The association between hypozincemia and aortic stenosis prevalence in hemodialysis patients: a single-center cross-sectional study

Abstract Background Hypozincemia contributes to phosphate-induced vascular calcification in model animals of renal failure, but the association between hypozincemia and aortic stenosis (AS) prevalence in patients with end-stage kidney disease remains unreported in clinical settings. Methods To investigate the association between hypozincemia and AS prevalence in patients undergoing hemodialysis, we designed a single-center cross-sectional study. Our outcome “AS” was defined as prevalence of moderate or severe AS or surgical history for AS. Depending on serum zinc levels, we divided patients undergoing hemodialysis into deciles. The association between hypozincemia and AS prevalence was analyzed via logistic regression adjusted for age, sex, dialysis vintage, diabetes history, serum albumin, and history of taking calcium-containing phosphate binder. Results Ninety-three patients undergoing hemodialysis were eligible. The mean serum zinc level was 61.3 ± 13.9 μg/dL. Twelve patients who belonged to 1st decile had serum zinc levels ≤ 48 μg/dL. Of these twelve patients, six patients (50 %) had AS. On the other hand, of eighty one patients who belonged to 2nd–10th deciles (serum zinc levels > 48 μg/dL), thirteen patients (16 %) had AS. Hypozincemia (serum zinc levels ≤ 48 μg/dL) was associated with AS prevalence (P = 0.038; odds ratio 4.43; 95% confidence interval 1.09–18.0). Conclusions AS was more prevalent in patients undergoing hemodialysis with severe hypozincemia in our cross-sectional study, although interventional studies are required to elucidate the benefit of zinc supplementation for AS progression.

Download Full-text

Estimation of serum zinc levels in children with febrile convulsions

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182556 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1518 ◽

Cited By ~ 1

Author(s):

Ubaidur Rehman H. ◽

Shamshad Ahmed Khan ◽

Prakash R. Saldanha

Keyword(s):

Serum Zinc ◽

Febrile Seizures ◽

Cross Sectional Study ◽

Zinc Level ◽

Sectional Study ◽

Serum Zinc Level ◽

Cross Sectional ◽

Significant Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Diﬀerent studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no signiﬁcant diﬀerence in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a signiﬁcant diﬀerence between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

Download Full-text

A study of zinc level in cord blood of neonates and its relationship with antropometric measurements in the neonates: a descriptive cross-sectional study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20190718 ◽

2019 ◽

Vol 6 (2) ◽

pp. 722

Author(s):

Syed Mohamed ◽

Santosh Kumar ◽

J. Kumutha

Keyword(s):

Cord Blood ◽

Growth Parameters ◽

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Cross Sectional ◽

Medical College ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Background: During pregnancy, fast growth and cell differentiation takes place in both mother and foetus. Maternal nutritional factors play an important role in the growth of the neonate. Among the micronutrient zinc is an important micronutrient whose deficiency is associated with poor pregnancy outcomes. The objective the current study was to evaluate the relationship of serum zinc concentration of the maternal blood and the neonatal cord blood with that of the infant’s anthropometric measurements.Methods: A descriptive cross-sectional study was performed under the Department of Neonatology, Saveetha medical college. Duration of the study was from April 2017 to June 2018. The study included 82 singleton mother baby dyads born in Saveetha medical college. Anthropometric measurements such as birth weight, head circumference, neonate length apart from other clinical features of both the mother and neonates were recorded for statistical analysis. Serum zinc levels were estimated using 2-(5-bromo-2-pyridylazo)-5-(N-Propyl-N-sulfopropylamino)-phenol (5-Br-PAPS) protocol.Results: The mean maternal age of the study population is 25.3±2.3 years. Majority of the mother had natural mode of delivery (57%). The mean cord serum zinc level was found to be 94.0±1.6microgram /dl and the mother’s serum zinc level was 93.8±30.7microgram /dl (range from 49 to 171microgram /dl) which was not found to be statistically significant. Serum zinc levels of the cord was compared with the child anthropometrics and mother’s serum zinc levels to assess for the significance, but there was no correlation observed between the umbilical cord, and the birth weight (r=0.03), length of the child (r=-0.02), head circumference (r=-0.07) and mothers serum zinc levels (r=-0.002).Conclusions: According to our results authors were unable to establish a relationship between Neonates growth parameters and zinc levels in neonates cord blood and zinc levels in the mother. Further studies with a larger sample size and prospective design would establish a causal relationship between zinc and growth parameters in the neonate.

