scholarly journals Association Between Hypoalbuminemia, Degree of Proteinuria, and Lupus Nephritis Class: A Single-Center Cross-Sectional Biopsy Study

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ngoc Nguyen Thi ◽  
Dien Tran Minh ◽  
Huong Nguyen Thu ◽  
Phuong Luong Thi ◽  
Nam Thai Thien ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Serum Albumin ◽  
Renal Biopsy ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Viet Nam ◽  
Albumin Concentration ◽  
Single Center ◽  
Cross Sectional ◽  
The Mean

Background: The current study intended to determine whether serum albumin level and urine protein/creatinine rate (uPCR) are appropriate predictors of severe lupus nephritis in childhood-onset SLE. Objectives: Following a cross-sectional single-center design, 85 LN children referred to the National Children Hospital, Ha Noi, Viet Nam, from 6/2019 to 6/2020 were recruited. Renal biopsy was performed for all participants. Methods: Following a cross-sectional single-center design, 85 LN children referred to the National Children Hospital, Ha Noi, Viet Nam, from 6/2019 to 6/2020 were recruited. Renal biopsy was performed for all participants. Results: The mean SLEDAI score of all patients was 14.69. The proportion of patients with high and very high SLEDAI was 61.2 and 17.6%, respectively. The mean concentration of serum albumin was 28.55 g/L, and the proportion of decreased albumin concentration was 55.3%. The median uPCR was 446.6 mg/mmol in which 76.5% of values were ≥ 200 mg/mmol. Pathological morphology of LN class from I to VI was observed in 0%, 17.6%, 37.6 %, 37.6%, 7.1%, and 0%, respectively. Serum albumin level and uPCR presented the predictive value for severe and active LN (class IV and V); (AUC: 0.725 P < 0.001 for both). Conclusions: Serum albumin and uPCR were appropriate predictors for severe and active LN in Vietnamese children.

Serum Albumin Level as a Prognostic Marker for Covid-19 Positive Patients in Western Uttar Pradesh - A Cross Sectional Study

2021 ◽  
Vol 8 (04) ◽  
pp. 204-207
Author(s):  
Shreyansh Talera ◽  
Saurabh Singhal ◽  
Nishant Wadhera ◽  
Mayank Arora ◽  
Ravi Pratap
Keyword(s):  
Serum Albumin ◽  
Prognostic Marker ◽  
Serum Albumin Level ◽  
Uttar Pradesh ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
The Body ◽  
Cross Sectional ◽  
Significant Difference

BACKGROUND WHO has declared Coronavirus disease 2019 (Covid-19) as a pandemic. Covid-19 leads to sickness and death. Human serum albumin (HSA) is the most common circulating protein in the body having oncotic as well as non-oncotic properties. The role of albumin in death among Covid-19 subjects, especially in this part of the country has not been frequently reported. The aim of the study was to analyse the role of serum albumin level as prognostic marker for Covid-19 positive patients. METHODS The present study was conducted in the department of Medicine at Chhatrapati Shivaji Subharti Hospital, Subharti Medical College, Meerut, UP. The study comprised of 100 subjects who were Covid positive from May 2020 to July 2020. A detailed explanation was given to all the participating respondents regarding the study and their contribution to it. Covid-19 was diagnosed on the basis of the WHO interim guidelines. A questionnaire was prepared to collect the patients’ demographic profile. Patients date of admission and discharge was recorded along with the outcome i.e., whether patient expired or survived. Patients’ diagnosis was identified along with the comorbidity (if present). Laboratory investigations comprised of CBC and serum albumin detection. Data so collected was tabulated in an excel sheet, under the guidance of statistician. Collected data was analysed using Statistical Package for the Social Sciences (SPSS) software version 24 and the tests used were t test and Fisher’s exact test and the level of significance was set at p < 0.05. RESULTS The study comprised of 100 subjects, out of which 45 were males and 55 were females. The overall mean age of the study subjects was 37.52 years. In our study, mortality was 35.29 %, 9.33 % and 85.7 % of the subjects having Covid-19+ type 2 diabetes (T2DM), only Covid-19 and Covid-19+ hypertension respectively with statistically significant difference as p < 0.05. Albumin level was significantly lower in expired patients (2.99) as compared to survivors (3.85) as p < 0.05. Hospital stay was also higher in expired patients. CONCLUSIONS Covid-19 patients had low serum albumin levels and that might play a role in the survival of patient. KEYWORDS Covid-19, Mortality, Albumin

scholarly journals ESOPHAGEAL VARICES;

