scholarly journals Primary Fallopian Tube Carcinoma (PFTC), A Rare Malignancy of Female Genital Tract

2019 ◽  
Vol 38 (1) ◽  
pp. 49-52
Author(s):  
Farhana Binte Rashid ◽  
Mohammad Abul Kalam Azad
Keyword(s):  
Fallopian Tube ◽  
Genital Tract ◽  
Frozen Section ◽  
Correct Diagnosis ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Ultrasound Finding ◽  
Fallopian Tube Carcinoma ◽  
Primary Fallopian Tube Carcinoma ◽  
Female Genital

Background: Primary fallopian tube carcinoma (PFTC) is one of the rarest malignancies of female genital tract. It represents <1% of all gynecologic malignancies. Preoperative diagnosis is uncommon due to its rarity and non-specific symptoms. In most cases diagnosis is made during surgery or histological examination. Rarity of this type of carcinoma prompted us to report it as individual case. Case: A 40-yearold parous women presented with bilateral PFTC. The patient gave a history of lower abdominal and pelvic pain for 2 years on several occasions. An abdominal ultrasound finding showed an adnexal mass and her CA125 level was 30IU/ml (normal- <35IU/ml). Clinically she was suspected as a case of pelvic inflammatory disease (PID). She underwent Total Abdominal Hysterectomy with bilateral salpingoophorectomy. Intraoperative findings were consistent with PID. Final pathologic analysis showed bilateral primary fallopian tube carcinoma —well differentiated serous adenocarcinoma. Post operatively she was referred for oncological management. Conclusion: Malignancy should be considered in the differential diagnosis of PID especially in premenopausal age and intraoperative frozen section biopsy is crucial to make correct diagnosis and to allow appropriate surgical staging. J Bangladesh Coll Phys Surg 2020; 38(1): 49-52

scholarly journals Primary fallopian tube carcinoma

2009 ◽  
Vol 62 (1-2) ◽  
pp. 31-36 ◽  
Author(s):  
Ljiljana Mladenovic-Segedi
Keyword(s):  
Ovarian Carcinoma ◽  
Fallopian Tube ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Cystic Mass ◽  
Common Finding ◽  
Ca 125 ◽  
Fallopian Tube Carcinoma ◽  
Brca1 And Brca2 ◽  
Primary Fallopian Tube Carcinoma

Introduction. Primary fallopian tube carcinoma is extremely rare, making 0.3-1.6% of all female genital tract malignancies. Although the etymology of this tumor is unknown, it is suggested to be associated with chronic tubal inflammation, infertility, tuberculous salpingitis and tubal endometriosis. High parity is considered to be protective. Cytogenetic studies show the disease to be associated with over expression of p53, HER2/neu and c-myb. There is also some evidence that BRCA1 and BRCA2 mutations have a role in umorogeneis. Clinical features. The most prevailing symptoms with fallopian tube carcinoma are abdominal pain, abnormal vaginal discharge/bleeding and the most common finding is an adnexal mass. In many patients, fallopian tube carcinoma is asymptomatic. Diagnosis. Due to its rarity, preoperative diagnosis of primary fallopian tube carcinoma is rarely made. It is usually misdiagnosed as ovarian carcinoma, tuboovarian abscess or ectopic pregnancy. Sonographic features of the tumor are non-specific and include the presence of a fluid-filled adnexal structure with a significant solid component, a sausage-shaped mass, a cystic mass with papillary projections within, a cystic mass with cog wheel appearance and an ovoid-shaped structure containing an incomplete separation and a highly vascular solid nodule. More than 80% of patients have elevated pretreatment serum CA-125 levels, which is useful in follow-up after the definite treatment. Treatment. The treatment approach is similar to that of ovarian carcinoma, and includes total abdominal hysterectomy and bilateral salpingo-oophorectomy. Staging is followed with chemotherapy.

scholarly journals A rare presentation of a pyosalpinx in a post-menopausal woman

2018 ◽  
Vol 7 (8) ◽  
pp. 3381
Author(s):  
Ashwin Rao ◽  
Reddi Rani ◽  
Setu Rathod
Keyword(s):  
Fallopian Tube ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Menopausal Woman ◽  
Fallopian Tube Carcinoma ◽  
Rare Presentation ◽  
Rare Tumour ◽  
Primary Fallopian Tube Carcinoma ◽  
Loss Of Appetite

Primary fallopian tube carcinoma is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, which is generally an intra-operative or a histological diagnosis.  It is a tumour that resembles epithelial ovarian cancer. A 61-year-old postmenopausal woman presented with complaints of continuous bleeding per vaginum with history of loss of appetite and weight for 6 months. She was also a known diabetic and hypertensive. On examination, per abdominal, per speculum and per vaginal findings were unremarkable.  A transvaginal ultrasonography done previously showed fluid in the endometrial cavity suggestive of hematometra/pyometra due to cervical stenosis. A fractional curettage done previously had shown strips of acanthotic squamous epithelium in the endocervical curetting.   She underwent abdominal hysterectomy with bilateral salpingo ovariectomy. Histopathological findings were suggestive of primary fallopian tube adenocarcinoma. Hence the patient was advised chemotherapy followed by a second look laparotomy. Preoperative diagnosis of fallopian tube carcinoma is difficult due to the silent course of this neoplasm and is usually first appreciated at the time of operation or by a pathologist. The treatment approach is similar to that of ovarian carcinoma, and it should consist of a total abdominal hysterectomy with bilateral salpingo-ovariectomy, omentectomy and lymph node dissection from the pelvic and the para-aortic regions.

