scholarly journals Three-dimensional printing of ramipril tablets by fused deposition modeling

2021 ◽  
Vol 10 (4) ◽  
pp. 79-87
Author(s):  
O. A. Terenteva ◽  
K. A. Gusev ◽  
V. V. Tikhonova ◽  
D. N. Maimistov ◽  
G. A. Shandryuk ◽  
...  
Keyword(s):  
Melting Point ◽  
Arterial Hypertension ◽  
Three Dimensional ◽  
Immediate Release ◽  
Processing Temperature ◽  
Melt Extrusion ◽  
Three Dimensional Printing ◽  
Matrix Polymer ◽  
Fused Deposition ◽  
Dimensional Printing

Introduction. Arterial hypertension is one of the main risk factors for the development of cardiovascular diseases. Drug treatment of arterial hypertension is associated with a number of difficulties: often requires combination therapy, also a possible change in either dosages or drugs during treatment during the patient's life. Three-dimensional printing allows to create individual medicines on-demand.Aim. Study suitability of Kollidon® VA 64 as a matrix-polymer for the preparation of immediate release ramipril printing tablets.Materials and methods. Substance: ramipril; excipients: Kollidon® VA 64, Kollidon® CL-F, Soluplus®, PEG 1500, sodium carbonate anhydrous, Poloxamer 188, sodium stearyl fumarate, mannitol; reagents: hydrochloric acid, acetonitrile for ultra-HPLC, sodium octanesulfonate for HPLC, orthophosphoric acid 85 %, sodium perchlorate analytical grade, triethylamine, standard: ramipril USP (№1598303). Ramipril filaments were prepared by hot melt extrusion on the extruder Haake™ miniCTW (Thermo Fisher Scientific). The tablets were printed on a hand-made 3D printer. The printlets were studied for friability and hardness. Uniformity and quantitative determination of ramipril and impurities in tablets and filaments were determined by high performance liquid chromatography on a Shimadzu Prominence LC liquid chromatograph. Stability of ramipril was studied on a DSC 3+ Mettler Toledo by differential scanning calorimetry. Also, the stability of ramipril was determined by the Raman spectroscopy on an analytical system ORTES-785TRS-2700.Results and discussion. Ramipril filaments with a diameter of 1.75 mm were obtained by melt extrusion at a temperature of 105 °C. They were homogeneous in quantitative content of the active substance. From the resulting filaments, tablets were printed in five configurations with three filling densities: 30 %, 50 % and 100 %. Degradation of ramipril in filaments and tablets is not observed. The melting point of the selected mixture is lower than the melting point of matrix-polymer. It makes possible to lower the processing temperature. Tablets with 100 % filling provide an immediate release of ramipril.Conclusion. Kollidon® VA 64 is suitable as a matrix-polymer for the development of immediate release ramipril printlets. Kollidon® VA 64 provides the necessary physical and processing properties of the filament required for FDM printing.

scholarly journals Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution

2021 ◽  
Vol 5 (1) ◽  
pp. 15
Author(s):  
Nuno Venâncio ◽  
Gabriela G. Pereira ◽  
João F. Pinto ◽  
Ana I. Fernandes
Keyword(s):  
Three Dimensional ◽  
Drug Dissolution ◽  
Fused Deposition Modelling ◽  
Three Dimensional Printing ◽  
Preliminary Results ◽  
Fused Deposition ◽  
3D Printed ◽  
Dimensional Printing ◽  
Hot Melt ◽  
Patient Centric

Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition modelling to produce tablets. Here, preliminary results evaluating the effect of infill geometry (cross, star, grid) on drug content and release are reported.

scholarly journals 3D-Printed Soft Structure of Polyurethane and Magnetorheological Fluid: A Proof-of-Concept Investigation of its Stiffness Tunability

Micromachines ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 655 ◽  
Author(s):  
Seong-Woo Hong ◽  
Ji-Young Yoon ◽  
Seong-Hwan Kim ◽  
Sun-Kon Lee ◽  
Yong-Rae Kim ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Permanent Magnets ◽  
Thermoplastic Polyurethane ◽  
Three Dimensional ◽  
Magnetorheological Fluid ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Dimensional Printing

In this study, a soft structure with its stiffness tunable by an external field is proposed. The proposed soft beam structure consists of a skin structure with channels filled with a magnetorheological fluid (MRF). Two specimens of the soft structure are fabricated by three-dimensional printing and fused deposition modeling. In the fabrication, a nozzle is used to obtain channels in the skin of the thermoplastic polyurethane, while another nozzle is used to fill MRF in the channels. The specimens are tested by using a universal tensile machine to evaluate the relationships between the load and deflection under two different conditions, without and with permanent magnets. It is empirically shown that the stiffness of the proposed soft structure can be altered by activating the magnetic field.

