scholarly journals Ureaplasma Urealyticum as a Possible Hidden Cause of Couple Infertility

2020 ◽  
Vol I (2) ◽  
pp. 23-24
Author(s):  
Andrea Fabiani
Keyword(s):  
In Vitro Fertilization ◽  
Male Infertility ◽  
Sexually Transmitted Disease ◽  
Ureaplasma Urealyticum ◽  
Sperm Count ◽  
Transmitted Disease ◽  
Vitro Fertilization ◽  
Sexually Transmitted ◽  
Sperm Mobility

Currently an high percentage of Oligoasthenoteratozoospermia (OAT) is deemed to be responsible for over 50% of cases of infertility in couples. A large percentage of sexually transmitted disease caused by intracellular germs seems to have a significant influence on couple fertility and in the outcome of In Vitro Fertilization Treatment (IVF). In particular, we considered the Ureaplasma Urealyticum (UU) infections. Less clear is their influence on male infertility alone. Several studies reported that UU is present in an high percentage of fertile men, despite being sometimes the likely cause of significant reductions in sperm count number, sperm mobility and morphology

scholarly journals Testis-Specific SEPT12 Expression Affects SUN Protein Localization and is Involved in Mammalian Spermiogenesis

2019 ◽  
Vol 20 (5) ◽  
pp. 1163 ◽  
Author(s):  
Chung-Hsin Yeh ◽  
Ya-Yun Wang ◽  
Shi-Kae Wee ◽  
Mei-Feng Chen ◽  
Han-Sun Chiang ◽  
...  
Keyword(s):  
Male Infertility ◽  
Nuclear Membrane ◽  
Sperm Count ◽  
Protein Localization ◽  
Cancer Cell Line ◽  
Structural Defects ◽  
Preimplantation Embryos ◽  
Severe Oligozoospermia ◽  
Vitro Fertilization

Male infertility is observed in approximately 50% of all couples with infertility. Intracytoplasmic sperm injection (ICSI), a conventional artificial reproductive technique for treating male infertility, may fail because of a severe low sperm count, immotile sperm, immature sperm, and sperm with structural defects and DNA damage. Our previous studies have revealed that mutations in the septin (SEPT)-coding gene SEPT12 cause teratozoospermia and severe oligozoospermia. These spermatozoa exhibit morphological defects in the head and tail, premature chromosomal condensation, and nuclear damage. Sperm from Sept12 knockout mice also cause the developmental arrest of preimplantation embryos generated through in vitro fertilization and ICSI. Furthermore, we found that SEPT12 interacts with SPAG4, a spermatid nuclear membrane protein that is also named SUN4. Loss of the Spag4 allele in mice also disrupts the integration nuclear envelope and reveals sperm head defects. However, whether SEPT12 affects SPAG4 during mammalian spermiogenesis remains unclear. We thus conducted this study to explore this question. First, we found that SPAG4 and SEPT12 exhibited similar localizations in the postacrosomal region of elongating spermatids and at the neck of mature sperm through isolated murine male germ cells. Second, SEPT12 expression altered the nuclear membrane localization of SPAG4, as observed through confocal microscopy, in a human testicular cancer cell line. Third, SEPT12 expression also altered the localizations of nuclear membrane proteins: LAMINA/C in the cells. This effect was specifically due to the expression of SEPT12 and not that of SEPT1, SEPT6, SEPT7, or SEPT11. Based on these results, we suggest that SEPT12 is among the moderators of SPAG4/LAMIN complexes and is involved in the morphological formation of sperm during mammalian spermiogenesis.

In-vitro fertilization, gamete- or zygote intra-Fallopian transfer for the treatment of male infertility

1991 ◽  
Vol 6 (2) ◽  
pp. 263-266 ◽  
Author(s):  
Herman Tournay ◽  
Michel Camus ◽  
Iqbal Khan ◽  
Catherine Staessen ◽  
André C. Van Steirteghem ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Male Infertility ◽  
Vitro Fertilization

scholarly journals PRETERM BIRTH AND LOW BIRTH WEIGHT IN SINGLETON PREGNANCIES AFTER IN VITRO FERTILIZATION- INFLUENCE OF INFERTILITY AND METHOD OF FERTILIZATION

2021 ◽  
Vol 27 (4) ◽  
pp. 4010-4013
Author(s):  
Sergei Slavov ◽  
◽  
Galina Yaneva ◽  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
In Vitro Fertilization ◽  
Low Birth Weight ◽  
Male Infertility ◽  
Average Weight ◽  
Tubal Infertility ◽  
Vitro Fertilization ◽  
Singleton Pregnancies

