scholarly journals Serum Albumin Level and Short-Term Outcome Following Stroke in Hospital Admitted Patients

2018 ◽  
Vol 9 (1) ◽  
pp. 27-30
Author(s):  
K Kirtania ◽  
A Khatun ◽  
RA Chowdhury ◽  
M Rukunuzzaman
Keyword(s):  
Serum Albumin ◽  
Acute Stroke ◽  
Inflammatory Diseases ◽  
Albumin Level ◽  
Short Term ◽  
Term Outcome ◽  
Cross Sectional ◽  
Short Term Outcome ◽  
Hospitalization Period ◽  
The Mean

Albumin is a non-glycosylated plasma protein synthesized primarily in the liver. It is a protein involved in the transport of small molecules in the blood and plays a key role in restricting fluid leakage from the vasculature into the tissue. Elevated level of serum albumin is related to haemoconcentration and reduced level is associated with malnutrition and chronic inflammatory diseases representing a negative acute phase protein. This cross sectional study was done to determine the association between admission serum albumin levels and short-term outcome following acute stroke. Consecutive first-ever acute stroke patients were enrolled between January 2016 and December 2016 at DMCH. On admission serum albumin were measured. Patients were then followed up for 10 days and outcome measure at the end of the study were 10- day mortality. Relationship between serum albumin and stroke outcome was determined. A total of 100 stroke cases were thus included in the study comprising 66 males and 34 females. The mean age of patients was 69.2±12.2 years. Of total, 74% patients were of ischemic stroke and 26% were of hemorrhagic stroke. Among them 22 patients expired in the hospitalization period within 10 days and remaining 78 patients were discharged. The mean serum level of albumin was 2.90±0.57 g/dl in the expired group and 3.79±0.51 g/dl in the discharged group. It may be concluded that low admission serum albumin may be significantly associated with poor outcome.Bangladesh J Med Biochem 2016; 9(1): 27-30

Procedural Complications During Early Versus Late Endovascular Treatment in Acute Stroke

Stroke ◽  
2021 ◽  
Author(s):  
Errikos Maslias ◽  
Stefania Nannoni ◽  
Federico Ricciardi ◽  
Bruno Bartolini ◽  
Davide Strambo ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Acute Stroke ◽  
Time Window ◽  
National Institutes Of Health ◽  
Late Time ◽  
Short Term ◽  
Term Outcome ◽  
Stroke Registry ◽  
Short Term Outcome ◽  
Procedural Complications

Background and Purpose: Endovascular treatment (EVT) in acute ischemic stroke is effective in the late time window in selected patients. However, the frequency and clinical impact of procedural complications in the early versus late time window has received little attention. Methods: We retrospectively studied all acute ischemic strokes from 2015 to 2019 receiving EVT in the Acute Stroke Registry and Analysis of Lausanne. We compared the procedural EVT complications in the early (<6 hours) versus late (6–24 hours) window and correlated them with short-term clinical outcome. Results: Among 695 acute ischemic strokes receiving EVT (of which 202 were in the late window), 113 (16.3%) had at least one procedural complication. The frequency of each single, and for overall procedural complications was similar for early versus late EVT (16.2% versus 16.3%, P adj =0.90). Procedural complications lead to a significantly less favorable short-term outcome, reflected by the absence of National Institutes of Health Stroke Scale improvement in late EVT (delta-National Institutes of Health Stroke Scale-24 hours, −2.5 versus 2, P adj =0.01). Conclusions: In this retrospective analysis of consecutive EVT, the frequency of procedural complications was similar for early and late EVT patients but very short-term outcome seemed less favorable in late EVT patients with complications.

