scholarly journals Neurotropic properties of new complex compounds of SnCl4 with salicyloyl hydrazones of benzaldehyde and 4-bromobenzaldehyde

2020 ◽  
Vol 14 (5) ◽  
Author(s):  
E. G. Prokopchuk ◽  
A. I. Aleksandrova ◽  
I. A. Kravchenko
Keyword(s):  
Oral Administration ◽  
Open Field ◽  
Field Test ◽  
Depressive Disorders ◽  
Open Field Test ◽  
Anxiolytic Effect ◽  
Complex Compounds ◽  
Anxiolytic Activity ◽  
Stress Factors ◽  
Light Dark Box

Existing data demonstrate that various medicines used for depressive disorders therapy had a number of additional effects such as sedation and mood improvement. In fact, signals from the environmental stress factors such as life-threatening hazards, social stressors and reaction to injury in the organism, firstly transmitted by the sensory nervous system and then this information are processed by the so-called emotional patterns in the brain. Treatment of various diseases that usually accompanied with neuropsychic disorders leads to «polypragmasia» – prescription of many medicines (5 and more) at the same time. Therefore, there is a big of interest to develop complex medicine with broad spectrum of the pharmacological action for the treatment of depressive disorders. Our previous research was focused on the anti-depressive properties of the complex compounds of SnCl4 with salicyloyl hydrazones of benzaldehyde (C-I) and 4-bromobenzaldehyde (C-II) and their functional aspects.The aim of the study is to determine anxiolytic and sedative activity of new complex compounds of SnCl4 with salicyloyl hydrazones of benzaldehyde and 4-bromobenzaldehyde in: «Open-field test» and «Light-dark box».Behaviour of experimental animals (mouse) was analysed by means of the test «light-dark box». It was conducted during 5 min in 1 h, 3 h, 5 and 24 h after the oral administration of substances, registering the following values: residence time in the light box and number of peeps from black to light box. Study of anxiety was conducted by means of «open-field test» during the equal time (1 h, 3 h, 5 h and 24 h). Examination was conducted during 5 min, registering numbers of stands on the hind paws (vertical mobility), numbers of peeps into holes (exploratory activity) and numbers of crossings the boxes(locomotor activity). To determine whether the complexes and functional groups that contained in C-I and C-II demonstrate anxiolytic effect, the anxiolytic action of benzaldehyde, 4-bromobenzaldehyde, salicyloyl hydrazone of benzaldehyde, salicyloyl hydrazones of 4-bromobenzaldehyde have been tested.The results of anxiolytic activity study of the complex compounds of SnCl4 with salicyloyl hydrazones of benzaldehyde and 4-bromobenzaldehyde demonstrated that after oral administration of these compounds the expressive neurotropic effect had observed during the 24 h of the experiment. The study of salicyloyl hydrazones of 4-bromobenzaldehyde indicated its significant contribution into the anxiolytic effect of the C-II. Probably the anxiolytic activity has occurred due to bromine atoms presence in the structure of the complexes.

scholarly journals A comparative analysis of anxiolytic activity of Arnica montana and alprazolam in rats using open field test

2018 ◽  
Vol 7 (4) ◽  
pp. 718
Author(s):  
Puja Jha ◽  
Seema Bhalerao ◽  
Mrunal Dhole
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Physical Dependence ◽  
Forced Swim Test ◽  
Anxiolytic Activity ◽  
Combination Group ◽  
Control Group ◽  
Arnica Montana ◽  
Group I

