scholarly journals Mashing up web-based participatory GIS : potential for future e-government services

2021 ◽  
Author(s):  
Jiansheng Gong
Keyword(s):  
Technology Integration ◽  
Case Studies ◽  
Rapid Development ◽  
Open Data ◽  
Data Sources ◽  
Web Based ◽  
Participatory Gis ◽  
Municipal Planning ◽  
Government Services ◽  
Recent Developments

Recent developments of Google Map, Yahoo! Map and MapQuest APIs have pushed map mashups almost to the top among other types of mashups such as news mashpups, search and shopping mashups, and video and photo mashups. However, map.mashups should not reply on these open data sources and services only. Developing a mashup in general, implies a number of challenges. This thesis first evaluates existing mashup technologies, such as Google Map, Yahoo! Map, and AOL (MapQuest) in the context of map mashups. The results are then used in creating two map mashups for the two selected case studies related to participatory GIS for e-government services. Several commonly used APIs have been selected and integrated into the prototype mashups to support municipal planning and West Nile reporting services, to assess the potential issues concerning data and technology integration for online participatory GIS. The results demonstrate that map mashup has great potential to improve and facilitate the rapid development of the future participatory GIS and e-government services. However the existing mashup technologies may not provide techniques or designs satisfying some special e-government requirements.

scholarly journals Mashing up web-based participatory GIS : potential for future e-government services

2021 ◽  
Author(s):  
Jiansheng Gong
Keyword(s):  
Technology Integration ◽  
Case Studies ◽  
Rapid Development ◽  
Open Data ◽  
Data Sources ◽  
Web Based ◽  
Participatory Gis ◽  
Municipal Planning ◽  
Government Services ◽  
Recent Developments

Recent developments of Google Map, Yahoo! Map and MapQuest APIs have pushed map mashups almost to the top among other types of mashups such as news mashpups, search and shopping mashups, and video and photo mashups. However, map.mashups should not reply on these open data sources and services only. Developing a mashup in general, implies a number of challenges. This thesis first evaluates existing mashup technologies, such as Google Map, Yahoo! Map, and AOL (MapQuest) in the context of map mashups. The results are then used in creating two map mashups for the two selected case studies related to participatory GIS for e-government services. Several commonly used APIs have been selected and integrated into the prototype mashups to support municipal planning and West Nile reporting services, to assess the potential issues concerning data and technology integration for online participatory GIS. The results demonstrate that map mashup has great potential to improve and facilitate the rapid development of the future participatory GIS and e-government services. However the existing mashup technologies may not provide techniques or designs satisfying some special e-government requirements.

Anticancer Active Heterocyclic Chalcones: Recent Developments

2020 ◽  
Vol 20 ◽  
Author(s):  
Prasad Dandawate ◽  
Khursheed Ahmed ◽  
Subhash Padhye ◽  
Aamir Ahmad ◽  
Bernhard Biersack
Keyword(s):  
Histone Deacetylases ◽  
Biological Activities ◽  
Synthetic Methods ◽  
Antitumor Activities ◽  
Web Based ◽  
Chemical Structures ◽  
Recent Developments ◽  
Number Of Publications ◽  
Tubulin Polymerization Inhibitors ◽  
Dna Binding Properties

Background: Chalcones are structurally simple compounds that are easily accessible by synthetic methods. Heterocyclic chalcones have gained the interest among scientists due to their diverse biological activities. The anti-tumor activities of heterocyclic chalcones are especially remarkable and the growing number of publications dealing with this topic warrants an up-to-date compilation. Methods: Search for antitumor active heterocyclic chalcones was carried out using Pubmed and Scifinder as common web-based literature searching tools. Pertinent and current literature is covered from 2015/2016 to 2019. Chemical structures, biological activities and modes of action of anti-tumor active heterocyclic chalcones are summarized. Results: Simply prepared chalcones have emerged over the last years with promising antitumor activities. Among them is a considerable number of tubulin polymerization inhibitors. But there are also new chalcones targeting special enzymes such as histone deacetylases or with DNA-binding properties. Conclusion: This review provides a summary of recent heterocyclic chalcone derivatives with distinct anti-tumor activities.

scholarly journals Targeting Genome Stability in Melanoma—A New Approach to an Old Field

2021 ◽  
Vol 22 (7) ◽  
pp. 3485
Author(s):  
Marta Osrodek ◽  
Michal Wozniak
Keyword(s):  
Genome Stability ◽  
Genome Instability ◽  
Checkpoint Inhibitors ◽  
Mapk Pathway ◽  
Rapid Development ◽  
Melanoma Cells ◽  
Old Field ◽  
Number Of Patients ◽  
Recent Developments ◽  
Mapk Inhibitors

