scholarly journals Analgesic, Anti-diarrheal, CNS-depressant, Membrane Stabilizing and Cytotoxic Activities of Canavalia virosa (Roxb.) W&A

2019 ◽  
Vol 22 (2) ◽  
pp. 214-218
Author(s):  
Mohammad Mahmudul Hasan ◽  
Mohammad Abdullah Taher ◽  
Md Azizur Rahman ◽  
Tanvir Muslim
Keyword(s):  
Acetylsalicylic Acid ◽  
Plant Extract ◽  
Castor Oil ◽  
Methanol Extract ◽  
Pharmaceutical Journal ◽  
Cytotoxic Activities ◽  
Cns Depressant ◽  
Vincristine Sulphate ◽  
Time Test ◽  
Cns Depressant Activity

The methanol extract of the leaves of Canavalia virosa (Roxb.) W&A was investigated for the evaluation of analgesic, anti-diarrheal and CNS-depressant activities in Swiss albino mice. The analgesic activity was assessed by formalin-induced paw licking method, where the crude extract of C. virosa (400 mg/kg, b.w.) exhibited 41.46% reduction of licking response in mice as compared to 73.17% reduction exhibited by standard acetylsalicylic acid. In the castor oil-induced diarrhea in mice, the plant extract at the dose of 200 mg/kg, b.w., demonstrated 56% reduction of diarrheal feces in mice, while the standard loperamide revealed 76% reduction of diarrheal feces. The CNS-depressant activity of the plant extract was assessed through phenobarbitone-Na induced sleeping time test. The methanol extract of C. virosa and its different Kupchan fractions were also subjected to screen membrane stabilizing and cytotoxic activities using acetylsalicylic acid and vincristine sulphate as standard, respectively. Bangladesh Pharmaceutical Journal 22(2): 214-218, 2019

scholarly journals Analgesic, Anti-diarrheal, Anti-depressant, Membrane Stabilizing and Cytotoxic Activities of Bridelia verrucosa Haines

2019 ◽  
Vol 22 (1) ◽  
pp. 50-55
Author(s):  
Tasmia Tabassum ◽  
Md Abdul Bari ◽  
Md Ruhul Kuddus ◽  
Mohammad A. Rashid
Keyword(s):  
Acetylsalicylic Acid ◽  
Plant Extract ◽  
Crude Extract ◽  
Castor Oil ◽  
Methanol Extract ◽  
Antidepressant Activity ◽  
Pharmaceutical Journal ◽  
Cytotoxic Activities ◽  
Vincristine Sulphate ◽  
Time Test

The present study was aimed for the evaluation of analgesic, anti-diarrheal and anti-depressant activities of methanol crude extract of Bridelia verrucosa leaves in Swiss albino mice. The analgesic activity was assessed by formalin-induced paw licking method, where the crude extract of B. verrucosa (400 mg/kg, b.w.) exhibited 54.55% reduction of licking response in mice as compared to 69.09% reduction exhibited by standard acetylsalicylic acid. In the castor oil-induced diarrhea in mice, the plant extract at the dose of 400 mg/kg, b.w., demonstrated 57.67% reduction of diarrheal feces in mice. The antidepressant activity of the plant extract was evaluated through phenobarbitone-Na induced sleeping time test. The methanol extract of B. verrucosa and its different Kupchan fractions were also subjected to screenings for membrane stabilizing and cytotoxic activities using acetylsalicylic acid and vincristine sulphate as standard, respectively. Bangladesh Pharmaceutical Journal 22(1): 50-55, 2019

scholarly journals Analgesic, Antidiarrheal and CNS-depressant Activities of Flemingia macrophylla (Willd.)

