scholarly journals A Novel 3E Method for Synthesis of 5-nitro 2-diethylamino 6-methyl pyridine Organic Crystal by Nitration of 2-diethylamino 6-methyl pyridine with H2SO4/HNO3

2021 ◽  
Vol 11 (4) ◽  
pp. 4131-4138
Keyword(s):  
Organic Synthesis ◽  
Innovation Process ◽  
Separation Process ◽  
Organic Crystal ◽  
Synthesis Process ◽  
The Novel ◽  
Chromatography Column ◽  
Column Separation ◽  
Energy Consuming ◽  
Methyl Pyridine

4-nitro 2-diethylamino 5-methyl pyridine (P-NitroC10N2H16) as an organic crystal which is the useful intermediate for pharmaceutical synthesis and for production of organic materials, which was usually synthesized by nitration of 2-diethylamino 5-methyl pyridine with H2SO4/HNO3 mixtures, followed by extraction, chromatography column separation and recrystallization three-step procedures. Here an innovation process for synthesizing 4-nitro 2-diethylamino 5-methyl pyridine crystal from the nitration of C10N2H16 without needing chromatography column separation step is presented. The novel organic synthesis process is more ecologic, economical, and environmentally-friendly (3E) than the traditional organic synthesis process since the chromatography column separation process is a material-consuming and energy-consuming step, which needs to dispose of a large amount of wasted silica beads.

scholarly journals Epoxy Coenzyme A Thioester Pathways for Degradation of Aromatic Compounds

2012 ◽  
Vol 78 (15) ◽  
pp. 5043-5051 ◽  
Author(s):  
Wael Ismail ◽  
Johannes Gescher
Keyword(s):  
Aromatic Ring ◽  
Aromatic Compounds ◽  
Coenzyme A ◽  
Environmental Pollutants ◽  
Bacterial Degradation ◽  
Ring Cleavage ◽  
The Novel ◽  
Energy Consuming ◽  
Coa Thioesters ◽  
Hydrolytic Mechanism

ABSTRACTAromatic compounds (biogenic and anthropogenic) are abundant in the biosphere. Some of them are well-known environmental pollutants. Although the aromatic nucleus is relatively recalcitrant, microorganisms have developed various catabolic routes that enable complete biodegradation of aromatic compounds. The adopted degradation pathways depend on the availability of oxygen. Under oxic conditions, microorganisms utilize oxygen as a cosubstrate to activate and cleave the aromatic ring. In contrast, under anoxic conditions, the aromatic compounds are transformed to coenzyme A (CoA) thioesters followed by energy-consuming reduction of the ring. Eventually, the dearomatized ring is opened via a hydrolytic mechanism. Recently, novel catabolic pathways for the aerobic degradation of aromatic compounds were elucidated that differ significantly from the established catabolic routes. The new pathways were investigated in detail for the aerobic bacterial degradation of benzoate and phenylacetate. In both cases, the pathway is initiated by transforming the substrate to a CoA thioester and all the intermediates are bound by CoA. The subsequent reactions involve epoxidation of the aromatic ring followed by hydrolytic ring cleavage. Here we discuss the novel pathways, with a particular focus on their unique features and occurrence as well as ecological significance.

Preparation of the Novel Nanocomposite Biurea/Montmorillonite via In Situ Synthesis

2012 ◽  
Vol 486 ◽  
pp. 388-393 ◽  
Author(s):  
Juan Xu ◽  
Li Li Jing ◽  
Can Xiong Guo
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Chemical Shifts ◽  
Thermal Analyses ◽  
Interlayer Spacing ◽  
Synthesis Process ◽  
Basal Spacing ◽  
The Novel ◽  
New Phase

Using the urea intercalated montmorillonite (Urea/MMT) as the precursor, a novel nanocomposite biurea intercalated montmorillonite (Biurea/MMT) was prepared via the in-situ synthesis process through the introduction of hydrazine hydrate (HY). The resulted nanocomposites were characterized by using techniques such as XRD, FTIR, solid state NMR as well as thermal analyses, etc. The influence of the concentration of the HY on the products was also investigated. The XRD results showed the variation of the interlayer spacing of MMT from 1.51 nm to 1.71 nm for Urea/MMT. When the concentration of HY was low, the substitution of urea by HY was taken place which resulted in the decrease of the interlayer distance to 1.27nm. When the concentration increased to greater than 40%, the new phase with basal spacing of 1.75 nm was dominated. It indicated that a novel nanocomposite was synthesized in-situ. The solid state NMR results confirmed the in-situ formation of Biurea/MMT in which the chemical shifts of13C and15N of the intercalated biurea were slightly different from the bulk biurea. The intercalated biurea decomposed easily than those bulk powders due to the highly dispersion in the interlayer space of MMT.

The Novel SO3H-Functionalized Ionic Liquids Promoted Synthesis of Xanthenedione Derivatives in Aqueous Media under Microwave Irradiation

2011 ◽  
Vol 391-392 ◽  
pp. 1354-1357 ◽  
Author(s):  
Bai Lin Li ◽  
Hua Ding Liang ◽  
Ai Guo Zhong ◽  
Dan Qian Xu
Keyword(s):  
Ionic Liquids ◽  
Microwave Irradiation ◽  
Organic Solvents ◽  
Catalytic System ◽  
Aqueous Media ◽  
Environmentally Friendly ◽  
Separation Process ◽  
The Novel ◽  
Simple Operation

Novel SO3H-functionalized ionic liquids were successfully applied as catalysts for synthesis of xanthenediones under microwave irradiation in Aqueous. Various types of Xanthenes were provided in 90-97% yields using the catalytic system of [(HSO3-p)2im][CF3SO3]/H2O. The products could be conveniently separated from the reaction mixture by filtration and the dissolved catalyst could be reused without any treatment, which of the separation process was performed in water without using any organic solvents. The method not only has the adventages of shrot time and simple operation, but also is environmentally friendly.

