Acute Tubulointerstitial Nephritis with Renal Failure Complicated by Typhoid Fever

2010 ◽  
Vol 14 (2) ◽  
pp. 236 ◽  
Author(s):  
Jung Min Oh ◽  
Na Ra Lee ◽  
Hyung Eun Yim ◽  
Kee Hwan Yoo ◽  
Woon Yong Jeong ◽  
...  
Keyword(s):  
Renal Failure ◽  
Typhoid Fever ◽  
Tubulointerstitial Nephritis ◽  
Acute Tubulointerstitial Nephritis

scholarly journals Preeclampsia, HELLP Syndrome, and Postpartum Renal Failure with Thin Basement Membrane Nephropathy: Case Report and a Brief Review of Postpartum Renal Failure

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
K. C. Janga ◽  
Pavani Chitamanni ◽  
Shraddha Raghavan ◽  
Kamlesh Kumar ◽  
Sheldon Greenberg ◽  
...  
Keyword(s):  
Renal Failure ◽  
Basement Membrane ◽  
Renal Biopsy ◽  
Hellp Syndrome ◽  
Tubulointerstitial Nephritis ◽  
Laboratory Evaluation ◽  
High Dose ◽  
Acute Tubulointerstitial Nephritis ◽  
Thin Basement Membrane Nephropathy ◽  
First Case

A 36-year-old primigravida female from a birthing center was referred for elevated blood pressure to the hospital two days after normal spontaneous vaginal delivery with nausea, vomiting, and diarrhea. During this two-day period, she was experiencing persistent vaginal bleeding and lower abdominal pains for which she took six doses of 600 mg ibuprofen. Further laboratory evaluation reflected leukocytosis, anemia, thrombocytopenia, elevation of liver enzymes, and renal failure with hyperkalemia requiring emergent hemodialysis once in the Medical Intensive Care Unit (MICU). She was diagnosed with HELLP syndrome with underlying preeclampsia. A week later, due to hypertension controlled with medications and nonoliguric renal failure with no active urine sediments, a renal biopsy was indicated to direct management. The renal biopsy supported the diagnosis of diffuse severe acute tubulointerstitial nephritis with hypereosinophilia and thin basement membrane nephropathy (see figures). She was subsequently treated with high-dose steroids which resulted in the normalization of blood pressures and renal function returning to baseline. We report the first case of acute tubulointerstitial nephritis in an individual with thin basement membrane nephropathy secondary to postpartum complications.

scholarly journals Successful Steroid Therapy for Cefdinir-induced Acute Tubulointerstitial Nephritis with Progressive Renal Failure.

2001 ◽  
Vol 40 (2) ◽  
pp. 114-117 ◽  
Author(s):  
Yasukazu KIMURA ◽  
Minoru KAWAMURA ◽  
Masahiko OWADA ◽  
Takuya FUJIWARA ◽  
Chihaya MAESAWA ◽  
...  
Keyword(s):  
Renal Failure ◽  
Steroid Therapy ◽  
Tubulointerstitial Nephritis ◽  
Acute Tubulointerstitial Nephritis ◽  
Progressive Renal Failure

Pathological evidence of rhabdomyolysis-induced acute tubulointerstitial nephritis accompanying Legionella pneumophila pneumonia: Figure 1

2008 ◽  
Vol 61 (9) ◽  
pp. 1062-1063 ◽  
Author(s):  
C Shimura ◽  
T Saraya ◽  
H Wada ◽  
S Takata ◽  
S Mikura ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Legionella Pneumophila ◽  
Tubulointerstitial Nephritis ◽  
Antimicrobial Treatment ◽  
Chest Roentgenogram ◽  
Muscle Dysfunction ◽  
High Grade ◽  
High Grade Fever ◽  
Acute Tubulointerstitial Nephritis

A case of Legionella pneumophila pneumonia with rhabdomyolysis-induced acute tubulointerstitial nephritis (ATIN) and prolonged renal dysfunction is presented. The patient was a 54-year-old man, admitted with high-grade fever, ataxia and muscle dysfunction; chest roentgenogram showed multilobular infiltrations. L pneumophila was detected in his sputum and urine, by PCR and by culture, and L pneumophila pneumonia was diagnosed. Despite antimicrobial treatment, he developed renal failure and rhabdomyolysis. Renal biopsy showed the presence of myoglobin casts that occluded the distal tubuli and tubulointerstitial nephritis, leading to the diagnosis of rhabdomyolysis-induced ATIN. Renal function subsequently normalised, and he was discharged. This is believed to be the first pathological evidence of involvement of rhabdomyolysis in legionellosis-associated ATIN.

scholarly journals Acute tubulointerstitial nephritis and polyclonal hypergammaglobulinaemia: Which is the culprit?