2019 ◽  
Vol 26 (03) ◽  
Author(s):  
Nadia Ijaz ◽  
Tazeen Nazar ◽  
Bilal Aziz
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis B ◽  
Serum Albumin ◽  
Esophageal Varices ◽  
Serum Albumin Level ◽  
Significant Negative Correlation ◽  
Albumin Level ◽  
P Value ◽  
Cross Sectional ◽  
Grade Ii

Objectives: To determine the correlation between serum albumin levels and the grades of esophageal varices in patients of liver cirrhosis due to hepatitis B and C. Study Design: Cross-sectional descriptive study. Place and Duration of Study: Unit I, Department of Medicine, Allied Hospital, Faisalabad from 29th June, 2014 to 28th December, 2014. Methodology: 95 patients of either sex between 20-70 years of age, with the diagnosis of liver cirrhosis due to hepatitis B and C were selected using non - probability consecutive sampling. The presence of esophageal varices was confirmed by endoscopy. Results: Out of a total of 95 patients, 59 (62.11%) were between the age group of 20-50 years while 36 (37.89%) were between 51-70 years of age. Mean+SD was calculated as 48.37+11.75 years. Gender distribution showed that 51 (53.68%) patients were males and 44 (46.32%) were females. Correlation between serum albumin level and the grade of esophageal varices in patients of liver cirrhosis due to hepatitis B & C showed that out of 26 cases with serum albumin level <2.8, 10 had Grade I and 16 had Grade II while out of 69 cases with ≥2.8 serum albumin level, 40 had grade I and 29 had grade II EV. r value was recorded to be -0.697 whereas p-value was calculated as 0.000. Conclusion: There is a significant negative correlation between serum albumin level and grade of esophageal varices in patients of liver cirrhosis due to hepatitis B and C.

scholarly journals KADAR ALBUMIN SERUM PENDERITA STROK ISKEMIK DAN STROK HEMORAGIK

2018 ◽  
Vol 16 (2) ◽  
pp. 55
Author(s):  
Fasni Halil ◽  
Hj. Darmawaty ER ◽  
Ruland DN Pakasi
Keyword(s):  
Serum Albumin ◽  
Ct Scan ◽  
Hemorrhagic Stroke ◽  
Serum Albumin Level ◽  
Accurate Method ◽  
Albumin Level ◽  
P Value ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Mean Values

To differentiate the ischemic and hemorrhagic stroke with the most accurate method can be carried out by Computerized Tomography(CT) scan. However, because the restrictor on access and cost, not all patients could gain the advantage of CT scan. Examination ofalbumin is a quick and easy test. The aim of this study was to evaluate the serum albumin level in patient suffering ischemic andhemorrhagic stroke. A cross sectional study of 60 ischemic and hemorrhagic stroke patients was performed at the Neurologic Departmentof Dr. Wahidin Sudirohusodo Hospital Makassar, from March up to August 2008. Albumin – levels was measured using the colorimetricBCG method, using the Cobas Integra 400 Autoanalyser. The data were than analyzed with SPSS 11.5 software and t test. Among the60 samples of the ischemic and hemorrhagic stroke were found mean values of serum albumin level is 3.38 ± 0.120 and hemorrhagicstroke is 3.51 ± 0.0938 with p value is 0.495. There were no significantly different between the serum albumin level of the ischemicand hemorrhagic stroke patients.

scholarly journals ANALISIS KADAR ALBUMIN SERUM DENGAN RASIO DE RITIS PADA PENDERITA HEPATITIS B

2018 ◽  
Vol 13 (2) ◽  
pp. 60
Author(s):  
AT. Lopa ◽  
B. Rusli ◽  
M. Arif ◽  
Hardjoeno Hardjoeno
Keyword(s):  
Hepatitis B ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Chronic Phase ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference

Hepatitis is a inflammation process which may present in an acute or chronic phase. A decrease of serum albumin level may befound in liver disease. Ratio de Ritis in mild hepatitis is < 1 while in alcoholic hepatitis is >1. To analyze serum albumin level withratio de Ritis in hepatitis B patients. A cross sectional study was carried out comprising 46 subjects from October 2005 to August 2006measuring albumin level SGOT and SGPT levels using Lyasis autoanalyzer. Thirty eight males and eight females, the level of serumalbumin decreased with an average of albumin level 2.98 gr/dL (p<0.05). Twenty two subjects showed a ratio de Ritis ≤ 1 with theaverage albumin level 3.00 gr/dL and 24 subjects were included in group ratio de Ritis > 1 with average albumin level 2.96 gr/dL(p value = 0.658). There was a decrease of serum albumin level in hepatitis B patient but no significant difference between decrease ofserum albumin level with ratio of de Ritis ≤ 1 and ratio of de Ritis >1.