Background: Anxiety affects around 7.3% of the total population worldwide. Benzodiazepines are preferred anxiolytic agents and are still frequently used in spite of the side effect profile including muscle relaxation, memory disturbances, sedation, physical dependence. Arnica montana, a traditional herb is known to possess significant anxiolytic effect at the dose of 100mg/kg. In this study, Arnica montana has been compared for the first time with alprazolam, a most commonly used anxiolytic drug.Methods: Forced swim test was used to induce anxiety. Anxiolytic action of study drugs which were given orally, was evaluated using Open field test (OFT) in healthy wistar rats of either sex. Behavior of rats, locomotion and number of squares crossed was recorded. Rats were divided into four groups with eight rats in each group. Study groups were Group I Control; Group II Alprazolam 0.08mg/kg; Group III Arnica montana extract (AME) 100mg/kg; Group IV AME + Alprazolam group 100mg/kg+0.08mg/kg. Statistical analysis was done using ANOVA followed by Tukey’s test (p<0.05).Results: Increase in frequency of rearing was significant (p<0.05) in AME group and highly significant (p<0.001) in Alprazolam and combination group in comparison to control. Decrease in frequency of grooming was highly significant (p<0.001) in Alprazolam and combination group. AME also showed significant (p<0.05) decrease in grooming activity.Conclusions: Arnica montana extract showed anxiolytic activity and can be used as an add on drug after further studies and validation in the treatment of anxiety disorders.

scholarly journals Study of the dynamics of anticonvulsant and anxiolytic action after oral administration of tin (II) chloride

2019 ◽  
Vol 23 (2) ◽  
pp. 204-208
Author(s):  
О. G. Prokopchuk ◽  
O. I. Aleksandrova ◽  
I. A. Kravchenko
Keyword(s):  
Oral Administration ◽  
Open Field ◽  
Depressive Disorders ◽  
Anxiolytic Effect ◽  
Mean Value ◽  
Control Group ◽  
Mean Deviation ◽  
Black And White ◽  
Generalized Seizures ◽  
Tonic Extension

This article is devoted to the study of anticonvulsant and anxiolytic activity of tin (II) chloride by oral administration. The anxiolytic effect was established in models of the Open Field and Black-and-White Camera tests; the anticonvulsant activity of SnCl (II) was evaluated in model of acute generalized seizures with the determination of pentylenetetrazole (PTZ) minimum effective doses inducing clonic-tonic convulsions and tonic extension in test animals. Statistical indicators were calculated using the Microsoft Excel software package using the arithmetic mean value (M) and the mean deviation mean value (m). The obtained data show that tin (II) chloride is a promising compound for the prevention of anxiety states, as well as disorders containing the convulsive component. Three hours after the start of the experiment, the minimum doses of pentylenetetrazole for inducing clonic-tonic convulsions and tonic extension, exceeded the control group data by an average of 75%. A decrease in motor activity by half compared with the control in the open field test during the 5 hours of the experiment indicates the sedative effect of tin (II) chloride. Tin (II) chloride is a promising compound for the relief of convulsive states and correction of depressive disorders. Thus, it is of interest to further study the spectrum of its pharmacological activity in order the use it in medicine.

scholarly journals PECULIARITIES OF MOTOR ACTIVITY OF RATS IN SIMULATION PHARMACOLOGICAL DEPRESSOGENIC STATES

2021 ◽  
Vol 74 (9) ◽  
pp. 2105-2108
Author(s):  
Antonina Sydorenko ◽  
Ruslan Lutsenko ◽  
Iryna Kniazkova ◽  
Nataliia Liakhovska ◽  
Olga Lutsenko
Keyword(s):  
Motor Activity ◽  
Open Field ◽  
Field Test ◽  
Chloride Solution ◽  
Depressive Disorders ◽  
Open Field Test ◽  
Mature Male ◽  
Control Group ◽  
Male Wistar Rats ◽  
Pronounced Inhibition

The aim: To analyze and compare the features of changes in the motor activity of rats on the background of pharmacological models of depressive disorders. Materials and methods: Depressive-like state was simulated on 40 mature male Wistar rats using: reserpine (15 mg/kg), clonidine (0.1 mg/kg), haloperidol (0.25 mg/kg). The control group was given as a single dose 0.5 ml of a 0.9% sodium chloride solution intraperitoneally. After 3, 12, 24, 48 and 72 hours from the beginning of the experiment, changes in motor activity in the “open field” test were examined by the number of crossed squares, the calculation was carried out within 5 minutes. Results: Reserpine at a dose of 15 mg/kg caused probable motor activity disorders in rats in the “open field” test during all study periods. The most pronounced inhibition of motor activity was observed within 12-48 hours from the beginning of the experiment. 3 hours after clonidine administration, the number of crossed squares decreased by 310% (p<0.001), after 12 hours – by 180% (p<0.001), after 24 hours – by 140% (p<0.001), after 48 hours – by 50% (p<0.005) in comparison with the control group. On 3rd day, the motor activity of rats was almost completely restored. The use of haloperidol after 3 hours most significantly impaired the motor activity of rats in the “open field” test, and its recovery was observed after 24 hours. Conclusions: Reserpine inhibited the motor activity of rats, most pronounced from 12 to 48 hours of the experiment. Clonidine inhibited mainly in the first hours of the study. Haloperidol impaired motor activity at 3rd and 12th hours of observation.