Heterocycles from methylenecyclopropanes

2015 ◽  
Vol 13 (31) ◽  
pp. 8379-8392 ◽  
Author(s):  
Lei Yu ◽  
Mingxuan Liu ◽  
Fenglin Chen ◽  
Qing Xu
Keyword(s):  
Organic Synthesis ◽  
Organic Reactions ◽  
The Novel

The construction of heterocycles from MCPs affords more opportunities for the quick synthesis of elaborately substituted products. This review aims to summarize the novel organic reactions of MCPs to produce heterocycles published in recent years, which have provided specific and powerful tools for organic synthesis.

Computational Synthesis of Product Architectures Based on Object-Oriented Graph Grammars

2012 ◽  
Vol 134 (2) ◽  
Author(s):  
Bergen Helms ◽  
Kristina Shea
Keyword(s):  
Innovation Process ◽  
Object Oriented ◽  
Oriented Graph ◽  
Computational Design ◽  
Building Blocks ◽  
Graph Representation ◽  
Synthesis Process ◽  
Graph Grammars ◽  
Computational Synthesis ◽  
The Impact

Computational design synthesis aims to iteratively and automatically generate solution spaces of standard and novel design alternatives to support the innovation process. New approaches are required to generate alternative solutions at the function and behavior level as well as to ease the computational modeling of design knowledge. This paper introduces the approach of object-oriented graph grammars for the computational synthesis of product models based on a Function–Behavior–Structure (FBS) representation. The approach combines the advantages of a generic and systematic design method with a highly computable graph representation and object-oriented concepts. Through this combination, advances in terms of extendibility, efficiency, and flexible formalization of declarative and procedural engineering knowledge are achieved. Validation of the method is given through the synthesis of hybrid powertrains. The generation of hybrid powertrain solution spaces is shown, especially focusing on the impact of an evolving vocabulary, or building blocks, for synthesis. Future work includes integrating search methods in the synthesis process along with quantitative evaluation using simulation methods.

scholarly journals A semi-automated module for the separation and purification of 99mTc from simulated molybdenum target

2021 ◽  
Author(s):  
Przemysław Koźmiński ◽  
Magdalena Gumiela ◽  
Rafał Walczak ◽  
Kamil Wawrowicz ◽  
Aleksander Bilewicz
Keyword(s):  
Radiochemical Purity ◽  
High Efficiency ◽  
Separation Process ◽  
Separation And Purification ◽  
Column Separation ◽  
Purification System ◽  
Radio Labeling

AbstractA semi-automated purification module for the cyclic separation of 99mTc was designed for production of [99mTc]TcO4– from γ irradiated 100Mo target. The separation process was carried out by using a 3-column purification system and the final product, [99mTc]TcO4–, was obtained in a total volume of 7 mL. To confirm proper separation achieved for 99mTc, a radio-labeling procedure using DTPA chelator was performed. The radiochemical purity was higher than 95%, which meets the strict radiopharmaceutical requirements. The yielded 99mTc can be separated with high efficiency from Mo in a quick and repeated way. Loss of 99mTc radioactivity during such a three-column separation process was not larger than 10%.

Ag–Fe3O4 nanocomposites@chitin microspheres constructed by in situ one-pot synthesis for rapid hydrogenation catalysis

2014 ◽  
Vol 16 (5) ◽  
pp. 2835-2845 ◽  
Author(s):  
Bo Duan ◽  
Feng Liu ◽  
Meng He ◽  
Lina Zhang
Keyword(s):  
Organic Synthesis ◽  
Packing Material ◽  
Column Packing ◽  
One Pot ◽  
Chromatography Column ◽  
One Pot Synthesis ◽  
Hydrogenation Catalysis

Ag–Fe3O4@chitin microspheres were developed as a retrievable catalyst and a potential chromatography column packing material for organic synthesis.

scholarly journals Convenient Synthesis of Benziodazolone: New Reagents for Direct Esterification of Alcohols and Amidation of Amines

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7355
Author(s):  
Michael T. Shea ◽  
Gregory T. Rohde ◽  
Yulia A. Vlasenko ◽  
Pavel S. Postnikov ◽  
Mekhman S. Yusubov ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Room Temperature ◽  
Hypervalent Iodine ◽  
The Novel ◽  
Chlorobenzoic Acid ◽  
Direct Esterification ◽  
X Ray ◽  
Convenient Synthesis

Hypervalent iodine heterocycles represent one of the important classes of hypervalent iodine reagents with many applications in organic synthesis. This paper reports a simple and convenient synthesis of benziodazolones by the reaction of readily available iodobenzamides with m-chloroperoxybenzoic acid in acetonitrile at room temperature. The structure of one of these new iodine heterocycles was confirmed by X-ray analysis. In combination with PPh3 and pyridine, these benziodazolones can smoothly react with alcohols or amines to produce the corresponding esters or amides of 3-chlorobenzoic acid, respectively. It was found that the novel benziodazolone reagent reacts more efficiently than the analogous benziodoxolone reagent in this esterification.

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