Stojicic ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Cell Cancer ◽  
Basal Layer ◽  
Hair Follicles ◽  
Histological Type ◽  
Basal Cell Cancer ◽  
External Covering

Basal cell carcinoma originates from pluripotent cells of basal layer of epiderm, external covering of hair follicles, sebaceous glands or other skin adnexa. It is characterized by local infiltrating and sometimes destructive growth. There are several types of basal cell carcinomas that may be manifested in over 12 clinical forms. Surgical treatment depends to a large extent on the histological type, localization and its clinical manifestation. The analysis included 250 patients of both gender and different age, operated for basal cell carcinoma. Clinical characteristics of basal cell carcinoma and the width of the excision were described. It was concluded that the width of the excision of basal cell cancer was in relation to histological type. .

Discrimination between basal cell carcinoma and hair follicles in skin tissue sections by Raman micro-spectroscopy

2011 ◽  
Vol 993 (1-3) ◽  
pp. 57-61 ◽  
Author(s):  
M. Larraona-Puy ◽  
A. Ghita ◽  
A. Zoladek ◽  
W. Perkins ◽  
S. Varma ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hair Follicles ◽  
Skin Tissue ◽  
Tissue Sections

scholarly journals Basal cell carcinoma developed from an epidermal cyst: A case report and review of the literature

2021 ◽  
Vol 13 (2) ◽  
Author(s):  
Tomoka Harada ◽  
Takeshi Fukumoto ◽  
Hideki Shimizu ◽  
Chikako Nishigori
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Basal Cell ◽  
Malignant Tumor ◽  
Subcutaneous Tissue ◽  
Hair Follicles ◽  
Epidermal Cyst ◽  
Immunoperoxidase Staining ◽  
Histopathological Analysis

Cutaneous epidermal cysts are common benign cysts derived from the epidermis or epithelium of hair follicles, and malignancy originating from epidermal cysts is uncommon. When a cutaneous epidermal cyst turns malignant, it is mostly squamous cell carcinoma, and basal cell carcinoma is rare. We present the case of a 58-year-old man with basal cell carcinoma originating from an epidermal cyst on the buttocks. Histopathological analysis with hematoxylin- eosin (H&E) staining showed the presence of the cyst, the wall of which was partially replaced by a malignant tumor. Moreover, the cyst was filled with malignant tumor cells in some areas. The tumor cells were basaloid, and extended through the dermis down to the subcutaneous tissue in a solid pattern. Immunoperoxidase staining for Ber-EP4 was positive. To our knowledge, there are 11 reported cases of BCC originating from epidermal cysts in English, and we reviewed these reports and examined potential trends. We estimate that some longstanding epidermal cysts may have the potential of malignant transformation, and chronic and repeated irritation might trigger malignancy from epidermal cysts. We emphasize that benignlooking cystic lesions showing progressive growth should be examined histopathologically.

scholarly journals Nodular trichoblastoma or basal cell carcinoma: A diagnostic dilemma of clinical significance

2021 ◽  
Vol 7 (4) ◽  
pp. 370-373
Author(s):  
Vaanika Kaira ◽  
Pankaj Kaira ◽  
Mamta Verma
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Basal Cell ◽  
Hair Follicles ◽  
Diagnostic Dilemma ◽  
Histological Features ◽  
Adnexal Tumor ◽  
Ihc Markers

Nodular Trichoblastoma (TB) is a rare and benign adnexal tumor originating from rudimentary hair follicles. Adnexal neoplasms show complex clinical and histological features. A panel of immunohistochemical (IHC) markers helps in distinguishing tumors of follicular origin from other cutaneous tumors especially Basal cell carcinoma (BCC). We herein describe the histological and immunohistochemical features of TB which clinically and histologically mimiced BCC.

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