scholarly journals Microwave-assisted Efficient Synthesis of Isatins and spiro-Thiadiazolines under Green Chemistry Protocol

2010 ◽  
Vol 2 (2) ◽  
pp. 322-329 ◽  
Author(s):  
M. M. Hossain ◽  
M. A. Foysal ◽  
M. Mahabub ◽  
Al- Amin
Keyword(s):  
Schiff Base ◽  
Green Chemistry ◽  
Schiff Bases ◽  
Aromatic Amines ◽  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Efficient Synthesis ◽  
Microwave Assisted ◽  
Primary Aromatic Amines ◽  
Mw Irradiation

MW-assisted treatment of oximinoacetanilides obtained from substituted primary aromatic amines was carried out in conc. H2SO4 medium for 5-10 sec to give cyclic amides (isatins) through intramolecular cyclization by means of electrophilic aromatic substitution. Isatins reacted with thiosemicarbazide under MW-condition gave the corresponding Schiff-bases. The Schiff-bases undergo cyclization in presence of minimal Ac2O under MW-irradiation for 3-4 min to give the spiro-thiadiazoline acetyl derivatives in excellent yield. Keywords:  Microwave-synthesis; Isatins; Schiff-base; spiro-Thiadiazoline; Green chemistry. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.  DOI: 10.3329/jsr.v2i2.3731               J. Sci. Res. 2 (2), 322-329 (2010)  

Synthesis, characterization, and reactivity of Pd(II) salicylaldimine complexes derived from aminophenols

2007 ◽  
Vol 85 (5) ◽  
pp. 392-399 ◽  
Author(s):  
Bennett J Tardiff ◽  
Joshua C Smith ◽  
Stephen J Duffy ◽  
Christopher M Vogels ◽  
Andreas Decken ◽  
...  
Keyword(s):  
Schiff Base ◽  
Green Chemistry ◽  
Schiff Bases ◽  
Cross Coupling ◽  
Boronic Acids ◽  
Aryl Bromides

Schiff bases, derived from the condensation of salicylaldehydes with 3- and 4-aminophenol, reacted with palladium(II) acetate to give the corresponding bis(N-arylsalicylaldiminato)palladium(II) complexes. These complexes have been found to be active catalysts for the Suzuki–Miyaura cross-coupling of aryl bromides and iodides with aryl boronic acids, using water as a solvent.Key words: cross-coupling, green chemistry, palladium, salicylaldimines, Schiff base, Suzuki–Miyaura.

scholarly journals Green Chemistry Approach for Efficient Synthesis of Schiff Bases of Isatin Derivatives and Evaluation of Their Antibacterial Activities

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Jnyanaranjan Panda ◽  
V. Jagannath Patro ◽  
Biswa Mohan Sahoo ◽  
Jitendriya Mishra
Keyword(s):  
Green Chemistry ◽  
Schiff Bases ◽  
Reaction Times ◽  
Antibacterial Activities ◽  
Primary Amines ◽  
Microwave Assisted Synthesis ◽  
Azomethine Group ◽  
Microwave Assisted ◽  
Isatin Derivatives

Microwave-assisted organic synthesis, a green chemistry approach, is nowadays widely used in the drug synthesis. Microwave-assisted synthesis improves both throughput and turnaround time for medicinal chemists by offering the benefits of drastically reduced reaction times, increased yields, and pure products. Schiff bases are the important class of organic compounds due to their flexibility, and structural diversities due to the presence of azomethine group which is helpful for elucidating the mechanism of transformation and rasemination reaction in biological system. This novel compound could also act as valuable ligands for the development of new chemical entities. In the present work, some Schiff bases of Isatin derivatives was synthesized using microwave heating method. Schiff base of Isatin were synthesized by condensation of the keto group of Isatin with different aromatic primary amines. They were characterized by means of spectral data and subsequently subjected to the in vitro antibacterial activities against gram positive and gram negative strains of microbes. It was observed that the compound with electron withdrawing substituents exhibited good antibacterial activities against almost all the micro organisms.

scholarly journals Rapid and Efficient Synthesis of [11C]Trifluoromethylarenes from Primary Aromatic Amines and [11C]CuCF3

ACS Omega ◽  
2020 ◽  
Vol 5 (31) ◽  
pp. 19557-19564
Author(s):  
Nicholas J. Young ◽  
Victor W. Pike ◽  
Carlotta Taddei
Keyword(s):  
Aromatic Amines ◽  
Efficient Synthesis ◽  
Primary Aromatic Amines

scholarly journals Exploring chemical diversity via a modular reaction pairing strategy

2012 ◽  
Vol 8 ◽  
pp. 1293-1302 ◽  
Author(s):  
Joanna K Loh ◽  
Sun Young Yoon ◽  
Thiwanka B Samarakoon ◽  
Alan Rolfe ◽  
Patrick Porubsky ◽  
...  
Keyword(s):  
Amino Alcohol ◽  
Building Blocks ◽  
Chemical Diversity ◽  
Nucleophilic Aromatic Substitution ◽  
Mitsunobu Reaction ◽  
Aromatic Substitution ◽  
Efficient Synthesis ◽  
Microwave Assisted ◽  
Computational Analyses ◽  
Pairing Protocol

The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (SNAr) diversification pathway is reported. Eight benzofused sultam cores were generated by means of a sulfonylation/SNAr/Mitsunobu reaction pairing protocol, and subsequently diversified by intermolecular SNAr with ten chiral, non-racemic amine/amino alcohol building blocks. Computational analyses were employed to explore and evaluate the chemical diversity of the library.