scholarly journals Nutritional Status and Short Term Outcome of Hospitalized Patients with Stroke

2015 ◽  
Vol 14 (2) ◽  
pp. 61-64
Author(s):  
Md Moazzem Hossain Chowdhury ◽  
Sheikh Khairul Kabir ◽  
Muhammed Syedul Alam ◽  
AKM Humayon Kabir ◽  
Sujat Paul ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Hospitalized Patients ◽  
Age Group ◽  
Hip Circumference ◽  
Term Outcome ◽  
Cross Sectional ◽  
Female Ratio ◽  
Hospital Outcome

Nutrition and stroke is an interrelated problem now-a-days. They influence the pattern and outcome of the stroke. The purpose of this study is to see the different nutritional parameters with their interrelation with stroke and in-hospital outcome of admitted stroke patients. It is a hospital based descriptive cross sectional study conducted on purposively selected (non-probability) hospitalized patients who had been admitted into the neurology wards, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during a period of 6 months. Cases (n = 50) with CT scan of brain done were interviewed and examined and had measurements of height, weight, waist and hip circumference, waist-to-Hip Ratio (WHR) and Mid-Upper Arm Circumference (MUAC) calculated along with serum albumin level. Out of 50 patients of this study 36 (72%) were males and 14 (28%) were females; Male to female ratio was 2.6:1. It was found that 26 (52%) patients were 60 years and above, 1 (2%) in the age group of 20-30 years, 3 (6%) in the age group of 30-39 years, 4 (8%) in the age group of 40-49 years and 16 (32%) were in the age group of 50-59 years The mean hip circumference of the study people was 95 cm. WHR was calculated for each patient, the result of which shows that 33 (66%) patients had abnormal WHR while 17 (34%) patients had been found to possess normal WHR. Body Mass Index (BMI) was calculated for each patient, the result of which shows that 24 (48%) patients had abnormal BMI while 26 (52%) patients had been found to possess normal BMI. MUAC was calculated for each patient, the result of which shows that 22 (44%) patients had abnormal MUAC while 28 (56%) patients had been found to possess normal MUAC. Serum albumin level was measured for each patient, the result of which shows that 17 (34%) patients had low serum albumin (<3gm/l) while 33 (66%) patients had been found to possess normal serum albumin (>3gm/l). Regarding analysis of BMI and WHR with different types of stroke WHR was found significantly different regarding normal and abnormal records (p<0.05). Regarding BMI it was not significant (p>0.05). Among 50 patients with stroke 32 (64%) patients got either partial (44%) or clinical recovery (20%) from the disease, 12 (24%) patients showed no noticeable improvement and 6 (12%) patients expired. The results revealed that nutrition has some influence and association with stroke and in-hospital outcome of the stroke patient varies.Chatt Maa Shi Hosp Med Coll J; Vol.14 (2); Jul 2015; Page 61-64

Correlation of Serum Albumin Level with Short Term Outcome of Acute Ischemic Stroke Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohammed Saad El-Din Mahmud ◽  
Hala Mahmoud EL-Khawas ◽  
Hossam El Din Mahmoud Afify ◽  
Mohamed Mohamed Tawfik
Keyword(s):  
Ischemic Stroke ◽  
Serum Albumin ◽  
Acute Ischemic Stroke ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Modified Rankin Scale ◽  
Stroke Patients ◽  
Short Term ◽  
The Mean ◽  
Discharge From Hospital

