scholarly journals Hypertension as an atypical presentation of unilateral ureteral obstruction

2021 ◽  
Vol 35 (3) ◽  
Author(s):  
Pedro Mantas ◽  
◽  
Rute Baptista ◽  
Raquel Santos ◽  
Ana Serrão ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ureteral Obstruction ◽  
Age Groups ◽  
Systematic Investigation ◽  
Upper Urinary Tract ◽  
Unilateral Ureteral Obstruction ◽  
Lumbar Pain ◽  
Older Children ◽  
Ureterovesical Junction ◽  
Asymptomatic Infant

Ureteral obstruction (ureteropelvic or ureterovesical junction obstruction) is frequently diagnosed during the workup investigation of an asymptomatic infant or child with upper urinary tract dilatation, commonly identified in a prenatal ultrasound. In older children, recurrent lumbar pain is a red flag for ureteral obstruction. Although less frequent, hypertension may be the initial and only manifestation of ureteral obstruction. The authors present two pediatric cases of unilateral ureteral obstruction with hypertension, in which the surgical treatment of the obstruction leads to blood pressure normalisation. In all pediatric age groups, a systematic investigation for secondary causes of hyperten‑ sion is of paramount importance. In some cases, especially those of an obstructive nature, early surgical management can be curative, with normalization of blood pressure levels and prevention of renal injury.

scholarly journals Unilateral Ureteral Obstruction as a Model of Kidney Fibrosis and Increasing of Systolic Blood Pressure in Mice

2019 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Blood Pressure ◽  
Kidney Disease ◽  
Systolic Blood Pressure ◽  
Ureteral Obstruction ◽  
Interstitial Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Tubulointerstitial Fibrosis ◽  
Obstructive Nephropathy ◽  
Kidney Fibrosis ◽  
End Stage

Background: Obstructive nephropathy can lead to progressive and permanent loss of kidney function characterized by interstitial inflammation and tubulointerstitial fibrosis. Tubulointerstitial fibrosis presents as the end result of various kidney injuries in general and can cause chronic kidney disease (CKD), which can progress to end-stage kidney disease and hypertension. Objective: This study aimed to determine the effectiveness of unilateral ureteral obstruction (UUO) as a model of renal fibrosis and hypertension. Method: Sixteen male Rattus norvegicus mice (150-200 g) were divided into control groups and UUO by ureteral ligation, eight mice each. The systolic blood pressure (SBP) were measured every seven days. After 30 days the animals were dissected to analyze the changes in renal interstitial fibrosis. Statistical analysis was carried out by unpaired t test or alternative test. Results: There was a significant increase in interstitial fibrosis in the UUO rat group [1% (0% - 5%) vs. 75% (20% - ­90%), p <0.001] and SBP [85.38 ± 1.69 mmHg vs 144.75 ± 4.27 mmHg, p <0.001]. Conclusion: UUO can be used as a model of fibrosis and hypertension, which can be used as the basis for the development of anti-fibrotic and anti-hypertensive drugs.

Indonesian Propolis Extractattenuates Unilateral Ureteral Obstruction Induced Renal Damage by Reducing Oxidative Stress and Blood Pressure

2017 ◽  
Vol 9 (6) ◽  
Author(s):  
Susanto A. ◽  
Purwanto B. ◽  
Mudigdo A. ◽  
Suroto Suroto
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction ◽  
Kidney Damage ◽  
Control Group ◽  
Free Oxygen Radicals ◽  
Propolis Extract ◽  
Group 3 ◽  
Group 2

Ureteral obstruction may result in permanent kidney damage. Research suggests that the Indonesian Propolis Extract (IPE) play a strong role on free oxygen radicals removal and prevents oxidative stress. This study aims to investigate the efficacy of IPE on malondialdehyde (MDA) reduction and systolic blood pressure (SBP) level down-regulationafter unilateral ureteral obstruction (UUO).A total of 32 rats were divided into four groups. Group 1 as control, Group 2 were rats with UUO, Group 3 were rats with UUO that were given IPE (oral 50 mg kg-1body weight) and Group 4 were rats with UUO that were given IPE (oral 100 mgkg-1 body weight). SBP level were measured once every week within duration of experiment and at day30 blood sample were taken for Malondialdehyde analysis. Statistical analysis was performed by one-way analysis of variance. There were statistically significant increase in MDA and blood pressure in Group 2, while there were significant decrease for MDA and blood pressure in Group 3 and 4 (p less than 0.001). In this experiment we suggest that IPE prevents kidney damage by decreasing oxidative stress (MDA) and SBP.

RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum

2017 ◽  
Vol 1 (6) ◽  
pp. 533-537
Author(s):  
Lorenz von Seidlein ◽  
Borimas Hanboonkunupakarn ◽  
Podjanee Jittmala ◽  
Sasithon Pukrittayakamee
Keyword(s):  
Protective Efficacy ◽  
Age Groups ◽  
Sub Saharan Africa ◽  
Phase Iii ◽  
European Medicines Agency ◽  
Older Children ◽  
Pivotal Phase ◽  
Malaria Epidemiology ◽  
Maximum Benefit ◽  
Sub Saharan

RTS,S/AS01 is the most advanced vaccine to prevent malaria. It is safe and moderately effective. A large pivotal phase III trial in over 15 000 young children in sub-Saharan Africa completed in 2014 showed that the vaccine could protect around one-third of children (aged 5–17 months) and one-fourth of infants (aged 6–12 weeks) from uncomplicated falciparum malaria. The European Medicines Agency approved licensing and programmatic roll-out of the RTSS vaccine in malaria endemic countries in sub-Saharan Africa. WHO is planning further studies in a large Malaria Vaccine Implementation Programme, in more than 400 000 young African children. With the changing malaria epidemiology in Africa resulting in older children at risk, alternative modes of employment are under evaluation, for example the use of RTS,S/AS01 in older children as part of seasonal malaria prophylaxis. Another strategy is combining mass drug administrations with mass vaccine campaigns for all age groups in regional malaria elimination campaigns. A phase II trial is ongoing to evaluate the safety and immunogenicity of the RTSS in combination with antimalarial drugs in Thailand. Such novel approaches aim to extract the maximum benefit from the well-documented, short-lasting protective efficacy of RTS,S/AS01.

Evaluation of preoperative ultrasonographic parameters to predict renal recovery in long-term survivors after treatment of feline ureteral obstructions: 2012–2019

2021 ◽  
pp. 1098612X2110236
Author(s):  
Elisa P McEntee ◽  
Allyson C Berent ◽  
Chick Weisse ◽  
Alexandre Le Roux ◽  
Kenneth Lamb
Keyword(s):  
Serum Creatinine ◽  
Ultrasound Imaging ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction ◽  
Biochemical Data ◽  
Preoperative Imaging ◽  
Long Term Outcome ◽  
Preoperative Ultrasound ◽  
Imaging Characteristics

Objectives The aim of this study was to determine whether preoperative ultrasound imaging characteristic(s) in cats suffering from unilateral benign ureteral obstructions are predictive of outcome after successful renal decompression with a subcutaneous ureteral bypass (SUB) device. Methods This was a retrospective study of 37 cats with unilateral, benign ureteral obstruction. Preoperative imaging characteristics (including renal pelvis diameter, parenchymal thickness [transverse plane], renal length and pelvic size:overall renal size) and biochemical data were evaluated for all cats diagnosed with a unilateral ureteral obstruction treated with a SUB device. Any patient with bilateral obstructions or documented bacteriuria/infection in the data collection period was excluded. All patients were followed between 3 and 6 months postoperatively to obtain postoperative biochemical data. Long-term outcome was defined as serum creatinine concentration at 3–6 months postoperatively. Results No preoperative imaging characteristics or biochemical findings were found to be significantly associated with long-term serum creatinine concentrations. The length of the kidney was found to be associated with change in blood urea nitrogen and creatinine with decompression but not with long-term renal values. Conclusions and relevance In this study, long-term renal function based on preoperative ultrasound imaging findings could not be predicted in cats with unilateral ureteral obstruction, regardless of the severity of the biochemical parameters, renal pelvic dilation (large or small pelvis), kidney size or thickness of renal parenchyma assessed.

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