scholarly journals Cyclic Voltammetric Study of the Interaction of Biologically Important Metal Ion with Proton Pump Inhibitors

2016 ◽  
Vol 64 (1) ◽  
pp. 25-30
Author(s):  
Milton C Das ◽  
Rajib Biswas ◽  
Humaiara Akter ◽  
MA Haque ◽  
PK Bakshi ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Metal Ion ◽  
Acetate Buffer Solution ◽  
Molar Ratio ◽  
Cathodic Peak ◽  
Buffer Solution ◽  
Cyclic Voltammetric ◽  
Cyclic Voltammetric Study ◽  
Voltammetric Study

Electrochemical studies on the interaction of Fe(III) with proton pump inhibitors (PPIs) (omeprazole, pantoprazole, esomeprazole and rabeprazole) in acetate buffer solution were carried out at gassy carbon electrode (GCE) at various pH (3.5, 4.0 and 4.5). In presence of omeprazole (Ome), the anodic and cathodic peak current for Fe(III) decreased in comparison to solely Fe(III). However, in some cases both the peaks were almost disappeared. Moreover, anodic and cathodic peaks shifted significantly towards negative potential. This is an indication that a strong interaction occurred between Fe(III) and Ome. The maximum interaction is found at 1:2 molar ratio of Fe(III) and Ome at above mentioned pH. The electrochemical interaction of Fe(III) and other PPIs was found as identical with the behavior of Ome. The electrochemical study of the interactions between metal ions and PPIs would provide important information for the technological application of PPIs in human body.Dhaka Univ. J. Sci. 64(1): 25-30, 2016 (January)

scholarly journals Voltammetric study of the interaction of Cu(II) with proton pump inhibitor at different pH

2015 ◽  
Vol 50 (3) ◽  
pp. 219-226
Author(s):  
R Biswas ◽  
MC Das ◽  
S Islam ◽  
MA Haque ◽  
AA Shaikh
Keyword(s):  
Proton Pump ◽  
Metal Ion ◽  
Acetate Buffer Solution ◽  
Molar Ratio ◽  
Cyclic Voltammograms ◽  
Buffer Solution ◽  
Cyclic Voltammetric ◽  
Voltammetric Study ◽  
Electrochemical Redox ◽  
Insight Into

The electrochemical redox behavior of transition metal ion, Cu(II) at different pH in acetate buffer solution has been investigated using cyclic voltammetric method at glassy carbon electrode (GCE). Cyclic voltammograms of Cu(II) show two cathodic and an anodic peaks those remain identical at various pH. The cyclic voltammetric response of the metal ion has been observed in presence of proton pump inhibitors (PPIs) such as omeprazole, pantoprazole, esomeprazole and rabeprazole at various proportions of metal ion and PPIs. The nature of cyclic voltammograms of Cu(II) has been changed dramatically in presence of the PPIs due to the strong interaction between metal ion and PPIs. Almost similar interaction was noticed for all the PPIs. However, the maximum interaction was found at 1:2 molar ratio of Cu(II) and PPIs. The result could provide deep insight into the interaction between various metal ions and the PPIs that have been taken quite regularly in human bodyBangladesh J. Sci. Ind. Res. 50(3), 219-226, 2015

scholarly journals Interaction of Manganese(II) with Proton Pump Inhibitor at Different pH: A Cyclic Voltammetric Study

2016 ◽  
Vol 64 (2) ◽  
pp. 115-120
Author(s):  
R Biswas ◽  
S Islam ◽  
MS Rahman ◽  
MA Haque ◽  
M Abu Hasan ◽  
...  
Keyword(s):  
Proton Pump ◽  
Suitable Condition ◽  
Acetate Buffer ◽  
Acetate Buffer Solution ◽  
Molar Ratio ◽  
Cyclic Voltammograms ◽  
Buffer Solution ◽  
Cyclic Voltammetric ◽  
Cyclic Voltammetric Study ◽  
Insight Into

