scholarly journals Caffeic Acid Phenethyl Ester with Mesenchymal Stem Cells Improve Behavioral and Histopathological Changes in the Rat Model of Parkinson' Disease

2021 ◽  
Author(s):  
Khojasteh Rahimi Jaberi ◽  
◽  
Manouchehr Safari ◽  
Vahid Semnani ◽  
Hamid Reza Sameni ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Caffeic Acid ◽  
Dopaminergic Neurons ◽  
Intranasal Administration ◽  
Caffeic Acid Phenethyl Ester ◽  
Substantia Nigra Pars Compacta ◽  
Tunel Staining ◽  
Apoptotic Cells ◽  
Protective Effects

Introduction: Parkinson's disease (PD) is the result of the destruction of Dopaminergic neurons in the brain. The aim of this study was to investigate the protective effects of natural antioxidants such as caffeic acid phenethyl ester for the maintenance of these neurons. Methods: Caffeic acid phenethyl ester (CAPE) is one of the main ingredients of Propolis. Intranasal administration of (1-methyl-4-phenyl-2;3;4;6-tetrahydropyridine) MPTP was used to generate PD model in rats. 2× 106 bone marrow stem cells (BMSCs) were injected from tail vein. Behavioral test, Immunohistochemistry, DiI, cresyl fast violet, TUNEL staining were evaluated, 2 weeks after treatment. Results: DiI staining method revealed in all treatment groups using stem cells, the cells migrated to the substantia nigra pars compacta after injection. Treatment with CAPE significantly protects dopaminergic neurons from MPTP. The highest number of tyrosine hydroxylase (TH (positive neurons was seen in group Pre CAPE+PD+Stem cell. The number of TH+ cells in all groups that received CAPE was significant in compared to groups that received the stem cells only (P <0.001). Intranasal administration of MPTP significantly increase the number of apoptotic cells. The lowest number of apoptotic cells was in group Pre CAPE+PD+ Stem cell. Conclusion: The results showed that the use of CAPE and stem cells in Parkinson's rats caused a significant reduction in the apoptotic cells.

AB0162 Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) on Cyclophosphamide Induced Hemorrhagic Cystitis in Rats

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 944.4-945
Author(s):  
E. Uysal ◽  
H.R. Yılmaz ◽  
Y. Ugan ◽  
A. Altuntas ◽  
A. Doğru ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Hemorrhagic Cystitis ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Effects

scholarly journals Antioxidant Effects of Caffeic Acid Lead to Protection of Drosophila Intestinal Stem Cell Aging

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiao Sheng ◽  
Yuedan Zhu ◽  
Juanyu Zhou ◽  
La Yan ◽  
Gang Du ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Caffeic Acid ◽  
Stress Responses ◽  
Adult Stem Cells ◽  
Cell Function ◽  
Cell Aging ◽  
Positive Effects ◽  
Age Related ◽  
Tissue Aging

The dysfunction or exhaustion of adult stem cells during aging is closely linked to tissue aging and age-related diseases. Circumventing this aging-related exhaustion of adult stem cells could significantly alleviate the functional decline of organs. Therefore, identifying small molecular compounds that could prevent the age-related decline of stem cell function is a primary goal in anti-aging research. Caffeic acid (CA), a phenolic compound synthesized in plants, offers substantial health benefits for multiple age-related diseases and aging. However, the effects of CA on adult stem cells remain largely unknown. Using the Drosophila midgut as a model, this study showed that oral administration with CA significantly delayed age-associated Drosophila gut dysplasia caused by the dysregulation of intestinal stem cells (ISCs) upon aging. Moreover, administering CA retarded the decline of intestinal functions in aged Drosophila and prevented hyperproliferation of age-associated ISC by suppressing oxidative stress-associated JNK signaling. On the other hand, CA supplementation significantly ameliorated the gut hyperplasia defect and reduced environmentally induced mortality, revealing the positive effects of CA on tolerance to stress responses. Taken together, our findings report a crucial role of CA in delaying age-related changes in ISCs of Drosophila.

Protective effects of caffeic acid phenethyl ester (CAPE) on amikacin-induced nephrotoxicity in rats

2006 ◽  
Vol 24 (4) ◽  
pp. 363-367 ◽  
Author(s):  
Hakan Parlakpinar ◽  
Mehmet Kaya Özer ◽  
Muharrem Ucar ◽  
Muhammed Gaffaroglu ◽  
Nigar Vardi ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Effects

scholarly journals Apelin-13 Protects Dopaminergic Neurons against Rotenone—Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation

2020 ◽  
Vol 21 (21) ◽  
pp. 8376
Author(s):  
Peng Chen ◽  
Youcui Wang ◽  
Leilei Chen ◽  
Ning Song ◽  
Junxia Xie
Keyword(s):  
Dopaminergic Neurons ◽  
Substantia Nigra Pars Compacta ◽  
Protective Effects ◽  
Gut Peptides ◽  
Neuroprotective Effects ◽  
Compound C ◽  
Apelin Receptor ◽  
Signaling Activation

Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Several brain–gut peptides are able to exert neuroprotective effects on the nigrostriatal dopaminergic system. Apelin-13 is a neuropeptide, conveying potential neuroprotective activities. However, whether, and how, apelin-13 could antagonize rotenone-induced neurotoxicity has not yet been elucidated. In the present study, rotenone-treated SH-SY5Y cells and rats were used to clarify whether apelin-13 has protective effects on dopaminergic neurons, both in vivo and in vitro. The results showed that apelin-13 could protect SH-SY5Y cells from rotenone-induced injury and apoptosis. Apelin-13 was able to activate autophagy, and restore rotenone induced autophagy impairment in SH-SY5Y cells, which could be blocked by the autophagy inhibitor 3-Methyladenine. Apelin-13 activated AMPK/mTOR/ULK-1 signaling, AMPKα inhibitor compound C, as well as apelin receptor blockage via siRNA, which could block apelin-13-induced signaling activation, autophagy activation, and protective effects, in rotenone-treated SH-SY5Y cells. These results indicated that apelin-13 exerted neuroprotective properties against rotenone by stimulating AMPK/mTOR/ULK-1 signaling-mediated autophagy via the apelin receptor. We also observed that intracerebroventricular injection of apelin-13 could alleviate nigrostriatal dopaminergic neuron degeneration in rotenone-treated rats. Our findings provide new insights into the mechanism by which apelin-13 might attenuate neurotoxicity in PD.

Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats

2009 ◽  
Vol 65 (4) ◽  
pp. 339-344 ◽  
Author(s):  
S. Oktar ◽  
Z. Yönden ◽  
M. Aydin ◽  
S. Ilhan ◽  
E. Alçin ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Liver Damage ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Effects

Protective Effects of Caffeic Acid Phenethyl Ester on Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats

2015 ◽  
Vol 29 (12) ◽  
pp. 559-563 ◽  
Author(s):  
Ersin Uysal ◽  
H. Ramazan Yılmaz ◽  
Yunus Ugan ◽  
Atila Altuntas ◽  
Atalay Dogru ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Hemorrhagic Cystitis ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Effects
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