scholarly journals Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

2016 ◽  
Vol 19 (2) ◽  
pp. 215-218
Author(s):  
Md Rahatullah Razan ◽  
Muhammed Mahfuzur Rahman ◽  
Faiza Tahia ◽  
Md Khalid Hossain ◽  
Mohammad A Rashid
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Castor Oil ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Pharmaceutical Journal ◽  
Activity Assay ◽  
Swiss Albino Mice

The methanol extract of leaf of Podocarpus neriifolius D. Don exhibited in vivo peripheral analgesic and antidiarrheal activities in Swiss Albino mice. In the peripheral analgesic activity assay, the methanolic extract showed 50.00 ± 8.57% and 70.25 ± 1.18% inhibition of acetic acid-induced writhing at 200 and 400 mg/kg body weight, respectively. In addition, the extract also revealed a dose dependant inhibition of castor oil- induced diarrhea with 43.77 ± 3.13% and 56.23 ± 6.49% inhibition of feces at 200 and 400 mg/kg body weight, respectivelyBangladesh Pharmaceutical Journal 19(2): 215-218, 2016

scholarly journals In vivo Analgesic activity of methanolic extract of Helianthus annuus seeds

2016 ◽  
Vol 5 (4) ◽  
pp. 38-40 ◽  
Author(s):  
Rubab Tarannum Islam ◽  
Ahmed Tanjimul Islam ◽  
Mir Monir Hossain ◽  
Kishor Mazumder
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Helianthus Annuus ◽  
Analgesic Activity ◽  
Latency Period ◽  
Pharmaceutical Journal ◽  
Mice Model ◽  
Hot Plate ◽  
Writhing Test

The sunflower seed is the seed of the sunflower (Helianthus annuus). The methanol extract of seeds of Helianthus annuus were screened for analgesic activity in mice model to systematically explore the medicinal values of the plant. Acetic acid induced writhing and hot plate methods were used to confirm the central and peripheral analgesic action. In case of acetic acid-induced writhing test the extract showed significant (P <0.05) analgesic potential at doses 100 and 200 mg/kg body weight (50.35 and 57.85% inhibition, respectively). In the hot plate method, increase (p < 0.05) of latency period was also observed in comparison to standard aspirin. At 60 minutes, the latency period of two different doses (100 and 200 mg/kg body weight) was found at 13 ± 0.91 and 16.5 ± 1.55 second. The results obtained support the use of Helianthus annuus seeds in painful conditions acting both centrally and peripherally.Islam et al., International Current Pharmaceutical Journal, March 2016, 5(4): 38-40http://www.icpjonline.com/documents/Vol5Issue4/02.pdf

scholarly journals Screening of analgesic activity of Phoenix sylvestris leaves in rodents

2018 ◽  
Vol 4 (1) ◽  
pp. 22-24
Author(s):  
Pankaj Jain ◽  
◽  
Sonika Jain ◽  
Surendra Kumar Swarnkar ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Leaf Extract ◽  
Methanolic Extract ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Tail Immersion ◽  
Albino Mice ◽  
Withdrawal Reflexes

Aim: The present study evaluated the central and peripheral analgesic activity of methanolic leaf extract of Phoenix sylvestris (PSLME) in swiss albino mice. Method: Peripheral and central analgesic activity was evaluated by tail immersion and acetic acid writhing in swiss albino mice. Dextropropoxyphene was used as a standard drug in the dose of 65mg/kg body weight in both models. PSLME was tested at 100 and 500mg/kg dose level. Results: The result revealed that methanolic extract exhibit 48% and 40.5% writhing inhibition at 500 and 100 mg/kg doses whereas ~30% tail withdrawal reflexes inhibition at 500mg/kg which was analogous to the standard drug dextropropoxyphene. Conclusion: Methanolic extract of leaves of P. sylvestris possesses both peripheral and central analgesic activity in experimental animal.

scholarly journals INVESTIGATION ON IN VIVO ANALGESIC ACTIVITY OF METHANOL EXTRACT OF MARINE BROWN ALGA SPATOGLOSSUM ASPERUM J. AGARTH

2018 ◽  
Vol 11 (11) ◽  
pp. 313
Author(s):  
Pandithurai M ◽  
Murugesan S ◽  
Sivamurugan V
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Brown Alga ◽  
Methanol Extract ◽  
Albino Rats ◽  
Significant Activity ◽  
Study Evaluation ◽  
Wistar Albino Rats

