scholarly journals Microfluidics – Organ-on-chip

2019 ◽  
Vol 1 (1) ◽  
pp. 2-8
Author(s):  
Iulia Ioana Lungu ◽  
Alexandru Mihai Grumezescu
Keyword(s):  
Cell Cultures ◽  
Systemic Effect ◽  
Usual Method ◽  
Single Chip ◽  
Animal Testing ◽  
Lab On Chip ◽  
The World ◽  
Different Types ◽  
On Chip ◽  
Single Organ

This review is an introduction into the world of organ-on-chip models. By briefly explaining the concept of microfluidics and ‘lab-on-chip’, the main focus is on organs-on-chip and body-on-a-chip. The usual method to test the toxicity of a drug is through animal testing. However, the results do not always correlate to humans. In order to avoid animal testing, but also attain useful results, human-derived cell cultures using microfluidics have gained attention. Among all the different types of organ-on-chip devices, this review focuses on three distinct organs: heart, skin and liver. The main requirements for each organ-on-chip, as well as recent researches are presented. There have been considerable advancements with organ-on-chip models; however, even these have their limitations. Due to the fact that the system mimics a single organ, the systemic effect of drugs cannot be fully tested. Therefore, body-on-a-chip systems have been developed; which basically are a composed of a single chip that has several chambers, each chamber accounting for a distinct organ. Multi-organ-on-chip systems have been investigated, and even commercialized, the field still being under extensive research.

scholarly journals Micro–Macro: Selective Integration of Microfeatures Inside Low-Cost Macromolds for PDMS Microfluidics Fabrication

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 576 ◽  
Author(s):  
Edgar Jiménez-Díaz ◽  
Mariel Cano-Jorge ◽  
Diego Zamarrón-Hernández ◽  
Lucia Cabriales ◽  
Francisco Páez-Larios ◽  
...  
Keyword(s):  
Soft Lithography ◽  
Low Cost ◽  
Cost Effective ◽  
Microfluidic Chips ◽  
Single Chip ◽  
Lab On Chip ◽  
Molding Method ◽  
On Chip ◽  
Selective Integration ◽  
Important Progress

Microfluidics has become a very promising technology in recent years, due to its great potential to revolutionize life-science solutions. Generic microfabrication processes have been progressively made available to academic laboratories thanks to cost-effective soft-lithography techniques and enabled important progress in applications like lab-on-chip platforms using rapid- prototyping. However, micron-sized features are required in most designs, especially in biomimetic cell culture platforms, imposing elevated costs of production associated with lithography and limiting the use of such devices. In most cases, however, only a small portion of the structures require high-resolution and cost may be decreased. In this work, we present a replica-molding method separating the fabrication steps of low (macro) and high (micro) resolutions and then merging the two scales in a single chip. The method consists of fabricating the largest possible area in inexpensive macromolds using simple techniques such as plastics micromilling, laser microfabrication, or even by shrinking printed polystyrene sheets. The microfeatures were made on a separated mold or onto existing macromolds using photolithography or 2-photon lithography. By limiting the expensive area to the essential, the time and cost of fabrication can be reduced. Polydimethylsiloxane (PDMS) microfluidic chips were successfully fabricated from the constructed molds and tested to validate our micro–macro method.

A lab-on-chip ultrasonic platform for real-time and nondestructive assessment of extracellular matrix stiffness

Lab on a Chip ◽  
2020 ◽  
Vol 20 (4) ◽  
pp. 778-788 ◽  
Author(s):  
Amin Zareei ◽  
Hongjie Jiang ◽  
Shirisha Chittiboyina ◽  
Jiawei Zhou ◽  
Beatriz Plaza Marin ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Ultrasonic Wave ◽  
Cell Cultures ◽  
Wave Attenuation ◽  
Matrix Stiffness ◽  
Lab On Chip ◽  
3D Cell Cultures ◽  
Extracellular Matrix Stiffness ◽  
Noninvasive Assessment ◽  
On Chip

On-chip ultrasonic platform enables noninvasive assessment of ECM stiffness in 3D cell cultures, by monitoring ultrasonic wave attenuation through targeted material.

scholarly journals Vertical microbubble column–A photonic lab-on-chip for cultivation and online analysis of yeast cell cultures

2012 ◽  
Vol 6 (3) ◽  
pp. 034106 ◽  
Author(s):  
Stefanie Demming ◽  
Gena Peterat ◽  
Andreu Llobera ◽  
Hannah Schmolke ◽  
Alexander Bruns ◽  
...  
Keyword(s):  
Yeast Cell ◽  
Cell Cultures ◽  
Online Analysis ◽  
Lab On Chip ◽  
On Chip

scholarly journals Integration of Biosensors and Associated Electronics on Lab-on-Chip Devices

1970 ◽  
Vol 110 (4) ◽  
pp. 61-66
Author(s):  
A. T. Giannitsis ◽  
T. Parve ◽  
M. Min
Keyword(s):  
Environmental Monitoring ◽  
Point Of Care ◽  
Single Chip ◽  
Sensing Element ◽  
Lab On Chip ◽  
Liquid Samples ◽  
On Chip ◽  
Miniaturized Devices

