scholarly journals Evaluation of Analgesic and Central Nervous System Depressant Effects of Holarrhena antidysenterica Stem on Swiss Albino Mice Model

2018 ◽  
Vol 20 (2) ◽  
pp. 205-212 ◽  
Author(s):  
Md Anamul Haque ◽  
Md Anwarul Haque ◽  
Md Anwar Ul Islam
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Open Field ◽  
Biological Activities ◽  
Pharmaceutical Journal ◽  
Depressant Effect ◽  
Mice Model ◽  
Cns Depressant ◽  
Holarrhena Antidysenterica ◽  
Central Nervous System Depressant

Plants are astonishing reservoir of bioactive natural compounds; many of these are able to exhibit outstanding biological activities in animals. Holarrhena antidysenterica is widely used as a traditional medicine. Aim of the present study was to investigate the possible analgesic and central nervous system (CNS) depressant effects of methanol (MHAS), petroleum ether (PHAS), chloroform (CHAS), dichloromethane (DHAS) and aqueous (AHAS) extracts of the H. antidysenterica stem. The analgesic effect was evaluated by acetic acid induced writhing and hot plate methods at 50 and 100 mg/kg dose. The CNS-depressant effect was assessed by using open field, hole cross and head deep tests at 100 and 200 mg/kg dose. All the extracts had exhibited significant (Pb < 0.01, Pa < 0.001) analgesic and CNS depressant effects at dose dependant manner. CHAL showed maximum analgesic and CNS-depressant effect. It had shown 71.34% inhibition of abdominal writhing and 70.39% elongation of paw licking time at 100mg/kg dose. In CNS-depressant study, it exhibited 88.51% inhibition in open field (locomotion), 83.20% inhibition in hole cross (locomotion) and 85.15% inhibition (head deeping) in head deep test at 200mg/kg dose. Among the five extracts CHAL is a potent analgesic and CNSdepressant agent.Bangladesh Pharmaceutical Journal 20(2): 205-212, 2017

scholarly journals In vivo CNS Depressant and Antinociceptive Studies of Microcos paniculata Stem Extracts on Animal Model

2017 ◽  
Vol 20 (1) ◽  
pp. 39-45
Author(s):  
Md Anamul Haque ◽  
Md Anwarul Haque ◽  
Md Anwar Ul Islam
Keyword(s):  
Central Nervous System ◽  
Open Field ◽  
Analgesic Effect ◽  
Pharmaceutical Journal ◽  
Depressant Effect ◽  
Hot Plate ◽  
Analgesic Effects ◽  
Cns Depressant ◽  
Antinociceptive Effects

The main objective of the study was to evaluate the possible central nervous system (CNS) depressant and antinociceptive effects of methanol (MMPS), petroleum ether (PMPS), chloroform (CMPS), dichloromethane (DMPS) and aqueous (AMPS) extracts of the Microcos paniculata (M. paniculata). The CNS-depressant effect of different extracts of M. paniculata stem on Swiss albino mice was assessed by using open field, hole cross and head deep tests at 100 and 200 mg/kg dose. Analgesic effect was evaluated by acetic acid-induced writhing and hot plate methods at 100 and 200 mg/kg dose. All the extracts had exhibited significant (Pb < 0.01, Pa < 0.001) CNS depressant and analgesic effects in a dose dependant manner. MMPS had shown highest CNSdepressant effect with 93.39% inhibition of mice movement (open field), 78.92% inhibition of hole cross and 86.90% inhibition of head deeping at 200 mg/kg dose. Besides, DMPS extracts showed maximum analgesic effect with 75.52% inhibition of abdominal writhing and 65.55% elongation of paw licking time at 200mg/kg dose. Among the five extracts, MMPS possesses potent CNS depressant effect while DMPS possesses potent analgesic effect. These findings may expose effectiveness of the extracts on anxiety and pain that may help to formulate a herbal medicine or to search a lead compound.Bangladesh Pharmaceutical Journal 20(1): 39-45, 2017

The effect of Qing Huan Ling combined risperidone on the open field behavior of schizophrenic mice model

2016 ◽  
Vol 33 (S1) ◽  
pp. s289-s289
Author(s):  
Y. Zhang ◽  
F. Liu ◽  
Z. Dai ◽  
B. Wu ◽  
Q. Wu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Locomotor Activity ◽  
Open Field ◽  
Open Field Test ◽  
Model Group ◽  
Mice Model ◽  
Blank Group ◽  
The Central Nervous System ◽  
Risperidone Group

ObjectiveTo observe the effect of Qing Huan Ling and (or) risperidone on locomotor activity and explorative behavior of schizophrenia mice model by open field test.MethodsSeventy kunming mice were randomly divided into 5 groups, one group as blank group. The rest groups ip MK-801 continuously 14 day, then randomly numbered: model group, risperidone group, Qing Huan Ling group and risperidone combined Qing Huan Ling group. Ig give corresponding drugs for each group 4 weeks, observe the change of locomotor activity and explorative behavior by open field test.ResultsAfter Ig 4 weeks, compared with the blank group, there were no obvious difference in locomotor activity and explorative behavior between risperidone group, Qing Huan Ling group and the combined group. Compared with the model group, risperidone had statistics meaning in the repression of explorative behavior (P < 0.05),the combined group has statistics meaning in the repression of locomotor activity and explorative behavior (78.92 ± 36.18 m vs. 186.92 ± 41.08 m, P < 0.01).ConclusionQing Huan Ling regulate the central nervous system of schizophrenia mice model; when combined with risperidone, it restrain the central nervous system of schizophrenia mice model and the effect is stronger than risperidone alone.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Evaluation of central nervous system depressant activity of Cleome rutidosperma

