scholarly journals Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract

2011 ◽  
Vol 64 (12) ◽  
pp. 1058-1063 ◽  
Author(s):  
Tsutomu Miyamoto ◽  
Keiko Ishii ◽  
Ryouichi Asaka ◽  
Akihisa Suzuki ◽  
Akiko Takatsu ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Urinary Tract ◽  
Gastrointestinal Tract ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Diagnostic Marker ◽  
Female Genital Tract ◽  
Keratan Sulfate ◽  
Digestive Organs ◽  
Female Genital

AimsThe authors previously reported the expression of keratan sulfate (KS), a glycosaminoglycan, in the epithelium of normal and neoplastic endometria. The aim of this study was to evaluate its potential use as a diagnostic marker, and the expression of KS was investigated in other human epithelial tissues.MethodsExpression was examined immunohistochemically using 102 samples of normal epithelia and 110 samples of carcinomas from the female genital tract (FGT; cervix, endometrium, ovary, fallopian tube), digestive organs (gastrointestinal tract, pancreas, liver), urinary tract, lung, mammary gland, thyroid and mesothelium.ResultsIn normal tissues, KS was consistently detected in the FGT and ectopic endometrium (25/26), but was not found in the digestive organs (1/42) and urinary tract (0/6), and was only partly detected in the lung (7/10), mammary gland (3/9) and thyroid (4/4). In malignant tissues, KS was consistently observed in carcinomas of the endometrium, ovary and fallopian tube (29/32), and was partly detected in carcinomas of the lung, mammary gland, thyroid, pancreas and mesothelium, but was absent in carcinomas of the gastrointestinal tract (0/17), liver (0/5) and urinary tract (0/11). Among carcinomas of the FGT, digestive organs and urinary tract, KS positivity suggested the possibility of FGT carcinomas, with 79.5% (31/39) sensitivity and 92.9% (39/42) specificity.ConclusionsKS is a potentially useful marker for the supportive diagnosis of the primary site of metastatic carcinomas or unknown primary carcinomas, especially in the abdominal cavity.

XXXVII.—Mendelian Action on Differentiated Sex

1909 ◽  
Vol 29 ◽  
pp. 607-618
Author(s):  
D. Berry Hart
Keyword(s):  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Definite Form ◽  
Human Male ◽  
Prostatic Utricle ◽  
Opposite Sex ◽  
Vaginal Tract ◽  
Appendix Testis ◽  
Female Genital

(Abstract)It has long been known that the male and the female human genital tract contain not only organs characteristic of their sex proper, but also certain parts of the opposite sex in a less developed but yet perfectly definite form. Thus the female genital tract is made up of, not only its characteristic organs, the ovaries, tubes, uterus, etc., but also the epoophoron (parovarium) and its duct, the equivalent of the epididymis and ductus epididymis of the testis. In the same way, the human male has his characteristic sexual organs and also the appendix testis and prostatic utricle, the representatives of the fimbriated end of the Fallopian tube and of the lower end of the vaginal tract (hymen mainly, but varying).

scholarly journals Primary Fallopian Tube Carcinoma (PFTC), A Rare Malignancy of Female Genital Tract

2019 ◽  
Vol 38 (1) ◽  
pp. 49-52
Author(s):  
Farhana Binte Rashid ◽  
Mohammad Abul Kalam Azad
Keyword(s):  
Fallopian Tube ◽  
Genital Tract ◽  
Frozen Section ◽  
Correct Diagnosis ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Ultrasound Finding ◽  
Fallopian Tube Carcinoma ◽  
Primary Fallopian Tube Carcinoma ◽  
Female Genital

Background: Primary fallopian tube carcinoma (PFTC) is one of the rarest malignancies of female genital tract. It represents <1% of all gynecologic malignancies. Preoperative diagnosis is uncommon due to its rarity and non-specific symptoms. In most cases diagnosis is made during surgery or histological examination. Rarity of this type of carcinoma prompted us to report it as individual case. Case: A 40-yearold parous women presented with bilateral PFTC. The patient gave a history of lower abdominal and pelvic pain for 2 years on several occasions. An abdominal ultrasound finding showed an adnexal mass and her CA125 level was 30IU/ml (normal- <35IU/ml). Clinically she was suspected as a case of pelvic inflammatory disease (PID). She underwent Total Abdominal Hysterectomy with bilateral salpingoophorectomy. Intraoperative findings were consistent with PID. Final pathologic analysis showed bilateral primary fallopian tube carcinoma —well differentiated serous adenocarcinoma. Post operatively she was referred for oncological management. Conclusion: Malignancy should be considered in the differential diagnosis of PID especially in premenopausal age and intraoperative frozen section biopsy is crucial to make correct diagnosis and to allow appropriate surgical staging. J Bangladesh Coll Phys Surg 2020; 38(1): 49-52

