scholarly journals Qualitative and Quantitative Analysis of AgNORs in FNAC Smears of Palpable Breast Lumps

2017 ◽  
Vol 15 (2) ◽  
pp. 14-20
Author(s):  
Tamanna Binta Hasan ◽  
Shoibul Karim ◽  
Mohammad Ismail Hossain ◽  
Md Quamrul Hassan ◽  
Sayeda Nasreen ◽  
...  
Keyword(s):  
Predictive Value ◽  
False Positive ◽  
Atypical Ductal Hyperplasia ◽  
False Negative ◽  
Benign Neoplasm ◽  
Duct Cell ◽  
True Positive ◽  
True Negative ◽  
Malignant Case ◽  
Ductal Hyperplasia

Background: The study aimed to evaluate the efficacy of AgNORs on FNAC smears of breast lesion.Methods: FNAC were done in 200 female patients of breast lump consecutively, Papanicolau and AgNOR staining was done in all 200 cases of FNA smears.Among them biopsy and histopathology were done in 99 cases. The findings of FNAC and AgNOR analysis were compared to histopathological findings.Results: By FNAC, 53 (26.5%) cases were non-neoplastic benign, 89(44.5%) cases were benign neoplasm, 07 (3.5%) cases were atypical ductal hyperplasia and 51(25.5%) cases were malignant (Duct cell carcinoma).Among them histopathology was done in 99 cases.Out of 40 FNAC malignant cases, histopathologically all were proved malignant. Out of 42 benign cases, 1 was found malignant. 4 atypical ductal hyperplasia were also diagnosed as malignant histopathologically. True positive cases are 40, True negative cases are 36, false positive are nil (0), and false negative is 01. The sensitivity is 97.56%, specificity is 100%, positive predictive value is 100%, Negative predictive value is 97.3%, and accuracy is 98.7%. AgNOR impression were analysed in 99 histopathologically confirmed cases. The results showed benign impression in 50 cases and malignant impression in 48 cases. 01 histopathologically malignant case was impressed as benign by AgNOR and 01 as suspicious which may be included as malignant by AgNOR impression. 2 histopathologically benign cases showed higher proliferative activities and counted as malignant. True positive cases are 46, True negative 49, false positive is 02 and false negative is 01. The sensitivity is 97.87%, Specificity 96.07%, PPV 95.83%, NPV 98%, Overall accuracy is 96.93%.Conclusion: The efficacy of FNAC and AgNOR analysis in the diagnosis of breast lesion was found more or less similar and mild over lapping.Chatt Maa Shi Hosp Med Coll J; Vol.15 (2); Jul 2016; Page 14-20

Prediction of Adnexal Torsion by Ultrasound in Women with Acute Abdominal Pain

2019 ◽  
Vol 41 (06) ◽  
pp. 688-694
Author(s):  
Ron Bardin ◽  
Noga Perl ◽  
Reuven Mashiach ◽  
Eitan Ram ◽  
Sharon Orbach-Zinger ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
False Positive ◽  
Acute Abdominal Pain ◽  
Cohort Analysis ◽  
False Negative ◽  
True Positive ◽  
Adnexal Torsion ◽  
Positive Group

Abstract Purpose To investigate the accuracy of ultrasound in the diagnosis of adnexal torsion. Materials and Methods Retrospective cohort analysis of 322 women, presenting to a tertiary medical center with acute abdominal pain, who underwent gynecological examination, sonographic evaluation and laparoscopic surgery, between 2010 and 2016. Findings for adnexal torsion were compared among three groups: positive sonographic findings consistent with surgically confirmed adnexal torsion (true positive, n = 228); negative sonographic findings inconsistent with surgically confirmed adnexal torsion (false negative, n = 42); and positive sonographic findings inconsistent with a surgical diagnosis other than adnexal torsion (false positive, n = 52). Outcome measures were sensitivity and positive predictive value of ultrasound, and its specific features, for the diagnosis of adnexal torsion. Results The sensitivity of ultrasound for adnexal torsion diagnosis was 84.4 %, and the positive predictive value was 81.4 %. Edematous ovary and/or tube, as well as positive whirlpool sign had the highest sensitivity and positive predictive value. The false-negative group had the highest frequency of ovarian cysts (p = 0.0086) and the lowest frequency of ovarian edema (p < 0.0001). The false-positive group had the lowest proportion of pregnant women (p = 0.0022). Significantly more women in the true-positive group had a prior event of adnexal torsion (p = 0.026). Conclusion Ultrasound examination is highly accurate in the diagnosis of adnexal torsion. Clinicians should be aware of the presence of demographic and clinical characteristics that may positively or negatively affect sonographic diagnostic accuracy.

