scholarly journals Low Serum Zinc in Critically Ill Patients Fed Oral and Enteral Nutrition in a Brazilian Terciary Hospital: A Cross-Sectional Study

2021 ◽  
Vol 6 (6) ◽  

Purpose: Since zinc is required for immunity and inflammation regulations, this paper aimed to investigate serum zinc levels in critically ill patients receiving Enteral (EN) and Oral Nutrition (ON) and correlate these values with demographic, clinical and laboratory parameters. Material and Methods: This is a cross-sectional study. Researchers collected data from electronic medical records in Intensive Care Units (ICUs) of a Brazilian tertiary hospital. Flame Atomic Absorption Spectrophotometry measured serum zinc (normal range: 70-120 mcg/dl). Evaluated variables: age, sex, diagnoses, ICU type, iron, hemoglobin, leukocytes, C-reactive protein, severity score, and mortality. Results: Researches assessed 203 medical records. Mean zinc score was low (EN: 59.13 ±16.26 mcg/dl; ON: 64.75 ±16.80 mcg/dl; p= 0.010). Mean age was high (EN: 77.48 ± 16.26 years; ON: 75.01 ± 13.03 years; p= 0.012). Iron was positively correlated with zinc in EN (p= 0.012). Age was correlated negatively with zinc in ON (p=0.001). Hemoglobin was correlated positively with zinc in EN (p= 0.007) and ON (p= 0.018). Conclusions: Most of the ICU patients had low zinc. EN had lower zinc levels than ON. L

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Satoshi Matsui ◽  
Tomonaga Ameku ◽  
Daisuke Takada ◽  
Shinji Ono

Abstract Background Hypozincemia contributes to phosphate-induced vascular calcification in model animals of renal failure, but the association between hypozincemia and aortic stenosis (AS) prevalence in patients with end-stage kidney disease remains unreported in clinical settings. Methods To investigate the association between hypozincemia and AS prevalence in patients undergoing hemodialysis, we designed a single-center cross-sectional study. Our outcome “AS” was defined as prevalence of moderate or severe AS or surgical history for AS. Depending on serum zinc levels, we divided patients undergoing hemodialysis into deciles. The association between hypozincemia and AS prevalence was analyzed via logistic regression adjusted for age, sex, dialysis vintage, diabetes history, serum albumin, and history of taking calcium-containing phosphate binder. Results Ninety-three patients undergoing hemodialysis were eligible. The mean serum zinc level was 61.3 ± 13.9 μg/dL. Twelve patients who belonged to 1st decile had serum zinc levels ≤ 48 μg/dL. Of these twelve patients, six patients (50 %) had AS. On the other hand, of eighty one patients who belonged to 2nd–10th deciles (serum zinc levels > 48 μg/dL), thirteen patients (16 %) had AS. Hypozincemia (serum zinc levels ≤ 48 μg/dL) was associated with AS prevalence (P = 0.038; odds ratio 4.43; 95% confidence interval 1.09–18.0). Conclusions AS was more prevalent in patients undergoing hemodialysis with severe hypozincemia in our cross-sectional study, although interventional studies are required to elucidate the benefit of zinc supplementation for AS progression.


2018 ◽  
Vol 4 (1) ◽  
pp. 76-82
Author(s):  
Irfany Nurul Hamid ◽  
Rr Sri Endang Pujiastuti ◽  
Dwi Ari Widigdo ◽  
Djenta Saha

Background: One of the complications of ventilator use in patients in Intensive Care Unit (ICU) is Ventilator-Associated Pneumonia (VAP). Oral hygienes is one of the methods to prevent VAP.Objective: The objective of this study was to compare the value of clinical infection score (CPIS) in critically ill patients after given oral hygiene using chlorhexidine and Piper betle Linn mouthwash.Methods: This was an observational study with cross-sectional study design, which consisted of two intervention groups. Thirty respondents were selected using total sampling, with 15 respondents randomly assigned in each group. Independent t-test was used for data analysis.Results: Findings showed that  the mean of CPIS in the Piper betle Linn group was 3.80 and the mean of CPIS in the chlorhexidine group was 4.07.Conclusion: CPIS in the treatment group using Piper betle Linn mouthwash was lower than the mean of CPIS in the treatment group using clorhexidine. 


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