Carcinosarcoma of the spleen: literature review of a very rare tumour

Open Medicine ◽  
2007 ◽  
Vol 2 (2) ◽  
pp. 230-235 ◽  
Author(s):  
Annapurna Rao ◽  
George Mathew ◽  
Kalimuthu Marimuthu ◽  
Urmila Pandey ◽  
Jane Worlding
Keyword(s):  
Gastrointestinal Tract ◽  
Connective Tissue ◽  
Literature Review ◽  
Genital Tract ◽  
Unique Feature ◽  
Female Genital Tract ◽  
Rare Tumour ◽  
Rare Tumours ◽  
Clinical Awareness ◽  
Female Genital

AbstractCarcinosarcomas are rare tumours, which have both epithelial, and connective tissue elements. They are most commonly seen in the female genital tract. Rarely they arise from the gastrointestinal tract. We report a case of Carcinosarcoma arising as a primary in the spleen of a male aged 60yrs. The most unique feature of this tumour is the presence of osteosarcomatous element. This report highlights the importance of clinical awareness of such rare tumours and gives a brief overview on presentation, probable aetiology, diagnosis and management with literature review of carcinosarcoma.

scholarly journals Congenital absence of a part of the fallopian tube: a case report

2016 ◽  
Vol 6 (1) ◽  
pp. 320
Author(s):  
Mukta Agarwal ◽  
Hemali H. Sinha ◽  
. Anamika
Keyword(s):  
Case Report ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Rare Case ◽  
Case Reports ◽  
Female Genital Tract ◽  
Fallopian Tubes ◽  
Rare Occurrence ◽  
Rare Case Report ◽  
Female Genital

Congenital malformations of female genital tract are frequently seen in Gynaecological clinics, incidence being upto 5-6% in cases of infertility. Most of these anomalies are related to uterus and vagina, abnormalities related to ovaries and fallopian tubes are of rare occurrence and the exact incidence of these anomalies are not known, only a few incidental case reports are available in literature. Here, we present a rare case report of absent mid- tubal segment of fallopian tube in a patient of infertility.

Uterine serous papillary carcinoma: Histopathologic changes within the female genital tract

2001 ◽  
Vol 11 (4) ◽  
pp. 283-289 ◽  
Author(s):  
L. B. Jordan ◽  
M. Abdul-Kader ◽  
A. Al-Nafussi
Keyword(s):  
Papillary Carcinoma ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
Tumor Spread ◽  
Histopathologic Changes ◽  
Serous Papillary Carcinoma ◽  
Female Genital

Abstract.Jordan LB, Abdul-Kader M, Al-Nafussi A. Uterine serous papillary carcinoma: Histopathologic changes within the female genital tract.The histopathologic features of 25 patients with uterine serous papillary carcinoma (USPC) were presented, with particular emphasis on the changes seen in the remaining müllerian epithelium. The mean age at presentation was 68.9 years; 52% of patients were stage III at the time of presentation and 40% died of their disease within 24 months of diagnosis. Histologic assessment revealed: 1) pure serous carcinoma in 56% of patients and mixed differentiation of serous and endometrioid in the remainder; 2) malignant epithelium reminiscent of that of USPC and akin to carcinoma in situ, frequently seen in the remaining endometrium, cervix, and, less commonly, the fallopian tube; 3) residual endometrium that, when identified (11/25 cases), was atrophic in all cases; 4) various types of cervical involvement in 17 cases (68%) ; 5) tumor within the fallopian tube in three cases (12%); and 6) carcinoma with in situ-like features in five cases (20%). In conclusion, it appears that USPC is frequently associated with malignant epithelial changes (as with carcinoma in situ) in the remaining müllerian epithelium. This finding suggests either a field change or, more likely, a transepithelial tumor spread. The latter theory is preferable, because this type of spread is frequently seen on serosal surfaces in cases of serous ovarian carcinoma. Uterine serous papillary carcinoma is, therefore, biologically more akin to its ovarian counterpart.

