scholarly journals Nodular trichoblastoma or basal cell carcinoma: A diagnostic dilemma of clinical significance

2021 ◽  
Vol 7 (4) ◽  
pp. 370-373
Author(s):  
Vaanika Kaira ◽  
Pankaj Kaira ◽  
Mamta Verma
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Basal Cell ◽  
Hair Follicles ◽  
Diagnostic Dilemma ◽  
Histological Features ◽  
Adnexal Tumor ◽  
Ihc Markers

Nodular Trichoblastoma (TB) is a rare and benign adnexal tumor originating from rudimentary hair follicles. Adnexal neoplasms show complex clinical and histological features. A panel of immunohistochemical (IHC) markers helps in distinguishing tumors of follicular origin from other cutaneous tumors especially Basal cell carcinoma (BCC). We herein describe the histological and immunohistochemical features of TB which clinically and histologically mimiced BCC.

scholarly journals Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia

2006 ◽  
Vol 26 (17) ◽  
pp. 6609-6622 ◽  
Author(s):  
Erica Nieuwenhuis ◽  
Jun Motoyama ◽  
Paul C. Barnfield ◽  
Yoshiaki Yoshikawa ◽  
Xiaoyun Zhang ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Genetic Disorder ◽  
Skin Lesions ◽  
Hair Follicles ◽  
Limb Bud ◽  
Epidermal Hyperplasia ◽  
Phenotypic Analysis ◽  
Developmental Abnormalities

ABSTRACT Hedgehog (Hh) signaling plays pivotal roles in tissue patterning and development in Drosophila melanogaster and vertebrates. The Patched1 (Ptc1) gene, encoding the Hh receptor, is mutated in nevoid basal cell carcinoma syndrome, a human genetic disorder associated with developmental abnormalities and increased incidences of basal cell carcinoma (BCC) and medulloblastoma (MB). Ptc1 mutations also occur in sporadic forms of BCC and MB. Mutational studies with mice have verified that Ptc1 is a tumor suppressor. We previously identified a second mammalian Patched gene, Ptc2, and demonstrated its distinct expression pattern during embryogenesis, suggesting a unique role in development. Most notably, Ptc2 is expressed in an overlapping pattern with Shh in the epidermal compartment of developing hair follicles and is highly expressed in the developing limb bud, cerebellum, and testis. Here, we describe the generation and phenotypic analysis of Ptc2 tm1/tm1 mice. Our molecular analysis suggests that Ptc2 tm1 likely represents a hypomorphic allele. Despite the dynamic expression of Ptc2 during embryogenesis, Ptc2 tm1/tm1 mice are viable, fertile, and apparently normal. Interestingly, adult Ptc2 tm1/tm1 male animals develop skin lesions consisting of alopecia, ulceration, and epidermal hyperplasia. While functional compensation by Ptc1 might account for the lack of a strong mutant phenotype in Ptc2-deficient mice, our results suggest that normal Ptc2 function is required for adult skin homeostasis.

A Monoclonal Antibody Established from the Immunization of Basal Cell Carcinoma (BCC) Tissues Reacts to the Intercellular Space of BCC and Hair Follicles

2002 ◽  
Vol 29 (11) ◽  
pp. 718-725 ◽  
Author(s):  
Satoshi Kore-eda ◽  
Norihisa Matsuyoshi ◽  
Masamichi Ueda ◽  
Yuji Horiguchi ◽  
Yoshiki Miyachi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Intercellular Space ◽  
Hair Follicles

scholarly journals The excision width in surgical treatment of basal cell carcinoma

2006 ◽  
Vol 53 (3) ◽  
pp. 53-57
Author(s):  
M. Jovanovic ◽  
D. Brasanac ◽  
L. Rasulic ◽  
M. Colic ◽  
M. Stojicic ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Cell Cancer ◽  
Basal Layer ◽  
Hair Follicles ◽  
Histological Type ◽  
Basal Cell Cancer ◽  
External Covering

Basal cell carcinoma originates from pluripotent cells of basal layer of epiderm, external covering of hair follicles, sebaceous glands or other skin adnexa. It is characterized by local infiltrating and sometimes destructive growth. There are several types of basal cell carcinomas that may be manifested in over 12 clinical forms. Surgical treatment depends to a large extent on the histological type, localization and its clinical manifestation. The analysis included 250 patients of both gender and different age, operated for basal cell carcinoma. Clinical characteristics of basal cell carcinoma and the width of the excision were described. It was concluded that the width of the excision of basal cell cancer was in relation to histological type. .