The electrochemistry of Mn2+ at different pH (3.5-4.5) in acetate buffer solution has been investigated, using cyclic voltammetric method at glassy carbon electrode (GCE). Cyclic voltammograms (CVs) of Mn2+ show two cathodic and an anodic peaks over the entire investigated pH. The CVs of Mn2+ has also been performed in presence of proton pump inhibitors (PPIs) such as omeprazole, pantoprazole, esomeprazole and rabeprazole to elucidate the interaction of Mn2+ with the PPIs in acetate buffer solution. At the studied pH, a reasonably strong interaction was observed between Mn2+ and PPIs at different molar ratio of Mn2+ ion and PPIs. However, maximum interaction has been found at 1:2 molar ratio of Mn2+ and PPIs. This indicates the most suitable condition for the interaction between Mn2+ and PPIs. These results could allow insight into the interactions of metal ions with the PPIs. Dhaka Univ. J. Sci. 64(2): 115-120, 2016 (July)

scholarly journals Interaction of Cu(II) with Cytosine in Britton-Robinson Buffer Solution - A Cyclic Voltammetric Study

2015 ◽  
Vol 63 (1) ◽  
pp. 31-36
Author(s):  
AA Shaikh ◽  
Jannatul Firdaws ◽  
S Islam ◽  
PK Bakshi
Keyword(s):  
Cyclic Voltammetry ◽  
Suitable Condition ◽  
Anodic Peak ◽  
Molar Ratio ◽  
Cathodic Peak ◽  
Buffer Solution ◽  
Cyclic Voltammetric ◽  
Cyclic Voltammetric Study ◽  
Voltammetric Study ◽  
Electrochemical Redox

Electrochemical redox behavior of Cu(II) at different pH in Britton-Robinson (BR) buffer solution has been investigated using cyclic voltammetry at glassy carbon electrode (GCE). Cu(II) shows a cathodic peak and a hump-like peak, and an intense anodic peak at pH, 0.59, 1.59, 3.01 and 4.08. Although at lower pH (0.59 and 1.59) a cathodic peak, a hump and an anodic peak are observed, at higher pH (3.01 and 4.08) the hump-like cathodic peak disappeared. Cyclic voltammetry has also been used to observe the interaction of Cu(II) with cytosine in BR buffer solution at various pH. A reasonably strong interaction between Cu(II) and cytosine at different Cu(II)/cytosine molar ratio is observed at all the studied pH. However, maximum interaction occurs at 1:4 molar ratio at pH 4.08, this is perhaps the most suitable condition for Cu(II)-cytosine interaction. DOI: http://dx.doi.org/10.3329/dujs.v63i1.21765 Dhaka Univ. J. Sci. 63(1): 31-36, 2015 (January)

scholarly journals Preparation and characterization of iron(iii) complex of saccharin

2014 ◽  
Vol 37 (2) ◽  
pp. 195-203 ◽  
Author(s):  
Taj Al Tanvir ◽  
Md Elius Hossain ◽  
Mohammad Al Mamun ◽  
MQ Ehsan
Keyword(s):  
Metal Ion ◽  
Complex Molecule ◽  
Cyclic Voltammetric ◽  
Electron Transfer Process ◽  
Cyclic Voltammetric Study ◽  
Voltammetric Study ◽  
Reversible Electron Transfer ◽  
Crystalline Water ◽  
Academy Of Sciences

Complex of iron(III) with saccharin, [Fe(C7H4O3SN)2Cl] has been prepared in aqueous medium. The IR and electronic spectral analysis suggest that two saccharin molecules are attached to the metal ion through N atom and there is no chemically coordinated or crystalline water in the complex molecule. The magnetic moment value indicates the paramagnetic character of the complex. The cyclic voltammetric study indicates a quasi-reversible electron transfer process due to the presence of iron in the compound. DOI: http://dx.doi.org/10.3329/jbas.v37i2.17560 Journal of Bangladesh Academy of Sciences, Vol. 37, No. 2, 195-203, 2013