2020 ◽  
Vol 23 (2) ◽  
pp. 141-145
Author(s):  
Asheka Rahman ◽  
Mohammad Mahmudul Hasan ◽  
Mohammad Abdullah Taher ◽  
Tanvir Muslim
Keyword(s):  
Methanol Extract ◽  
Pharmaceutical Journal ◽  
Developed Countries ◽  
Dependent Manner ◽  
Flemingia Macrophylla ◽  
Cns Depressant ◽  
Time Test ◽  
Analgesic Activities ◽  
Dose Dependent ◽  
Developing And Developed Countries

Plants are the priceless sources of bioactive natural compounds. Medicinal plants have been used since time immemorial in both developing and developed countries. Flemingia macrophylla (Willd.) is widely used as a hereditary medicines. The current study was designed to observe the analgesic, antidiarrheal and CNS depressant activities of methanol extract of the leaves of F. macrophylla (MEFM) and its petroleum ether (PEFM), dichloromethane (DFM), chloroform (CFM) and aqueous (AFM) fractions. The analgesic activities was assessed by acetic acid induced writhing method at doses 200- and 400- mg/kg body weight. The CNS-depressant effect was assayed by phenobarbitone sodium-induced sleeping time test. The anti-diarrheal activity of the extract was evaluated using castor oil-induced diarrhea in mice. The crude extract displayed significant peripheral analgesic activity at both test doses with 56.72- to 59.70-% inhibition of writhing responses, respectively. In CNS-depressant test, the extract revealed its activity in a dose dependent manner. In screening for antidiarrheal activity, the extract exhibited 20.83 and 41.67 % inhibition of defecation at 200- and 400-mg/kg bw, respectively whereas the standard loperamide (50 mg/kg bw) displayed 70.83 % inhibition of defecation. Bangladesh Pharmaceutical Journal 23(2): 141-145, 2020

scholarly journals Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

2016 ◽  
Vol 19 (2) ◽  
pp. 215-218
Author(s):  
Md Rahatullah Razan ◽  
Muhammed Mahfuzur Rahman ◽  
Faiza Tahia ◽  
Md Khalid Hossain ◽  
Mohammad A Rashid
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Castor Oil ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Pharmaceutical Journal ◽  
Activity Assay ◽  
Swiss Albino Mice

The methanol extract of leaf of Podocarpus neriifolius D. Don exhibited in vivo peripheral analgesic and antidiarrheal activities in Swiss Albino mice. In the peripheral analgesic activity assay, the methanolic extract showed 50.00 ± 8.57% and 70.25 ± 1.18% inhibition of acetic acid-induced writhing at 200 and 400 mg/kg body weight, respectively. In addition, the extract also revealed a dose dependant inhibition of castor oil- induced diarrhea with 43.77 ± 3.13% and 56.23 ± 6.49% inhibition of feces at 200 and 400 mg/kg body weight, respectivelyBangladesh Pharmaceutical Journal 19(2): 215-218, 2016

scholarly journals Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth.

2018 ◽  
Vol 21 (2) ◽  
pp. 80-86 ◽  
Author(s):  
Shanta Islam ◽  
Md Shafiullah Shajib ◽  
Bidyut Kanti Datta ◽  
Mohammad A Rashid
Keyword(s):  
Open Field ◽  
Plant Extract ◽  
Methanol Extract ◽  
Dependent Manner ◽  
Albizia Lebbeck ◽  
Sodium Thiopental ◽  
Sleeping Time ◽  
Time Test ◽  
Dose Dependent ◽  
Crude Methanol Extract

Albizia lebbeck (Linn.) Benth. is a deciduous tree which is planted as ornamental and avenue tree almost all over Bangladesh. Leaves of the plant are used in ethnomedicine for the treatment of convulsion and CNS related disorder. This study was aimed to evaluate the neuropharmacological effects of the methanol extract of A. lebbeck leaves in Swiss albino mice. The locomotor effect of crude methanol extract of the plant was investigated by open field and hole cross tests while the anxiolytic activity was determined using elevated plus-maze (EPM) and light/dark box (LDB) tests. Furthermore, the sedative activity of the plant extract was assessed by sodium thiopental-induced sleeping time test. The results demonstrated that the methanol extract significantly (p < 0.001) reduced locomotion of the animals in both hole cross and open field tests in dose-dependent manner at 200-400 mg/kg b.w. In both EPM and LDB tests, the plant extract produced significant anxiolytic effect (p < 0.05) at the doses of 100-400 mg/kg b.w. In addition, it showed significant (p < 0.001) dose-dependent decrease in the onset of sleep and an increase in duration of sleep in sodium thiopental-induced sleeping time test. Preliminary phytochemical analyses of the plant extract revealed the presence of alkaloid, flavonoid, glycoside, saponin, tannin and resin. In acute toxicity test, the leaf extract did not exhibit any adverse effect in mice during 7 days treatment. The results of the present studies suggest that the crude methanol extract of A. lebbeck leaves possesses significant CNS depressant, anxiolytic and sedative properties and rationalize the traditional uses of the plant.Bangladesh Pharmaceutical Journal 21(2): 80-86, 2018

