Sadomasochistic dynamics inside and outside the consulting room

2020 ◽  
Vol 2 (1) ◽  
pp. 13-25
Author(s):  
Carine Minne
Keyword(s):  
Main Function ◽  
Acting Out ◽  
Original Meaning ◽  
Life Threatening

This article will illustrate sadomasochistic dynamics as they arise within the consulting room and highlight the main function of perversions. Although the term “perversion” can be considered outdated, or worse, pejorative, if used in its original meaning, it remains the most appropriate term to describe the plight of certain patients who suffer from a specific sexualised form of acting out. One aim of the perversion is to attempt to reverse an earlier trauma by turning that passive experience, often not consciously remembered, into an active one. The patient suffering from a perversion replaces unwanted or unbearable historical affects with current actions that are sadomasochistic, sexually exciting, and highly gratifying, albeit temporarily, thereby keeping the patient’s mind far away from the desolation of the initial trauma. At times, the actions patients are driven to for survival are paradoxically life-threatening. I will briefly refer to the difficulties of the countertransference in working with perverse patients.

scholarly journals Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1β by Monocytic Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Anca-Laura Amati ◽  
Anna Zakrzewicz ◽  
Robin Siebers ◽  
Sigrid Wilker ◽  
Sarah Heldmann ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Mononuclear Leukocytes ◽  
Main Function ◽  
U937 Cells ◽  
Monocytic Cells ◽  
Nicotinic Acetylcholine ◽  
Leukocyte Mobilization ◽  
Life Threatening ◽  
Calcium Independent Phospholipase A2

Chemokines and ATP are among the mediators of inflammatory sites that can enter the circulation via damaged blood vessels. The main function of chemokines is leukocyte mobilization, and ATP typically triggers inflammasome assembly. IL-1β, a potent inflammasome-dependent cytokine of innate immunity, is essential for pathogen defense. However, excessive IL-1β may cause life-threatening systemic inflammation. Here, we hypothesize that chemokines control ATP-dependent secretion of monocytic IL-1β. Lipopolysaccharide-primed human monocytic U937 cells were stimulated with the P2X7 agonist BzATP for 30 min to induce IL-1β release. CCL3, CCL4, and CCL5 dose dependently inhibited BzATP-stimulated release of IL-1β, whereas CXCL16 was ineffective. The effect of CCL3 was confirmed for primary mononuclear leukocytes. It was blunted after silencing CCR1 or calcium-independent phospholipase A2 (iPLA2) by siRNA and was sensitive to antagonists of nicotinic acetylcholine receptors containing subunits α7 and α9. U937 cells secreted small factors in response to CCL3 that mediated the inhibition of IL-1β release. We suggest that CCL chemokines inhibit ATP-induced release of IL-1β from U937 cells by a triple-membrane-passing mechanism involving CCR, iPLA2, release of small mediators, and nicotinic acetylcholine receptor subunits α7 and α9. We speculate that whenever chemokines and ATP enter the circulation concomitantly, systemic release of IL-1β is minimized.

Basic Psychoanalytic Concepts: VI. Acting Out

1970 ◽  
Vol 117 (538) ◽  
pp. 329-334 ◽  
Author(s):  
J. Sandler ◽  
A. Holder ◽  
C. Dare
Keyword(s):  
Acting Out ◽  
Original Meaning ◽  
Wide Range

We have previously suggested that a number of psychoanalytic concepts have undergone changes of meaning when extended to wider settings both within psychoanalysis and outside it (Sandler, Dare, and Holder, 1970a, b; Sandler, Holder and Dare, 1970a, b, c). This has led to situations in which the same term can have a variety of meanings attached to it, with consequent confusion and loss of precision. A clear example of this is the concept oftransference,which is now given a wide range of meanings, including that of being simply a synonym for ‘relationship'—a usage substantially different from its original meaning (Sandler, Dare and Holder, 1970b).

scholarly journals Children Without Childhood: The Emotionality of Orphaned Children and Images of Their Rescuers in Selected Works of English and Canadian Literature

2017 ◽  
Vol 50 (1-2) ◽  
pp. 95-135
Author(s):  
Irena Avsenik Nabergoj
Keyword(s):  
Charles Dickens ◽  
Child Victims ◽  
Acting Out ◽  
Great Expectations ◽  
Orphaned Children ◽  
Victorian Era ◽  
Anne Michaels ◽  
Life Threatening ◽  
Victims Of Violence ◽  
The 19Th Century

This article deals with literary depictions of social, political, cultural and religious circumstances in which children who have lost one or both parents at birth or at a later age have found themselves. The weakest members of society, the children looked at here are exposed to dangers, exploitation and violence, but are fortunate enough to be rescued by a relative or other sympathetic person acting out of benevolence. Recognizing that the relationship between the orphaned child, who is in mortal danger, and a rescuer, who most frequently appears unexpectedly in a relationship, has been portrayed in narratives throughout the ages and that we can therefore speak of it as being an archetypal one, the article focuses especially on three novels by Charles Dickens – Oliver Twist (1837–1839), David Copperfield (1849–1850) and Great Expectations (1860–1861) – and in Fugitive Pieces (1996) by Canadian writer Anne Michaels. Charles Dickens earned the reputation of a classic writer through his original literary figures of orphaned children in the context of the rough capitalism of the Victorian era of the 19th century. Such originality also distinguishes Anne Michaels, whose novel Fugitive Pieces portrays the utterly traumatic circumstances that a Jewish boy is exposed to after the Germans kill his parents during the Holocaust. All the central children’s lives in these extreme situations are saved by generous people, thus highlighting the central idea of both selected authors: that evil cannot overcome good. Rescuers experience their selfless resolve to save extremely powerless and unprotected child victims of violence from life-threatening situations as a self-evident moral imperative. Through their profound and deeply experienced descriptions of memories of traumas successfully overcome by central literary figures in a spirit of compassion and solidarity, Charles Dickens and Anne Michaels have left testaments of hope against hope for future generations.

Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

1995 ◽  
Vol 53 ◽  
pp. 840-841
Author(s):  
Z. Hong Zhou ◽  
Jing He ◽  
Joanita Jakana ◽  
J. D. Tatman ◽  
Frazer J. Rixon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
3D Structure ◽  
Structure Study ◽  
Herpes Simplex Virus 1 ◽  
Shell Proteins ◽  
Life Threatening ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

1743: Risk Count Assessment: A New Concept for Detection of Life Threatening Prostate Cancer During a Window of Curability

2007 ◽  
Vol 177 (4S) ◽  
pp. 579-580 ◽  
Author(s):  
H. Ballentine Carter ◽  
Anna E. Kettermann ◽  
Luigi Ferrucci ◽  
Patricia Landis ◽  
E. Jeffrey Metter
Keyword(s):  
Prostate Cancer ◽  
Life Threatening

Proximal deep venous thrombosis following PTA of the superficial femoral artery – an obligation to disclose a complication that is rarely taken into account

VASA ◽  
2006 ◽  
Vol 35 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Klein-Weigel ◽  
Pillokat ◽  
Klemens ◽  
Köning ◽  
Wolbergs ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Femoral Artery ◽  
Superficial Femoral Artery ◽  
Rare Complication ◽  
Femoral Vein ◽  
Vein Thrombosis ◽  
Explicit Information ◽  
Life Threatening ◽  
Legal Consequences

We report two cases of femoral vein thrombosis after arterial PTA and subsequent pressure stasis. We discuss the legal consequences of these complications for information policies. Because venous thrombembolism following an arterial PTA might cause serious sequel or life threatening complications, there is a clear obligation for explicit information of the patients about this rare complication.

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