Download Full-text

Zinc Status and Febrile Seizures: Results from a Cross-sectional Study

Journal of Neurosciences in Rural Practice ◽

10.1055/s-0040-1715992 ◽

2020 ◽

Vol 11 (04) ◽

pp. 597-600

Author(s):

Janani Arul ◽

Peter Prasanth Kumar Kommu ◽

Ananthanarayanan Kasinathan ◽

Lopamudhra Ray ◽

Lalitha Krishnan

Keyword(s):

Odds Ratio ◽

Serum Zinc ◽

Febrile Seizures ◽

Cross Sectional Study ◽

Zinc Level ◽

Demographic Variables ◽

Sectional Study ◽

Cross Sectional ◽

Zinc Levels ◽

Level Of Significance

Abstract Objective To estimate the serum zinc levels in children under the age of 5 years with febrile seizures and febrile children without seizures Materials and Methods In this cross-sectional study from 2017 to 2018, 40 children with febrile seizures (simple and complex) were taken as cases. Forty age- and sex-matched febrile children without convulsions were recruited as controls. Serum zinc estimates were analyzed using a spectrophotometer (Biolis 50i–Autoanalyzer). Statistical Analysis The demographic variables and serum zinc estimates were analyzed using the Mann–Whitney test. The odds ratio was used to calculate the association of zinc deficiency in febrile seizures; 5% level of significance was considered. Results The mean serum concentrations of zinc in the cases and controls were 83.8 ± 33.1 μg/dL and 116.3 ± 30.3 μg/dL, respectively (p = 0.002). Hypozincemia defined by “a serum zinc level of less than 63 μg/dL” was found in 12 (30%) cases and 2(5%) controls with an odds ratio of 8:1. Conclusion Children with febrile seizures had significantly reduced concentrations of zinc in the serum.

Download Full-text

SERUM ZINC LEVELS IN CHILDREN HOSPITALIZED WITH PNEUMONIA – A CROSS-SECTIONAL STUDY

Indian Journal of Child Health ◽

10.32677/ijch.2019.v06.i10.007 ◽

2019 ◽

Vol 06 (10) ◽

pp. 545-547

Author(s):

Madhura Shivalingaiah ◽

Savitha Mysore Ramaraj

Keyword(s):

Serum Zinc ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Zinc Levels ◽

Serum Zinc Levels

Download Full-text

Influence of Breastfeeding and Complementary Feeding on Serum and Erythrocyte Zinc Levels in Preterm and Term Infants: A Cross-sectional Study

10.21203/rs.3.rs-514609/v1 ◽

2021 ◽

Author(s):

Talita Rodrigues Azevedo e Silva ◽

Anna Caroline Pereira Vivi ◽

Fernando Luiz Affonso Fonseca ◽

Cibele Wolf Lebrão ◽

Maria Wany Louzada Strufaldi ◽

...

Keyword(s):

Nutritional Status ◽

Preterm Infants ◽

Complementary Feeding ◽

Serum Zinc ◽

Cross Sectional Study ◽

Sectional Study ◽

Term Infants ◽

Cross Sectional ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background: Zinc is an important micronutrient involved in cell division, growth, and immune system function. Most studies evaluating the nutritional status related to zinc and prematurity were conducted with hospitalized preterm infants. These studies show controversial results regarding the prevalence of deficiency, clinical implications, and the effect of zinc supplementation on mortality, infectious diseases, and growth in these groups. This study aimed to compare serum and erythrocyte zinc levels in a group of preterm and term infants during complementary feeding and related the zinc levels to dietary intake, and current nutritional condition in both groups. Methods: Cross-sectional study with 43 preterm infants (24 to 33 weeks) aged 9-24 months (mean: 14.3±6.4 months), compared with 47 term healthy infants. Data collected: socioeconomic status and maternal health during pregnancy, dietary history, anthropometry (weight, height, and head circumference), and current dietary intake. Laboratory tests: blood count, serum and erythrocyte zinc concentrations, and C-reactive protein.Results: Males predominated (24, or 55.8%) in the preterm group; the mean birth weight was 1,245±381.7 grams. Serum zinc levels <65 µg/dL and anemia were observed in four preterm (5.1%) and four term infants (5.3%), respectively. No infant had erythrocyte zinc < 40 µg/gHb. The variables independently associated with serum zinc levels were breastfeeding at the time of evaluation (20.11 µg/dL; 95% CI 9.62 to 30.60; p<0.001) and late (4-7 months) introduction of complementary feeding (6.6 µg/dL; 95% CI 5.3 to 11.4; p<0.001). Breastfeeding was also independently and directly associated with erythrocyte zinc levels (18.8 ug/dL; 95% CI 3.7 to 33.8; p=0.015). Conclusions: No difference was observed in the nutritional status related to zinc between preterm and term infants during complementary feeding. Serum and erythrocyte zinc levels were influenced by breastfeeding and the onset of solid foods.

Download Full-text

Low Serum Zinc in Critically Ill Patients Fed Oral and Enteral Nutrition in a Brazilian Terciary Hospital: A Cross-Sectional Study

Medical & Clinical Research ◽

10.33140/mcr.06.06.11 ◽

2021 ◽

Vol 6 (6) ◽

Keyword(s):