scholarly journals Evaluation of Antidiarheal and Antidiabetic Activities of Wrigthia arborea (Dennst.) Mabb.

2015 ◽  
Vol 16 (2) ◽  
pp. 211-216
Author(s):  
Ronok Zahan ◽  
Laizuman Nahar ◽  
Zahangir Alam ◽  
Mst Luthfun Nesa ◽  
M Ekramul Haque
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Castor Oil ◽  
Methanol Extract ◽  
Pharmaceutical Journal ◽  
Diabetic Rats ◽  
Deciduous Tree ◽  
Elevated Blood ◽  
Antidiabetic Effect ◽  
Elevated Blood Glucose Level

Wrigthia arborea (Dennst.) Mabb., locally known as Shet-kurchi, is a small deciduous tree. These species are important in the traditional healthcare, especially in menstrual and renal complaints. The present study was designed to investigate the antidiarheal and antidiabetic activities of methanol extract of W. arborea. The methanol extract was studied for antidiarrhoeal properties using castor oil and magnesium sulphate induced diarrhoeal model in mice. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the study period. Antidiabetic effect was also evaluated in normal and alloxan induced diabetic rats. Considerable drop of elevated blood glucose level was observed in the normoglycemic and alloxan induced diabetic rats at a dose of 150 and 300 mg/kg b.w. when the extract was given intraperitoneally. Altogether, these results suggest that the methanol extract could be used for treating diarrhea and diabetes. This is the first report of antidiarheal and antidiabetic potential of W. arborea. DOI: http://dx.doi.org/10.3329/bpj.v16i2.22306 Bangladesh Pharmaceutical Journal 16(2): 211-216, 2013

scholarly journals Preliminary In Vitro Biological and Phytochemical Screenings of Parmentiera cereifera Seem

2012 ◽  
Vol 15 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Md Reyad-ul-Ferdous ◽  
Ridwan Bin Rashid ◽  
Md Al Amin Sikder ◽  
Fahima Aktar ◽  
Mohammad A Rashid
Keyword(s):  
Methanol Extract ◽  
Radical Scavenging ◽  
Pharmaceutical Journal ◽  
Antimicrobial Activities ◽  
Artemia Salina ◽  
Butylated Hydroxytoluene ◽  
Leaf Extracts ◽  
Scavenging Effect ◽  
Vincristine Sulphate

In this present study, the leaf extracts of Parmentiera cereifera were subjected to a comparative evaluation of the antioxidant capacities, phenol and polyphenols content, membrane stabilization, thrombolytic, antimicrobial activities and cytotoxicity to brine shrimps (Artemia salina). When the DPPH (1,1- Diphenyl-2-picryl hydrazyl) radical scavenging effect was determined spectrophotometrically significant radical scavenging property was observed in crude methanol extract (ME) with IC50 of 21.95 ?g/ml. Here, butylated hydroxytoluene (BHT) and ascorbic acid (ASA) were used as standard antioxidants. The phenol and polyphenol content of the extractives varied between 56.84 to 89.58 mg of GAE/gm of dried extract. The thrombolytic and membrane stabilizing activities were assessed by using human erythrocyte and the results were compared with standard streptokinase (SK) and standard anti-inflammatory drug, acetyl salicylic acid (ASA), respectively. The extracts demonstrated significant toxicity to A. salina with LC50 values ranging from 6.07 to 7.83 ?g/ml as compared to standard Vincristine sulphate (VS, LC50 value 0.45 ?g/ml). On the other hand, the chloroform soluble fraction (CSF) of methanol extract revealed moderate antibacterial activity against some microorganisms used in the screening. Preliminary phytochemical investigation suggested the presence of flavonoids, saponins, tannins, triterpenoids and steroids. DOI: http://dx.doi.org/10.3329/bpj.v15i2.12572 Bangladesh Pharmaceutical Journal 15(2): 103-106, 2012