XXXVII.—Mendelian Action on Differentiated Sex

1909 ◽  
Vol 29 ◽  
pp. 607-618
Author(s):  
D. Berry Hart
Keyword(s):  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Definite Form ◽  
Human Male ◽  
Prostatic Utricle ◽  
Opposite Sex ◽  
Vaginal Tract ◽  
Appendix Testis ◽  
Female Genital

(Abstract)It has long been known that the male and the female human genital tract contain not only organs characteristic of their sex proper, but also certain parts of the opposite sex in a less developed but yet perfectly definite form. Thus the female genital tract is made up of, not only its characteristic organs, the ovaries, tubes, uterus, etc., but also the epoophoron (parovarium) and its duct, the equivalent of the epididymis and ductus epididymis of the testis. In the same way, the human male has his characteristic sexual organs and also the appendix testis and prostatic utricle, the representatives of the fimbriated end of the Fallopian tube and of the lower end of the vaginal tract (hymen mainly, but varying).

scholarly journals Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract

2011 ◽  
Vol 64 (12) ◽  
pp. 1058-1063 ◽  
Author(s):  
Tsutomu Miyamoto ◽  
Keiko Ishii ◽  
Ryouichi Asaka ◽  
Akihisa Suzuki ◽  
Akiko Takatsu ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Urinary Tract ◽  
Gastrointestinal Tract ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Diagnostic Marker ◽  
Female Genital Tract ◽  
Keratan Sulfate ◽  
Digestive Organs ◽  
Female Genital

AimsThe authors previously reported the expression of keratan sulfate (KS), a glycosaminoglycan, in the epithelium of normal and neoplastic endometria. The aim of this study was to evaluate its potential use as a diagnostic marker, and the expression of KS was investigated in other human epithelial tissues.MethodsExpression was examined immunohistochemically using 102 samples of normal epithelia and 110 samples of carcinomas from the female genital tract (FGT; cervix, endometrium, ovary, fallopian tube), digestive organs (gastrointestinal tract, pancreas, liver), urinary tract, lung, mammary gland, thyroid and mesothelium.ResultsIn normal tissues, KS was consistently detected in the FGT and ectopic endometrium (25/26), but was not found in the digestive organs (1/42) and urinary tract (0/6), and was only partly detected in the lung (7/10), mammary gland (3/9) and thyroid (4/4). In malignant tissues, KS was consistently observed in carcinomas of the endometrium, ovary and fallopian tube (29/32), and was partly detected in carcinomas of the lung, mammary gland, thyroid, pancreas and mesothelium, but was absent in carcinomas of the gastrointestinal tract (0/17), liver (0/5) and urinary tract (0/11). Among carcinomas of the FGT, digestive organs and urinary tract, KS positivity suggested the possibility of FGT carcinomas, with 79.5% (31/39) sensitivity and 92.9% (39/42) specificity.ConclusionsKS is a potentially useful marker for the supportive diagnosis of the primary site of metastatic carcinomas or unknown primary carcinomas, especially in the abdominal cavity.

scholarly journals Primary Fallopian Tube Carcinoma: A Case Report and Literature Review

2017 ◽  
Vol 5 (3) ◽  
pp. 344-348 ◽  
Author(s):  
Meral Rexhepi ◽  
Elizabeta Trajkovska ◽  
Hysni Ismaili ◽  
Florin Besimi ◽  
Nagip Rufati
Keyword(s):  
Fallopian Tube ◽  
Female Genital Tract ◽  
Lower Abdominal Pain ◽  
Ca 125 ◽  
Histopathological Diagnosis ◽  
Fallopian Tube Carcinoma ◽  
Rare Tumour ◽  
Initial Surgery ◽  
Primary Fallopian Tube Carcinoma ◽  
The Right

BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, and it is very difficult to diagnose preoperatively, because of its non-specific symptomatology. In most cases, it is an intraoperative finding or a histopathological diagnosis. It is a tumour that histologically and clinically resembles epithelial ovarian cancer.CASE PRESENTATION: We are reporting a case of a 62-year-old, postmenopausal women with primary fallopian tube carcinoma of the right fallopian tube in stage IA. The patient has lower abdominal pain, watery vaginal discharge and repeated episodes of bleeding from the vagina. The clinical and radiological findings suggested a right adnexal tumour with elevated CA-125 levels. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy and peritoneal washing were performed. Pathologic confirmation of primary serous cystadenocarcinoma of the right fallopian tube was made. Peritoneal washings were negative for malignancy. FIGO stage was considered as IA, and the patient received no courses of chemotherapy and postoperative radiation because she refused it. Ten months after initial surgery, the patient is alive and in good condition.CONCLUSION: Cytoreduction surgery followed by adequate cycles of chemotherapy is an important strategy to improve patients’ prognosis.