2018 ◽  
Vol 8 (4) ◽  
Author(s):  
Ana E. Sirvent ◽  
Ricardo Enríquez ◽  
Tania Muci ◽  
Francisco Javier Ardoy-Ibañez ◽  
Isabel Millán ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Serum Creatinine ◽  
Renal Biopsy ◽  
Proton Pump ◽  
Tubulointerstitial Nephritis ◽  
Systemic Disease ◽  
Acute Tubulointerstitial Nephritis ◽  
Long Period

Proton pump inhibitors (PPIs) are among the most frequent implicated drugs in acute tubulointerstitial nephritis (ATIN), nevertheless it is important to report cases with atypical profiles. A 80-year-old female, exposed during 34 months to omeprazole, presented with polyclonal hypergammaglobulinaemia and renal failure. After stopping omeprazole there was a partial improvement in serum creatinine and IgG. Renal biopsy revealed ATIN; immunohistochemistry for IgG4 was negative. Treatment with steroids and mycophenolate sodium improved renal function and normalized immunoglobulins. The lack of data of other entities and the patient’s evolution strongly point omeprazole as the culprit. After 27 months of follow-up, she remains clinical and analytically stable. ATIN caused by PPIs may appear after a long period of exposure and may be accompanied by analytical anomalies that simulate a systemic disease.

Case Review of lgG4-Related Disease Patient with Combined Tubulointerstitial Nephritis and Membranous Nephropathy Coexisting with Cholangiocarcinoma: Case Report

2020 ◽  
Vol 103 (11) ◽  
pp. 1230-1235
Keyword(s):  
Renal Failure ◽  
Membranous Nephropathy ◽  
Tubulointerstitial Nephritis ◽  
Disease Patient ◽  
Case Review ◽  
Related Disease ◽  
Phospholipase A2 Receptor ◽  
Wide Range ◽  
Serum Igg4 ◽  
Secondary Membranous Nephropathy

Immunoglobulin G4-related disease (IgG4-RD) has recently been recognized as an autoimmune disorder involving multiple organs. The kidney is a represented organ with a wide range of renal manifestations. The authors report a case of an 83-year-old Thai male with combined IgG4 tubulointerstitial nephritis and membranous nephropathy coexisting with cholangiocarcinoma. The patient presented with proteinuria, acute renal failure, eosinophilia, hypocomplementemia, and high serum IgG4 concentration. The diagnosis was IgG 4-related tubulointerstitial nephritis and membranous nephropathy on renal biopsy, with negative immunohistochemistry for anti-phospholipase A2 receptor antibodies. Magnetic resonance imaging (MRI) abdomen showed two wedge shaped arterial enhancing lesions of liver. Liver biopsy revealed adenocarcinoma, compatible with cholangiocarcinoma. Proteinuria and renal failure were resolved with initial steroid treatment. Meanwhile, IgG4-related membranous nephropathy should be considered in the differential diagnosis for patients with proteinuria. Potentially, IgG4-RD may be rarely associated with carcinoma development. However, further studies are recommended to ratify and confirm the association between IgG4-RD and incidence of malignancies. Keywords: IgG4-related disease, Membranous nephropathy, Secondary membranous nephropathy, Tubulointerstitial nephritis, Cholangiocarcinoma

Acute tubulointerstitial nephritis in children and chronic kidney disease

2019 ◽  
Vol 26 (5) ◽  
pp. 290-294 ◽  
Author(s):  
S. Clavé ◽  
C. Rousset-Rouvière ◽  
L. Daniel ◽  
M. Tsimaratos
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Tubulointerstitial Nephritis ◽  
Acute Tubulointerstitial Nephritis

scholarly journals Urinary Cytokines Reflect Renal Inflammation in Acute Tubulointerstitial Nephritis: A Multiplex Bead-Based Assay Assessment

2021 ◽  
Vol 10 (13) ◽  
pp. 2986
Author(s):  
Laura Martinez Valenzuela ◽  
Juliana Draibe ◽  
Oriol Bestard ◽  
Xavier Fulladosa ◽  
Francisco Gómez-Preciado ◽  
...  
Keyword(s):  
Tubulointerstitial Nephritis ◽  
Urinary Concentration ◽  
Blood Eosinophil ◽  
Acute Tubulointerstitial Nephritis ◽  
Luminex Assay ◽  
Non Invasive ◽  
Urinary Levels ◽  
Histological Data ◽  
The Individual ◽  
Multiplex Bead

Background: Acute tubulointerstitial nephritis (ATIN) diagnosis lays on histological assessment through a kidney biopsy, given the absence of accurate non-invasive biomarkers. The aim of this study was to evaluate the accuracy of different urinary inflammation-related cytokines for the diagnostic of ATIN and its distinction from acute tubular necrosis (ATN). Methods: We included 33 patients (ATIN (n = 21), ATN (n = 12)), and 6 healthy controls (HC). We determined the urinary levels of 10 inflammation-related cytokines using a multiplex bead-based Luminex assay at the time of biopsy and after therapy, and registered main clinical, analytical and histological data. Results: At the time of biopsy, urinary levels of I-TAC/CXCL11, CXCL10, IL-6, TNFα and MCP-1 were significantly higher in ATIN compared to HC. A positive correlation between the extent of the tubulointerstitial cellular infiltrates in kidney biopsies and the urinary concentration of I-TAC/CXCL11, MIG/CXCL9, CXCL10, IL17, IFNα, MCP1 and EGF was observed. Notably, I-TAC/CXCL11, IL-6 and MCP-1 were significantly higher in ATIN than in ATN, with I-TAC/CXCL11 as the best discriminative classifier AUC (0.77, 95% CI 0.57–0.95, p = 0.02). A combinatory model of these three urinary cytokines increased the accuracy in the distinction of ATIN/ATN compared to the individual biomarkers. The best model resulted when combining the three cytokines with blood eosinophil and urinary leukocyte counts (LR = 9.76). Follow-up samples from 11ATIN patients showed a significant decrease in I-TAC/CXCL11, MIG/CXCL9 and CXCL10 levels. Conclusions: Urinary I-TAC/CXCL11, CXCL10, IL6 and MCP-1 levels accurately distinguish patients developing ATIN from ATN and healthy individuals and may serve as novel non-invasive biomarkers in this disease.