Ethnopharmacological investigation of the aerial part of Phragmites karka (Poaceae)

2017 ◽  
Vol 28 (3) ◽  
Author(s):  
Ramiz Ahmed Sultan ◽  
Mohammad Shah Hafez Kabir ◽  
Mir Muhammad Nasir Uddin ◽  
Mohi Uddin ◽  
Zobaer Al Mahmud ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Sleep Latency ◽  
Biological Activities ◽  
Glucose Load ◽  
Mice Model ◽  
Plant Parts ◽  
Cns Depressant ◽  
Phragmites Karka ◽  
Time Test ◽  
Cns Depressant Activity

AbstractBackground:In this ethnopharmacological study, methanolic extract of the aerial plant parts ofMethods:The cold methanolic extract of the aerial plant parts ofResults:In the mice model, the MEPK, PEFMEPK, and CTFMEPK fractions showed significant peripheral analgesic activity at a dose of 400 mg/kg body weight with percentage of inhibition of acetic acid-induced writhing 77.67 (p<0.001), 33.50 (p<0.001), and 40.29 (p<0.001), respectively, compared to the standard dichlofenac (60.68%, p<0.001) group. The hypoglycemic properties of MEPK, PEFMEPK, and CTFMEPK extracts were evaluated in normoglycemic mice where the reduction of blood glucose level after 30 min of glucose load were 69.85%, 78.91%, and 72.73%, respectively, and for standard glibenclamide, the reduction was 72.85%. All results were significant (p<0.05). In the case of the CNS depressant activity by phenobarbitone-induced sleeping time test, the crude ME significantly reduced sleep latency by 57.14% and increased the duration of sleep by 63.29% compared to the control, which were comparable to that of standard diazepam (65.71% and 77.62%, respectively). Among all the extract and fractions, methanolic extract showed the maximum antidiarrheal effect. The methanolic extract at 200 mg/kg dose induced a significant decrease in the total number of defecation in 4 h (69.05% of inhibition, p<0.001) and at 400 mg/kg dose showed 76.19% of inhibition (p<0.001).Conclusions:In light of the available literature, these findings represent the first experimental investigation of biological activities of

scholarly journals Anti-diarrhoeal and CNS Depressant Activity of Methanolic Extract of Saccharum spontaneum Linn.

1970 ◽  
Vol 1 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Md Mynol Islam Vhuiyan ◽  
Israt Jahan Biva ◽  
Moni Rani Saha ◽  
Muhammad Shahidul Islam
Keyword(s):  
Castor Oil ◽  
Methanolic Extract ◽  
Experimental Models ◽  
Saccharum Spontaneum ◽  
Cns Depressant ◽  
Whole Plant ◽  
The Central Nervous System ◽  
Dose Dependent Decrease ◽  
Cns Depressant Activity ◽  
Dose Dependent

Preliminary phytochemical screening of the methanolic extract of the whole plant of Saccharum spontaneum Linn. (Family- Gramineae) revealed the presence of alkaloids, flavonoids, reducing sugar, tannins and saponins. The antidiarrhoeal activity of the extract (200 and 400 mg/kg) was assessed on experimental animal and a dose dependent decrease in the total number of faecal dropping was obsereved in castor oil induced diarrhoea in mice. The plant extract was also assessed for effect on the central nervous system (CNS) using a number of neuropharmacological experimental models in mice. The extract produced a dosedependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field and hole cross tests. These results suggest that the extract possesses antidiarrhoeal and CNS depressant activity. Key Words: Saccharum spontaneum, Castor oil, Loperamide, Pentobarbitone.     doi:10.3329/sjps.v1i1.1810 S. J. Pharm. Sci. 1(1&2): 63-68

scholarly journals Phytochemical screening, antinociceptive, anthelmintic and cytotoxicity studies of the leaves of Carissa carandas Linn. (Family: Apocynaceae)