Parotid Tumors: Fine-Needle Aspiration and/or Frozen Section

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P42-P43
Author(s):  
Peter Zbaren ◽  
Heinz Loosli ◽  
Edouard Stauffer
Keyword(s):  
Sensitivity And Specificity ◽  
Fine Needle Aspiration ◽  
False Positive ◽  
Frozen Section ◽  
False Negative ◽  
Needle Aspiration ◽  
True Positive ◽  
True Negative ◽  
Fine Needle ◽  
Parotid Neoplasms

Objective Assess the difficulties of preoperative and intraoperative tumor typing of parotid neoplasms. Know the advantages and pitfalls of fine-needle-aspiration cytology (FNAC) and frozen section (FS) analysis in primary parotid neoplasms. Methods In 113 parotid neoplasms (70 malignancies and 43 benign tumors) preoperative FNAC as well as intraoperative FS analysis were performed. FNAC and FS findings were analyzed and compared with the final histopathologic diagnosis. Results The FNAC smear was non-diagnostic in 6 tumors. In 2 FS specimens, it was not possible to determine the tumor dignity. FNAC findings and FS findings were both available in 105 neoplasMS The FNAC findings were true positive for malignancy in 54, true negative in 36, false positive in 4, and false negative in 11 tumors. The accuracy, sensitivity, and specificity were 86%, 83%, and 90% respectively. The FS findings were true positive in 60, true negative in 38, false positive in 2, and false negative in 5 tumors. The accuracy, sensitivity, and specificity were 93%, 92% and 95% respectively. The exact histologic tumor typing by FNAC was correct, false or not mentioned in 58%, 20% and 22% true positive or true negative evaluated tumors, and by FS in 83%, 5% and 12% true positive or true negative evaluated tumors. Conclusions The current analysis showed a superiority of FS compared with FNAC regarding the diagnosis of malignancy and especially of tumor typing. FNAC alone is not prone in many cases to determine the surgical management of primary parotid carcinomas.

scholarly journals SPK Penentuan Lokasi ATM Menggunakan Metode AHP dan SAW

2019 ◽  
Vol 5 (1) ◽  
pp. 49-56
Author(s):  
Gede Surya Mahendra ◽  
Kadek Yota Ernanda Aryanto
Keyword(s):  
False Positive ◽  
Confusion Matrix ◽  
False Negative ◽  
True Positive ◽  
True Negative

Persaingan industri perbankan saat ini semakin meningkat, baik dalam hal penyediaan inovasi produk serta peningkatan kualitas transaksi dan pelayanan. Untuk mengatasi masalah tersebut diciptakan sebuah terminal yang dikenal dengan ATM. Namun fungsionalitas dan efektifitas ATM tersebut belum memenuhi kebutuhan nasabah dikarenakan pengambilan keputusan penentuan lokasi ATM belum menggunakan SPK sehingga banyak kriteria yang terlupakan dalam penentuan lokasi ATM terbaik. Metode AHP yang merupakan sebuah hierarki fungsional dengan input utamanya adalah persepsi manusia sedangkan metode SAW dengan konsep dasar mencari penjumlahan terbobot dari rating kinerja pada setiap alternatif pada semua atribut. AHP digunakan untuk memberikan pembobotan pada masing-masing kriteria dan SAW untuk melakukan perangkingan dari masing-masing alternatif. Terdapat 7 kriteria dengan 11 sub kriteria pada pembobotan dan 76 data alternatif. Pengujian dilakukan dengan membandingkan hasil delpoyment ATM dengan hasil perhitungan sistem. Dari 76 data alternatif yang diujikan, terdapat 38 lokasi deployment ATM. Dari hasil pengujian yang ditampilkan dalam confusion matrix, pada kriteria yang tidak teruji signifikansi didapatkan 33 data True Positive, 38 True Negative, 5 False Negative dan 5 False Positive dengan akurasi sebesar 86,84%, dan pada kriteria yang teruji signifikansi didapatkan 35 data True Positive, 35 True Negative, 3 False Negative dan 3 False Positive memiliki akurasi 92,11%.

scholarly journals Otkrivanje infekcija u abdomenu primenom radioobelezenog antibiotika

