Case series of seven cases of urticaria, angioedema, and anaphylaxis (LTP syndrome) due to foods (nuts, lentils, and citrus foods) related to tree pollen (Prosopis juliflora and Holoptelea integrifolia) sensitization

Lipid transfer protein syndrome (LTPS) results from a primary sensitization to LTP belonging to the PR-14 family of pathogenesis-related PR-proteins which are plant food allergens, stable against heat and digestive enzymes, and can induce systemic reactions of urticaria, angioedema, and anaphylaxis. Here, we report a case series of seven patients with nsLTP syndrome. Our six cases of LTPS were significantly sensitized to Prosopis juliflora and Holoptelea integrifolia and one case was sensitized to H. integrifolia only. In our seven cases, we hypothesized that symptoms of hypersensitivity reaction to foods were due to cross-reactivity by IgE reactive protein of ns-LTP as a major allergenic protein in foods.

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The many faces of nonspecific Lipid Transfer Protein Allergy (nsLTP) : A case series of patients seen in an adult tertiary allergy centre in the North West of England with nsLTP allergy

10.26226/morressier.5acc8ad4d462b8028d89ac8e ◽

2018 ◽

Author(s):

Roweida Sammour

Keyword(s):

Lipid Transfer Protein ◽

Case Series ◽

Lipid Transfer ◽

North West ◽

Transfer Protein ◽

The North ◽

Nonspecific Lipid Transfer Protein ◽

The Many

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Plant Lipid Transfer Protein Allergens: No Cross-Reactivity between Those from Foods and Olive and Parietaria Pollen

International Archives of Allergy and Immunology ◽

10.1159/000323503 ◽

2011 ◽

Vol 156 (3) ◽

pp. 291-296 ◽

Cited By ~ 37

Author(s):

Leticia Tordesillas ◽

Sofía Sirvent ◽

Araceli Díaz-Perales ◽

Mayte Villalba ◽

Javier Cuesta-Herranz ◽

...

Keyword(s):

Lipid Transfer Protein ◽

Cross Reactivity ◽

Lipid Transfer ◽

Plant Lipid ◽

Transfer Protein

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Characterization of an Oxidative Stress Inducible Nonspecific Lipid Transfer Protein Coding cDNA and its Promoter from Drought Tolerant Plant Prosopis juliflora

Plant Molecular Biology Reporter ◽

10.1007/s11105-009-0127-y ◽

2009 ◽

Vol 28 (1) ◽

pp. 32-40 ◽

Cited By ~ 14

Author(s):

Suja George ◽

Ajay Parida

Keyword(s):

Oxidative Stress ◽

Lipid Transfer Protein ◽

Prosopis Juliflora ◽

Lipid Transfer ◽

Protein Coding ◽

Transfer Protein ◽

Drought Tolerant ◽

Tolerant Plant ◽

Nonspecific Lipid Transfer Protein

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Sensitization Prevalence, Antibody Cross-Reactivity and Immunogenic Peptide Profile of Api g 2, the Non-Specific Lipid Transfer Protein 1 of Celery

PLoS ONE ◽

10.1371/journal.pone.0024150 ◽

2011 ◽

Vol 6 (8) ◽

pp. e24150 ◽

Cited By ~ 37

Author(s):

Gabriele Gadermaier ◽

Michael Hauser ◽

Matthias Egger ◽

Rosetta Ferrara ◽

Peter Briza ◽

...

Keyword(s):

Lipid Transfer Protein ◽

Cross Reactivity ◽

Lipid Transfer ◽

Peptide Profile ◽

Transfer Protein ◽

Immunogenic Peptide ◽

Specific Lipid

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Wheat Apoplast-Localized Lipid Transfer Protein TaLTP3 Enhances Defense Responses Against Puccinia triticina

Frontiers in Plant Science ◽

10.3389/fpls.2021.771806 ◽

2021 ◽

Vol 12 ◽

Author(s):

Jiaojie Zhao ◽

Weishuai Bi ◽

Shuqing Zhao ◽

Jun Su ◽

Mengyu Li ◽

...

