scholarly journals Study of the dynamics of anticonvulsant and anxiolytic action after oral administration of tin (II) chloride

2019 ◽  
Vol 23 (2) ◽  
pp. 204-208
Author(s):  
О. G. Prokopchuk ◽  
O. I. Aleksandrova ◽  
I. A. Kravchenko
Keyword(s):  
Oral Administration ◽  
Open Field ◽  
Depressive Disorders ◽  
Anxiolytic Effect ◽  
Mean Value ◽  
Control Group ◽  
Mean Deviation ◽  
Black And White ◽  
Generalized Seizures ◽  
Tonic Extension

This article is devoted to the study of anticonvulsant and anxiolytic activity of tin (II) chloride by oral administration. The anxiolytic effect was established in models of the Open Field and Black-and-White Camera tests; the anticonvulsant activity of SnCl (II) was evaluated in model of acute generalized seizures with the determination of pentylenetetrazole (PTZ) minimum effective doses inducing clonic-tonic convulsions and tonic extension in test animals. Statistical indicators were calculated using the Microsoft Excel software package using the arithmetic mean value (M) and the mean deviation mean value (m). The obtained data show that tin (II) chloride is a promising compound for the prevention of anxiety states, as well as disorders containing the convulsive component. Three hours after the start of the experiment, the minimum doses of pentylenetetrazole for inducing clonic-tonic convulsions and tonic extension, exceeded the control group data by an average of 75%. A decrease in motor activity by half compared with the control in the open field test during the 5 hours of the experiment indicates the sedative effect of tin (II) chloride. Tin (II) chloride is a promising compound for the relief of convulsive states and correction of depressive disorders. Thus, it is of interest to further study the spectrum of its pharmacological activity in order the use it in medicine.

scholarly journals Neurotropic properties of new complex compounds of SnCl4 with salicyloyl hydrazones of benzaldehyde and 4-bromobenzaldehyde

2020 ◽  
Vol 14 (5) ◽  
Author(s):  
E. G. Prokopchuk ◽  
A. I. Aleksandrova ◽  
I. A. Kravchenko
Keyword(s):  
Oral Administration ◽  
Open Field ◽  
Field Test ◽  
Depressive Disorders ◽  
Open Field Test ◽  
Anxiolytic Effect ◽  
Complex Compounds ◽  
Anxiolytic Activity ◽  
Stress Factors ◽  
Light Dark Box

Existing data demonstrate that various medicines used for depressive disorders therapy had a number of additional effects such as sedation and mood improvement. In fact, signals from the environmental stress factors such as life-threatening hazards, social stressors and reaction to injury in the organism, firstly transmitted by the sensory nervous system and then this information are processed by the so-called emotional patterns in the brain. Treatment of various diseases that usually accompanied with neuropsychic disorders leads to «polypragmasia» – prescription of many medicines (5 and more) at the same time. Therefore, there is a big of interest to develop complex medicine with broad spectrum of the pharmacological action for the treatment of depressive disorders. Our previous research was focused on the anti-depressive properties of the complex compounds of SnCl4 with salicyloyl hydrazones of benzaldehyde (C-I) and 4-bromobenzaldehyde (C-II) and their functional aspects.The aim of the study is to determine anxiolytic and sedative activity of new complex compounds of SnCl4 with salicyloyl hydrazones of benzaldehyde and 4-bromobenzaldehyde in: «Open-field test» and «Light-dark box».Behaviour of experimental animals (mouse) was analysed by means of the test «light-dark box». It was conducted during 5 min in 1 h, 3 h, 5 and 24 h after the oral administration of substances, registering the following values: residence time in the light box and number of peeps from black to light box. Study of anxiety was conducted by means of «open-field test» during the equal time (1 h, 3 h, 5 h and 24 h). Examination was conducted during 5 min, registering numbers of stands on the hind paws (vertical mobility), numbers of peeps into holes (exploratory activity) and numbers of crossings the boxes(locomotor activity). To determine whether the complexes and functional groups that contained in C-I and C-II demonstrate anxiolytic effect, the anxiolytic action of benzaldehyde, 4-bromobenzaldehyde, salicyloyl hydrazone of benzaldehyde, salicyloyl hydrazones of 4-bromobenzaldehyde have been tested.The results of anxiolytic activity study of the complex compounds of SnCl4 with salicyloyl hydrazones of benzaldehyde and 4-bromobenzaldehyde demonstrated that after oral administration of these compounds the expressive neurotropic effect had observed during the 24 h of the experiment. The study of salicyloyl hydrazones of 4-bromobenzaldehyde indicated its significant contribution into the anxiolytic effect of the C-II. Probably the anxiolytic activity has occurred due to bromine atoms presence in the structure of the complexes.