Denture flask fabrication using fused deposition modeling three-dimensional printing

2020 ◽  
Vol 64 (2) ◽  
pp. 231-234 ◽  
Author(s):  
Heechul Kim ◽  
Doyun Lee ◽  
Soo Young Lee ◽  
Hongso Yang ◽  
Sang-Won Park ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Dimensional Printing

Multimaterial printing and characterization for mechanical and surface properties of functionally graded prototype

2019 ◽  
Vol 233 (19-20) ◽  
pp. 6741-6753 ◽  
Author(s):  
Sudhir Kumar ◽  
Rupinder Singh ◽  
TP Singh ◽  
Ajay Batish
Keyword(s):  
Polylactic Acid ◽  
Surface Properties ◽  
Fused Deposition Modeling ◽  
Mechanical Performance ◽  
Three Dimensional ◽  
Surface Hardness ◽  
Functionally Graded ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Dimensional Printing

In this work, an effort has been made for multimaterial three-dimensional printing of functionally graded prototypes of polylactic acid matrix (tensile specimens as per ASTM D638 type IV) followed by characterization of mechanical and surface properties. The work is an extension of previous reported studies on twin-screw extrusion process for the preparation of multimaterial wires as feedstock filaments in possible three-dimensional printing applications. The results of the study suggest that the highest peak strength (46.28 MPa) and break strength (41.65 MPa) was obtained for multimaterial three-dimensional printed samples at infill density 100%, infill angle 45°, and infill speed of 90 mm/s on commercial open source fused deposition modeling setup. Further surface hardness measurements performed on two extreme surfaces (top surface comprising magnetite (Fe3O4)-reinforced polylactic acid and bottom with polylactic acid without any reinforcement) revealed that the hardness for the bottom layer was more than the hardness for the top layer. From fractured surface analysis (using photomicrographs), it has been observed that the three-dimensional printed samples with low infill density resulted into more void formation due to which the performance while mechanical testing was poor in comparison to samples printed with higher infill density. The results are also supported by rendered images of photomicrographs, which revealed that high roughness value of samples printed with low infill density was also one of the reasons for poor mechanical performance of multimaterial three-dimensional printed functionally graded prototypes.

scholarly journals Development of a computer-aided engineering–supported process for the manufacturing of customized orthopaedic devices by three-dimensional printing onto textile surfaces

2020 ◽  
Vol 15 ◽  
pp. 155892502091762
Author(s):  
Dustin Ahrendt ◽  
Arturo Romero Karam
Keyword(s):  
Three Dimensional ◽  
Computer Aided Engineering ◽  
Two Dimensional ◽  
Three Dimensional Printing ◽  
Textile Materials ◽  
Fused Deposition ◽  
Custom Made ◽  
Computer Aided ◽  
Dimensional Printing ◽  
Textile Fabric

Today, additive manufacturing, also called three-dimensional printing, is used for producing prototypes as well as other products for various industrial sectors. Although this technology is already well established in the automotive, aviation and space travel, building, dental and medical sectors, its integration in the textile and ready-made industry is still in progress. At present, there is a lack of specific application scenarios for the combination of three-dimensional printing and textile materials, apart from fashion and shoe design. Hence, this article presents a digital computer-aided engineering–supported process to manufacture customized orthopaedic devices by three-dimensional printing directly onto a textile fabric. State-of-the-art fabrication methods for orthoses are typically labour intensive. The combination of three-dimensional scanning, computer-aided design modelling and three-dimensional printing onto textile materials open up new possibilities for producing custom-made products. After three-dimensional scanning of a patient’s individual body shape, the surface is prepared for constructing the textile pattern cuts by reverse engineering. The transformation of the designed three-dimensional patterns into two-dimensional is software supported. Additional positioning lines in accordance with specific body measurements are transferred onto the two-dimensional pattern cuts, which are then used as the basis for the design of the three-dimensional printed functional elements. Subsequently, the design is saved in STL (Standard Triangulation/Tessellation Language) file format, prepared by slicing and directly printed onto textile pattern cuts by means of fused deposition modelling. The last manufacturing step involves the assembly of the textile fabric. The proposed process is demonstrated by an example application scenario, thus proving its potential for industrial use in the textile and ready-made industry.

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