Objective: In the present study, evaluation of the methanol extract of Spatoglossum asperum, brown marine algae on the analgesic activity using animal model was focussed.Methods: Acetic acid-induced writhing test on Wistar albino rats at a dosage of 10 mg/kg body weight of algal extract have been carried out. It showed significant analgesic activity by reducing the number of acetic acid-induced writhing.Results: The animals at a dosage of 10 mg/kg body weight exhibited, 70.52% of the animals were protected using S. asperum extract, on the other hand, the standard, diclofenac protected 84.21% of the animals. The results are statistically significant at p<0.001, and the investigation revealed dose-dependent significant activity in comparison with standard and control.Conclusion: Hence, it can be concluded that the methanol extracts of the brown alga S. asperum have potent analgesic activity at moderate doses.

scholarly journals Boehmeria glomerulifera Miq. Exhibits in vivo Antidepressant and Antidiarrheal Activities

2019 ◽  
Vol 22 (2) ◽  
pp. 181-184
Author(s):  
Muhammed Mahfuzur Rahman ◽  
Sharmin Khandker Shampa ◽  
Md Abdul Bari ◽  
Mohammad Kaisarul Islam ◽  
Mohammad A Rashid
Keyword(s):  
Crude Extract ◽  
Castor Oil ◽  
Methanolic Extract ◽  
Antidepressant Activity ◽  
Pharmaceutical Journal ◽  
The Other ◽  
Mice Model ◽  
Rural People ◽  
The Family

Boehmeria glomerulifera Miq., is medicinal herb belongs to the family Urticaceae. It is used for treating various diseases by folk practitioners and rural people. The CNS antidepressant and antidiarrhoeal activities of the crude extract were investigated at 200 and 400 mg/kg bw in Swiss Albino mice model. The crude methanolic extract revealed significant (p < 0.05) antidepressant activity in mice at 400 mg/kg bw. On the other hand, in the castor oil-induced antidiarrheal assay, the extract demonstrated significant (p < 0.05) antidiarrhoeal activity at 400 mg/kg bw. Bangladesh Pharmaceutical Journal 22(2): 181-184, 2019

Analgesic Activity of Tragia involucrata

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
M Alimuzzaman ◽  
Muniruddin Ahmed
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Oral Dose ◽  
Ethyl Acetate ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Radiant Heat ◽  
Tail Flick ◽  
Methanolic Extracts ◽  
Whole Plant

The work was carried out to investigate the analgesic activity of the whole plant of Tragia involucrata Linn. The dried whole plant was successively extracted with petroleum ether, ethyl acetate and methanol. Experiments were carried out with these extracts for their peripheral and central antinociceptive potentials on acetic acid induced writhing and radiant heat tail-flick models in mice, respectively. Both the ethyl acetate and methanolic extracts showed significant writhing inhibition while the elongation of tail-flick time was most prominent with methanolic extract at an oral dose of 500 mg/kg body weight. Key words: Tragia involucrata, Analgesic activity, Acetic acid induced writhing, Radiant heat tail-flick. Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Membrane stabilizing, thrombolytic, analgesic, anti-diarrheal and CNS activities of Polyalthia longifolia (Sonn.)

2014 ◽  
Vol 4 (3) ◽  
pp. 104-109
Author(s):  
Ridwan Islam ◽  
Md. Al Amin Sikder ◽  
Rafeeq Alam Khan ◽  
Mansoor Ahmed ◽  
Mohammad A. Rashid
Keyword(s):  
Analgesic Activity ◽  
Castor Oil ◽  
Methanol Extract ◽  
Bark Extract ◽  
Tail Flick ◽  
Swiss Albino Mice ◽  
Tail Flick Latency ◽  
Albino Mice ◽  
Polyalthia Longifolia ◽  
Crude Methanol Extract

Different fractions of Polialthia longifolia (Sonn.) bark were evaluated for membrane stabilizing, thrombolytic, analgesic, anti-diarrheal and CNS de-pressant activities upon oral administration at 200 and 400 mg/kg body weight. The membrane stabilizing activity was assessed by heat and hypo-tonic solution. Carbon tetrachloride fraction of methanol extract of P. longi-folia bark demonstrated strong membrane stabilizing activity, while the crude methanol extract demonstrated mild to moderate thrombolytic activi-ty in human blood specimen. The analgesic activity was assessed by tail im-mersion and formalin-induced pain method in Swiss-albino mice. The crude methanol extract of P. longifolia bark exhibited significant peripheral and central analgesic activity, since inhibited chemical induced writhing at 200 mg/kg and increased tail flick latency time both at 200 and 400 mg/kg. The anti-diarrheal activity of the bark extract was assessed by using castor oil induced diarrhea in mice however significant anti-diarrheal activity was not revealed. The CNS inhibitory activity of the methanol extract was assessed in Swiss albino mice where it reduced phenobarbitone sodium induced sleep-ing time at 400 mg/kg.