scholarly journals Phytoestrogens are the correctors of vasomotor and psychoemotional reactions after experimental ovariectomy

2011 ◽  
Vol 10 (5) ◽  
pp. 82-85
Author(s):  
T. M. Plotnikova ◽  
N. V. Vasiliyeva ◽  
A. M. Anishchenko
Keyword(s):  
Motor Activity ◽  
Open Field ◽  
Sex Hormones ◽  
Blood Level ◽  
Field Test ◽  
Open Field Test ◽  
Anxiolytic Activity ◽  
Hot Flushes ◽  
Vasoactive Agents ◽  
Maackia Amurensis

The effects of Maackia amurensis extract (200 mg/kg, p.o. during the 14 days) on the vasomotor and psychoemotional reactions in rats after ovariectomy were investigated. The Maackia amurensis extract did not change the blood level of sex hormones, showed anxiolytic activity with the models of anxious disorders, did not influence considerably on the motor activity in «open field» test. Maackia amurensis extract reduced the pathological vasomotor reactions, showing by the change in vessels reactions on vasoactive agents and «hot flushes».

scholarly journals Toxicity and Neuropharmacological Effects of Elenine

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eduardo Navarro ◽  
S. J. Alonso ◽  
R. Navarro
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chemical Structure ◽  
Open Field Test ◽  
Control Group ◽  
General Behaviour ◽  
Similar Chemical ◽  
Sedative Effects ◽  
Traction Test ◽  
Central Depressant

Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived fromJusticia hyssopifolia. (Family: Acanthaceae). Elenoside is a β-D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity. In the present study, elenine was given to mice and rats at doses of 10, 20, and 40 mg/kg. Acute toxicity (24 h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10 mg/kg of chlorpromazine. Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test). Spontaneous activity was lower in the Varimex test. The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test. Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.

scholarly journals Participation ofGABAAChloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Juan Francisco Rodríguez-Landa ◽  
Rosa Isela García-Ríos ◽  
Jonathan Cueto-Escobedo ◽  
Blandina Bernal-Morales ◽  
Carlos M. Contreras
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chloride Channels ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Acid Mixture ◽  
Plus Maze ◽  
Gaba Binding ◽  
Defensive Burying

Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μg%; C14:0, myristic acid, 6.9 μg%; C16:0, palmitic acid, 35.3 μg%; C16:1, palmitoleic acid, 16.4 μg%; C18:0, stearic acid, 8.5 μg%; C18:1cis, oleic acid, 18.4 μg%; C18:1trans, elaidic acid, 3.5 μg%; C18:2, linoleic acid, 10.1 μg%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement ofγ-aminobutyric acid-A (GABAA) receptors, a possibility not yet explored. Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test. In different groups, threeGABAAreceptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg),GABAAbenzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitiveGABAAchloride channel antagonist picrotoxin (1 mg/kg). The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test. TheGABAAantagonists alone did not produce significant changes in the behavioral tests. Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M. Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects throughGABAAreceptor chloride channels.

Acute effects of ethanol on behavioral responses of male and female zebrafish in the open field test with the influence of a non-familiar object

2021 ◽  
pp. 104474
Author(s):  
Thiele P. Souza ◽  
Francini Franscescon ◽  
Flavia V. Stefanello ◽  
Talise E. Müller ◽  
Laura W. Santos ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Behavioral Responses ◽  
Familiar Object ◽  
Acute Effects ◽  
Male And Female ◽  
Female Zebrafish
Sign in / Sign up

Export Citation Format

Share Document