scholarly journals ESTIMATION OF THE ANXIOLYTIC-LIKE EFFECT OF THE β-CARBOLINE ALKALOID HARMINE ON STRESSED PREGNANT RATS

2017 ◽  
Vol 9 (5) ◽  
pp. 166
Author(s):  
Rima Benatoui ◽  
Abdelmadjid Bairi ◽  
Abdelkrim Tahraoui
Keyword(s):  
Open Field ◽  
Anxiolytic Effect ◽  
Treated Group ◽  
Female Rats ◽  
Male Rats ◽  
Control Group ◽  
Pregnant Rats ◽  
Footshock Stress ◽  
Plus Maze ◽  
Light Dark Box

Objective: During the last decade, the role of the β-carboline alkaloid harmine has essentially been studied with regard to its anxiolytic effect, as it was done in our laboratory; therefore, this study has been progressed to cover the effect of this alkaloid on pregnant wistar rats.Methods: The molecule was used at doses of 10 mg/kg, 15 mg/kg, pregnant female rats were divided into three groups according to the stage of pregnancy: first, second, and the third week of pregnancy. Each group has been subdivided into seven subgroups: control group, two treated groups with harmine, acute footshock stress at 1,2mA, sub-acute footshock stress at 0,4mA, psychological stress, and the treated group that footshocked after with 1,2mA, all groups were carried out open field test, plus maze test and light/dark box test.Results: Thigmotaxis is reflected by the significant increase in the traveled distance in peripheral area in the open field of the three groups ‘weeks’ at dose of 10 mg/kg, the enhancement in the number and time of rearing, at both doses, during the second and the last week, the significant increase in the number of entries ‘in open arms’ in plus-maze during the first and third weeks at 15 mg/kg, and the significant decreased in time spent in the light compartment of the light/dark box at the same dose of all groups ‘weeks’ were noticed, which confirm the anxiolytic effect of the alkaloid, even in the case of the footschock stressed pregnant rats of all groups ‘weeks’ that enhancement of number of enties into open arms during the plus maze test.Conclusion: So we can conclude that the anxiolytic effect of harmine not shortening to male rats, but expands to female pregnant wistar rats, and establishes its effect by diminishing time in light compartment of light/dark box and number of entries in open arms of plus maze, in other hand, the increase in the number and the time of rearing reflects the enhancement of exploratory behavior.

scholarly journals Effect of Agaricus blazei Murill on exploratory behavior of mice-model

2024 ◽  
Vol 84 ◽  
Author(s):  
M. M. Ali ◽  
M. T. Baig ◽  
A. Huma ◽  
S. Ibrahim ◽  
S. A. Khan ◽  
...  
Keyword(s):  
Oral Administration ◽  
Anxiolytic Effect ◽  
Treated Group ◽  
Vehicle Control ◽  
Control Group ◽  
Alcoholic Extract ◽  
Agaricus Blazei ◽  
Mice Model ◽  
Vehicle Control Group ◽  
Anxiolytic Drugs

Abstract Increased anxiety and depressive symptoms have reported to be its association with long term illness. Because of having unwanted effects of newly available drugs, patients administering anxiolytic drugs usually discontinue the treatment before they are completely recovered. Therefore, there is a serious need to develop new anxiolytic drugs. The anxiolytic effect of hydro-alcoholic extract of Agaricus blazei in animal models was assessed. 24 male mice (Mus musculus genus) were included in the study. Four groups were prepared and each group contained six animals. The groups were vehicle control, positive control (diazepam 1.0 mg/kg, i.p.) as well as two treatment groups receiving Agaricus blazei hydro-alcoholic extract at a dose of 136.50 mg/kg and 273.0 mg/kg orally. The Marble burying test, Nestlet shredding test and Light and Dark box test used to assess anxiolytic activity. Mice administered with diazepam 1.0 mg/kg, i.p. while hydro-alcoholic extract of AbM (136.50 and 273.0 mg/kg, respectively) was administered via oral route which exhibited marked reduction in number of marbles-burying as compared to vehicle control group. Mice administered with diazepam 1.0 mg/kg, i.p. and Oral administration of hydro-alcoholic extract of AbM (136.50 and 273.0 mg/kg, respectively) exhibited significant decrease in nestlet shredding in comparison to vehicle control group. The oral administration of hydro-alcoholic extract at a dose of 136.5mg/kg and 273mg/kg showed elevation in time spent in light box and was comparable to standard treated group while time spent by mice following oral administration of hydro-alcoholic extract of Agaricus blazei at a dose of 273.0 mg/kg also showed elevation and was found to be more near to standard treated group (diazepam 1 mg/kg, i.p.).

