What is Philosophy of Medicine?

PARADIGMI ◽  
2011 ◽  
pp. 11-28
Author(s):  
Elselijn Kingma

Philosophy of Medicine is considered a new and emerging discipline. This paper presents an overview of philosophy of medicine, discusses its relation to bioethics and to other areas of philosophy, and introduces three potential topics for research in the philosophy of medicine: concepts of health and disease, the relationship between medicine and psychiatry, and the problems of medical knowledge and evidence.

Author(s):  
Kenneth F. Schaffner ◽  
H. Tristram Engelhardt

The philosophy of medicine can be generally defined as encompassing those issues in epistemology, axiology, logic, methodology and metaphysics generated by or related to medicine. Issues have frequently focused on the nature of the practice of medicine, on concepts of health and disease, and on understanding the kind of knowledge that physicians employ in diagnosing and treating patients. The history of philosophical reflections concerning medicine reaches back to ancient Greece. Medical knowledge took a further step in the nineteenth century with the introduction of clinical pathological correlations, statistical methods, and systematic experimentation, out of which grew substantive literature exploring the character of medical reasoning and the framing of diagnoses. Debates also developed over contrasting physiological, ontological, nominalist and realist accounts of disease entities. Contemporary philosophy of medicine has been concerned with the nature of medicine in an increasingly scientific context, a concern that has generated several models of medicine, including George Engel’s biopsychosocial model, as well as analyses of the nature of the physician–patient interaction. The longstanding debate over the ontological status of health and disease has been recapitulated and extended by a number of authors, favouring an objective, statistically-based account, while others argue for an irreducible social and valuational element in these concepts. Several approaches to diagnostic logic, including Bayesian and computer-based analyses, have been developed, and sophisticated methods of determining disease causation and therapeutic efficacy, including analyses of the randomized clinical trial, have also been explored. Whether the philosophy of medicine is a distinct discipline or a branch of the philosophy of science has provoked vigorous arguments.


2020 ◽  
Vol 20 (5) ◽  
pp. 654-669
Author(s):  
Thea Magrone ◽  
Manrico Magrone ◽  
Emilio Jirillo

Mast cells (MCs) have recently been re-interpreted in the context of the immune scenario in the sense that their pro-allergic role is no longer exclusive. In fact, MCs even in steady state conditions maintain homeostatic functions, producing mediators and intensively cross-talking with other immune cells. Here, emphasis will be placed on the array of receptors expressed by MCs and the variety of cytokines they produce. Then, the bulk of data discussed will provide readers with a wealth of information on the dual ability of MCs not only to defend but also to offend the host. This double attitude of MCs relies on many variables, such as their subsets, tissues of residency and type of stimuli ranging from microbes to allergens and food antigens. Finally, the relationship between MCs with basophils and eosinophils will be discussed.


Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 868
Author(s):  
Jiayang Zhang ◽  
Ruoyu Sun ◽  
Tingting Jiang ◽  
Guangrui Yang ◽  
Lihong Chen

Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes, however the underlying molecular mechanisms are still not clear. In this review, we briefly summarized the current understanding of the circadian BP regulation and provided therapeutic overview of the relationship between circadian BP rhythm and cardiovascular and renal health and disease.


SURG Journal ◽  
2019 ◽  
Vol 11 ◽  
Author(s):  
Maarij Siddiqi

While the impacts of modifiable and non-modifiable risk factors on chronic diseases such as cardiovascular disease (CVD) are widely established, the interactions between such coexisting risk factors and their subsequent effects on the promotion or suppression of CVD are less known. As part of the diet, functional foods are considered a modifiable factor that influence health beyond their basic nutritional value. The relationship between these functional foods and the underlying genome, along with their joint implication in health and disease, forms the focus of the emerging field of nutrigenomics. Reviewed in this paper are some prominent gene-diet interactions demonstrated in CVD etiology. Specifically, the interaction between foods such as phytosterols and isoflavones with genetic factors of the consuming population are examined in relation to CVD. By determining how nutritional intake affects genetics and vice versa, we create the potential to offer improved dietary guidelines to certain individuals, subgroups, or populations in order to maximize health benefits of specific diets.


2017 ◽  
Author(s):  
Maryl Kreider

Intelligent management of pulmonary disease requires a fundamental understanding of the complex interrelationships between multiple elements that interact to maintain homeostasis in the respiratory system. This chapter discusses the physiologic basis for pulmonary function testing and the use of these tests to diagnose disease, quantitate functional impairments, and follow the effects of treatment. Figures illustrate the relationships between lung volume, airway conductance, and airway resistance; the relationship between forced expiratory volume and time (spirogram); the relationship between spirometry and maximum expiratory flow volume; dynamic airway compression; patterns of abnormalities seen on flow-volume curves; lung volumes and capacities; pressure-volume relationships in health and disease; and the clinical assessment of lung function. Tables list the capacities and volumes of gas contained in the lungs during various breathing maneuvers, conditions associated with alterations in diffusing capacity, and recommendations for tests for various clinical scenarios. This review contains 7 highly rendered figures, 3 tables, and 86 references.


1988 ◽  
pp. 80-117
Author(s):  
Wim J. van der Steen ◽  
P. J. Thung

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