Study on the Inclusion Behavior of Cucurbit [n] uril with Phenylalanine

2011 ◽  
Vol 197-198 ◽  
pp. 1153-1156
Author(s):  
Ning Chen ◽  
Ya Bin Li
Keyword(s):  
1H Nmr ◽  
Interaction Mechanism ◽  
Acetate Buffer Solution ◽  
Molar Ratio ◽  
High Concentration ◽  
Buffer Solution ◽  
Visible Absorption ◽  
Nmr Spectrum ◽  
Application Range ◽  
Uv Visible

The characteristics of host-guest complexes between cucurbit[n]uril (CB [n]) and phenylalanine were investigated by UV-visible absorption spectroscopy in acetate buffer solution at room temperature. It was found that the UV-visible absorption increased steadily with constantly dropping the high concentration of cucurbit[6]uril (CB [6]) and cucurbit[8]uril (CB [8]) in the phenylalanine solution which indicates that there are some interaction betweenCB [n] and phenylalanine.Then CB [6] and phenylalanine at molar ratio of 1:1 to weigh while CB [8] and phenylalanine at molar ratio of 1:2, respectively, are both demonstrated by 1H NMR spectra. 1H NMR spectrum of complexes was obtained, indicating an enthalpic driving force for host-guest complexes. The possible interaction mechanism and inclusion mode were also discussed. This work may extend the application range of CB [n] in supramolecular and pharmaceutical analysis.

The use of photogenerated iodine in determination of the dibazol content in solid and liquid dosage formulations

2021 ◽  
Vol 87 (2) ◽  
pp. 19-24
Author(s):  
E. V. Turusova
Keyword(s):  
Generation Time ◽  
Quantitative Estimation ◽  
Potato Starch ◽  
Analytical Signal ◽  
Acetate Buffer Solution ◽  
Molar Ratio ◽  
Buffer Solution ◽  
Solution Ph ◽  
Solid Dosage

A rapid method for the determination of Dibazol (bendazol hydrochloride) in liquid and solid dosage forms (DF) has been developed. The method is based on converting the drug into an analytical form and titrating the physiologically active compound (PAC) with a solution of photogenerated iodine obtained by irradiation of an auxiliary solution containing potassium iodide, a mixture of sensitizers (sodium eosinate: fluorescein: auramine, taken in a molar ratio of 1:1:1) and an acetate buffer solution (pH 5.6). A decrease in the titrant content in the cell due to interaction with Dibazol was recorded by a decrease in the current in the amperometric circuit. Stabilization of the current in the circuit indicated the completeness of the reaction, thus providing for estimation of the PAC content in a DF. Further irradiation of the solution and measurement of the generation time required to replenish the titrant loss in the cell also ensure the quantitative estimation of the PAC content in the preparation. The method has been tested on solid dosage form and sterile solutions of Dibazol intended for intramuscular and intravenous administration. A slight effect of stabilizers (hydrochloric acid, ethanol) and auxiliary substances (potato starch) present in the DF on the photogeneration of the titrant was observed. The determined Dibazol content in solid and liquid DF falls within the range recommended by the order of the Ministry of Health of the Russian Federation (26.10.2015 No. 751n) and OFS.1.4.2.0009.15, which indicates that the quality of the drug meets the GMP standards. The linear dependence of the analytical signal on the Dibazol concentration is observed in the range of 13.5 – 134.7 mg for the drug «Dibazol-UBF, tablets, 20 mg». The calculated limits of Dibazol detection and quantitative determination by changes in the current strength and generation time are (4.71; 3.56) and (14.26; 10.77) mg, respectively. The use of developed technique in the analysis of drugs containing Dibazol reduces both the time of single determination due to the absence of the need for standardization of solutions, and the cost of a single analysis, since it does not require the use of expensive equipment and reagents.

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