2012 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Anindya Bose ◽  
Anuradha Khuntia ◽  
Jayanta Kumar Gupta ◽  
Sudam Si
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ethanol Extract ◽  
Traditional Use ◽  
Cns Depressant ◽  
Aerial Parts ◽  
Central Nervous System Depressant ◽  
The Central Nervous System ◽  
Cns Depressant Activity ◽  
Cleome Rutidosperma

The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P&lt;0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

scholarly journals Central nervous system activity of the methanol extracts of Helianthus annuus seeds in mice model

2015 ◽  
Vol 5 (1) ◽  
pp. 1-4
Author(s):  
Rubab Tarannum Islam ◽  
Ahmed Tanjimul Islam ◽  
Mir Monir Hossain ◽  
Kishor Mazumder
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Helianthus Annuus ◽  
Methanol Extract ◽  
Biological Activities ◽  
Antidepressant Activity ◽  
Anxiolytic Activity ◽  
Moderate Increase ◽  
Mice Model ◽  
Central Nervous System Activity

Helianthus annuus seeds contain various chemical components and evaluate different biological activities. The present study was carried out to investigate the central nervous system (CNS) activity of methanolic extract of Helianthus annuus seeds in mice model. General behaviour, antidepressant activity and anxiolytic activity was observed. The results revealed that the methanol extract of Helianthus annuus seeds at 100 and 200 mg/kg caused a significant increase in the spontaneous activity (general behavioural profile), moderate increase in anxiolytic activity (light-dark box and elevated plus maze test) and remarkable increase in antidepressant activity (tail suspension test). The results suggest that methanol extract of Helianthus annuus exhibit significant antidepressant and moderate anxiolytic activity in tested animal models.Islam et al., International Current Pharmaceutical Journal, December 2015, 5(1): 1-4

scholarly journals Analgesic and Neuropharmacological Investigations of the Aerial Part of Achyranthes aspera Linn.

1970 ◽  
Vol 1 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Md Ashraful Alam ◽  
Nazmuj Slahin ◽  
Riaz Uddin ◽  
SM Raquibul Hasan ◽  
Raushanara Akter ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acetic Acid ◽  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Sleeping Time ◽  
Achyranthes Aspera ◽  
Central Nervous System Depressant ◽  
Thiopental Sodium

Analgesic and central nervous system depressant activity of the methanol extract of Achyranthes aspera Linn. was assessed by using acetic acid induced writhing test, thiopental sodium induced sleeping time determination, hole cross test and open field test in albino mice. The extract (250 and 500mg/kg) showed a dose dependent inhibition of writhing response generation by acetic acid compared to reference drug diclofenac sodium (50mg/kg). Methanol (70%) extract of Achyranthes aspera (500 mg/kg) also produced rapid onset and maximized the duration of sleeping time when administered with thiopental sodium. The extract also decreased the motor activity and exploratory behavior of mice in hole cross and open field test. The overall experimental results suggest the analgesic and central nervous system depressant activity of the methanolic extract of Achyranthes aspera and justify its use in folkloric remedies. Key Words: Achyranthes aspera, Analgesic activity, Central nervous system depressant activity. doi:10.3329/sjps.v1i1.1807 S. J. Pharm. Sci. 1(1&2): 44-50

scholarly journals Central nervous system depressant activity of ethanol leaf extract of Globimetula braunii (Engler) (Loranthaceae) growing on Terminalia catappa L. (Combretaceae)

2020 ◽  
Vol 12 (1) ◽  
pp. 321-327
Author(s):  
Suleiman Danladi ◽  
Musa Aliyu Muhammad ◽  
Abdullahi Hamza Yaro
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Leaf Extract ◽  
Lethal Dose ◽  
Median Lethal Dose ◽  
Cns Depressant ◽  
Board Test ◽  
Central Nervous System Depressant ◽  
Hole Board ◽  
Hole Board Test

This study was carried out to determine phytochemical constituents, median lethal dose (LD50) and central nervous system depressant activity of ethanol leaf extract of Globimetula braunii using laboratory animal models. The intraperitoneal median lethal dose (LD50) of ethanol leaf extract of Globimetula braunii was determined in mice according to the method described by Lorke, 1983. The CNS depressant activity of Globimetula braunii leaf extract was determined using diazepam induced sleep, hole board test and beam walk assay. The ethanol leaf extract of Globimetula braunii revealed the presence of tannins, saponins, steroids, triterpenes, flavonoids and glycoside. The intraperitoneal median lethal dose of the leaf extract of Globimetula braunii was estimated to be 2852 mg/kg bodyweight in mice. The ethanol leaf extract of Globimetula braunii significantly (p <0.05) prolonged the duration of sleep in mice at the dose of 800 mg/kg. The extract prolonged the time to complete the beam walk, and exhibited significant decrease in number of head dips there by indicating a decrease in the exploratory behaviour of the animal. This study suggests that Globimetula braunii possesed sedative property. Keywords: Beam walk assay, diazepam induced sleep, hole board test, central nervous system, Globimetula braunii

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