Cockayne syndrome with recurrent acute tubulointerstitial nephritis

2006 ◽  
Vol 56 (11) ◽  
pp. 678-682 ◽  
Author(s):  
Satoshi Funaki ◽  
Shori Takahashi ◽  
Hitohiko Murakami ◽  
Kensuke Harada ◽  
Hiroshi Kitamura
Keyword(s):  
Tubulointerstitial Nephritis ◽  
Cockayne Syndrome ◽  
Acute Tubulointerstitial Nephritis

scholarly journals Acute Tubulointerstitial Nephritis in a Patient on Anti-Programmed Death-Ligand 1 Triggered by COVID-19: A Case Report

2021 ◽  
Vol 8 ◽  
pp. 205435812110147
Author(s):  
Dimitry Buyansky ◽  
Catherine Fallaha ◽  
François Gougeon ◽  
Marie-Noëlle Pépin ◽  
Jean-François Cailhier ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Tubulointerstitial Nephritis ◽  
Checkpoint Inhibitor ◽  
Checkpoint Inhibitors ◽  
High Dose ◽  
Programmed Death Ligand 1 ◽  
Acute Tubulointerstitial Nephritis ◽  
Programmed Death ◽  
Kidney Involvement

Rationale: Immune checkpoint inhibitors are monoclonal antibodies used in the treatment of various types of cancers. The downside of using such molecules is the potential risk of developing immune-related adverse events. Factors that trigger these autoimmune side effects are yet to be elucidated. Although any organ can potentially be affected, kidney involvement is usually rare. In this case report, we describe the first known instance of a patient being treated with an inhibitor of programmed death-ligand 1 (anti-PD-L1, a checkpoint inhibitor) who develops acute tubulointerstitial nephritis after contracting the severe acute respiratory syndrome coronavirus 2. Presenting concerns of the patient: A 62-year-old patient, on immunotherapy treatment for stage 4 squamous cell carcinoma, presents to the emergency department with symptoms of lower respiratory tract infection. Severe acute kidney injury is discovered with electrolyte imbalances requiring urgent dialysis initiation. Further testing reveals that the patient has contracted the severe acute respiratory syndrome coronavirus 2. Diagnosis: A kidney biopsy was performed and was compatible with acute tubulointerstitial nephritis. Interventions: The patient was treated with high dose corticosteroid therapy followed by progressive tapering. Outcomes: Rapid and sustained normalization of kidney function was achieved after completion of the steroid course. Novel findings: We hypothesize that the viral infection along with checkpoint inhibitor use has created a proinflammatory environment which led to a loss of self-tolerance to renal parenchyma. Viruses may play a more important role in the pathogenesis of autoimmunity in this patient population than was previously thought.

scholarly journals Anatomo-pathological and epidemiological analysis of urinary tract lesions in dogs

2016 ◽  
Vol 46 (8) ◽  
pp. 1443-1449 ◽  
Author(s):  
Carolina da Fonseca Sapin ◽  
Luisa Cerqueira Silva-Mariano ◽  
Jordana Nunes Bassi ◽  
Fabiane Borelli Grecco
Keyword(s):  
Renal Failure ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Tubulointerstitial Nephritis ◽  
Acute Cystitis ◽  
Anatomical Distribution ◽  
Epidemiological Analysis ◽  
Regional Laboratory ◽  
Kidney Lesions ◽  
Lower Urinary

ABSTRACT: In dogs, diseases of the urinary tract are common and can be caused by disorders of varied etiology. The objective of this study was to classify qualitatively and quantitatively urinary tract lesions of 363 dogs, which were classified according to its anatomical distribution and etiology. The data was obtained from the revision of 36 years of protocols from the Regional Laboratory of Diagnosis (LRD/UFPel) and it represents 4.0% of diagnoses from a total of 8980 for that period and species. Renal injury accounted for 93.1% of cases, with 309 being primary kidney lesions; from which the main lesions were the tubulointerstitial nephritis (142 cases) often associated with Leptospirosis (47). Injuries of lower urinary tract accounted for 6.9% of the cases where acute cystitis stands out (19). In this study, renal failure, acute or chronic, represented an important cause of death in dogs.

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