Keyword(s):

Leaf Rust ◽

Lipid Transfer Protein ◽

Puccinia Triticina ◽

Defense Responses ◽

Transgenic Wheat ◽

Lipid Transfer ◽

Transfer Protein ◽

Pathogenesis Related ◽

Rust Pathogen ◽

Wheat Lines

Plant apoplast serves as the frontier battlefield of plant defense in response to different types of pathogens. Many pathogenesis-related (PR) proteins are accumulated in apoplastic space during the onset of plant–pathogen interaction, where they act to suppress pathogen infection. In this study, we found the expression of Triticum aestivum lipid transfer protein 3 (TaLTP3) gene was unregulated during incompatible interaction mediated by leaf rust resistance genes Lr39/41 at the early infection stage. Stable transgenic wheat lines overexpressing TaLTP3 exhibited enhanced resistance to leaf rust pathogen Puccinia triticina. Transcriptome analysis revealed that overexpression of TaLTP3 specifically activated the transcription of pathogenesis-related protein 1a (TaPR1a) and multiple plant hormone pathways, including salicylic acid (SA), jasmonic acid (JA), and auxin, in response to the infection of the model bacterial pathogen Pseudomonas syringae pv. tomato DC3000. Further investigation indicated that TaLTP3 physically associated with wheat TaPR1a protein in the apoplast. Transgenic wheat lines overexpressing TaLTP3 and TaPR1a showed higher accumulations of reactive oxygen species (ROS) during plant defense responses. All these findings suggested that TaLTP3 is involved in wheat resistance against leaf rust pathogen infection and forming a TaLTP3-TaPR1a complex in apoplast against this pathogen, which provides new insights into the functional roles of PR proteins.

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Cabbage Lipid Transfer Protein Bra o 3 is a Major Allergen Responsible for Cross-Reactivity between Plant Foods and Pollens

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2005.12.1194 ◽

2006 ◽

Vol 117 (2) ◽

pp. S302

Author(s):

J. Cumplido ◽

A. Palacín ◽

J. Figueroa ◽

O. Ahrazem ◽

R. Sánchez-Monge ◽

...

Keyword(s):

Lipid Transfer Protein ◽

Major Allergen ◽

Cross Reactivity ◽

Lipid Transfer ◽

Plant Foods ◽

Transfer Protein

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Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens

Clinical & Experimental Allergy ◽

10.1111/j.1365-2222.2004.02053.x ◽

2004 ◽

Vol 34 (9) ◽

pp. 1415-1421 ◽

Cited By ~ 90

Author(s):

M. Lombardero ◽

F. J. Garcia-Selles ◽

F. Polo ◽

L. Jimeno ◽

M. J. Chamorro ◽

...

Keyword(s):

Lipid Transfer Protein ◽

Cross Reactivity ◽

Lipid Transfer ◽

Transfer Protein ◽

Art V 1

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A Case Report of Allergy to Peach’s Lipid Transfer Protein

Asian Journal of Pediatric Research ◽

10.9734/ajpr/2021/v6i130186 ◽

2021 ◽

pp. 22-25

Author(s):

F. Yatribi ◽

F. Benbrahim ◽

N. Elhafidi ◽

S. Benchekroun ◽

C. Mahraoui

Keyword(s):

Lipid Transfer Protein ◽

Strong Association ◽

Specific Ige ◽

Skin Tests ◽

Lipid Transfer ◽

Heat Management ◽

Transfer Protein ◽

Primary Sensitization ◽

The Difference ◽

Pru P 3

Peach belongs to the Rosaceae family. One of the particularities of this allergy is the difference in clinical reactivity according to geography. We report a 4-year 8-month-old boy with well-controlled asthma and no symptoms of allergic rhinitis, that at the age of 1 year, 15 minutes after the ingestion of a fruit compote, presented urticaria with respiratory discomfort. At the age of 3 years, following ingestion of fruit salad, the child presented a few minutes later, a similar episode but of greater intensity. At the age of 4, following contact with a fruit basket, the child immediately presented a generalized reaction more severe and intense than the previous ones. Investigation of allergies to aerial allergens was negative. Skin tests for cooked and raw peach were positive for the peel and pulp. Specific-IgE was positive for Pru p 3 (5.7 KIU/l) and negative for Pru p 1. LTPs are particularly stable and resistant to proteolysis and heat. Management consisted of avoidance of peach, education of the child and family, and prescription of an emergency kit including self-injectable adrenaline. Our observation highlights the strong association between Pru p 3: peach’s Lipid Transfer Protein (LTP) positivity and the severity of allergy symptoms. We consider this case as a primary sensitization to peach’s LTP.

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