scholarly journals Antidiarrhoeal activity of rind of Punica granatum

2013 ◽  
Vol 2 (5) ◽  
pp. 101-104 ◽  
Author(s):  
Saleha Akter ◽  
Amit Sarker ◽  
Md. Sanowar Hossain
Keyword(s):  
Body Weight ◽  
Animal Models ◽  
Magnesium Sulfate ◽  
Castor Oil ◽  
Methanolic Extract ◽  
Punica Granatum ◽  
Pharmaceutical Journal ◽  
Phytochemical Screening ◽  
Traditional Use ◽  
Standard Drug

Punica granatum (Family: Punicaceae) is a widely consumed fruit in Bangladesh locally known as Anar or Bedana. Traditionally the plant is used to treat diarrhoea, dysentery, hemorrhage, tuberculosis and chronic periodontitis. The present study was undertaken in order to justify and authenticate the traditional use of rind of P. granatum fruit in diarrhoea. Methanolic extract of the rind of the fruit was tested in castor oil- and magnesium sulfate-induced diarrhoea in mice at the doses of 200 and 400 mg/kg body weight. The results of the present study revealed significant antidiarrhoeal activity (p<0.001) in both animal models. The extract inhibited 31.25% defaecation at the dose of 200 mg/kg and 53.75% at the dose of 400 mg/kg in castor oil-induced diarrhoea while standard drug loperamide inhibited 71.25% defaecation. In magnesium sulfate-induced diarrhoea the inhibition of defaecation was 45.71 and 57.14% at the doses of 200 and 400 mg/kg respectively while loperamide inhibited 64.29% defaecation. The antidiarrhoeal effect of the extract was concentration dependent in both castor oil-induced diarrhoea and magnesium sulfate-induced diarrhoea. Phytochemical screening of the extract revealed the presence of flavonoids and alkaloids that may play key role in its antidiarrhoeal activity. The results of the present study validate the folkloric use of the rind of P. granatum in the treatment of diarrhoea.DOI: http://dx.doi.org/10.3329/icpj.v2i5.14437 International Current Pharmaceutical Journal, April 2013, 2(5): 101-104

Anti-diarrheal, Analgesic and Anti-microbial activities of the plant Lalmesta (Hibiscus sabdariffa): A review

2012 ◽  
Vol 1 (3) ◽  
Author(s):  
Md Raihan Sarkar ◽  
SM Moazzem Hossen ◽  
Md Sariful Islam Howlader ◽  
Md Ashfaqure Rahman ◽  
Avijit Dey
Keyword(s):  
Antimicrobial Activity ◽  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Castor Oil ◽  
Ethanolic Extract ◽  
Diffusion Method ◽  
Hibiscus Sabdariffa ◽  
Phytochemical Screening ◽  
Writhing Test

The aim of this study was to phytochemically investigate the ethanolic extract of Hibiscus sabdariffa Linn. calyces and to evaluate the analgesic, anti-microbial and anti-diarrheal activities of this. The calyces of Hibiscus sabdariffa were separated from the other plant parts and sun dried and extracted using ethanol and phytochemically and pharmacologically evaluated.Different Phytochemical tests were performed for phytochemical screening and for determining the functional groups. Different methods like Disc diffusion method for antimicrobial activity determination, Castor oil induced diarrhea in mice method for the antidiarrheal study and Acetic acid induced writhing test for analgesic activity were employed. Phytochemical screening of the calyces of Hibiscus sabdariffa ensured the presence of alkaloid, flavonoids, saponins, tannins in the crude ethanolic extract. The peripheral analgesic activity was evaluated by acetic acid induced Writhing method. The extract produced 66.85% (p< 0.001) inhibition of writhing in mice at the dose of 500-mg/kg body weight, which is comparable to diclofenac sodium (78.45% (p<0.001) at the dose of 25mg/kg). The anti-diarrheal activity of the crude extract of Hibiscus sabdariffa was evaluated using the model of castor oil induced diarrhea in mice. The crude etanolic extract of Hibiscus sabdariffa (calyces) showed a marked antidiarrhoeal activity at dose of 500 mg/kg-body weight as compared to the standard antidiarrhoeal agent loperamide (dose:50mg/kg-body weight). Hibiscus sabdariffa caused an increase in latent period i.e. delayed the onset of diarrhoeal episode and decreased the frequency of defecation. Anti-microbial activity was tested using a number of micro-organisms. The peripheral analgesic activity of the ethanolic extract of the calyces of Hibiscus sabdariffa against acute inflammatory pain was significantly high as compared to potent inhibitory activity of Diclofenac (25mg/kg). Therefore, it is likely that the ethanolic extract at a dose of 400mg/kg might suppress the formation of these substances or antagonize the action of these substances and thus exerts its analgesic activity in acetic acid-induced writhing test. Anti-diarrheal activity was present in the ethanolic extract (500mg/kg) which indicate that the drug in decreased intestinal motility. This plant sample didn’t show any antimicrobial activity. DOI: http://dx.doi.org/10.3329/ijpls.v1i3.12978 International Journal of Pharmaceutical and Life Sciences Vol.1(3) 2012