scholarly journals Experimental research on the interactions between some anxiolytics and dietary sodium monoglutamate

2014 ◽  
Vol 60 (6) ◽  
pp. 260-264
Author(s):  
Anca Buzescu ◽  
Nicoleta Aurelia Cristea ◽  
Alexandra Chiriac ◽  
C. Chiriță
Keyword(s):  
Oral Administration ◽  
Monosodium Glutamate ◽  
Anxiolytic Effect ◽  
Dietary Sodium ◽  
Control Group ◽  
First Line Therapy ◽  
Adult Mice ◽  
Low Degree ◽  
Medium Time ◽  
Flavour Enhancer

Abstract Objectives: Monosodium glutamate, the salt of glutamic acid, is largely used as a flavour enhancer (E621). In this study, we determine if monosodium glutamate, after repeated oral administration, can induce any degree of anxiety. Taking into account the interdependence between glutamate and GABA neurotransmissions, we studied the possible interactions of monosodium glutamate with some representatives belonging to benzodiazepines therapeutical class, diazepam and alprazolam, used as first line therapy for the treatment of anxiety. Methods: For determining the degree of anxiety, the specific cross-labyrinth test was used. The medium time spent in the closed-arms of the crosslabyrinth is correlated with increased anxiety and the medium time spent in the opened arms is correlated with a low degree anxiety. NMRI adult mice received 300 mg/kg monosodium glutamate for 21 days, dose representing 1/50 from mice LD50 (15000mg/kg) and twice the maximum admitted dose/ day for human. Results: When compared to control group, the group receiving monosodium glutamate, showed a not statistically significant slight increase in the degree of anxiety. The groups receiving benzodiazepines presented a significant reduction of the degree of anxiety, proving their anxiolytic effect. The groups receiving glutamate and diazepam or alprazolam, showed a lower reduction of the degree of anxiety, than group receiving only benzodiazepines, phenomenon which proves an antagonism between glutamate and the anxiolytics used in this study. Conclusions: The oral administration of monosodium glutamate increases slightly, not statistically significant, the degree of anxiety in mice and significantly alters the response to the benzodiazepines therapy, reducing the effect for both alprazolam and diazepam.

scholarly journals PECULIARITIES OF MOTOR ACTIVITY OF RATS IN SIMULATION PHARMACOLOGICAL DEPRESSOGENIC STATES

2021 ◽  
Vol 74 (9) ◽  
pp. 2105-2108
Author(s):  
Antonina Sydorenko ◽  
Ruslan Lutsenko ◽  
Iryna Kniazkova ◽  
Nataliia Liakhovska ◽  
Olga Lutsenko
Keyword(s):  
Motor Activity ◽  
Open Field ◽  
Field Test ◽  
Chloride Solution ◽  
Depressive Disorders ◽  
Open Field Test ◽  
Mature Male ◽  
Control Group ◽  
Male Wistar Rats ◽  
Pronounced Inhibition

The aim: To analyze and compare the features of changes in the motor activity of rats on the background of pharmacological models of depressive disorders. Materials and methods: Depressive-like state was simulated on 40 mature male Wistar rats using: reserpine (15 mg/kg), clonidine (0.1 mg/kg), haloperidol (0.25 mg/kg). The control group was given as a single dose 0.5 ml of a 0.9% sodium chloride solution intraperitoneally. After 3, 12, 24, 48 and 72 hours from the beginning of the experiment, changes in motor activity in the “open field” test were examined by the number of crossed squares, the calculation was carried out within 5 minutes. Results: Reserpine at a dose of 15 mg/kg caused probable motor activity disorders in rats in the “open field” test during all study periods. The most pronounced inhibition of motor activity was observed within 12-48 hours from the beginning of the experiment. 3 hours after clonidine administration, the number of crossed squares decreased by 310% (p<0.001), after 12 hours – by 180% (p<0.001), after 24 hours – by 140% (p<0.001), after 48 hours – by 50% (p<0.005) in comparison with the control group. On 3rd day, the motor activity of rats was almost completely restored. The use of haloperidol after 3 hours most significantly impaired the motor activity of rats in the “open field” test, and its recovery was observed after 24 hours. Conclusions: Reserpine inhibited the motor activity of rats, most pronounced from 12 to 48 hours of the experiment. Clonidine inhibited mainly in the first hours of the study. Haloperidol impaired motor activity at 3rd and 12th hours of observation.

