An association between heart rate variability and serum cortisol, dehydroepiandrosterone-sulfate, as an index of stress status and adrenal insufficiency

The purpose of this study was to evaluate whether linear and non-linear measures of heart rate variability (HRV) could be used as indicators of piglet castration pain. Thirty piglets were allocated to 1 of 4 treatments: i) sham castrated HRV (SHRV; n = 8); ii) surgical castrated HRV (CHRV; n = 7); iii) sham castrated blood collection (SBC; n = 7); or iv) surgical castrated blood collection (CBC; n = 8). Piglets in the SHRV and CHRV treatment groups underwent a 1-h HRV and postural behaviour evaluation on day –1, day 0 (castration treatment), day 1 and day 3 of the experimental procedure. Piglets in the SBC and CBC groups underwent blood collection for serum cortisol analysis at –0.5, 1, 2, 3, 24, 48 and 72 h relative to castration treatment. Castrated piglets (CHRV) exhibited greater low to high frequency ratio, lower sample entropy and greater percent determinism compared to SHRV piglets, indicating greater pain-related stress due to the surgical castration procedure. Serum cortisol was greater in CBC pigs at 1 h post-castration compared to SBC piglets. No effect of treatment was found for amount of time spent lying post-castration. In conclusion, surgically castrated pigs exhibited greater pain-related stress than their sham castrated counterparts. Additionally, non-linear HRV measures seem to complement traditional linear HRV measures and may be valuable for assessing pain-related stress in future studies investigating swine welfare.

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Saturated Fat Intake Is Related to Heart Rate Variability in Women with Polycystic Ovary Syndrome

Annals of Nutrition and Metabolism ◽

10.1159/000484325 ◽

2017 ◽

Vol 71 (3-4) ◽

pp. 224-233 ◽

Cited By ~ 3

Author(s):

Scheila K. Graff ◽

Fernanda M. Mario ◽

Jose A. Magalhães ◽

Ruy S. Moraes ◽

Poli Mara Spritzer

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Polycystic Ovary Syndrome ◽

Dietary Intake ◽

Fruits And Vegetables ◽

Polycystic Ovary ◽

Dehydroepiandrosterone Sulfate ◽

Sex Hormone Binding Globulin ◽

Calorie Intake ◽

Ovary Syndrome

Background/Aims: There is a heightened risk for cardiovascular diseases in women with polycystic ovary syndrome (PCOS). Alterations in heart rate variability (HRV) may reflect subclinical cardiovascular disease, with a putative association between HRV and dietary fat. This study evaluated HRV in PCOS and control women based on the dietary intake of saturated fatty acid (SFA). Methods: Biochemical/hormonal profile, resting metabolic rate, physical activity, HRV in response to the Stroop test, and dietary intake were assessed in 84 PCOS and 54 control women stratified by median SFA intake in the PCOS group (8.5% of daily energy intake). Results: Body mass index (p = 0.041), blood pressure (p < 0.01), and HOMA-IR (p = 0.003) were higher in PCOS vs. controls. PCOS women had higher testosterone (p = 0.001), dehydroepiandrosterone sulfate (p = 0.012), and free androgen index (p = 0.001), and lower sex hormone-binding globulin levels than controls (p = 0.001). In both groups, the clinical profile and calorie intake were similar between SFA categories. In PCOS, testosterone was lower when SFA intake <8.5%. PCOS women with SFA <8.5% consumed more beans, fruits, and vegetables and had better frequency and time domain HRV indices. No differences in HRV were detected between SFA categories in controls. In PCOS, age and SFA intake were independent predictors of HRV. Conclusions: Lower SFA intake is related to improved cardiovascular autonomic function in PCOS.