2018 ◽  
Vol 4 (5) ◽  
pp. 119 ◽  
Author(s):  
Most. Nazma Parvin
Keyword(s):  
Cytotoxic Activity ◽  
Methanol Extract ◽  
Anthelmintic Activity ◽  
Antinociceptive Activity ◽  
Cytotoxic Activities ◽  
Phytochemical Screening ◽  
Standard Drug ◽  
Cytotoxicity Studies ◽  
Vincristine Sulphate ◽  
Carissa Carandas

<em><em></em></em><p class="abstract"><strong>Background:</strong> <em>Carissa carandas </em>Linn. (Bengali name- Karamya, Karancha, Karamcha, English name-Karaunda) commonly known as Karanda is a widly used medicinal plants belongs to apocynaceae family<em>. </em>The various plant parts of <em>C. carandas </em>have been used for ethnomedicine in the treatment of human diseases, such as diarrhea, stomachic, anorexia, intermittent fever, mouth ulcer and sore throat, syphilitic pain, burning sensation, scabies and epilepsy. The current studies were aimed to investigate the phytochemical constituents, antinociceptive, anthelmintic and cytotoxic activities of the methanol extract of leaves of <em>C. carandas</em>.</p><p class="abstract"><strong>Methods:</strong> The antinociceptive property of the methanol leaves extract of <em>C. carandas</em> was evaluated in swiss albino mice by using acetic acid-induced writhing test and anthelmintic activity of the fresh leaves juice was performed by observing the time of paralysis and the time of death of earth worms <em>Pheretima posthuma. </em>On the other hand, the methanol extract of leaves of <em>C. carandas</em> was screened for cytotoxic activity by brine shrimp lethality bioassay.  </p><p class="abstract"><strong>Results:</strong> Phytochemical screening showed that the methanol leaves extract contained alkaloids, steroids, flavanoids, tannins, saponins and reducing sugar. The antinociceptive activity test revealed that the extract showed significant antinociceptive activity and the fresh juice of the leaves of <em>C. carandas </em>showed potent anthelmintic activity. In cytotoxicity studies, the methanol leaves extract displayed moderate cytotoxic activity when compared with standard drug, vincristine sulphate.</p><p class="abstract"><strong>Conclusions:</strong> In the current studies, these observations also support the use of this plant for medicinal purposes and encourage further investigations for more fruitful results.</p>

scholarly journals In vivo CNS Activity of Methanolic Extract of Ficus racemosa Fruits in Experimental Animals

2018 ◽  
Vol 21 (2) ◽  
pp. 139-144
Author(s):  
Mst Shirajum Munira ◽  
Md Shariful Islam ◽  
Md Baharuddin ◽  
Sabiha Ferdowsy Koly
Keyword(s):  
Methanolic Extract ◽  
Pharmaceutical Journal ◽  
Tail Suspension ◽  
Experimental Animals ◽  
Cns Depressant ◽  
Cns Activity ◽  
Ficus Racemosa ◽  
Cns Depressant Activity ◽  
Dose Dependent

The purpose of the study was to evaluate the CNS activity of the methanolic extract of Ficus racemosa fruits. The powdered fruits of F. racemosa were extracted with methanol to investigate the effect on central nervous system in Swiss albino mice. The CNS depressant activity was evaluated by observing the reduction of locomotor activity by open field and hole cross tests. The anti-depressant activity was tested by forced swimming and tail suspension methods. For CNS activity, two test doses of the extracts such as 200 and 400 mg/kg body weight were used. However, the extracts showed significant dose dependent CNS depressant activity when compared to the control in animal models. From our research, it can be concluded that the methanolic extract of F. racemosa fruits possesses significant CNS depressant activity. So, further studies are recommended for the isolation of compounds responsible for this activity.Bangladesh Pharmaceutical Journal 21(2): 139-144, 2018

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