scholarly journals Multigene panels enjoy a broad psychological acceptance by patients

2021 ◽  
Author(s):  
Mike Fillon
Keyword(s):  
Multigene Panels ◽  
Psychological Acceptance

Diagnosing copy number variation disorders via multigene panels

2021 ◽  
Vol 132 ◽  
pp. S109
Author(s):  
Nicole Bertsch ◽  
Zeinab Ammous
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Number Variation ◽  
Multigene Panels

Functioning with fibromyalgia: The role of psychological flexibility and general psychological acceptance

2018 ◽  
Vol 54 (3) ◽  
pp. 214-224 ◽  
Author(s):  
Heather Trainor ◽  
John Baranoff ◽  
Miriam Henke ◽  
Helen Winefield
Keyword(s):  
Psychological Flexibility ◽  
Psychological Acceptance

Role of psychological acceptance between personality and happiness

2018 ◽  
Author(s):  
Huei-Lin Juang ◽  
Yevvon Yi-Chi Chang ◽  
Bei-Lu Tseng ◽  
Chia-Chun Chang ◽  
Yung-Jong Shiah
Keyword(s):  
Psychological Acceptance

Utilization of Multigene Panels in Hereditary Cancer Predisposition Testing

2015 ◽  
pp. 459-482
Author(s):  
Holly LaDuca ◽  
Tina Pesaran ◽  
Aaron M. Elliott ◽  
Virginia Speare ◽  
Jill S. Dolinsky ◽  
...  
Keyword(s):  
Hereditary Cancer ◽  
Cancer Predisposition ◽  
Multigene Panels ◽  
Hereditary Cancer Predisposition

scholarly journals Acceptance and Avoidance Processes at Different Levels of Psychological Recovery from Enduring Mental Illness

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Vinicius R. Siqueira ◽  
Lindsay G. Oades
Keyword(s):  
Mental Illness ◽  
Experiential Avoidance ◽  
Rural Areas ◽  
Recovery Process ◽  
Well Being ◽  
Clear Correlation ◽  
Psychological Well Being ◽  
Psychological Recovery ◽  
Axis I ◽  
Psychological Acceptance

Objective. This study examined the use of psychological acceptance and experiential avoidance, two key concepts of Acceptance and Commitment Therapy (ACT), in the psychological recovery process of people with enduring mental illness.Method. Sixty-seven participants were recruited from the metropolitan, regional, and rural areas of New South Wales, Australia. They all presented some form of chronic mental illness (at least 12 months) as reflected in DSM-IV Axis I diagnostic criteria. The Acceptance and Action Questionnaire (AAQ-19) was used to measure the presence of psychological acceptance and experiential avoidance; the Recovery Assessment Scale (RAS) was used to examine the levels of psychological recovery; and the Scales of Psychological Well-Being was used to observe if there are benefits in utilizing psychological acceptance and experiential avoidance in the recovery process.Results. An analysis of objectively quantifiable measures found no clear correlation between the use of psychological acceptance and recovery in mental illness as measured by the RAS. The data, however, showed a relationship between psychological acceptance and some components of recovery, thereby demonstrating its possible value in the recovery process.Conclusion. The major contribution of this research was the emerging correlation that was observed between psychological acceptance and positive levels of psychological well-being among individuals with mental illness.

Patterns of genetic screening for hereditary cancer syndromes: Effect of Supreme Court’s ruling invalidating single gene patent rights.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1580-1580
Author(s):  
Zhen Ni Zhou ◽  
Melissa K Frey ◽  
Dimitrios Nasioudis ◽  
Ann Carlson ◽  
Jessica Fields ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Supreme Court ◽  
Dna Sequences ◽  
Single Gene ◽  
Categorical Variables ◽  
Court Ruling ◽  
Supreme Court Ruling ◽  
Gene Testing ◽  
The Supreme Court ◽  
Multigene Panels

1580 Background: In 6/2013 the Supreme Court ruled that isolated DNA sequences found in nature could not be patented, resulting in rapid uptake of multigene panels. We sought to explore trends in genetic testing since this ruling. Methods: Results of all patients undergoing genetic testing and counseling at a single institution between 7/1/13 and 12/31/16 were reviewed. Associations between categorical variables were evaluated by chi-square tests or Fisher's exact tests as appropriate for category size. Results: 1663 patients underwent genetic testing over the study period. The median age was 49 years (range 18-86). Use of multigene panels versus targeted gene testing increased significantly in the years following the Supreme Court ruling (Table 1, P<0.001). While the percentage of patients found to have pathogenic mutations remained stable over the study period (9%), detection of variants of uncertain significance (VUS) increased significantly (Table 1, P<0.001). In 2013 BRCA1/2 mutations accounted for 91% of identified mutations; however this number decreased over time (2014-83%, 2015-70%, 2016-58%, P=0.01). Use of multigene panels detected 71% of mutations in non- BRCA1/2 genes such as CHEK(19), APC(44), MSH6(1), P53(1), and PTEN(1). Patients with a personal history of breast and/or ovarian cancer were more likely to have targeted testing than patients with other cancer types (590, 66% vs. 9, 33%, P=0.001). Conclusions: The uptake of multigene panels has increased since the 2013 Supreme Court ruling. While this technology allowed for the identification of many cancer-related genes that would be missed on targeted BRCA1/2 testing, it also resulted in a significantly increased detection of VUS, a finding with unknown clinical implications. [Table: see text]

Outcomes of retesting BRCA negative patients using multigene panels

2016 ◽  
Vol 16 (3) ◽  
pp. 319-328 ◽  
Author(s):  
Siddhartha Yadav ◽  
Ashley Reeves ◽  
Sarah Campian ◽  
Amy Paine ◽  
Dana Zakalik
Keyword(s):  
Multigene Panels ◽  
Brca Negative
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