Educational program strategy in rising the awareness for adverse drug reactions reporting and improved pharmacovigilance practice in the Republic of North Macedonia

This chapter investigates in a case study the limitations of adverse drug reactions reporting (ADRr) and the challenges facing counterfeit drugs monitoring in the African developing countries with a focus on the Republic of Benin and proposes solutions to improve the adverse drug reporting method and infrastructures as well as the counterfeit drugs monitoring. The study aims at implementing an ADRr system using the m-health technology to overcome the limitations and ease the use of the “yellow card” in the developing world. Furthermore, a real-time notification system is provided to promptly disseminate among the populations any registered and proved ADR.

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Pharmacovigilance and Adverse Drug Reactions (Adrs) Practice of Healthcare Professionals

10.53350/pjmhs2115123473 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3473-3475

Author(s):

Elsadig Yousif Mohamed

Keyword(s):

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Good Practice ◽

Cross Sectional Study ◽

University Hospital ◽

Drug Reactions ◽

Cross Sectional ◽

Pharmacovigilance Center ◽

Spss Software ◽

Pharmacovigilance Practice

Aim: To assess pharmacovigilance and adverse drug reactions practice of healthcare professionals in Ribat University Hospital, Khartoum, Sudan. Methods: This was a cross-sectional study to evaluate pharmacovigilance and ADRs practice among physicians, pharmacist and nurses working in the National Ribat University, Khartoum, Sudan. The sample size was calculated as 100. Data were collected by a pre-tested questionnaire after obtaining ethics approval. Data analysis was performed by SPSS software. Results: The HCPs who acquired good and poor pharmacovigilance practice were 16 (16%) and 84 (84%) respectively. Ninety-eight (98%) of the healthcare professionals have ever experienced ADR in their patients during professional practice. Ninety-four (94%) have ever seen ADR reporting form. Forty (40%) have ever reported ADR to the pharmacovigilance center. Pharmacists, Physicians and nurses with good practice were30.8%, 18.4% and 7.9% respectively. Conclusion: Most healthcare professionals acquire good pharmacovigilance practice. The pharmacist acquires higher level of pharmacovigilance practice followed by physicians and nurses. Healthcare professionals with shorter years of experience have significantly higher pharmacovigilance practice. Keywords: Pharmacovigilance, Adverse Drug Reactions, Healthcare Professionals

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ANALYSIS OF SPONTANEOUS REPORTS OF ADVERSE REACTIONS IN PATIENTS WITH CORONARY ARTERY DISEASE IN THE REPUBLIC OF CRIMEA

Complex Issues of Cardiovascular Diseases ◽

10.17802/2306-1278-2018-7-4-26-32 ◽

2018 ◽

Vol 7 (4) ◽

pp. 26-32

Author(s):

O. V. Matveev ◽

A. E. Krasheninnikov ◽

N. M. Kiseleva ◽

E. A. Egorova ◽

A. G. Dormidor

Keyword(s):

Coronary Artery Disease ◽

Drug Reaction ◽

Coronary Artery ◽

Adverse Drug Reactions ◽

Ace Inhibitors ◽

Adverse Reactions ◽

Drug Reactions ◽

Spontaneous Reports ◽

The Republic ◽

Artery Disease

Aim. To analyze spontaneous reports of adverse drug reactions in patients with coronary artery disease in the Republic of Crimea for the fve-year period from January 2011 to August 2016.Methods. 332 reports of adverse drug reactions in patients with coronary artery disease collected in the “ARCADe” database were analyzed. Out of them, 231 reports on essential drugs affecting the cardiovascular system were selected. The age of patients who reported adverse drug reactions ranged from 37 to 90 years.Results. The rate of adverse drug reaction reports increased with patients’ aging, reaching its maximum (31.6% of all drug reaction reports) by 70–80 years. The incidence of adverse reactions was higher among women (63.6%), which is generally consistent with other studies. However, men receiving nitrates had a 3.4-fold increase in the rate of adverse drug reactions compared to women. The highest rate of adverse drug reactions was associated with ACE inhibitors (29.0%), and in particular Enalapril, which is probably explained by a higher rate of their prescriptions, compared to other drugs.Conclusion. Most of the reported adverse drug reactions were expected. The frequent development of allergic reactions (16% out of all adverse reactions in this study) in patients with coronary artery disease were associated with ACE inhibitors, betablockers and antithrombotic agents.

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