Sex-Specific Differences in Short-Term and Long-Term Outcomes in Acute Stroke Patients from Qatar

2020 ◽  
Vol 83 (2) ◽  
pp. 154-161 ◽  
Author(s):  
Naveed Akhtar ◽  
Mahesh Kate ◽  
Saadat Kamran ◽  
Rajvir Singh ◽  
Zain Bhutta ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Major Adverse Cardiovascular Events ◽  
Stroke Patients ◽  
Long Term Outcomes ◽  
Short Term ◽  
Term Outcome ◽  
Contributory Factors ◽  
Short Term Outcome

Background: Sex differences may determine presentation, utility of treatment, rehabilitation, and occurrences of major adverse cardiovascular events (MACEs) in acute stroke (AS). Objective:The purpose of the study was to evaluate the short-term prognosis and long-term outcomes in MACEs in Qatari nationals admitted with AS. Methods: All AS patients admitted between January 2014 and February 2019 were included. We evaluated the preadmission modified Rankin scale (mRS) score, etiology and severity of symptoms, complications, and functional recovery at discharge and 90 days. MACEs were recorded for 5 years. Results: There were 891 admissions for AS (mean age 64.0 ± 14.2 years) (male, n = 519 [mean age ± SD 62.9 ± 14.1 years]; female, n = 372 [mean age ± SD 65.6 ± 14.2 years] p = 0.005). There were no differences in the preadmission mRS and severity of symptoms as measured on National Institute of Stroke Scale. At discharge, the outcome was better (mRS 0–2) in men (57.8 vs. 46.0%), p = 0.0001. This difference persisted at the 90-day follow-up (mRS 0–2, male 69.4% vs. female 53.2%, p = 0.0001). At the 90-day follow-up, more women died (total deaths 70; women 38 [10.2%] versus men 32 [6.2%], p = 0.03). MACEs occurred in 25.6% (133/519) males and 30.9% (115/372) females over the 5-year follow-up period (odds ratio 0.77, 95% confidence interval 0.57–1.0, p = 0.83). Conclusions: Female patients have a poor short-term outcome following an AS when corrected for age and comorbidities. While our study cannot explain the reasons for the discrepancies, higher poststroke depression and social isolation in women may be important contributory factors, and requires further studies are required to confirm these findings.

scholarly journals The mean platelet volume and plateletcrit as predictors of short-term outcome of acute ischemic stroke

2019 ◽  
Vol 55 (1) ◽  
Author(s):  
Al-Amir Bassiouny Mohamed ◽  
Hassan Mohamed Elnady ◽  
Hazem Kamal Alhewaig ◽  
Hesham Moslem Hefny ◽  
Ashraf Khodery
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
The Mean

Single-Center Experience and Short-term Outcome with the JenaValve: A Second-Generation Transapical Transcatheter Aortic Valve Implantation Device

2014 ◽  
Vol 9 (5) ◽  
pp. 368-374 ◽  
Author(s):  
Oliver Reuthebuch ◽  
Devdas Thomas Inderbitzin ◽  
Florian Ruter ◽  
Raban Jeger ◽  
Christoph Kaiser ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Transcatheter Aortic Valve Implantation ◽  
Second Generation ◽  
Short Term ◽  
Term Outcome ◽  
Transcatheter Aortic Valve ◽  
Short Term Outcome ◽  
The Mean ◽  
Aortic Valve Implantation ◽  
Valve Implantation