Lab-on-chip devices comprise a class of bioelectronic miniaturized devices that incorporate microfluidic and biosensing apparatuses on a single chip. They are dedicated for analyzing and processing biochemical liquid samples, which may consist of enzymes, proteins, nucleotides, or even cells and viruses. Furthermore, lab-on-chips may enhance synthesis of biochemical products. The importance of lab-on-chip devices lies on their potentiality of advancing the development of environmental monitoring sensors and also point-of-care analyzers in medicine. This article presents the usual microfabrication methods for manufacturing lab-on-chip devices, with emphasis on the integration of the biosensor, the biocompatibility of the sensing element of the biosensor, and the essential electronics. Three major types of biosensors are analyzed: optical, impedimetric and electrochemical ones. Ill. 7, bibl. 28 (in English; abstracts in English and Lithuanian).http://dx.doi.org/10.5755/j01.eee.110.4.288

scholarly journals Design and Fabrication of Multichannel PDMS Microfluidic

2021 ◽  
Vol 2129 (1) ◽  
pp. 012048
Author(s):  
M N Afnan Uda ◽  
U Hashim ◽  
M N A Uda ◽  
N A Parmin ◽  
V Thivina
Keyword(s):  
Contact Area ◽  
Microfluidic Chip ◽  
Point Of Care ◽  
Main Tool ◽  
Morphological Properties ◽  
Single Chip ◽  
Lab On Chip ◽  
Micro Channels ◽  
On Chip ◽  
Disease Analysis

Abstract Microfluidic delivers miniaturized fluidic networks for processing liquids in the microliter range. In the recent years, lab-on-chip (LOC) is become a main tool for point-of-care (POC) diagnostic especially in the medical field. In this paper, we presented a design and fabrication on multi disease analysis using single chip via delivery of fluid with the multiple transducers is the pathway of multi-channel microfluidic based LOC’s. 3 in 1 nano biosensor kit was attached with the microfluidic to produce nano-biolab-on-chip (NBLOC). The multi channels microfluidic chip was designed including the micro channels, one inlet, three outlet and sensor contact area. The microfluidic chip was designed to include multiplex detection for pathogen that consists of multiple channels of simultaneous results. The LOC system was designed using Design Spark Mechanical software and PDMS was used as a medium of the microfluidic. The microfluidic mold and PDMS microfluidic morphological properties have been characterized by using low power microscope (LPM), high power microscope (HPM) and surface profiler. The LOC system physical was experimental by dropping food coloring through the inlet and collecting at the sensor contact area outlet.

HV-CMOS single-chip electronics platform for lab-on-chip DNA analysis

2016 ◽  
Author(s):  
David L. Sloan ◽  
Benjamin Martin ◽  
Gordon Hall ◽  
Andrew Hakman ◽  
Philip Marshall ◽  
...  
Keyword(s):  
Dna Analysis ◽  
Single Chip ◽  
Lab On Chip ◽  
On Chip

Parametric Study and Thickness Evaluation of Photoresist Development for the Formation of Microgap Electrodes Using Surface Nanoprofiler

2012 ◽  
Vol 626 ◽  
pp. 942-947 ◽  
Author(s):  
Q. Humayun ◽  
U. Hashim
Keyword(s):  
Single Chip ◽  
Simple Method ◽  
Lab On Chip ◽  
Positive Photoresist ◽  
Challenging Tasks ◽  
Micro Features ◽  
On Chip ◽  
Pattern Transformation ◽  
Chrome Mask ◽  
Spin Coater

A compact nanolaboratory on single chip is one of the challenging tasks for future reproductively of sensitive and selective lab-on-chip. This paper reports a simple and controllable technique for patterning microgap structures on (PR-1 2000A) positive photoresist. For the pattern transformation conventional lithography technique was used integrated with precise resolution mask namely chrome mask. This technique provides an especially simple method for the formation of micro features sizes of gaps onto the photoresist. The thickness of developed microgap structures on photoresist directly relates with the coating speed of spin coater.

Knowledge and Awareness of Dengue Fever

2018 ◽  
pp. 219-222
Author(s):  
Y. Arockia Suganthi ◽  
Chitra K. ◽  
J. Magelin Mary
Keyword(s):  
Dengue Fever ◽  
Prevention And Control ◽  
Control Measures ◽  
Infection Transmission ◽  
Standard Guideline ◽  
The World ◽  
Different Types ◽  
Prevention And Control Measures ◽  
Dengue Prevention ◽  
And Control

Dengue fever is a painful mosquito-borne infection caused by different types of virus in various localities of the world. There is no particular medicine or vaccine to treat person suffering from dengue fever. Dengue viruses are transmitted by the bite of female Aedes (Ae) mosquitoes. Dengue fever viruses are mainly transmitted by Aedes which can be active in tropical or subtropical climates. Aedes Aegypti is the key step to avoid infection transmission to save millions of people in all over the world. This paper provides a standard guideline in the planning of dengue prevention and control measures. At the same time gives the priorities including clinical management and hospitalized dengue patients have to address essentially.

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