Multiple nevoid basal-cell carcinoma syndrome (Gorlin's syndrome): Possible confusion with metastatic medulloblastoma

1979 ◽  
Vol 50 (1) ◽  
pp. 100-102 ◽  
Author(s):  
John C. Hawkins ◽  
Harold J. Hoffman ◽  
Laurence E. Becker
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Total Excision ◽  
Diagnostic Dilemma ◽  
Content Type ◽  
X Ray ◽  
Lytic Lesions ◽  
Fine Print

✓ The authors report a diagnostic dilemma involving a child who, 8 years previously, had total excision of a medulloblastoma. On x-ray studies, lytic lesions of the skull were seen. The differential diagnosis and some of the clinical and pathological aspects of the nevoid basal-cell carcinoma syndrome versus metastases are discussed.

scholarly journals Histological and Clinical Features of Primary and Recurrent Periocular Basal Cell Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Guy J. Ben Simon ◽  
Semion Lukovetsky ◽  
Fabio Lavinsky ◽  
Nahum Rosen ◽  
Mordechai Rosner
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Clinical Characteristics ◽  
Frozen Section ◽  
Surgical Excision ◽  
Anatomical Location ◽  
Duration Of Symptoms ◽  
Histological Features ◽  
Margin Control

Background. Basal cell carcinoma (BCC) is the most common malignancy of the eyelids. Medial canthal BCCs tends to recur more often. Purpose. To evaluate the clinical and histological features of primary and recurrent periocular BCC, in order to identify any existing associations. Methods. Data from 87 patients (71 primary and 16 recurrent) were analyzed in this study. All patients underwent tumor excision with frozen section margin control at the Goldschleger Eye Institute between 1/1995 to 12/1997. Statistical analysis was performed to identify possible associations between histological and clinical characteristics of primary and recurrent BCC. Main Outcome Measures. Anatomical location, clinical presentation, and histology of peri-ocular BCC. Results. No association was found between histopathological and clinical characteristics of BCC. Similar features with regard to eyelid location and histology were found in primary and recurrent peri-ocular BCCs, whereas recurrent BCCs tended to involve a greater eyelid extent with a longer duration of symptoms. Medial canthal BCCs, morpheaform, or sclerosing histology were not more common in the recurrent BCC group. Conclusions. Similar clinical and histological characteristics were noted in primary and recurrent periocular BCC, implying that incomplete surgical excision rather than anatomical location or histological features is the main cause for recurrence.

scholarly journals The Role Protein Sonic Hedgehog in Carcinoma Basal Cell

2020 ◽  
Vol 5 (1) ◽  
pp. 212-218
Author(s):  
Yulia Farida Yahya ◽  
Radema Maradom ◽  
Hari Darmawan ◽  
Theresia L. Toruan ◽  
Ika Kartika
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Significant Relationship ◽  
Hair Follicles ◽  
Chi Square ◽  
Gene Target ◽  
Paraffin Block ◽  
Chi Square Test ◽  
Histopathologic Features

A B S T R A C TIntroduction: Basal cell carcinoma (KSB) is a non-melanoma skin cancer (KKNM),which is most commonly found compared to other skin cancers. KSB originates fromstem cells in the bulk of hair follicles or inter-follicular epidermis, through the Sonichadgehog (SHH) activation pathway, an increase in Sonic hadgehog (SHH) proteinexpression, involving Patches protein (PTCH), smothened protein (SMO), in the formof increased protein transcription activation Glia (GLI) in the nucleus, binds to DNAto initiate tumor-aggressive growth and tissue. Objective: to determine therelationship between Sonic hadgehog (SHH) expression and non-aggressive andaggressive basal cell carcinoma. Methods: The study was carried out in anobservational laboratory with 35 primary KSB patients, the tissue was taken usingelliptic biopsy technique, made paraffin block specimens for histopathologicalexamination of the subtype of KSB consisting of 20 non-aggressive KSB patients,namely nodular and superficial KSB; 15 patients with aggressive KSB werepigmented KSB; Infiltrates KSB, micronodular KSB, metypical KSB (basosquamousKSB) and SHH immunohistochemical (CPI) examination using SHH antibodies, inthe Anatomy Pathology section, FK Unsri / RSMH Palembang. The characteristics ofKSB patients were recorded, namely sex, age, occupation based on the length ofexposure to BC, namely exposure <3 hours / day, exposure 3-6 hours / day,exposure ≥ 6 hours / day. The data were processed using the Statistical AnalysisSoftware Package (SPSS) version 20.0 (IBM Corporation), tested with Pearsoncorrelation test and chi square test and presented in the form of diagrams, andnarrative tables. Results: Pearson's test showed a significant correlation betweenthe clinical features of KSB and the histopathologic features of non-aggressive andaggressive types of KSB (p 0.020), there was a significant relationship between thesubtypes of histopathologic features of KSB with non-aggressive and aggressivetypes of KSB (p 0.000), there was a significant relationship between strong SHHexpression and BCC aggressive compared to non-aggressive KSB, p 0.000 (p <05α),and r = 732 Conclusion: There is a relationship between SHH expression and KSBaggressiveness. The increase in strong SHH expression shows the aggressiveness ofKSB, SHH expression can be used as a biological gene target both as a prognosticindicator and can be used as a target for treatment of aggressive KSB, especially inthe elderly.

Clinical significance ofIL-2andIL-10gene polymorphisms and serum levels in patients with basal-cell carcinoma

2016 ◽  
Vol 10 (2) ◽  
pp. 185-195 ◽  
Author(s):  
Michał Sobjanek ◽  
Monika Zabłotna ◽  
Ewa Bień ◽  
Jolanta Gleń ◽  
Małgorzata Sokołowska-Wojdyło ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Basal Cell ◽  
Serum Levels
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