scholarly journals Epidermal Proliferation and Differentiation in Ichthyosis Vulgaris

2021 ◽  
Vol 5 (2) ◽  
pp. 266-278
Author(s):  
Nopriyati ◽  
Deddy Deddy ◽  
Rusmawardiana ◽  
Mutia Devi
Keyword(s):  
Human Body ◽  
Therapeutic Target ◽  
External Environment ◽  
Epidermal Differentiation ◽  
Proteolytic Degradation ◽  
Ichthyosis Vulgaris ◽  
Proliferation And Differentiation ◽  
Epidermal Proliferation ◽  
Keratolytic Agents ◽  
Chromosome 1Q21

A B S T R A C TEpidermal proliferation and differentiation is a physiological process which playscrucial role in protecting human body from external environment. Ichthyosisvulgaris is a disease caused by disruption of epidermal differentiation process.Disrupted of profilaggrin conversion to filaggrin caused by mutations from thefilaggrin gene (FLG) located on chromosome 1q21. Recently, caused of ichthyosisvulgaris is mutation of the CASP14 gene on chromosome 19p13.12 which producescaspase-14, is involved in the proteolytic degradation of filaggrin. Clinicalmanifestations of ichthyosis vulgaris are hyperlinear palmar and plantar, keratosispilaris, xerosis, and localized or generalized scaling of the skin. Application ofemollients, humectants and keratolytic agents are the main treatment of ichthyosisvulgaris. Further research on caspase-14 as a therapeutic target is needed in thetreatment of ichthyosis vulgaris.

scholarly journals IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

2021 ◽  
Vol 22 (14) ◽  
pp. 7538
Author(s):  
Hitomi Sugino ◽  
Yu Sawada ◽  
Motonobu Nakamura
Keyword(s):  
Immune Response ◽  
Autoimmune Diseases ◽  
Organ Dysfunction ◽  
Human Body ◽  
Therapeutic Approach ◽  
Viral Infections ◽  
External Environment ◽  
Iga Vasculitis ◽  
Epigenetic Changes ◽  
Flexible Response

IgA, previously called Henoch-Schönlein vasculitis, is an essential immune component that drives the host immune response to the external environment. As IgA has the unique characteristic of a flexible response to broad types of microorganisms, it sometimes causes an autoreactive response in the host human body. IgA vasculitis and related organ dysfunction are representative IgA-mediated autoimmune diseases; bacterial and viral infections often trigger IgA vasculitis. Recent drug developments and the presence of COVID-19 have revealed that these agents can also trigger IgA vasculitis. These findings provide a novel understanding of the pathogenesis of IgA vasculitis. In this review, we focus on the characteristics of IgA and symptoms of IgA vasculitis and other organ dysfunction. We also mention the therapeutic approach, biomarkers, novel triggers for IgA vasculitis, and epigenetic modifications in patients with IgA vasculitis.

scholarly journals Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

2002 ◽  
Vol 159 (1) ◽  
pp. 103-112 ◽  
Author(s):  
Ti Cai ◽  
Keigo Nishida ◽  
Toshio Hirano ◽  
Paul A. Khavari
Keyword(s):  
Epidermal Cell ◽  
Mapk Signaling ◽  
Dominant Negative ◽  
Mapk Activity ◽  
Ras Activation ◽  
Proliferation And Differentiation ◽  
Epidermal Proliferation ◽  
Epidermal Growth ◽  
Docking Protein