Dental Maturation in Children with Shunt-Treated Hydrocephalus

2004 ◽  
Vol 41 (6) ◽  
pp. 651-654 ◽  
Author(s):  
P. Pirttiniemi ◽  
A. Poikela ◽  
J. Huggare ◽  
T. Löppönen
Keyword(s):  
Mean Value ◽  
Control Group ◽  
Mean Deviation ◽  
Dental Age ◽  
Dental Maturation ◽  
Somatic Development ◽  
Pituitary Secretion ◽  
Pubertal Stages ◽  
The Mean ◽  
Genetically Determined

Objective The aim of this study was to examine the relationship between dental maturation and somatic development and to discover their possible deviations in children with shunt-treated hydrocephalus. Design Radiographs (orthopantomogram and hand-wrist radiograph) from children with shunt-treated hydrocephalus were analyzed with respect to the dental maturation and compared with values of an age- and sex-matched control group and population standards. Patients Forty-one children with shunt-treated hydrocephalus (27 boys and 14 girls) aged from 5 to 16 years (median age 11.0 years). Results The mean deviation of dental age from chronological age was significantly greater in the hydrocephalic group than in the control group. The mean value of dental age deviation was advanced in early pubertal stages but reduced in later pubertal stages. Conclusions These findings can be explained by changes in the endocrinological conditions, which are due to disturbed pituitary secretion. The present results could also partly reflect an adaptable developmental pathway in an otherwise strictly genetically determined process.

The influence of probiotic drug Biolax-U on morphological and biochemical parameters of blood in cows

2020 ◽  
pp. 70-76
Author(s):  
A. Farkhutdinova
Keyword(s):  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Experimental Studies ◽  
Positive Influence ◽  
Biologically Active ◽  
Feed Consumption ◽  
Control Group ◽  
Animal Blood ◽  
Black And White ◽  
White Breed

The expediency of using the probiotic drug Biolax-U in the rations of lactating and dry cows of Black-and-White breed has been studied and scientifically proved. The influence of this drug on the morphological and biochemical parameters of animal blood has been determined. The composition of the probiotic drug Biolax-U consists of eight strains of a balanced complex of living lactic acid bacteria, yeast and actinomycetes, as well as biologically active substances. For experimental studies conducted on 2 groups of cows have been selected by the method of pairs-analogs, the influence of feeding of feed have been prepared with the use of the microbiological drug with probiotic action Biolax-U on feed consumption, morphological and biochemical changes in blood has been studied. Analysis of the rations of cows indicates that the content of calcium, phosphorus, magnesium, sulfur and trace elements such as manganese, copper, zinc and cobalt in the feed has been reduced. It has been found by studies that the use of probiotic drug Biolax-U had the positive influence on the feed intake, digestibility and better assimilation of feed nutrients and contributed to the improvement of blood morphological and biochemical parameters. For example, in animals of the experimental group hemoglobin has increased by 3,6 % (Р < 0,05), red blood cells by 10,1 (P ≤ 0,05), the content of leukocytes by 4,43, carotene by 9,6, glucose by 3,4; reserve alkalinity by 15,6, calcium by 19,4 (P ≤ 0,01), and phosphorus by 18,4 % compared with the control group of animals. During the lactation significantly improved hematological parameters including alkalinity reserve by 5,11 %, calcium level by 11,1, phosphorus by 8,6, hemoglobin by 14,2 %, the content of erythrocytes by 12,3, leukocyte by 3,86, and carotene 11,1 % against the parameters of animals of control group. The improvement of morphological and biochemical parameters of blood of cows indicates about stimulating effect on hematopoiesis and the general clinical condition of animals that contributes to the improvement of metabolic processes when using feed prepared with the use of microbiological drug with probiotic action Biolax-U.