2003 ◽  
Vol 50 (2) ◽  
pp. 25-29 ◽  
Author(s):  
Vera Artiko ◽  
Branka Davidovic ◽  
Nadezda Nikolic ◽  
Milorad Petrovic ◽  
Nebojsa Petrovic ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Surgical Treatment ◽  
False Positive ◽  
Bacterial Infections ◽  
Conservative Therapy ◽  
False Negative ◽  
True Positive ◽  
True Negative ◽  
Exact Localization

The aim of the study is detection of the abdominal infective foci using 99mTc-ciprofloxacin, radiopharmaceutical supposed to distuinguish inflammation from infection. Twenty one patient was investigated. There were 11 true positive findings, 7 true negative, two were false negative, while 1 was false positive. Sensitivity of the method was 79% and specificity 91%. According to our results, scintigraphy with infecton is a useful method for detection and assessment of exact localization of deep seated bacterial infections, which might be useful for (differential) diagnosis, surgical treatment in due time as well as monitoring of the treatment of conservative therapy.

scholarly journals Preferred screening test for Cushing’s syndrome screening

2020 ◽  
Vol 4 (1) ◽  
pp. 01-05
Author(s):  
Ahmed Siddiqi
Keyword(s):  
False Positive ◽  
Screening Test ◽  
False Negative ◽  
True Positive ◽  
True Negative ◽  
Inhaled Steroids ◽  
Free Cortisol ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Hospital General

Background: In our practice 24 hours urine collection for free cortisol (24Hr UFC) and overnight dexamethasone suppression test (ONDST) are initial investigations to screen patients for hyper-cortisolism. I audited our practice to find our clinicians’ and patients’ choice of first screening investigation for hyper-cortisolism. Method & material: Electronic and paper medical records of patients who underwent 24Hr UFC and/or ONDST at our hospital over previous consecutive twenty four months were examined. 62 such patients were identified but 12 patients were excluded from analysis. We tried to contact 30 patients over consecutive 48 hours over the phone who underwent both 24Hr UFC and ONDST. We managed to contact 18 patients and asked them two study questions. Data & results: 33 (66%) patients were female and 17 (33%) were male. 20 (40%) had 24Hr UFC alone and 30 (60%) patients had both. In total 80 such investigations completed 30 being ONDST and 50 24hr UFC. 53 (66%) of the investigations were requested by Endocrinologists, 21 (26%) by Hospital General Physicians and 6 (8%) by General practitioners (GP). For UFC 10 (20%) were true positive, 31 (62%) were false positive, 6 (12%) were true negative and 0% false negative. 3 (6%) 24Hr UFC samples were not collected properly and were not processed for results. Out of the total false positives (31 patients), 6 (19.3%) cases were of alcohol excess, 4 (13%) of dépression, 3 (9.7%) of inhaled steroids and 1 (3.2%) of sleep apnea. For the ONDST 7 (23.3%) true positive, 4 (13.3%) false positive 19 (63.4%) true negative and 0% false negative. All 18 patients contacted over the phone answered both questions. 16 preferred ONDST over 24Hr UFC, 1 patient had no preference and 1 patient preferred 24Hr UFC over ONDST. Conclusion: Patients overwhelmingly preferred ONDST as first screening test in contrast to physician’s choice of 24Hr UFC.

scholarly journals Efficacy of Transcranial Motor Evoked Potential Monitoring During Intra- and Extramedullary Spinal Cord Tumor Surgery: A Prospective Multicenter Study of the Monitoring Committee of the Japanese Society for Spine Surgery and Related Research

2021 ◽  
pp. 219256822110114
Author(s):  
Hiroki Ushirozako ◽  
Go Yoshida ◽  
Shiro Imagama ◽  
Kazuyoshi Kobayashi ◽  
Kei Ando ◽  
...  
Keyword(s):  
Spinal Cord ◽  
False Positive ◽  
Evoked Potential ◽  
Spinal Cord Tumor ◽  
False Negative ◽  
Motor Evoked Potential ◽  
True Positive ◽  
True Negative ◽  
Intramedullary Spinal Cord ◽  
Transcranial Motor Evoked Potential

