Highlights of this issue

Clinical psychiatry has always been more accommodative of the divergent methods of scientific enquiry and focus is back on enhancing the core clinical skills in Psychiatry. We are re-discovering the values of single case reports, case series as much as we look forward to systematic reviews. The standardisation of reporting with the acceptance of guidelines (eg.Equator Network) has helped immensely in ensuring transparency and quality of health research. In this issue of the journal, we have articles that cover diverse areas like First Episode Psychosis, Sleep Disorders, Interface of SLE and Psychiatry, medication adherence in depression, antenatal depression, and epigenetics.

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Retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine

BMJ Case Reports ◽

10.1136/bcr-2018-228539 ◽

2019 ◽

Vol 12 (8) ◽

pp. e228539 ◽

Cited By ~ 2

Author(s):

Matthew Roughley ◽

Marc Lyall

Keyword(s):

Side Effects ◽

Low Dose ◽

Case Series ◽

First Episode Psychosis ◽

Retrograde Ejaculation ◽

First Episode ◽

Antipsychotic Medications ◽

Sexual Side Effects ◽

Episode Psychosis

Sexual side-effects are common among those using antipsychotic medication and may result in poor compliance and reduced quality of life. Retrograde ejaculation (RE) has been described occurring with a number of antipsychotic medications (thioridazine, risperidone, iloperidone and clozapine) but there are no guidelines regarding management of antipsychotic-associated RE. Imipramine has been suggested as a treatment for antipsychotic-associated RE in one small study of patients prescribed thioridazine and a case series of patients prescribed iloperidone. Quetiapine is a commonly used antipsychotic and is thought to be associated with less sexual side-effects relative to other antipsychotic medications. This case report describes a 25-year-old man with first episode psychosis who developed RE during treatment with quetiapine which improved with low-dose imipramine. This is the first description of RE occurring with quetiapine and successful treatment of quetiapine-associated RE with imipramine.

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QUALITY OF INDIVIDUAL AND GROUP LEVEL INTERVENTIONS FOR FIRST EPISODE PSYCHOSIS AT THE TERTIARY PSYCHIATRIC HOSPITAL IN UGANDA.

10.31234/osf.io/hrygs ◽

2020 ◽

Author(s):

Emmanuel Kiiza Mwesiga ◽

Noeline Nakasujja ◽

Lawrence Nankaba ◽

Juliet Nakku ◽

Seggane Musisi

Keyword(s):

Psychiatric Hospital ◽

Psychotic Disorders ◽

First Episode Psychosis ◽

First Episode ◽

Group Level ◽

Group Interventions ◽

Episode Psychosis ◽

Essential Components ◽

The Individual

Introduction: Individual and group level interventions have the largest effect on outcomes in patients with the first episode of psychosis. The quality of these individual and group level interventions provided to first-episode psychosis patients in Uganda is unclear.Methods: The study was performed at Butabika National Psychiatric Teaching and referral hospital in Uganda. A retrospective chart review of recently discharged adult in-patients with the first episode of psychosis was first performed to determine the proportion of participants who received the different essential components for individual and group level interventions. From the different proportions, the quality of the services across the individual and group interventions was determined using the first-Episode Psychosis Services Fidelity Scale (FEPS-FS). The FEPS-FS assigns a grade of 1-5 on a Likert scale depending on the proportion of patients received the different components of the intervention. Results: The final sample included 156 first-episode psychosis patients. The median age was 27 years [IOR (24-36)] with 55% of participants of the female gender. 13 essential components across the individual and group interventions were assessed and their quality quantified. All 13 essential components had poor quality with the range of scores on the FEPS-FS of 1-3. Only one essential component assessed (use of single antipsychotics) had moderate quality.Discussion: Among current services at the National psychiatric hospital of Uganda, the essential for individual and group level interventions for psychotic disorders are of low quality. Further studies are required on how the quality of these interventions can be improved.

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P.545 Facial emotion recognition in first-episode psychosis: correlations with functionality and quality of life

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2020.09.397 ◽

2020 ◽

Vol 40 ◽

pp. S306-S307

Author(s):

J. Vouk-Kamenski ◽

D. Bosnjak Kuharic ◽

M. Rojnic Kuzman

Keyword(s):

Quality Of Life ◽

Emotion Recognition ◽

First Episode Psychosis ◽

Facial Emotion Recognition ◽

Facial Emotion ◽

First Episode ◽

Episode Psychosis

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Relationship of subjective quality of life with symptomatology, neurocognition and psychosocial functioning in first-episode psychosis: a structural equation modelling approach

European Archives of Psychiatry and Clinical Neuroscience ◽

10.1007/s00406-021-01309-0 ◽

2021 ◽

Author(s):

Sandra Chi Yiu Wong ◽

Wing Chung Chang ◽

Christy Lai Ming Hui ◽

Sherry Kit Wa Chan ◽

Edwin Ho Ming Lee ◽

...

Keyword(s):

Psychosocial Functioning ◽

Structural Equation ◽

First Episode Psychosis ◽

First Episode ◽

Subjective Quality Of Life ◽

Equation Modelling ◽

Episode Psychosis ◽

Relationship Of ◽

Modelling Approach

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iMAgery focused psychological therapy for persecutory delusions in PSychosis (iMAPS): a multiple baseline experimental case series

Behavioural and Cognitive Psychotherapy ◽

10.1017/s1352465820000168 ◽

2020 ◽

Vol 48 (5) ◽

pp. 530-545

Author(s):

Christopher D.J. Taylor ◽

Penny E. Bee ◽

James Kelly ◽

Richard Emsley ◽

Gillian Haddock

Keyword(s):

Case Series ◽

First Episode Psychosis ◽

Psychological Therapy ◽

Multiple Baseline ◽

Psychotic Symptoms ◽

First Episode ◽

Multiple Baseline Design ◽

Persecutory Delusions ◽

Baseline Design ◽

Episode Psychosis

AbstractBackground:Many people with psychosis experience persecutory delusions and report negative schematic beliefs and intrusive mental images which may be maintaining factors for psychotic symptoms.Aims:This study examined the feasibility and acceptability of a new psychological therapy targeting schemas and images (iMAPS therapy).Method:The study used a randomised multiple baseline design. Participants with first episode psychosis were randomised using a multiple baseline design with 2–5 assessments. Six sessions of therapy, consisting of a combination of imagery techniques and imagery rescripting techniques, was used. In each session, participants completed a Mental Imagery in Psychosis Questionnaire (MIPQ) and imagery interview. Mood and delusional beliefs (PSYRATS) were also measured at each session.Results:Five participants with first episode psychosis completed the baseline visits and attended all therapy sessions. One participant declined the final assessment. Results demonstrated significant reductions in negative schematic beliefs, delusions, imagery distress and other measures of schema (YSQ, SMI). Although multiple baseline randomisation strengthens the study, it lacked a control arm and blind assessments.Conclusions:iMAPS appears a feasible and acceptable treatment for psychosis, and further evaluation is indicated.

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