Objective We present the post-CE(Conformité Européenne)-mark single-center implantation experience and short-term outcome with the second-generation transapical JenaValve transcatheter aortic valve implantation system. Methods Patients [N = 27; 9 women; mean (SD) age, 80.3 (5.5) years] were operated on between November 2011 and August 2012. Via a transapical approach, the valve was positioned, in some cases, repositioned, and finally implanted. All data were collected during the hospital stay. Results The implantation success rate was 100%; the mean (SD) operation time was 124.7 (43.2) minutes; and the size of the implanted prosthesis was 23 mm (n = 6), 25 mm (n = 14), and 27 mm (n = 7). The in-hospital major adverse cardiac and cerebrovascular events were as follows: intraoperative resuscitation with subsequent aortic rupture (n = 1), postoperative hemorrhage needing revision (n = 1), myocardial infarction (n = 1), atrioventricular block needing a definitive pacemaker (n = 1), new-onset renal failure needing hemodialysis (n = 1), and stroke (n = 1). The 30-day mortality was 11.1% (n = 3). The mean (SD) intensive care unit/total stay was 2.2 (1.7)/11.7 (7.9) days. Postoperative echocardiography [day 6.7 (4.8)] revealed residual para-valvular leakage of trace to grade 1 in 12 patients (44.5%) and no leakage in 15 patients, with a mean (SD) transvalvular pressure gradient of 11.6 (5.6) mm Hg with significant reduction by 36.0 (17.7) mm Hg ( P = 0.0001, Wilcoxon signed rank test). Conclusions This second-generation repositionable transcatheter aortic valve implantation device could safely and successfully be implanted with a fast learning curve, significant reduction in pressure gradients, overall clinical improvement at discharge, as well as an acceptable morbidity and mortality rate in this highest-risk patient cohort.

scholarly journals Factors Affecting Short-Term Outcome of Critically Ill Children with Malignancies Admitted in Pediatric Intensive Care Unit: A Retrospective Observational Study

2021 ◽  
Vol 42 (04) ◽  
pp. 333-338
Author(s):  
Priyanka Aggarwal ◽  
Ishan Kumar ◽  
Sunil Kumar Rao ◽  
K Pradhap ◽  
Vineeta Gupta
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Adverse Outcome ◽  
Pediatric Intensive Care ◽  
Critically Ill Children ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
The Mean

Abstract Introduction Pediatric cancer contributes <1% of all malignancies. Childhood cancer survival has improved dramatically with the use of more intensive chemotherapy regimens, better stratification, and improvement in supportive care with enhanced facilities in pediatric intensive care unit (PICU). Objective The aim of this study was to identify the risk factors responsible for poor outcome in critically ill children with malignancies admitted in PICU. Materials and Methods Sixty-four children with a primary diagnosis of malignancy admitted in PICU with disease or treatment related complications were enrolled retrospectively. The short-term outcome, that is, shifting from PICU to ward, was assessed in relation to the presence of febrile neutropenia, organ failure, hepatitis, acute renal failure as well as requirement of inotropes and mechanical ventilation. Death was considered as an adverse outcome in this study. Results The mean age of study population was 6.25 ± 3.91 and M:F ratio 2.4:1. The majority of children had hematological malignancies (81.25%), that is, pre-B acute lymphoblastic leukemia (ALL) (45.3%), non-Hodgkin lymphoma (21.3%), acute myeloid leukemia (12.5%), T ALL (10.9%), and Hodgkin lymphoma (3.1%). Few children also had retinoblastoma (4.7%) and Langerhans cell histiocytosis (1.6%). The mean duration of PICU stay was 3.16 ± 2.31 days. Sepsis (37.5%) was the most common indication for PICU admission, followed by metabolic disturbance (26.6%), respiratory failure (17.2%), neurological complaints (15.6%), and anaphylactic shock (3.1%). Children requiring mechanical ventilation (p < 0.001), inotrope support (p < 0.001), having acute renal failure (p = 0.001), and >1 organ failure (p < 0.001) were associated with adverse outcome. The overall survival at the time of discharge from PICU was 64%. Conclusion In the context of low- and middle-income countries, optimal resource utilization by early identification of risk factors for clinical deterioration is required to allow timely admission to PICU and delivery of life-saving therapy to salvageable patients.

scholarly journals Association Between Hypoalbuminemia, Degree of Proteinuria, and Lupus Nephritis Class: A Single-Center Cross-Sectional Biopsy Study

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ngoc Nguyen Thi ◽  
Dien Tran Minh ◽  
Huong Nguyen Thu ◽  
Phuong Luong Thi ◽  
Nam Thai Thien ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Serum Albumin ◽  
Renal Biopsy ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Viet Nam ◽  
Albumin Concentration ◽  
Single Center ◽  
Cross Sectional ◽  
The Mean