Extruded lupine as a part of energy-protein concentrate in the ration of lactating cows

2020 ◽  
pp. 65-73
Author(s):  
Z. Fedorova
Keyword(s):  
Farm Animals ◽  
Feed Consumption ◽  
Control Group ◽  
Protein Concentrate ◽  
Cattle Farm ◽  
Black And White ◽  
Lactating Cows ◽  
White Breed ◽  
Kaliningrad Region ◽  
Experimental Group

In order to fi ll the existing protein defi ciency in the rations of farm animals in particular dairy cows it is necessary to input feed lupins as widely as possible in crop rotations. Lupin is a very versatile forage crop it can be used in feed as herbage, in the form of haylage, silage, in compound feed as a protein additive, as well as a green manure crop to increase soil fertility. Questions of protein nutrition should be to be quickly resolved, both in the production of protein and in its standardized rational use. Unbalanced protein rations increase feed consumption per unit of production, thereby increasing its prime cost. In the world soya is generally recognized as a protein feed, but in the Kaliningrad region as in most of regions in our country, it does not maturate being a heat-loving crop. Under these environments the inclusion of extruded lupine grain in the composition of energy-protein concentrates for the production of compound feed has become an alternative to replacing expensive soya. The researches have been carried out it the cattle farm of LLC “Temp” in the Guryevsky area in the Kaliningrad region (March-May 2019) on feeding lactating cows energy-protein concentrate from extruded grain of narrow-leaved lupine, fl ax, triticale, subjected to heat treatment on a press extruder. For this purpose two groups of lactating cows of Black-and-White breed (control and experimental) have been formed using the method of pairs of analogs per 11 heads in each. Cows of the control group have received the main ration of the farm, and cows of the experimental group in addition to the main ration have received compound feed with extruded energy-protein concentrate based on lupine. As a result of research, the positive infl uence of energy-protein concentrate based on lupine in compound feed on the dairy productivity of cows has been established. Recipes of concentrate and compound feed with concentrate for lactating cows, the volume of inclusion of components in the concentrate and in the compound feed have been calculated. During the experiment, the milk yield in the experimental group of cows has increased by 62,4 kg or 8,0 %, than in the control group. From the cows of the experimental group the conditional profi t has been received in the amount of 1684,8 rubles per head.

The effectiveness of use RUSMA additive in the rations of lactating cows

2020 ◽  
pp. 28-37
Author(s):  
S. Sukhanova ◽  
N. Pozdnyakova ◽  
F. Yaroslavtsev
Keyword(s):  
Milk Fat ◽  
Raw Materials ◽  
Fat Content ◽  
Feed Additives ◽  
Control Group ◽  
New Mineral ◽  
Milk Productivity ◽  
Black And White ◽  
Lactating Cows ◽  
Experimental Group

The results of researches on the development of new mineral feed additives based on raw materials produced by Uralchem and the study of the eff ectiveness of their use in the rations of lactating cows have been presented in the article. The experiment has been carried out in the conditions of LLC “PF Barabinskoe” in the Dalmatovsky area in the Kurgan region where 3 groups of lactating cows of Black-and-White breed have been formed. Animals in the control group have been received the ration adopted in the farm, the 1st experimental group with the additive RusMA No. 1 at a dose of 150 g, the 2nd experimental group– with the additive RusMA No. 2 at the dose of 350 g. The use of experimental mineral additives in feeding lactating cows allowed us to increase their milk productivity and profi tability of production. At the same time, the best eff ectiveness was shown by the additive RusMA No. 2 at the dose of 350 g/head/day. The use of RusMA additives during the experiment period (105 days) allowed to increase the milk productivity of cows in the 1st experimental group by 6,03 % and in the 2nd experimental group by 8,24 %. Taking into account the fat content in milk, this diff erence was 6,31 and 8,53 %, respectively. The energy value of milk from cows of the experimental groups was higher compared to the control group by 2,45 and 1,76 %, respectively. According to the content of dry matter in milk, cows of the 2nd experimental group exceeded the control and 1st experimental group by 0,39 and 0,12 abs.%, respectively. The maximum milk fat content has been observed in the milk of cows of the 1st experimental group by 0,03 and 0,01 abs.% more than in the control and 2nd experimental groups, respectively. In terms of protein content, the cows of the 2nd experimental group signifi cantly exceeded the control group by 0,10 abs.% and the 1st experimental by 0,04 abs.%. The content of milk sugar in the 2nd experimental group was higher than in the control by 0,30 abs.% and compared to the 1st experimental by 0,11 %. Signifi cantly more calcium and phosphorus were contained in the milk of cows of the 2nd experimental group by 4,58 % (Р ≤ 0,001) and 2,86 % (Р ≤ 0,05), compared with the control group. The expenditures of feed in the EFU for the production of 1 kg of milk in animals of the 2nd experimental group was less by 5,13 % than in control cows and by 2,63 % compared to the 1st experimental group. The prime cost of 1 centner of milk was lower in the 2nd experimental group by 3,94 %, in the 1st experimental group by 2,65 % compared to the control group. The level of profi tability of milk production in the 2nd experimental group was higher by 9,0 and 1,0 abs.% in comparison with the control and 1st experimental groups, respectively.