Study Design: Multicenter prospective study. Objectives: Although intramedullary spinal cord tumor (IMSCT) and extramedullary SCT (EMSCT) surgeries carry high risk of intraoperative motor deficits (MDs), the benefits of transcranial motor evoked potential (TcMEP) monitoring are well-accepted; however, comparisons have not yet been conducted. This study aimed to clarify the efficacy of TcMEP monitoring during IMSCT and EMSCT resection surgeries. Methods: We prospectively reviewed TcMEP monitoring data of 81 consecutive IMSCT and 347 EMSCT patients. We compared the efficacy of interventions based on TcMEP alerts in the IMSCT and EMSCT groups. We defined our alert point as a TcMEP amplitude reduction of ≥70% from baseline. Results: In the IMSCT group, TcMEP monitoring revealed 20 true-positive (25%), 8 rescue (10%; rescue rate 29%), 10 false-positive, a false-negative, and 41 true-negative patients, resulting in a sensitivity of 95% and a specificity of 80%. In the EMSCT group, TcMEP monitoring revealed 20 true-positive (6%), 24 rescue (7%; rescue rate 55%), 29 false-positive, 2 false-negative, and 263 true-negative patients, resulting in a sensitivity of 91% and specificity of 90%. The most common TcMEP alert timing was during tumor resection (96% vs. 91%), and suspension surgeries with or without intravenous steroid administration were performed as intervention techniques. Conclusions: Postoperative MD rates in IMSCT and EMSCT surgeries using TcMEP monitoring were 25% and 6%, and rescue rates were 29% and 55%. We believe that the usage of TcMEP monitoring and appropriate intervention techniques during SCT surgeries might have predicted and prevented the occurrence of intraoperative MDs.

scholarly journals Helicobacter pylori infection in various groups of patients studied, estimated by 14C: Urea breath test

2011 ◽  
Vol 58 (1) ◽  
pp. 95-98 ◽  
Author(s):  
Milica Stojkovic ◽  
Darija Durutovic ◽  
Milorad Petrovic ◽  
Mirjana Stojkovic ◽  
Nebojsa Petrovic ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Predictive Value ◽  
Breath Test ◽  
False Negative ◽  
Urea Breath Test ◽  
True Positive ◽  
Clinical Validity ◽  
Gastric Diseases ◽  
True Negative ◽  
Significant Difference

The aim of this study was the detection of helicobacter pylori (HP) infection and estimation of the clinical validity and the accuracy of the 14C-urea breath test in the groups of patients studied. A total of 248 patients with gastric diseases were examined. There were 38 patients with gastric ulcer, 41 with duodenal ulcer, 43 with gastroduodenitis erosiva, 26 with hiatus hernia, 36 with gastric carcinoma and 64 patients with gastritis. There were 103 true positive (TP), 139 true negative (TN), 4 false negative (FN) and 2 false positive (FP) patients. There was no significant difference in the incidence of the HP infection between the groups of patients studied (p>0.05). Sensitivity of the method was 96.3%, specificity 98.6%, positive predictive value 98.1%, negative predictive value 97.2% and accuracy 97.6%. Our results point out that the method is very accurate for the detection of HP infection.

scholarly journals Assessment of Health Monitoring Trustworthiness of Avionics Systems

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Vladimir Ulansky ◽  
Igor Machalin ◽  
Iryna Terentyeva
Keyword(s):  
Health Monitoring ◽  
False Positive ◽  
False Negative ◽  
Measuring Channel ◽  
True Positive ◽  
Very High Frequency ◽  
True Negative ◽  
Automated Test Equipment ◽  
Intermittent Faults ◽  
Reliability Characteristics

The article provides a methodology for assessing the trustworthiness of health monitoring the dismounted avionics systems with automated test equipment (ATE). The indicators include the probabilities of false-positive, false-negative, true-positive, and true-negative. For the first time, we introduced into consideration the instability of the source of stimulus signal (SSS), the random and systematic component of the measuring channel error, and the reliability characteristics of the systems themselves. We consider a specific case of an exponential distribution of permanent failures and intermittent faults and derive formulas for calculating the trustworthiness indicators. Numerical calculations illustrate how the probabilities of correct and incorrect decisions depend on accuracy parameters. We show that the probabilities of false-positive and false-negative increase much faster than the probabilities of true-positive and true-negative decrease when the standard deviation of stimulus signal increases. For a Very High-Frequency Omni-Directional Range (VOR) receiver, we demonstrate that even with a zero random error generated by the source of the stimulus signal, the probabilities of false-positive and false-negative are different from zero.