Background: The current study intended to determine whether serum albumin level and urine protein/creatinine rate (uPCR) are appropriate predictors of severe lupus nephritis in childhood-onset SLE. Objectives: Following a cross-sectional single-center design, 85 LN children referred to the National Children Hospital, Ha Noi, Viet Nam, from 6/2019 to 6/2020 were recruited. Renal biopsy was performed for all participants. Methods: Following a cross-sectional single-center design, 85 LN children referred to the National Children Hospital, Ha Noi, Viet Nam, from 6/2019 to 6/2020 were recruited. Renal biopsy was performed for all participants. Results: The mean SLEDAI score of all patients was 14.69. The proportion of patients with high and very high SLEDAI was 61.2 and 17.6%, respectively. The mean concentration of serum albumin was 28.55 g/L, and the proportion of decreased albumin concentration was 55.3%. The median uPCR was 446.6 mg/mmol in which 76.5% of values were ≥ 200 mg/mmol. Pathological morphology of LN class from I to VI was observed in 0%, 17.6%, 37.6 %, 37.6%, 7.1%, and 0%, respectively. Serum albumin level and uPCR presented the predictive value for severe and active LN (class IV and V); (AUC: 0.725 P < 0.001 for both). Conclusions: Serum albumin and uPCR were appropriate predictors for severe and active LN in Vietnamese children.

scholarly journals Short term outcome of patients with hyperglycemia and acute stroke

2017 ◽  
Vol 5 (3) ◽  
pp. 93-98 ◽  
Author(s):  
Ahmed Al-Weshahy ◽  
Rania El-Sherif ◽  
Khaled Abd Al-Wahhab Selim ◽  
Ayman Heikal
Keyword(s):  
Acute Stroke ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome

scholarly journals Outcome of Stereotactic Radiotherapy for Patients with Uncontrolled Acromegaly

2009 ◽  
Vol 36 (4) ◽  
pp. 468-474 ◽  
Author(s):  
Syed Ali Imran ◽  
Ian G. Fleetwood ◽  
Colleen M. O'Connell ◽  
Thomas P. Ransom ◽  
Liam A. Mulroy ◽  
...  
Keyword(s):  
Tumor Volume ◽  
Pharmacologic Therapy ◽  
Pituitary Hormone ◽  
Short Term ◽  
Visual Field Examination ◽  
Term Outcome ◽  
Stereotactic Radiation ◽  
Short Term Outcome ◽  
The Mean

Objective:Linear accelerator based stereotactic radiation therapy (SRT) has been used for the treatment of pituitary tumours; however, little is known concerning the use of this modality for the treatment of patients with acromegaly. We have prospectively studied the short-term outcome of SRT in 12 acromegaly patients who failed to achieve biochemical remission despite surgery and/or pharmacologic therapy.Methods:We identified all patients who had biochemically uncontrolled acromegaly and were treated with SRT between April 2003 and December 2006. All patients were followed prospectively based on a pre-defined protocol that included Goldman visual field examination, MRI of the sella, and pituitary hormone testing at 3, 6, 12 months, and then yearly.Results:A total of 12 patients with acromegaly were treated with SRT. There were 9 females and the median age of the group was 50 years. The median follow-up was 28.5 months during which time the mean tumor volume decreased by 40%, the median GH fell from 4.1 μg/L to 1.3 μg/L (p=0.003) and the median IGF-1 dropped more than half from 545.5 μg/L to 260.5 μg/L (p=0.002). Four patients achieved normal, while an additional 2 achieved near-normal, IGF-1 levels. One patient was able to discontinue and two were able to reduce their acromegaly medications while maintaining a normal IGF-1. A new pituitary hormonal deficit was found at 24 months in one patient who developed hypoadrenalism requiring corticosteroid replacement.Conclusion:Based on our early experience, we believe that SRT should be considered in treating patients with uncontrolled acromegaly.

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