The aim of our study was to determine the effect of infertility and the method of fertilization on the frequency of preterm birth and low birth weight in singleton pregnancies achieved by in vitro fertilization (IVF). The study was conducted in the period 01.2013 - 12.2017 and included 286 patients with births from singleton IVF pregnancies. Classical IVF received 107 patients (group A1) and ICSI fertilization - 148 (group A2). Cases with tubal infertility were 81 (group B1), and 85 were with male infertility (group B2). In group A1, birth prior to 37 weeks of gestation (w.g.) was found in 33 (30.8%) cases, compared to 26 (17.6%) in group A2 (p=0.029).In group A1, birth weight <2500 g was observed in 27 (25.3%) of cases, and in group A2 - in 17 (11.5%) of cases (p=0.015). In group B1, birth prior to 37 w.g. was established in 26 (32.1%) of the cases, compared to 9 (10.6%) in group B2 (p=0.003). In group B1 there was birth weight <2500 g in 19 (23.5%) of patients, compared to 6 (7.1%) in group B2 (p = 0.009). The average weight of the newborn and average duration of pregnancy was lower in groups with IVF fertilization and tubal infertility compared to ICSI fertilization and male infertility. Tubal infertility and classical IVF fertilization are independent risk factors that increase the frequency of preterm birth and low birth weight in IVF singleton pregnancies.

scholarly journals Case Report on Primary Infertility with Hypothyroidism and Diabetes Mellitus

2021 ◽  
pp. 263-266
Author(s):  
Thool Bali ◽  
Lokhande Shalini ◽  
A. Lalawmpuii ◽  
Ambule Kalyani ◽  
Shendre Vaishnavi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
In Vitro Fertilization ◽  
Sperm Count ◽  
Vitro Fertilization ◽  
Primary Infertility ◽  
History Of ◽  
Irregular Menses ◽  
One Year ◽  
Loss Of Appetite

Introduction: Infertility is the inability, by natural means, of an animal to reproduce. Typically, adult species are not in their normal state of health. A woman who is unable to conceive well will define infertility as unable to bear a full-term pregnancy. Because of any ejaculating disease, and any declining sperm count, men are directly liable for 30-40% infertility. The WHO estimates the overall prevalence of primary infertility in India at 3.9% and 16.8%. Fertility estimates differ widely between India and 3.7% in Utter Pradesh and Maharashtra. Case Presentation: On 9/12/2020, a 38-year-old female came for In Vitro Fertilization with a known case of primary infertility in AVBR Hospital, Wardha. Her complaint was inability to conceive for 4 years, irregular menses, headache, sleep disturbance, loss of appetite. She was admitted for in-vitro fertilization therapy for the 2nd cycle. She had a history of hypothyroidism for 8 years for which she has been taking Thyrox 50mg OD tablet and has Diabetes Mellitus for one year since she is taking Metformin 500mg BD tablet. Instead, she has no concerns about asthma, tuberculosis, epilepsy, etc. On 9/12/2020, she underwent an embryo transfer. Diagnostic Evaluation: The diagnostic hysteroscopy was conducted at the private hospital in Amravati 2 years ago. She has been diagnosed with nullipara for 4 years as a primary infertility. She has already undergone 2 cycles of Intra Uterine Insemination (IUI) and 1 cycle of in vitro fertilization. Hysterosalpingography: Both fallopian tubes are normal & patent uterus is normal. Conclusion: There is multifactorial infertility. In both men and women, anatomy, physiology, the environment, hormones and genetics all play a role in causing infertility. Therefore, in the coming years, it is a very important problem and research in this zone is very essential.

A Clinical study on the efficacy of Udvartana and Nasya on Ovulatory functions w.s.r. to Female infertility in Moderate Obese (Sthula) individuals

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Sayeda Nikhat Inamdar ◽  
Prashanth A S ◽  
Anita H
Keyword(s):  
Clinical Study ◽  
In Vitro Fertilization ◽  
Female Infertility ◽  
Treatment Modalities ◽  
Coping With Stress ◽  
Vitro Fertilization ◽  
Sexually Transmitted ◽  
Alternative Medicines ◽  
Ayurvedic Treatment

Childlessness and infertility are rising dramatically in cities. The increase may be due to many reasons like the way of living, coping with stress, job pressure, obesity, postponing parenthood, galloping urbanization, sexually transmitted infections and many others. Hence treating infertility is the challenging job for the doctors in present era. The failure to ovulate is the major problem in approximately 40% cases of female infertility. This can be anovulation or severe oligo ovulation. In the latter case even though the ovulation does occur, its relative infrequency decreases the womanand#39;s chance of pregnancy. Hence the infertility and especially ovarian factor induced female infertility needs an immediate attention from alternative medicines. Over last decades, fertility therapy has expanded more than any other field of medicine. Hormonal therapy, In vitro Fertilization (IVF), Embryo Transfer (ET), Gamete Intra Fallopian Transfer (GIFT) etc., all these have a minimal success rate. Additionally these procedures are associated with adverse effects andamp; are not affordable to all. Ayurveda may give a promising hand to cure this condition with the various treatment modalities mentioned in the classics. For the present clinical study, an effort was made to study the efficacy of Udvartana and Nasya followed by Shamanaushadhis in reversing the pathology of this disease and giving a “Never-Ending Joy” of parenthood to the couples through the Ayurvedic treatment.

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