Despite recent groundbreaking advances in the treatment of cutaneous melanoma, it remains one of the most treatment-resistant malignancies. Due to resistance to conventional chemotherapy, the therapeutic focus has shifted away from aiming at melanoma genome stability in favor of molecularly targeted therapies. Inhibitors of the RAS/RAF/MEK/ERK (MAPK) pathway significantly slow disease progression. However, long-term clinical benefit is rare due to rapid development of drug resistance. In contrast, immune checkpoint inhibitors provide exceptionally durable responses, but only in a limited number of patients. It has been increasingly recognized that melanoma cells rely on efficient DNA repair for survival upon drug treatment, and that genome instability increases the efficacy of both MAPK inhibitors and immunotherapy. In this review, we discuss recent developments in the field of melanoma research which indicate that targeting genome stability of melanoma cells may serve as a powerful strategy to maximize the efficacy of currently available therapeutics.

scholarly journals A Large-Scale COVID-19 Twitter Chatter Dataset for Open Scientific Research—An International Collaboration

Epidemiologia ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 315-324
Author(s):  
Juan M. Banda ◽  
Ramya Tekumalla ◽  
Guanyu Wang ◽  
Jingyuan Yu ◽  
Tuo Liu ◽  
...  
Keyword(s):  
Large Scale ◽  
Social Dynamics ◽  
Additional Data ◽  
Open Data ◽  
Data Sources ◽  
Research Projects ◽  
Research Groups ◽  
The World ◽  
Data Source

As the COVID-19 pandemic continues to spread worldwide, an unprecedented amount of open data is being generated for medical, genetics, and epidemiological research. The unparalleled rate at which many research groups around the world are releasing data and publications on the ongoing pandemic is allowing other scientists to learn from local experiences and data generated on the front lines of the COVID-19 pandemic. However, there is a need to integrate additional data sources that map and measure the role of social dynamics of such a unique worldwide event in biomedical, biological, and epidemiological analyses. For this purpose, we present a large-scale curated dataset of over 1.12 billion tweets, growing daily, related to COVID-19 chatter generated from 1 January 2020 to 27 June 2021 at the time of writing. This data source provides a freely available additional data source for researchers worldwide to conduct a wide and diverse number of research projects, such as epidemiological analyses, emotional and mental responses to social distancing measures, the identification of sources of misinformation, stratified measurement of sentiment towards the pandemic in near real time, among many others.

scholarly journals Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1145
Author(s):  
Yuan Zhao ◽  
Xuecheng Zhu ◽  
Wei Jiang ◽  
Huilin Liu ◽  
Baoguo Sun
Keyword(s):  
Rapid Development ◽  
Chiral Molecules ◽  
Future Prospects ◽  
Chiral Drugs ◽  
Recognition Mechanism ◽  
Practical Applications ◽  
Food Industries ◽  
Global Industry ◽  
Endocrine Disrupting ◽  
Recent Developments

With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.

scholarly journals IoT Cloud Security Review

2021 ◽  
Vol 54 (4) ◽  
pp. 1-36
Author(s):  
Fei Chen ◽  
Duming Luo ◽  
Tao Xiang ◽  
Ping Chen ◽  
Junfeng Fan ◽  
...  
Keyword(s):  
Case Studies ◽  
Service Providers ◽  
Risk Mitigation ◽  
Rapid Development ◽  
Security Analysis ◽  
Cloud Security ◽  
Future Research ◽  
Security Risk ◽  
Research Attention ◽  
Cloud Systems

Recent years have seen the rapid development and integration of the Internet of Things (IoT) and cloud computing. The market is providing various consumer-oriented smart IoT devices; the mainstream cloud service providers are building their software stacks to support IoT services. With this emerging trend even growing, the security of such smart IoT cloud systems has drawn much research attention in recent years. To better understand the emerging consumer-oriented smart IoT cloud systems for practical engineers and new researchers, this article presents a review of the most recent research efforts on existing, real, already deployed consumer-oriented IoT cloud applications in the past five years using typical case studies. Specifically, we first present a general model for the IoT cloud ecosystem. Then, using the model, we review and summarize recent, representative research works on emerging smart IoT cloud system security using 10 detailed case studies, with the aim that the case studies together provide insights into the insecurity of current emerging IoT cloud systems. We further present a systematic approach to conduct a security analysis for IoT cloud systems. Based on the proposed security analysis approach, we review and suggest potential security risk mitigation methods to protect IoT cloud systems. We also discuss future research challenges for the IoT cloud security area.

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