scholarly journals Evaluation of Antidiarheal and Antidiabetic Activities of Wrigthia arborea (Dennst.) Mabb.

2015 ◽  
Vol 16 (2) ◽  
pp. 211-216
Author(s):  
Ronok Zahan ◽  
Laizuman Nahar ◽  
Zahangir Alam ◽  
Mst Luthfun Nesa ◽  
M Ekramul Haque
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Castor Oil ◽  
Methanol Extract ◽  
Pharmaceutical Journal ◽  
Diabetic Rats ◽  
Deciduous Tree ◽  
Elevated Blood ◽  
Antidiabetic Effect ◽  
Elevated Blood Glucose Level

Wrigthia arborea (Dennst.) Mabb., locally known as Shet-kurchi, is a small deciduous tree. These species are important in the traditional healthcare, especially in menstrual and renal complaints. The present study was designed to investigate the antidiarheal and antidiabetic activities of methanol extract of W. arborea. The methanol extract was studied for antidiarrhoeal properties using castor oil and magnesium sulphate induced diarrhoeal model in mice. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the study period. Antidiabetic effect was also evaluated in normal and alloxan induced diabetic rats. Considerable drop of elevated blood glucose level was observed in the normoglycemic and alloxan induced diabetic rats at a dose of 150 and 300 mg/kg b.w. when the extract was given intraperitoneally. Altogether, these results suggest that the methanol extract could be used for treating diarrhea and diabetes. This is the first report of antidiarheal and antidiabetic potential of W. arborea. DOI: http://dx.doi.org/10.3329/bpj.v16i2.22306 Bangladesh Pharmaceutical Journal 16(2): 211-216, 2013

scholarly journals Bioactivities of Chukrasia tabularis (A. Juss.)

2015 ◽  
Vol 18 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Sharmin Aktar ◽  
Marzia Bilkiss ◽  
Faiza Tahia ◽  
Md Al Amin Sikder ◽  
Ridwan B Rashid ◽  
...  
Keyword(s):  
Body Weight ◽  
Free Radical ◽  
Analgesic Activity ◽  
Crude Extract ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Soluble Fraction ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Chukrasia Tabularis

The methanol extracts of bark and leaves of Chukrasia tabularis and their organic and aqueous soluble materials were subjected to screenings for antioxidant, cytotoxic, thrombolytic, membrane stabilizing, antimicrobial, analgesic and antidiarrhoel activities. In the DPPH free radical scavenging assay, the methanolic extract of bark of C. tabularis and the aqueous soluble fraction of methanol extract of leaves of C. tabularis revealed the highest free radical scavenging activity with IC50 values of 2.95 ?g/ml and 5.31 ?g/ml, respectively. The pet ether soluble fraction of methanolic extract of leaves and bark of C. tabularis displayed the highest cytotoxic potential having LC50 values 0.0167 ?g/ml and 3.89 ?g/ml, as compared to standard vincristine sulphate (LC50 value of 0.45 ?g/ml). During thrombolytic assay, the aqueous soluble fraction of leaves and carbon tetrachloride soluble fraction of bark of C. tabularis showed 34.04% and 56.37% clot lysis, respectively. In the membrane stabilizing assay, the carbontetrachloride and aqueous soluble materials of methanol extract of leaf inhibited 21.03% and 49.68% hypotonic solution- and heat-induced haemolysis of RBC, respectively. The crude extract of leaves of C. tabularis exhibited mild antibacterial activity, while that of leaves and bark revealed significant central analgesic activity at 400 mg/kg body weight. The crude extracts demonstrated significant peripheral analgesic activity at 200- and 400- mg/kg body weight. On the other hand, the crude extract of leaves of C. tabularis revealed significant antidiarrhoel activity.Bangladesh Pharmaceutical Journal 18(2): 126-131, 2015

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