scholarly journals Congenital absence of a part of the fallopian tube: a case report

2016 ◽  
Vol 6 (1) ◽  
pp. 320
Author(s):  
Mukta Agarwal ◽  
Hemali H. Sinha ◽  
. Anamika
Keyword(s):  
Case Report ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Rare Case ◽  
Case Reports ◽  
Female Genital Tract ◽  
Fallopian Tubes ◽  
Rare Occurrence ◽  
Rare Case Report ◽  
Female Genital

Congenital malformations of female genital tract are frequently seen in Gynaecological clinics, incidence being upto 5-6% in cases of infertility. Most of these anomalies are related to uterus and vagina, abnormalities related to ovaries and fallopian tubes are of rare occurrence and the exact incidence of these anomalies are not known, only a few incidental case reports are available in literature. Here, we present a rare case report of absent mid- tubal segment of fallopian tube in a patient of infertility.

Uterine serous papillary carcinoma: Histopathologic changes within the female genital tract

2001 ◽  
Vol 11 (4) ◽  
pp. 283-289 ◽  
Author(s):  
L. B. Jordan ◽  
M. Abdul-Kader ◽  
A. Al-Nafussi
Keyword(s):  
Papillary Carcinoma ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
Tumor Spread ◽  
Histopathologic Changes ◽  
Serous Papillary Carcinoma ◽  
Female Genital

Abstract.Jordan LB, Abdul-Kader M, Al-Nafussi A. Uterine serous papillary carcinoma: Histopathologic changes within the female genital tract.The histopathologic features of 25 patients with uterine serous papillary carcinoma (USPC) were presented, with particular emphasis on the changes seen in the remaining müllerian epithelium. The mean age at presentation was 68.9 years; 52% of patients were stage III at the time of presentation and 40% died of their disease within 24 months of diagnosis. Histologic assessment revealed: 1) pure serous carcinoma in 56% of patients and mixed differentiation of serous and endometrioid in the remainder; 2) malignant epithelium reminiscent of that of USPC and akin to carcinoma in situ, frequently seen in the remaining endometrium, cervix, and, less commonly, the fallopian tube; 3) residual endometrium that, when identified (11/25 cases), was atrophic in all cases; 4) various types of cervical involvement in 17 cases (68%) ; 5) tumor within the fallopian tube in three cases (12%); and 6) carcinoma with in situ-like features in five cases (20%). In conclusion, it appears that USPC is frequently associated with malignant epithelial changes (as with carcinoma in situ) in the remaining müllerian epithelium. This finding suggests either a field change or, more likely, a transepithelial tumor spread. The latter theory is preferable, because this type of spread is frequently seen on serosal surfaces in cases of serous ovarian carcinoma. Uterine serous papillary carcinoma is, therefore, biologically more akin to its ovarian counterpart.

Pituitary adenylate cyclase-activating polypeptide: occurrence and relaxant effect in female genital tract

1995 ◽  
Vol 269 (1) ◽  
pp. E108-E117 ◽  
Author(s):  
B. R. Steenstrup ◽  
P. Alm ◽  
J. Hannibal ◽  
J. C. Jorgensen ◽  
C. Palle ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Adenylate Cyclase ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Nerve Fibers ◽  
Female Reproductive Tract ◽  
Human Female ◽  
Pituitary Adenylate Cyclase ◽  
Female Genital

The distribution, localization, and smooth muscle effects of pituitary adenylate cyclase-activating polypeptide (PACAP) were studied in the human female genital tract. The concentrations of PACAP-38 and PACAP-27 were measured by radioimmunoassays, and both peptides were found throughout the genital tract. The highest concentrations of PACAP-38 were detected in the ovary, the upper part of vagina, and the perineum. The concentrations of PACAP-27 were generally low, in some regions below the detection limit and in other regions 1 to 5% of the PACAP-38 concentrations. Immunocytochemistry revealed that PACAP was located in delicate varicose nerve fibers that were most abundant in the internal cervical os, where they mainly seemed to innervate blood vessels and smooth muscle cells. PACAP-38 and PACAP-27 (10(-10)-10(-6) M) caused a concentration-dependent relaxation of the spontaneous activity of the nonvascular smooth muscle strips from fallopian tube and myometrium in vitro. Likewise, both peptides (10(-10)-10(-6) M) caused relaxation of nonrepinephrine (10(-6) M)-precontracted intramyometrial arteries. No effect of the PACAP sequences, PACAP-(6-27), PACAP-(16-38), and PACAP-(18-27), on fallopian tube was observed. The findings suggest a smooth muscle regulatory role of PACAP in the human female reproductive tract.

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