Abstract Objectives We aimed to Detect if there is association between serum albumin level in acute ischemic stroke patients and its short term neurological and functional outcome in a tertiary care hospital in Cairo. Methods The study was carried out as descriptive (cross-sectional) study conducted on 50 cases first-ever acute ischemic stroke patients were enrolled between June 2018 to December 2018 with follow up after 30 days of discharge from hospital. Inclusion and exclusion criteria were strictly exercised. National Institute of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS) score was noted. Serum albumin (SA) was estimated from blood Clinical, functional, and radiological evaluation was done for the patients. Statistical SPSS 20.0 software and Microsoft excel were used for statistical analysis (P ≤ 0.05).Relationship between serum albumin and stroke outcome was determined. Results A total of 50 stroke cases were thus included in the study comprising 34 males and 16 females. The mean age of patients was 40-65 [59.26±6.25] years, we found the most prevalent risk factors in the present study results were hypertension 36 (72.0%). The mean serum level of albumin were (3.73±0.63) on day o of onset and (3.72±0.63) after 30 days of discharge from hospital. Bivariate analysis shows serum albumin was inversely associated with NIHS score and mRS on day o of onset and after 30 days of discharge from hospital which were NIHSS(r= -0.264, P = 0.044) (r= -0.645, P = &lt;0.001) and mrs (r= -0.321, P = 0.031) (r= -0.587, P = &lt;0.001) respectively. Conclusion Hypoalbuminemia had influence to degree of stroke severity, degree of disability and functional outcome. Serum albumin levels had a negatively correlation with NIHSS score and modified Rankin scale. Low serum albumin levels associated with poor prognosis in acute ischemic stroke patients.

scholarly journals Serum Albumin Levels in Severe Traumatic Brain Injury: Role as a Predictor of Outcome

2020 ◽  
Vol 17 (01) ◽  
pp. 24-27
Author(s):  
Raghavendra Nayak ◽  
Nitin Jagdhane ◽  
Sanjeev Attry ◽  
Samarendranath Ghosh
Keyword(s):  
Traumatic Brain Injury ◽  
Serum Albumin ◽  
Severe Head Injury ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Normal Serum ◽  
Severe Tbi ◽  
The Mean ◽  
Low Serum

Abstract Background Serum albumin has long been considered as an outcome marker in various critical illnesses. The aim of our study is to ascertain the role of serum albumin as a predictor of outcome in severe head injury patients. Materials and Methods This is a prospective observational study of patients with severe traumatic brain injury (TBI). Depending on the serum albumin level at admission, patients were dichotomized into two groups: one with normal serum albumin and other with hypoalbuminemia. Their outcomes at 6-month follow-up were assessed by the modified Glasgow Outcome Score. Result Eighty patients (57 males and 23 females) with severe TBI were included in the study. The mean age of the study patients was 39.6 + 13.1 years and the mean serum albumin level at admission was 3.7 + 1.2 g/dL with lowest being 2.2 mmol/L and highest being 6.1 mmol/L. Thirty-four patients (42.5%) had low serum albumin level (< 3.5 g/dL) at admission. At 6-month follow-up, 58 (72.5%) patients had a good neurological outcome and 22 (27.5%) had a poor outcome. The group with normal serum albumin levels showed a significantly better outcome compared with the hypoalbuminemia group (p = 0.01). On multiple regression analysis, low serum albumin emerged as the only predictor of the poor outcome in severe head injury patients. Conclusion Serum albumin at admission is an independent predictor of outcome in severe TBI patients. Larger prospective studies are required to confirm these findings.

Conditioning factors influencing evolution of experimental glomerulonephritis in rabbits

1959 ◽  
Vol 196 (2) ◽  
pp. 457-460 ◽  
Author(s):  
Constantin V. Teodoru ◽  
Abraham Saifer ◽  
Harry Frankel
Keyword(s):  
Serum Albumin ◽  
Serum Albumin Level ◽  
Clinical Manifestations ◽  
Albumin Level ◽  
Immune Serum ◽  
The Other ◽  
Chronic Glomerulonephritis ◽  
Acute Glomerulonephritis ◽  
Albumin Concentration ◽  
Conditioning Factors

Unilateral nephrectomy (UN) and/or oral saline administration in rabbits did not induce alterations in the concentration of various blood serum constituents for observation periods ranging from 1 to 6 months. Duck antirabbit-kidney immune serum (NTX) given i.v. to UN animals produced an acute glomerulonephritis significantly more severe than in parallel controls. All UN animals died from dry uremia within 3–4 weeks following serum administration. As compared to the other groups, the UN showed the highest retention of urea nitrogen, creatinine and uric acid. When injected into saline-drinking animals, NTX produced either subacute glomerulonephritis, anasarca, convulsions and death from wet uremia, or chronic glomerulonephritis with polyuria and hyposthenuria as the main clinical manifestations. As compared to the other groups, the saline-drinking animals showed lowest serum albumin and highest cholesterol levels. The serum albumin level appeared to be related to the urinary loss of albumin and not to the severity of the disease. The albumin concentration per unit volume was similar in the urine of various groups; hence the albumin loss depended upon the 24-hour urine output, i.e. highest in saline drinking, lowest in UN groups. Hypercholesterolemia and edema inversely paralleled the serum albumin level, being pronounced in saline-drinking and mild in UN animals.

