scholarly journals Retinopathy and Neuropathy in Patients with End Stage Renal Disease on Haemodialysis- A Hospital Based Study

2015 ◽  
Vol 6 (1) ◽  
pp. 14-19
Author(s):  
Nazneen Mahmood ◽  
Shaila Safia Chowdhury
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Neurological Manifestation ◽  
Diabetic Patients ◽  
Hypertensive Retinopathy ◽  
Medical College ◽  
Stage Renal Disease ◽  
End Stage

Bacground: Chronic renal failure is irreversible and progressive process that results in end stage renal disease (ESRD) where the patient has to be dependent on renal replacement therapy for survival. Retinopathy and neuropathy are often asymptomatic in their most treatable stage; delay in diagnosis can result in significant increase in the patient's risk of visual loss and disability. Ocular condition is also an indicator of the metabolic control of the disease process. This study is an attempt to access the ocular status/complications as well as neurological manifestation associated with end stage renal disease on haemodialysis.Methodology: This is a cross sectional descriptive type of observational study on patients of end stage renal disease getting haemodialysis in Medical College for Women and Hospital. Duration of study was 3 years from January 2011 to December 2013. This study is an attempt to access the ocular status/complications as well as neurological manifestation associated with end stage renal disease on haemodialysis.Result: Among 81 patients, 42 patients had hypertension (HTN) and 19 had diabetes mellitus (DM) and 20 had other causes of chronic kidney disease(CKD). In our study, out of 19 patients of diabetes mellitus, 73.68%(14) had diabetic retinopathy(DR) and 26.32%(5) had normal fundus. All the 42 patients had hypertensive retinopathy(HR). Regarding fundal examination of patients with hypertensive retinopathy(HR), 32.26% had gradel, and 17.74%, 43.55% and 6.45% were of grade ll, lll, lV respectively. It was found that non-proliferative changes in ocular fundal examination in diabetic patients were the commonest abnormality. On fundal examination of diabetic retinopathy (DR), 26.32% had normal fundus, 26.32% had dot and blot haemorrhages, 21.05% had hard exudates and cotton wool, 21.05% had new vascularization while 5.26% had retinal detachment.The following types of neuropathy were seen among our patients; 48.15% had symmetrical distal sensory motor polyneuropathy, 19.75% had a symmetrical polyneuropathy, 19.75% had mononeuropathy and cranial nerve palsies were detected in 12.35%.Conclusion: Detailed ocular and neurological examination should be undertaken in patients of end stage renal disease(ESRD) on maintenance haemodialysis(HD) for early diagnosis and treatment of the complications. Awareness is needed of the potential ocular and neurological complications of the disease process.Anwer Khan Modern Medical College Journal Vol. 6, No. 1: January 2015, Pages 14-19

scholarly journals End stage renal disease patients on haemodialysis profiled epidemiologically at medical college of sub-Himalayan region of India

2019 ◽  
Vol 7 (5) ◽  
pp. 1594
Author(s):  
Pankaj Kumar Gupta ◽  
Dinesh Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Organ Damage ◽  
Common Complication ◽  
Common Cause ◽  
Heart Damage ◽  
Medical College ◽  
Stage Renal Disease ◽  
End Stage

Background: Mostly, end organ damage becomes the reason for morbidity and mortality among patients with non-communicable diseases (NCDs) due their chronicity. Derangement of renal function along with brain and heart damage are considered to be a significant problem of NCDs. The objectives of this study were on this background of end stage renal disease (ESRD) as a common complication for common NCDs, present study was planned to study the distribution of responsible NCDs.Methods: Over three-year period, all the cases reported GFR <15ml/min/1.73m2 were studied.Results: Total 100 patients (male:65) were studied with mean age of 51.0±13.0 years. Diabetes mellitus (38.0%), hypertension (28.0%), and glomerulonephritis (16.0%) were three leading cause for ESRD. Idiopathic cause was observed among 12.0% patients. Fifteen percent patients could not survive.Conclusions: NCDs mainly diabetes mellitus and hypertension observed to be most common cause for ESRD.

The effect of diabetes mellitus and end-stage renal disease on the number of CD34+ cells in the blood

2013 ◽  
Vol 92 (9) ◽  
pp. 1189-1194 ◽  
Author(s):  
Cigdem Pala ◽  
Ilker Altun ◽  
Yavuz Koker ◽  
Fatih Kurnaz ◽  
Serdar Sivgin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cd34 Cells ◽  
Stage Renal Disease ◽  
End Stage

DIABETIC RETINOPATHY, CLASSIFIED USING THE LESION-AWARE DEEP LEARNING SYSTEM, PREDICTS DIABETIC END-STAGE RENAL DISEASE IN CHINESE PATIENTS

2020 ◽  
Vol 26 (4) ◽  
pp. 429-443 ◽  
Author(s):  
Lijun Zhao ◽  
Honghong Ren ◽  
Junlin Zhang ◽  
Yana Cao ◽  
Yiting Wang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Learning System ◽  
Chinese Patients ◽  
Glomerular Lesions ◽  
Stage Renal Disease ◽  
End Stage

Objective: To characterize the relationship between diabetic retinopathy (DR) and diabetic nephropathy (DN) in Chinese patients and to determine whether the severity of DR predicts end-stage renal disease (ESRD). Methods: Bilateral fundic photographs of 91 Chinese type 2 diabetic patients with biopsy-confirmed DN, not in ESRD stage, were obtained at the time of renal biopsy in this longitudinal study. The baseline severity of DR was determined using the Lesion-aware Deep Learning System (RetinalNET) in an open framework for deep learning and was graded using the Early Treatment Diabetic Retinopathy Study severity scale. Cox proportional hazard models were used to estimate the hazard ratio (HR) for the effect of the severity of diabetic retinopathy on ESRD. Results: During a median follow-up of 15 months, 25 patients progressed to ESRD. The severity of retinopathy at the time of biopsy was a prognostic factor for progression to ESRD (HR 2.18, 95% confidence interval 1.05 to 4.53, P = .04). At baseline, more severe retinopathy was associated with poor renal function, and more severe glomerular lesions. However, 30% of patients with mild retinopathy and severe glomerular lesions had higher low-density lipo-protein-cholesterol and more severe proteinuria than those with mild glomerular lesions. Additionally, 3% of patients with severe retinopathy and mild glomerular changes were more likely to have had diabetes a long time than those with severe glomerular lesions. Conclusion: Although the severity of DR predicted diabetic ESRD in patients with type 2 diabetes mellitus and DN, the severities of DR and DN were not always consistent, especially in patients with mild retinopathy or microalbuminuria. Abbreviations: CI = confidence interval; DM = diabetic mellitus; DN = diabetic nephropathy; DR = diabetic retinopathy; eGFR = estimated glomerular filtration rate; ESRD = end-stage renal disease; HbA1c = hemoglobin A1c; HR = hazard ratio; NPDR = nonproliferative diabetic retinopathy; PDR = proliferative diabetic retinopathy; SBP = systolic blood pressure; T2DM = type 2 diabetes mellitus; VEGF = vascular endothelial growth factor

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