669 TOTAL FLUID AND WATER CONSUMPTION AND THE JOINT EFFECT OF EXPOSURE TO DISINFECTION BY-PRODUCTS ON RISK OF BLADDER CANCER

2009 ◽  
Vol 8 (4) ◽  
pp. 288 ◽  
Author(s):  
Rojo D. Garcia ◽  
D.S. Michaud ◽  
C. Villanueva ◽  
C. Serra ◽  
N. Rothman ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Water Consumption ◽  
Joint Effect ◽  
By Products ◽  
Total Fluid

scholarly journals Total Fluid and Water Consumption and the Joint Effect of Exposure to Disinfection By-Products on Risk of Bladder Cancer

2007 ◽  
Vol 115 (11) ◽  
pp. 1569-1572 ◽  
Author(s):  
Dominique S. Michaud ◽  
Manolis Kogevinas ◽  
Kenneth P. Cantor ◽  
Cristina M. Villanueva ◽  
Monteserrat Garcia-Closas ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Water Consumption ◽  
Joint Effect ◽  
By Products ◽  
Total Fluid

Nutrition, total fluid and bladder cancer

2008 ◽  
Vol 42 (sup218) ◽  
pp. 25-36 ◽  
Author(s):  
Maree Brinkman ◽  
Maurice P. Zeegers
Keyword(s):  
Bladder Cancer ◽  
Total Fluid

scholarly journals Bladder Cancer and Exposure to Water Disinfection By-Products through Ingestion, Bathing, Showering, and Swimming in Pools

2006 ◽  
Vol 165 (2) ◽  
pp. 148-156 ◽  
Author(s):  
C. M. Villanueva ◽  
K. P. Cantor ◽  
J. O. Grimalt ◽  
N. Malats ◽  
D. Silverman ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Water Disinfection ◽  
By Products

scholarly journals Age above 70 years and Charlson Comorbidity Index higher than 3 are associated with reduced survival probabilities after radical cystectomy for bladder cancer. Data from a contemporary series of 334 consecutive patients

2021 ◽  
Vol 93 (1) ◽  
pp. 15-20
Author(s):  
Massimo Maffezzini ◽  
Vincenzo Fontana ◽  
Andrea Pacchetti ◽  
Federico Dotta ◽  
Mattia Cerasuolo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Survival Data ◽  
Charlson Comorbidity Index ◽  
Death Rate ◽  
Joint Effect ◽  
Cancer Data ◽  
Multivariate Modelling ◽  
Comorbidity Index ◽  
Nonlinear Trends

Objective: To assess the joint effect of age and comorbidities on clinical outcomes of radical cystectomy (RC).Methods: 334 consecutive patients undergoing open RC for bladder cancer (BC) during the years 2005-2015 were analyzed. Pre-, peri- and post-operative parameters, including age at RC (ARC) and Charlson Comorbidity Index (CCI), were evaluated. Overall and cancer-specific survivals (OS, CSS) were assessed by univariate and multivariate modelling. Furthermore, a three-knot restricted cubic spline (RCS) was fitted to survival data to detect dependency between death-rate ratio (HR) and ARC. Results: Median follow-up time was 3.8 years (IQR = 1.3-7.5) while median OS was 5.9 years (95%CL = 3.8-9.1). Globally, 180 patients died in our cohort (53.8%), 112 of which (62.2%) from BC and 68 patients (37.8%) for unrelated causes. After adjusting for preoperative, pathological and perioperative parameters, patients with CCI > 3 showed significantly higher death rates (HR = 1.61; p = 0.022). The highest death rate was recorded in ARC = 71-76 years (HR = 2.25; p = 0.034). After fitting an RCS to both OS and CSS rates, two overlapping nonlinear trends, with common highest risk values included in ARC = 70-75 years, were observed. Conclusions: Age over 70 years and CCI > 3 were significant factors limiting the survival of RC and should both be considered when comparing current RC outcomes.

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