În epidermis, Ras can influence proliferation and differentiation; however, regulators of epidermal Ras function are not fully characterized, and Ras effects on growth and differentiation are controversial. EGF induced Ras activation in epidermal cells along with phosphorylation of the multisubstrate docking protein Gab1 and its binding to SHP-2. Expression of mutant Gab1Y627F deficient in SHP-2 binding or dominant-negative SHP-2C459S reduced basal levels of active Ras and downstream MAPK proteins and initiated differentiation. Differentiation triggered by both Gab1Y627F and SHP-2C459S could be blocked by coexpression of active Ras, consistent with Gab1 and SHP-2 action upstream of Ras in this process. To study the role of Gab1 and SHP-2 in tissue, we generated human epidermis overexpressing active Gab1 and SHP-2. Both proteins stimulated proliferation. In contrast, Gab1Y627F and SHP-2C459S inhibited epidermal proliferation and enhanced differentiation. Consistent with a role for Gab1 and SHP-2 in sustaining epidermal Ras/MAPK activity, Gab1−/− murine epidermis displayed lower levels of active Ras and MAPK with postnatal Gab1−/− epidermis, demonstrating the hypoplasia and enhanced differentiation seen previously with transgenic epidermal Ras blockade. These data provide support for a Ras role in promoting epidermal proliferation and opposing differentiation and indicate that Gab1 and SHP-2 promote the undifferentiated epidermal cell state by facilitating Ras/MAPK signaling.

Comparison of clinical and cost effectiveness of accelerated study of sterility of intravascular catheters and drains

2021 ◽  
pp. 44-47
Author(s):  
V. G. Kormilitsyna ◽  
V. G. Zaletaeva ◽  
S. O. Sharapchenko ◽  
R. Sh. Saidgareev ◽  
M. Yu. Sinyak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cost Effectiveness ◽  
Hospital Mortality ◽  
Human Body ◽  
External Environment ◽  
Invasive Procedure ◽  
Central Venous ◽  
Life Threatening ◽  
Associated Conditions ◽  
Intravascular Catheters

The results of a new method for detecting the contamination of intravascular catheters and drains are presented to assess its clinical and cost-effectiveness. Catheters are one of the most widely used devices in critically ill patients. The insertion of a catheter into the central venous system is an invasive procedure that can potentially lead to life-threatening complications for the patient. Catheters are a gateway for infection as they connect the external environment to the internal parts of the human body, causing catheter-associated infections. More than 15 % of patients with an established IVC develop complications, of which the most frequent and requiring removal of the vascular catheter are infectious (5–26 %) and mechanical (up to 25 %). Risk factors for catheter-associated conditions are crucial for hospital mortality.

Genetic Analysis of the Epidermal Differentiation Complex (EDC) on Human Chromosome 1q21: Chromosomal Orientation, New Markers, and a 6-Mb YAC Contig

Genomics ◽  
1996 ◽  
Vol 37 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Ingo Marenholz ◽  
Armin Volz ◽  
Andreas Ziegler ◽  
Angela Davies ◽  
Ioannis Ragoussis ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Human Chromosome ◽  
Epidermal Differentiation ◽  
Epidermal Differentiation Complex ◽  
Yac Contig ◽  
Chromosome 1Q21

Preposterous Nature in Shakespeare’s Tragedies

2016 ◽  
Author(s):  
Philip Armstrong
Keyword(s):  
Early Modern ◽  
Human Body ◽  
External Environment ◽  
Bruno Latour ◽  
Representations Of Nature

Nature is always a slippery word, not least in Shakespeare’s tragedies. This chapter focuses on the plays’ evocations of and engagements with material nature, in regard to both the external environment (for example weather, plants and animals) and the human body (for example the various humoural substances and vital spirits that constitute what Gail Kern Paster calls the ‘psychophysiology’ of the early modern body). In so doing, the chapter seeks to demonstrate some of the differences between Shakespearean representations of nature and those bequeathed by what Bruno Latour calls ‘the Modern Constitution’.

scholarly journals Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation

2016 ◽  
Vol 26 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Teresa Tsai ◽  
Sophie Veitinger ◽  
Irina Peek ◽  
Daniela Busse ◽  
Josephine Eckardt ◽  
...  
Keyword(s):  
Olfactory Receptors ◽  
Proliferation And Differentiation ◽  
Epidermal Proliferation
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