Prognostic value of FDG-PET in Hodgkin lymphoma for posttreatment evaluation. Long-term follow-up results

2009 ◽  
Vol 150 (47) ◽  
pp. 2133-2138
Author(s):  
Zsuzsa Molnár ◽  
Zsófia Simon ◽  
Zita Borbényi ◽  
Beáta Deák ◽  
LászLÓ Galuska ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Predictive Value ◽  
False Positive ◽  
Fdg Pet ◽  
Clinical Stage ◽  
False Negative ◽  
True Negative ◽  
Significant Difference ◽  
The Difference

In the past few decades Hodgkin lymphoma (HL) has become a highly curable malignant disease, as a result of using modern polychemotherapy and irradiation. Differentiation of active tumor from fibrosis or necrosis within residual radiographic masses represents a problem of interpretation. Aims: The aim of this retrospective study is to assess the value of FDG-PET for prediction of remission or relapse in HL. Patients and methods: Data of 128 patients, who had residual masses on CT after completion of their planned treatment, have been analyzed. FDG-PET was performed between January 1995 and February 2005. Results: The median duration of the follow-up from PET was 75.5 months (range: 20–180 months). 89 (70%) patients had negative and 39 (30%) patients had positive FDG-PET results. The numbers of true-positive, true-negative, false-positive and false-negative subjects were 29, 83, 10 and 6, respectively. Sensitivity of post-treatment FDG-PET was 83%, specificity 93%, positive predictive value 74%, negative predictive value 93%, and accuracy 88%. The difference between the event free survival of PET positive and negative cases is highly significant (p = 0.0000), according to the Mantel-Cox test. Conclusion: Our results, in accordance with literature, clearly indicate that patients with negative FDG-PET results are unlikely to progress or relapse during a long follow-up. However, false positive uptake is a problem. We have investigated the effect of age, histological subtype, clinical stage and the type of treatment on the accuracy, but on the basis of these facts we could not find any significant difference. However, the date of the investigation influenced the results: before 2000 the number of false results was significantly higher than after that time, which shows the importance of investigators’ experience.

Clinical significance of prenatal diagnosis of macrosomia by ultrasound

2014 ◽  
Vol 63 (3) ◽  
pp. 12-20
Author(s):  
Irina Yuryevna Bayeva
Keyword(s):  
Birth Weight ◽  
Prenatal Diagnosis ◽  
False Positive ◽  
False Negative ◽  
Fetal Weight ◽  
True Positive ◽  
Perinatal Complications ◽  
True Negative ◽  
Average Accuracy ◽  
Study Population

Оbjective: Establish the diagnostic value of ultrasound examination in prenatal diagnosis of macrosomia among the women without diabetes and to determine its effect on birth outcomes. Мethods: This is a retrospective cohort study done at the Orenburg municipal perinatal center and maternity hospital № 2 since 2006 to 2012. In this study 3760 pregnant women were analyzed who delivered term, singleton, live born infants. The estimated fetal sonographic weight by the formula Hadlock’s was obtained within the last week prior to delivery. The study population was divided into 4 groups (true positive, true negative, false positive, false negative) according to the estimated fetal weight (EFW) and regarding the birth weight (BW). Receiver-operating characteristics (ROC) curves were generated to compare the prediction of macrosomia when using different observation methods. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were calculated. The mean value of two groups were compared using two sample t test and χ² test for comparison of proportions. Results: In order to assess the accuracy of the ultrasound in prenatal diagnosis of macrosomia the study population was divided into 4 groups according to the estimated fetal weight (EFW) and regarding the birth weight (BW): true positive (n-147), false negative (n-229 ), false positive (n-353), true negative (n-3031). Results of the study showed no statistically significant differences between the birth weight and estimated fetal weifht by ultrasound alone only in the macrosomia group with true-positive results (p = 0.9). In applying the ROC (Receiver Operating Characteristic curve) performance analysis sensitivity and spesificity in the prediction of the macrosomia by ultrasound revealed the average predictive power of the method. Area under the curve (Area under ROC curve, AUC) made 0.7295 (95 % CI: 0.695-0.781), which corresponds to a predetermined average accuracy. The accuracy of macrosomia prediction by ultrasound methods was 90 %, sensitivity - 35 %, specificity - 93,5 %. Сesarian sections were performed for 40 % of the pregnant women, where fetal macrosomia was truly ruled in (true positive) and 16% of the women who delivered normal weight infants (true negative). Overestimation of fetal weight (false positive) has led to the 30 % rate of cesarean sections. Underestimation of fetal weight (false negative) has decreased to the 24% rate of cesarean sections but in this case perinatal complications have increased. Conclusion: Results showed an average accuracy in predicting macrosomia by the formula Hadlock’s. The results of the study have proved that the inappropriate prediction macrosomia of fetal weight has influence on the mode of delivery. Overestimation of fetal weight has led the proportion of cesarian sections. Underestimation of fetal macrosomia has increased perinatal complications.

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