ВЛИЯНИЕ КОМПЛЕКСНОЙ МИНЕРАЛЬНО-ВИТАМИННОЙ КОРМОВОЙ ДОБАВКИ НА ГЕМАТОЛОГИЧЕСКИЕ И БИОХИМИЧЕСКИЕ ПОКАЗАТЕЛИ КРОВИ ТЕЛЯТ

2020 ◽  
Author(s):  
M.T. SABITOV ◽  
A.R. FARKHUTDINOVA ◽  
M.G. MALIKOVA ◽  
N.G. FENCHENKO ◽  
N.I. KHAIRULLINA ◽  
...  
Keyword(s):  
Animal Feed ◽  
Food Additives ◽  
Test Group ◽  
Feed Additives ◽  
Feed Additive ◽  
Control Group ◽  
Special Role ◽  
Young Stock ◽  
Black And White ◽  
Calcium Phosphorus

Изучена целесообразность использования в рационах телят черно-пестрой породы комплексной минерально-витаминной кормовой добавки (КМВКД). Установлено пониженное содержание в кормах таких элементов, как кальций, фосфор, магний, сера, марганец, медь, цинк и кобальт. Соотношение питательных и минеральных веществ, степень их доступности для усвоения организмом не обеспечивают их потребность. Использование КМВКД способствовало улучшению всех гематологических показателей. Все испытываемые рецепты, имеющие в своем составе разные варианты макро-, микроэлементов и витаминов положительно влияют на обменные про- цессы в организме животных. У молодняка опытной группы, получавшей подкормку по рецепту 1, количество эритроцитов в сравнении с животными контрольной группы увеличилось на 6,6, гемоглобина на 6,93 соответственно, по рецепту 2 11,05 и 11,39 по рецепту 3 16,75 и 15,27, то есть соотношение макро- и микроэлементов, имеющихся в составе КМВКД и взаимодействие между собой меди, железа и кобальта сыграли особую роль на концентрацию форменных элементов. У молодняка, получавшего подкормку по рецепту 1 количество общего белка в сравнении с животными контрольной группы увеличилось на 1,99, кальция на 16,02, каротина на 10,92 соответственно, по рецепту 2 4,91, 25,96 и 19,12 по рецепту 3 на 3,58, 27,07 и 20,21. Значительное повышение содержания белка, кальция, фосфора и каротина по сравнению с животными контрольной группы объясняется тем, что недостаток их в рационах восполнялся за счет используемой подкормки, в результате их содержание увеличилось в сыворотке, но не выходило за пределы нормативных данных и соответствовало физиологическим нормам.Practicability of using a complex mineral and vitamin feed additive (CMVFA) in the ration of black-and-white calf breed was studied. Decreased content of such elements as calcium, phosphorus, magnesium, sulfur, manganese, copper, zinc, and cobalt was registered. The correlation of nutritive and mineral substances, and the level of their availability for digestion did not provide for their need. CMVFA use facilitated the increase of all hematologic parameters. Tested recipes which had different content of sapropel and zeolite, as well as various types of macronutrients, microelements, and vitamins, positively influenced the digestive processes in animal bodies. Young stock from the test group that was receiving food additives according to recipe No. 1 showed 6.6 increase in the quantity of red blood cells compared to control group animals, and 6.93 increase in hemoglobin quantity the ones who were fed according to recipe No. 2 demonstrated the increase by 11.05 and 11.39 recipe No. 3 showed 16.75 and 15.27 increase, which means that the ratio of macronutrients and microelements present in CMVFA and the mutual interaction of copper, iron, and cobalt played a special role in the concentration of formed elements due to the fact that they are integral elements of blood. Total protein of young stock that was receiving food additives according to recipe No. 1 was 1.99 higher than in test group animals calcium 16.02 higher carotene 10.92 as for recipe No. 2 the values were increased by 4.91, 25.96, and 19.12 recipe No. 3 3.58, 27.07, and 20.21. Substantial increase in the content of protein, calcium, phosphorus, and carotene compared to control group animals can be explained by the fact that their insufficiency in animal feed was replenished due to the use of feed additives, and as a result their content increased in the serum but did not go beyond the norm and corresponded to physiological norms.

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