Critically Ill ◽

Critically Ill Patients ◽

Medical Records ◽

Serum Zinc ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Oral Nutrition ◽

Flame Atomic Absorption ◽

Zinc Levels

Purpose: Since zinc is required for immunity and inflammation regulations, this paper aimed to investigate serum zinc levels in critically ill patients receiving Enteral (EN) and Oral Nutrition (ON) and correlate these values with demographic, clinical and laboratory parameters. Material and Methods: This is a cross-sectional study. Researchers collected data from electronic medical records in Intensive Care Units (ICUs) of a Brazilian tertiary hospital. Flame Atomic Absorption Spectrophotometry measured serum zinc (normal range: 70-120 mcg/dl). Evaluated variables: age, sex, diagnoses, ICU type, iron, hemoglobin, leukocytes, C-reactive protein, severity score, and mortality. Results: Researches assessed 203 medical records. Mean zinc score was low (EN: 59.13 ±16.26 mcg/dl; ON: 64.75 ±16.80 mcg/dl; p= 0.010). Mean age was high (EN: 77.48 ± 16.26 years; ON: 75.01 ± 13.03 years; p= 0.012). Iron was positively correlated with zinc in EN (p= 0.012). Age was correlated negatively with zinc in ON (p=0.001). Hemoglobin was correlated positively with zinc in EN (p= 0.007) and ON (p= 0.018). Conclusions: Most of the ICU patients had low zinc. EN had lower zinc levels than ON. L

Download Full-text

Decreasing Zinc Levels in Stunting Toddlers in Lampung Province, Indonesia

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1633 ◽

2019 ◽

Vol 12 (1) ◽

pp. 239-243

Author(s):

Khairun Nisa Berawi ◽

Maya Nurul Hidayati ◽

Susianti Susianti ◽

Roro Rukmi W. Perdami ◽

Tiwuk Susantiningsih ◽

...

Keyword(s):

Univariate Analysis ◽

Serum Zinc ◽

Zinc Content ◽

Zinc Level ◽

Bivariate Analysis ◽

Cross Sectional ◽

The Mean ◽

The Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Stunting is a condition of chronic malnutrition in children that causes the posture is not optimal and triggers other disorders such as deacreasing of immunity and intelligence. The level of adequacy of zinc is one of the factors that influence the incidence of stunting. Zinc is needed to activate and begin the synthesis of Growth Hormone (GH) so that children with zinc deficiency cause GH receptors to be disrupted and GH production to be resistant. This study aims to examine the decrease in zinc levels by looking at the difference in mean zinc levels in stunting and non-stunting toddlers. The research method was carried out observational analytic with a cross sectional approach used in this study. The study sample was 40 toddlers aged 24-60 months with 18 stunting toddlers and 22 non-stunting toddlers in Gunung Sugih District, Central Lampung Regency. The results of univariate analysis revealed that the average zinc level of toddlers serum was 52.60 ug / dl with the largest value of 76 ug / dl and the lowest value was 24 ug / dl. The results of bivariate analysis showed that there were significant differences in the mean zinc levels of stunting and non-stunting children (p = 0.01). The mean zinc content of stunting infants was 45.06 ± 12.21 lower than the mean zinc level of non-stunting infants 58.77 ± 12.98. There is a decrease in serum zinc levels in stunting toddlers compared to non stunting toddlers.

Download Full-text

Is Serum Zinc Level Associated with Prediabetes and Diabetes?: A Cross-Sectional Study from Bangladesh

PLoS ONE ◽

10.1371/journal.pone.0061776 ◽

2013 ◽

Vol 8 (4) ◽

pp. e61776 ◽

Cited By ~ 21

Author(s):

Md. Rafiqul Islam ◽

Iqbal Arslan ◽

John Attia ◽

Mark McEvoy ◽

Patrick McElduff ◽

...

Keyword(s):

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Sectional Study ◽

Serum Zinc Level ◽

Cross Sectional

Download Full-text

A Study of Serum Zinc level in Cirrhosis of Liver

Bangladesh Journal of Medical Biochemistry ◽

10.3329/bjmb.v5i2.13340 ◽

2013 ◽

Vol 5 (2) ◽

pp. 44-47

Author(s):

F Atia ◽

N Sultana ◽

S Ahmed ◽

S Ferdousi ◽

R Sultana ◽

...

Keyword(s):

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Serum Zinc Level ◽

Cross Sectional ◽

Medical College ◽

Cirrhotic Patients ◽

Cirrhosis Of Liver ◽

Zinc Levels ◽

Age Range

Cirrhosis is a consequence of chronic liver diseases. Zinc is a micronutrient that plays an important role in the function of liver. This cross-sectional study was carried out in the Department of Biochemistry, Dhaka Medical College, from July 2010 to June 2011 to observe the association of serum zinc level with liver cirrhosis. A total of 100 adults, both males and females with age range of 18-60 years, of which 50 were healthy subjects and 50 adult hospitalised cirrhotic patients were selected purposively for the study according to selection crieteria. Fasting serum zinc level was measured with atomic absorption spectrophotometer. Serum zinc level was found to be low in 72% patients. Mean ±SD of serum zinc levels (?g/L) were 610.32 ± 169.60 and 827.66 ± 267.32 in cases and controls respectively. In cirrhotic patients serum zinc level was significantly lower than that of healthy controls (P<0.001). Though, it is difficult to draw any definite conclusion from this study, because of reduced level serum of zinc found in cirrhotics, Zn may be supplemented to them with a hope of better treatment response. DOI: http://dx.doi.org/10.3329/bjmb.v5i2.13340 Bangladesh J Med Biochem 2012; 5(2): 44-47

Download Full-text