scholarly journals Correlação entre Trihalometanos e o Desenvolvimento do Câncer de Bexiga

2021 ◽  
Vol 67 (4) ◽  
Author(s):  
Beatriz de Almeida Affornalli ◽  
Nadinne Maria Macetti ◽  
Camila Moraes Marques ◽  
Diancarlos Pereira de Andrade ◽  
Rosiane Guetter Mello
Keyword(s):  
Bladder Cancer ◽  
By Products

Introdução: Os trihalometanos (THM) constituem um grupo de subprodutos gerados pela desinfecção da água por meio da cloração. Desde a primeira vez em que foram reportados, em 1974, são alvos de estudos que buscam estabelecer uma relação positiva entre a exposição dos humanos a esses compostos e o desenvolvimento de câncer. Objetivo: Revisão da literatura cientifica disponível sobre a presença de THM na água e sua relação com o desenvolvimento do câncer de bexiga. Método: Levantamento bibliográfico da revisão feito nas bases de dados ScienceDirect e PubMeb. Os descritores utilizados foram ‘‘trihalomethane’’, ‘‘disinfection by-products’’ e ‘‘bladder cancer’’ dos Descritores em Ciências da Saúde (DeCS) da Biblioteca Virtual em Saúde. Os artigos selecionados foram publicados nos últimos cinco anos. Resultados: A amostra final desta revisão foi constituída por 31 artigos, sendo a maioria deles publicados em jornais e revistas sobre meio ambiente. Analisaram-se estudos descritivos, metanálises e outros estudos individuais com delineamento experimental, encontrando uma associação positiva, mas controversa, entre os THM e o câncer, associada a diferentes mecanismos. A relação mais consistente tem sido entre a exposição crônica e o câncer de bexiga. Conclusão: Os estudos reconhecem que existem riscos significativos a saúde relacionados aos THM, no entanto, evidencias que esclareçam os mecanismos de ação e o papel que outros fatores de risco possuem, juntamente com os THM, ainda permanecem incertas.

scholarly journals Total Fluid and Water Consumption and the Joint Effect of Exposure to Disinfection By-Products on Risk of Bladder Cancer

2007 ◽  
Vol 115 (11) ◽  
pp. 1569-1572 ◽  
Author(s):  
Dominique S. Michaud ◽  
Manolis Kogevinas ◽  
Kenneth P. Cantor ◽  
Cristina M. Villanueva ◽  
Monteserrat Garcia-Closas ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Water Consumption ◽  
Joint Effect ◽  
By Products ◽  
Total Fluid

scholarly journals Bladder Cancer and Exposure to Water Disinfection By-Products through Ingestion, Bathing, Showering, and Swimming in Pools

2006 ◽  
Vol 165 (2) ◽  
pp. 148-156 ◽  
Author(s):  
C. M. Villanueva ◽  
K. P. Cantor ◽  
J. O. Grimalt ◽  
N. Malats ◽  
D. Silverman ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Water Disinfection ◽  
By Products

scholarly journals Chlorination by-products in drinking water and risk of bladder cancer – a population-based cohort study

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Emilie Helte ◽  
Melle Säve Söderbergh ◽  
Henrik Ugge ◽  
Katja Fall ◽  
Susanna C. Larsson ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Cohort Study ◽  
Population Based ◽  
By Products

Water disinfection by-products and bladder cancer: is there a European specificity? A pooled and meta-analysis of European case-control studies

2011 ◽  
Vol 68 (5) ◽  
pp. 379-385 ◽  
Author(s):  
N. Costet ◽  
C. M. Villanueva ◽  
J. J. K. Jaakkola ◽  
M. Kogevinas ◽  
K. P. Cantor ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Meta Analysis ◽  
Case Control ◽  
Water Disinfection ◽  
Case Control Studies ◽  
By Products

669 TOTAL FLUID AND WATER CONSUMPTION AND THE JOINT EFFECT OF EXPOSURE TO DISINFECTION BY-PRODUCTS ON RISK OF BLADDER CANCER

2009 ◽  
Vol 8 (4) ◽  
pp. 288 ◽  
Author(s):  
Rojo D. Garcia ◽  
D.S. Michaud ◽  
C. Villanueva ◽  
C. Serra ◽  
N. Rothman ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Water Consumption ◽  
Joint Effect ◽  
By Products ◽  
Total Fluid

Disinfection By-Products and Bladder Cancer in a Case-control Study in New England

2013 ◽  
Vol 2013 (1) ◽  
pp. 3471
Author(s):  
Laura Beane Freeman ◽  
Kenneth P. Cantor ◽  
Dalsu Baris ◽  
John R. Nukcols ◽  
Karla Armenti ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
New England ◽  
Case Control Study ◽  
Case Control ◽  
By Products ◽  
Control Study

40 years on: what do we know about drinking water disinfection by-products (DBPs) and human health?

2015 ◽  
Vol 15 (4) ◽  
pp. 667-674 ◽  
Author(s):  
Steve E. Hrudey ◽  
John Fawell
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Human Health ◽  
Mechanistic Model ◽  
Water Disinfection ◽  
Water Safety ◽  
Consistent Finding ◽  
Increased Risk ◽  
Chlorinated Drinking Water ◽  
By Products

2014 marks the 40th anniversary of the seminal discovery by Johannes Rook, in 1974, that trihalomethanes (THMs) were formed by the chlorination of natural organic matter (NOM) in drinking water. Since this discovery, which revolutionized how we viewed drinking water safety and quality, hundreds of other classes of disinfection by-products (DBPs) have been discovered. The finding in 1976 by the US National Cancer Institute that chloroform, the dominant THM, was a rodent carcinogen spurred a large number of epidemiology and toxicology studies into chlorinated drinking water. In 1985, this cancer finding was shown to be wrong. We should now be asking: What do we know about the human health impacts of DBPs in drinking water? Bladder cancer has been the most consistent finding from epidemiologic studies in North America and Europe and the possibility that chlorinated drinking water contributes an increased risk of bladder cancer remains a viable hypothesis. Despite some recent improvements in exposure assessments to focus on inhalation and dermal exposures rather than ingestion, no causal agent with sufficient carcinogenic potency has been identified, nor has a mechanistic model been validated. Consequently, a sensible precautionary approach to managing DBPs remains the only viable option based on four decades of evidence.

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