Pituitary adenylate cyclase-activating polypeptide: occurrence and relaxant effect in female genital tract

1995 ◽  
Vol 269 (1) ◽  
pp. E108-E117 ◽  
Author(s):  
B. R. Steenstrup ◽  
P. Alm ◽  
J. Hannibal ◽  
J. C. Jorgensen ◽  
C. Palle ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Adenylate Cyclase ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Nerve Fibers ◽  
Female Reproductive Tract ◽  
Human Female ◽  
Pituitary Adenylate Cyclase ◽  
Female Genital

The distribution, localization, and smooth muscle effects of pituitary adenylate cyclase-activating polypeptide (PACAP) were studied in the human female genital tract. The concentrations of PACAP-38 and PACAP-27 were measured by radioimmunoassays, and both peptides were found throughout the genital tract. The highest concentrations of PACAP-38 were detected in the ovary, the upper part of vagina, and the perineum. The concentrations of PACAP-27 were generally low, in some regions below the detection limit and in other regions 1 to 5% of the PACAP-38 concentrations. Immunocytochemistry revealed that PACAP was located in delicate varicose nerve fibers that were most abundant in the internal cervical os, where they mainly seemed to innervate blood vessels and smooth muscle cells. PACAP-38 and PACAP-27 (10(-10)-10(-6) M) caused a concentration-dependent relaxation of the spontaneous activity of the nonvascular smooth muscle strips from fallopian tube and myometrium in vitro. Likewise, both peptides (10(-10)-10(-6) M) caused relaxation of nonrepinephrine (10(-6) M)-precontracted intramyometrial arteries. No effect of the PACAP sequences, PACAP-(6-27), PACAP-(16-38), and PACAP-(18-27), on fallopian tube was observed. The findings suggest a smooth muscle regulatory role of PACAP in the human female reproductive tract.

scholarly journals Ovarian enterobiasis: a case report

2018 ◽  
Vol 6 (3) ◽  
pp. 1055 ◽  
Author(s):  
Geethu G. Nair ◽  
Prejisha Balan
Keyword(s):  
Gastrointestinal Tract ◽  
Cross Section ◽  
Genital Tract ◽  
Histopathological Examination ◽  
Incidental Finding ◽  
Female Genital Tract ◽  
Inflammatory Cells ◽  
Enterobius Vermicularis ◽  
Intestinal Nematode ◽  
Female Genital

Enterobius vermicularis (the pinworm) is the most common intestinal nematode in gastrointestinal tract of humans. It commonly infests the lumen of the intestine but on rare occasions has been found in the wall or in the tissues outside the gastrointestinal tract; female genital tract and peritoneum being the commonest sites. It is usually seen as an incidental finding. This is a case of 29-year-old female presented for elective sterilization. A tiny nodule was noted on the surface of ovary during procedure which was sent for histopathological examination. Lesion was composed of necrotic areas and inflammatory cells with cross section of a degenerated worm. The features of the eggs were diagnostic of Enterobius vermicularis. Multiple histologic sections may be required to establish diagnosis in older lesions as in this case.

scholarly journals A case report of necrotizing fasciitis with growth of Actinomyces europaeus and Actinotignum schaalii

2019 ◽  
Vol 2019 (10) ◽  
Author(s):  
Nicole Joanne Kus ◽  
Bryan Jordan Kim ◽  
Howard M Ross
Keyword(s):  
Case Report ◽  
Urinary Tract ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Decubitus Ulcers ◽  
Necrotizing Soft Tissue Infection ◽  
First Case ◽  
Tract Infections ◽  
Human Flora ◽  
Female Genital

Abstract Actinomyces europeaeus and Actinotignum schaalii are two facultative anaerobes that are common contaminants of human flora; namely the urinary tract, the female genital tract and the gastrointestinal tract. A. europeaeus has been linked with abscesses, decubitus ulcers and purulent urethritis, while A. schaalii has been associated with urinary tract infections, bacteremia and Fournier’s gangrene. Here we present a case report of an 84-year-old female patient found to have a necrotizing soft tissue infection caused by A. europeaeus and A. schaalii. To our knowledge, this is the first case report that documents A. europeaeus as a causal agent of a necrotizing infection.

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