3-Amino-2-methylquinazolin-4-(3H)-one Schiff Bases Synthesis – a Green Chemistry Approach – a Comparison of Microwave and Ultrasound Promoted Synthesis with Mechanosynthesis.

2020 ◽  
Vol 07 ◽  
Author(s):  
Mario Komar ◽  
Fran Prašnikar ◽  
Tatjana Gazivoda Kraljević ◽  
Krunoslav Aladić ◽  
Maja Molnar
Keyword(s):  
Mass Spectrometry ◽  
Green Chemistry ◽  
Schiff Bases ◽  
13C Nmr Spectroscopy ◽  
Synthetic Methods ◽  
Reaction Conditions ◽  
1H And 13C Nmr ◽  
Microwave Assisted ◽  
Ultrasound Assisted ◽  
High Yields

: A green chemistry methods are important modern pathways in synthetic chemistry with main advantages such as milder reaction conditions, shorter time and higher yields. A series of quinazolinone based Schiff bases (1−27) have been successfully synthesized by using green synthetic methods including microwave-assisted, ultrasound-assisted and mechanochemical synthesis, respectively. Desired compounds were prepared from 3-amino-2-methylquinazolin-4(3H)- one and substituted benzaldehydes with moderate to high yields (11−90%). Benzoxazinone and 3-amino-2- methylquinazolin-4(3H)-one, the precursors of Schiff bases, were prepared by microwave induced synthesis. The structures of all Schiff bases are confirmed by 1H and 13C NMR spectroscopy and mass spectrometry as well. A novelty of this research is the application and comparison of green chemistry methods in the synthesis of desired compounds are listed above. The simplicity of synthesis includes ethanol as solvent and no need for further purification.

scholarly journals Microwave Assisted Efficient Synthesis of Some Flavones for Antimicrobial and ADMET Studies

2020 ◽  
Vol 12 (4) ◽  
pp. 673-685
Author(s):  
M. A. Rahim ◽  
M. M. H. Bhuiayan ◽  
M. M. Matin
Keyword(s):  
Fungal Pathogens ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Oxidative Cyclization ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Microwave Assisted ◽  
Ft Ir ◽  
Mw Irradiation

Microwave (MW) assisted synthetic technique was applied for the preparation of chalcone derivatives 5-7 employing Claisen-Schmidt condensation between 2-hydroxyacetophenone and aromatic aldehydes. These chalcones were further subjected to oxidative cyclization via MW irradiation and furnished the related flavones 8-10 which were characterized by FT-IR, 1H and 13CNMR spectra. The use of these MW assisted reactions provided higher productivity (92-98%) in shorter reaction time (2-6 min) with eco-friendly mild reaction conditions and hence found to be a convenient method as compared to conventional synthesis. These chalcones 5-7, and flavones 8-10 were screened for in vitro antimicrobial activities against five bacterial and three fungal pathogens. The study indicated that they were more active against fungal pathogens than that of bacterial organisms and comparable to the standard antifungal antibiotic nystatin. Interestingly, the prediction of activity spectra for substances (PASS) was also found in agreement with the in vitro results. Some of the compounds were found to have good ADMET properties.

scholarly journals Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones

2004 ◽  
Vol 1 (5) ◽  
pp. 263-266
Author(s):  
B. D. Naik ◽  
K. R. Desai
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Spectral Analysis ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Thioglycolic Acid ◽  
Efficient Synthesis ◽  
Microwave Assisted

As a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-(coumarin-3-yl)-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. The resulting compound 2-amino-4-(coumarin-3-yl)- thiazole was treated with different Aldehydes to give the intermediate Schiff base, which on further reaction with Thioglycolic acid and Thiolactic acid to give titled compound Thiazolidinone. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activity of the compounds has also been screened againstStaphylococcus aureusandEscherichia coil.

ChemInform Abstract: One-Pot Microwave Assisted Synthesis under Green Chemistry Conditions, Antioxidant Screening, and Cytotoxicity Assessments of Benzimidazole Schiff Bases and Pyrimido[1,2-a]benzimidazol-3(4H)-ones.

ChemInform ◽  
2011 ◽  
Vol 42 (17) ◽  
pp. no-no
Author(s):  
Constantinos G. Neochoritis ◽  
Tryfon Zarganes-Tzitzikas ◽  
Constantinos A. Tsoleridis ◽  
Julia Stephanidou-Stephanatou ◽  
Christos A. Kontogiorgis ◽  
...  
Keyword(s):  
Green Chemistry ◽  
Schiff Bases ◽  
Microwave Assisted Synthesis ◽  
One Pot ◽  
Microwave Assisted
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