Residual Renal Function in a Large Cohort of Peritoneal Dialysis Patients: Change over Time, Impact on Mortality and Nutrition

2000 ◽  
Vol 20 (4) ◽  
pp. 439-444 ◽  
Author(s):  
Douglas Shemin ◽  
Andrew G. Bostom ◽  
Cynthia Lambert ◽  
Connie Hill ◽  
Jenny Kitsen ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Renal Dialysis ◽  
Residual Renal Function ◽  
Albumin Level ◽  
The Mean ◽  
The Relationship ◽  
Over Time ◽  
Solute Clearance

Objective Residual renal function contributes importantly to total solute clearance in peritoneal dialysis (PD) patients. This study was designed to examine the progression of residual renal function over time and its impact on nutrition and mortality in PD patients in the six New England states (ME, NH, VT, CT, MA, RI) comprising End Stage Renal Disease (ESRD) Network 1. Design As part of the ESRD Clinical Indicators Project, data on 990 PD patients in Network 1 were abstracted from data supplied by dialysis units in the fourth quarter of 1997. This included demographic information; dose of PD in L/day; weekly renal, dialysis, and total Kt/V urea; weekly renal, dialysis, and total creatinine clearance (CCr); serum albumin level; and mortality and transplantation information. Data collection was repeated in the second and fourth quarters of 1998 and in the second quarter of 1999. Patients 990 PD patients in Network 1. Outcome Measures The change in total and renal solute clearances over time, the relationship between renal clearance and mortality, and the relationship between renal clearance and nutritional status, as represented by serum albumin. Results Over the 2-year period, mean weekly renal Kt/V urea and weekly renal CCr dropped significantly. To examine the effect of residual renal function on mortality, patients were divided into high and low (above and below the median) weekly renal Kt/V urea and weekly renal CCr groups. Patients above the median levels of both weekly renal Kt/V urea and weekly renal CCr had a significantly decreased risk of dying during the observation period, after controlling for age, gender, serum albumin level, and diabetic status [OR for high vs low renal Kt/V urea 0.54 (CI 0.34 – 0.84), OR for high vs low renal CCr 0.61 (CI 0.40 – 0.94)]. The mean weekly renal Kt/V urea was significantly and directly correlated with the mean serum albumin level by Spearman rank correlation ( R = 0.133, p < 0.001), as was the mean weekly renal CCr ( R = 0.115, p < 0.001). Conclusions Residual renal function is an important contributor to total solute clearance in PD patients. Even at low levels it is linked to decreased mortality and better nutritional status.

scholarly journals Serum Albumin Level and Short-Term Outcome Following Stroke in Hospital Admitted Patients

2018 ◽  
Vol 9 (1) ◽  
pp. 27-30
Author(s):  
K Kirtania ◽  
A Khatun ◽  
RA Chowdhury ◽  
M Rukunuzzaman
Keyword(s):  
Serum Albumin ◽  
Acute Stroke ◽  
Inflammatory Diseases ◽  
Albumin Level ◽  
Short Term ◽  
Term Outcome ◽  
Cross Sectional ◽  
Short Term Outcome ◽  
Hospitalization Period ◽  
The Mean

Albumin is a non-glycosylated plasma protein synthesized primarily in the liver. It is a protein involved in the transport of small molecules in the blood and plays a key role in restricting fluid leakage from the vasculature into the tissue. Elevated level of serum albumin is related to haemoconcentration and reduced level is associated with malnutrition and chronic inflammatory diseases representing a negative acute phase protein. This cross sectional study was done to determine the association between admission serum albumin levels and short-term outcome following acute stroke. Consecutive first-ever acute stroke patients were enrolled between January 2016 and December 2016 at DMCH. On admission serum albumin were measured. Patients were then followed up for 10 days and outcome measure at the end of the study were 10- day mortality. Relationship between serum albumin and stroke outcome was determined. A total of 100 stroke cases were thus included in the study comprising 66 males and 34 females. The mean age of patients was 69.2±12.2 years. Of total, 74% patients were of ischemic stroke and 26% were of hemorrhagic stroke. Among them 22 patients expired in the hospitalization period within 10 days and remaining 78 patients were discharged. The mean serum level of albumin was 2.90±0.57 g/dl in the expired group and 3.79±0.51 g/dl in the discharged group. It may be concluded that low admission serum albumin may be significantly associated with poor outcome.Bangladesh J Med Biochem 2016; 9(1): 27-30

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