Formulation, Development and Evaluation of Colloidosomes of Glipizide

Glipizide is a potent oral antidiabetic agent, a second generation sulphonyl urea used in lowering blood glucose in patients with type II diabetes mellitus. It has a short half life of 2-4 hours. The objective of the present study was development and evaluation of colloidosomes of glipizide for controlled/sustained drug release. An attempt was made to formulate and evaluate colloidosomes of glipizide as a model drug using water in oil emulsion based method by using CaCO3 with a view to deliver drug at controlled/sustained manner in GIT and consequently into systemic circulation. The prepared colloidosomes were evaluated for particle size, shape and surface morphology, FTIR study, % yield, zeta potential, SEM, % drug entrapment efficiency and in-vitro drug release studies. The obtained colloidosomes were found to be discrete and spherical in shape and found to possess mean particle size range of 2228 nm to 3551 nm. The drug entrapment efficiency was found to be 52.13±1.2% to 71.18±1.25%. Amongst the prepared batches, Glipizide colloidosomes of Batch C formulation were stable and exhibited good sustained release of the drug for a period of 12 hours.The release profile was compared with alginate gel spheres. This implied that the developed formulations have a potential to deliver the drug in a sustained manner. This outcome from the release profiling strongly recommends that the developed glipizide loaded colloidosomes may prove to be a useful delivery carrier to deliver the drug in controlled release manner which is a prime requirement for the treatment of type II diabetes mellitus.

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A comparative study on effect of polymers on release kinetics glimepiride matrix tablet

Pharmaceutical and Biological Evaluations ◽

10.26510/2394-0859.pbe.2017.16 ◽

2017 ◽

Vol 4 (2) ◽

pp. 103

Author(s):

Sonia Chowdhury ◽

Mandava Nithin Babu ◽

K. Ankitha ◽

B. Shirisha ◽

Madhurika Sirigadi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Drug Release ◽

Type Ii Diabetes ◽

Release Kinetics ◽

Type Ii Diabetes Mellitus ◽

Matrix Tablet ◽

Type Ii ◽

Stability Studies ◽

Natural Polymers ◽

Sustained Release Formulation

Objective: The Present investigation was performed to find out the effect of synthetic and natural polymers on the release properties of glimepiride matrix tablet. Glimepiride is a first third generation sulphonyl urea agent for the treatment of type- II diabetes mellitus. Methocel K15M, Olibanum Gum were used as key release modifying polymers.Methods: Nine formulations were prepared taking different concentration of natural and synthetic polymers, The drug excipient mixtures were subjected to pre-compression studies. The tablets were prepared by direct compression method; all formulations were subjected to physicochemical studies, in- vitro drug release, kinetic studies and stability studies. The physicochemical results were found within the limits.Results: FTIR study interpretation did not show any drug–excipient interaction The drug release from the optimized formulation F-7 was extended for a period of 12 hours. The release kinetics of F-7 formulation showed that the release of drug follows zero order models. The optimized formulations were subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern.Conclusions: Results of the present study indicated the suitability of the above mentioned polymers in the preparation of sustained release formulation of Glimepiride for the management of type-II diabetes mellitus effectively.

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