The Relationship of Candida albicans with the Oral Bacterial Microbiome in Health and Disease

Author(s):  
Martinna Bertolini ◽  
Anna Dongari-Bagtzoglou
Neurosurgery ◽  
1986 ◽  
Vol 19 (1) ◽  
pp. 111-113 ◽  
Author(s):  
David J. Gower ◽  
Kerry Crone ◽  
Eben Alexander ◽  
David L. Kelly

Abstract Infection of cerebrospinal fluid shunts with Candida albicans is reported in two patients. Scanning electron microscopy in one case demonstrates the relationship of the Candida hyphae to the white blood cells and to silicone plastic. A review of 10 previously reported cases of Candida shunt infection indicates that the infection usually follows a major bacterial infection or direct contamination or occurs spontaneously, Previous therapy has usually involved removal of the shunt, and the role of parenteral antifungal therapy is still unclear. Overall mortality to date is 25%.


Author(s):  
Iván Enrique Naranjo Logroño ◽  
Leslie Gricel Cuzco Macías ◽  
Alison Tamara Ruiz Chico ◽  
Anthony Alfonso Naranjo Coronel

Introduction: The human microbiome refers to the presence of microorganisms that live with its host. Objective: To analyze the relationship between the maternal perinatal microbiome and the development of the infant’s immune system, at the origins of the development of health and disease. Methodology: A non-systematic bibliographic review was carried out, including those controlled and randomized clinical trials focused on the relationship of the prenatal maternal microbiome and the infant’s immune system. And all those works whose approach was different from the topic raised were excluded. Discussion: 20 min after birth, the microbiome of newborns by vaginal delivery resembles the microbiota of their mother’s vagina, while those born by caesarean section house microbial communities that are usually found in human skin. The acquisition of the microbiome continues during the first years of life, with a microbiome of the baby’s gastrointestinal tract beginning to resemble that of an adult from the first year of life. Conclusion: Bacteria are microorganisms that have managed to colonize the vast majority of land surfaces, showing great adaptability. The human being is not indifferent, and hypotheses have been raised that affirm his participation in the development of health and the onset of the disease. Keywords: microbiota, inmune system, infant nutritional physiological phenomena. RESUMEN Introducción: El microbioma humano se refiere a la presencia de microorganismos que conviven con su hospedero. Objetivo: Analizar la relación existente entre el microbioma materno perinatal y el desarrollo del sistema inmune del lactante, en los orígenes del desarrollo de la salud y enfermedad. Metodología: Se realizó una revisión bibliográfica no sistemática, donde se incluyeron aquellos ensayos clínicos controlados y randomizados enfocados en la relación del microbioma materno prenatal y el sistema inmune del lactante. Y se excluyeron todos aquellos trabajos cuyo enfoque fue diferente al tema planteado. Resultados: Se encontraron 61 fuentes bibliográficas, de las cuales se incluyeron 53 artículos que contenían la información relacionada al tema y publicados en los últimos 11 años. Discusión: 20 min después del nacimiento, el microbioma de los recién nacidos por parto vaginal se asemeja a la microbiota de la vagina de su madre, mientras que los nacidos por cesárea albergan comunidades microbianas que generalmente se encuentran en la piel humana. La adquisición del microbioma continúa durante los primeros años de vida, con un el microbioma del tracto gastrointestinal del bebé comienza a parecerse al de un adulto desde el primer año de vida. Conclusiones: Las bacterias, son microorganismos que han logrado colonizar la gran mayoría de las superficies terrestres, mostrando una gran capacidad de adaptación. El ser humano, no es indiferente, y se han planteado hipótesis que aseveran su participación en el desarrollo de la salud e inicio de la enfermedad. Palabras clave: microbiota, sistema inmunológico, fenómenos fisiológicos nutricionales del lactante.


2011 ◽  
Vol 10 (4) ◽  
pp. 302-306 ◽  
Author(s):  
Michael A. Curtis ◽  
Camille Zenobia ◽  
Richard P. Darveau

Author(s):  
Jean-Michel Rabaté

This article explores the relationship of decadence and psychoanalysis in the work of four major figures: Max Nordau, Sabina Spielrein, Georg Groddeck, and Italo Svevo. Sigmund Freud and Nordau agreed on the need to launch a scientific psychology but disagreed on the relative function of disease and health in culture, the latter famously explored in Nordau’s Entartung (Degeneration; 1892–1893). Spielrein’s “Destruction as the Cause of Becoming” (1912) influenced Freud’s concept of the “death drive” while also examining the “decadent” interaction between Wagner and Nietzsche. Spielrein’s thinking, along with Otto Gross’s, influenced Georg Groddeck, from whom Freud derived the concept of the id. Groddeck’s psychoanalytical novel Der Seelensucher (The soulseeker; 1921) anticipates Svevo’s Zeno’s Conscience (1923) and Regeneration (1928), a comic play that meditates on health and disease and gives a final twist to a psychoanalytically inflected rethinking of the uses and abuses of the concept of decadence.


2020 ◽  
Vol 99 (6) ◽  
pp. 746-757 ◽  
Author(s):  
J. Ebersole ◽  
S. Kirakodu ◽  
J. Chen ◽  
R. Nagarajan ◽  
O.A. Gonzalez

This investigation evaluated the relationship of the oral microbiome and gingival transcriptome in health and periodontitis in nonhuman primates ( Macaca mulatta). Subgingival plaque samples and gingival biopsies were collected from healthy sites and at sites undergoing ligature-induced periodontitis. Microbial samples were analyzed with 16S amplicon sequencing to identify bacterial profiles in young (3 to 7 y) and adult (12 to 23 y) animals. The gingival transcriptome was determined with a microarray analysis and focused on the expression level of 452 genes that are associated with the development of inflammation and innate and adaptive immune responses. Of the 396 total operational taxonomic units (OTUs) identified across the samples, 81.8% were detected in the young group and 99.5% in the adult group. Nevertheless, 58 of the OTUs composed 88% of the signal in adults, and 49 OTUs covered 91% of the OTU readouts in the young group. Correlation analyses between the microbiome members and specific gingival genes showed a high number of significant bacteria-gene correlations in the young healthy tissues, which decreased by 75% in diseased tissues. In contrast, these correlations increased by 2.5-fold in diseased versus healthy tissues of adult animals. Complexes of bacteria were delineated that related to specific sets of immune genes, differing in health and disease and in the young versus adult animals. The correlated gene profiles demonstrated selected pathway overrepresentation related to particular bacterial complexes. These results provide novel insights into microbiome changes with disease and the relationship of these changes to specific gene profiles and likely biologic activities occurring in healthy and diseased gingival tissues in this human-like periodontitis model.


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