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Association between Disease Severity, Heart Rate Variability (HRV) and Serum Cortisol Concentrations in Horses with Acute Abdominal Pain

Animals ◽

10.3390/ani10091563 ◽

2020 ◽

Vol 10 (9) ◽

pp. 1563

Author(s):

Heidrun Gehlen ◽

Maria-Dorothee Faust ◽

Remigiusz M. Grzeskowiak ◽

Dagmar S. Trachsel

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Pearson Correlation ◽

Serum Cortisol ◽

Autonomous Nervous System ◽

Noninvasive Technique ◽

Laboratory Variables ◽

Group 3 ◽

Over Time ◽

Group 1

Heart rate variability (HRV) is a noninvasive technique to detect changes in the autonomous nervous system. It has rarely been investigated in horses with colic. Therefore, the objective was to assess the evolution of HRV parameters and cortisol concentrations in horses with colic. The 43 horses included in this study were categorized into three groups according to the treatment (1, surgical; 2, conservative; 3, euthanized). The HRV and laboratory variables were measured at admission (T1), the day after admission (T2), and at discharge (T3) and compared between groups and over time with an ANOVA with Bonferroni correction. Relationships between the HRV parameters themselves and the laboratory variables was assessed by Pearson correlation coefficients. Evolution of the heart rate (HR) over time, mean normal to normal R intervals (meanNN) and cortisol concentrations indicate a decreased sympathetic stimulation over time in group 1 and 2, in contrast to group 3. For group 3, the meanNN and HR differed significantly to group 2 at T1 and to group 1 and 2 at T2. Treatment induced a change in the HRV and cortisol response in horses managed conservatively or surgically but not in horses that required euthanasia. However, further studies are required to assess the validity of HRV analyses in horses with colic.

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Adrenal Insufficiency, Heart Rate Variability, and Complex Biologic Systems: A Study of 1,871 Critically Ill Trauma Patients

Yearbook of Surgery ◽

10.1016/s0090-3671(08)79182-1 ◽

2008 ◽

Vol 2008 ◽

pp. 86-87

Author(s):

D.W. Mozingo

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Adrenal Insufficiency ◽

Critically Ill ◽

Trauma Patients

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Heart rate variability, serum cortisol levels and temperament in a sample of workers exposed to occupational stress: a preliminary report

Psychology Health & Medicine ◽

10.1080/13548506.2021.2019812 ◽

2021 ◽

pp. 1-8

Author(s):

Rodolfo Buselli ◽

Antonello Veltri ◽

Martina Corsi ◽

Riccardo Marino ◽

Gabriele Necciari ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Occupational Stress ◽

Preliminary Report ◽

Serum Cortisol ◽

Cortisol Levels

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Early and late analysis of postpartum stress in newborn foals

Arquivo Brasileiro de Medicina Veterinária e Zootecnia ◽

10.1590/1678-4162-9205 ◽

2017 ◽

Vol 69 (4) ◽

pp. 785-792

Author(s):

R.K.S. Cruz ◽

A. Alfonso ◽

M.L.G. Lourenço ◽

F.F. Souza ◽

E. Oba ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Blood Glucose ◽

Negative Correlation ◽

Serum Cortisol ◽

The Other ◽

Environment Adaptation ◽

Neonatal Stress ◽

Postpartum Stress ◽

Positive Correlations

ABSTRACT The aim of this study was to evaluate newborn foals stress in the first 48 hours of life. Heart rate (HR), heart rate variability (HRV) and serum cortisol concentrations, blood glucose, and lactate were determined in foals (n = 20, Paint Horse). Cortisol concentrations decreased significantly between four and 48 hours, with the highest concentration at 4 hours after birth. Positive correlations between cortisol and lactate occurred between 12 and 16 hours. And there was a negative correlation between cortisol and lactate 4 hours after birth. Among the values obtained for HR, there was significantly difference between the the value obtained at twelve hours of life moment and all the other moments measured, the highest values were at birth, 24 and 48 hours of life. Among HRV indexes, there were no statistical differences between the variables analysed. The cortisol, HR and HRV alterations were consistent to neonatal stress, but might be related to extrauterine environment adaptation associated to sympathoadrenal response, since those foals were healthy.

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