Retinopathy of prematurity-mimicking retinopathy in full-term babies

Purpose. To characterize the clinical features in young patients with angle closure and to determine the characteristics associated with acquired anterior segment abnormality following retinopathy of prematurity (ROP) treatment. Methods. We performed two retrospective case-control series. In the first series, we identified consecutive young angle closure patients without prior surgeries, with and without a history of ROP treatment; in the second series we identified consecutive patients who underwent ROP treatment, without and without anterior segment changes. Results. In the first series, 25 eyes of 14 consecutive angle closure patients were included: 19 eyes (11 patients, 78.6%) had a history of treated ROP, while 6 eyes (3 patients) belonged to full-term patients. The treated ROP eyes had significantly shallower anterior chambers (1.77 ± 0.17 mm vs 2.72 ± 0.18 mm, P<0.0001) and thicker lenses (5.20 ± 0.54 mm vs 3.98 ± 0.20 mm, P=0.0002) compared to the full-term controls. In the second series, 79 eyes of 40 patients were included, with median gestational age of 24.6 weeks. Acquired iridocorneal adhesion was noted in the eight eyes (10.1%) at a mean age of 4.7 years and was associated with prior zone 1 and plus disease (P=0.0013), a history of initial intravitreal bevacizumab treatment (IVB, P=0.0477) and a history of requiring additional IVB after initial treatment (P=0.0337). Conclusions. Many young angle closure patients may have a history of treated ROP and may present with the triad of increased lens thickness, microcornea, and angle closure.

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Anatomic features of anterior chamber angle in children with glaucoma depending on the degree of the cicatricial retinopathy of prematurity

Ophthalmology journal ◽

10.17816/ov2019121-26 ◽

2019 ◽

Vol 12 (1) ◽

pp. 21-26

Author(s):

Maria A. Makarova ◽

Viktoria M. Panchishena ◽

Elena V. Brusakova ◽

Regina V. Ershova ◽

Elvira I. Saidasheva ◽

...

Keyword(s):

Anterior Chamber ◽

Retinopathy Of Prematurity ◽

Full Term ◽

Congenital Glaucoma ◽

Control Group ◽

Study Group ◽

Anterior Chamber Angle ◽

Anatomic Structure ◽

Preterm Children ◽

Chamber Angle

Introduction. The retinopathy of prematurity (ROP) is a leading condition in the nosological structure of ophthalmic pathology in preterm children. A number of researchers note the increase in frequency of glaucoma development in such patients, considerably worsening the prognosis of the disease. At the same time, features of ocular hydrostatics and hydrodynamics taking into account the immaturity of the eye are studied insufficiently. The purpose of the study was to estimate the anterior chamber angle anatomy in preterm children with glaucoma depending on the cicatricial ROP severity. Materials and methods. The study group included 45 preterm children (87 eyes) aged from 6 months to 18 years with glaucoma on the background of cicatricial ROP. The control group consisted of 27 full-term children (54 eyes) with congenital glaucoma. As an addition to traditional ophthalmologic examination, iridocorneal goniography using a pediatric retinal camera was performed. Results. In children of the study group, anomalies of anterior chamber angle anatomic structure were diagnosed in the absolute majority of cases 97.7% of cases (85 eyes) and depended on the cicatricial ROP severity: at degrees 1-3 they were similar to those in congenital glaucoma in full-term children; at degrees 4-5 glaucoma was of secondary nature and developed as a result of a combination of dysgenesis signs in the anterior chamber angle. Conclusion. Cicatricial ROP of any degree is a high risk factor for the development of secondary glaucoma.

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Drug-induced mydriasis in infants born at different gestation terms

Ophthalmology journal ◽

10.17816/ov11485-92 ◽

2018 ◽

Vol 11 (4) ◽

pp. 85-92

Author(s):

Elvira I. Saidasheva ◽

Svetlana V. Biyanovskaya ◽

Fedor V. Kovshov ◽

Marina S. Petrachkova ◽

Olga S. Dolgova ◽

...

Keyword(s):

Side Effects ◽

Retinopathy Of Prematurity ◽

Full Term ◽

Eye Drops ◽

Drug Induced ◽

Term Infants ◽

Extremely Preterm ◽

Extremely Preterm Infants ◽

Term Newborns ◽

Group 2

Background. At the present time, the problem of choice of eye drops to achieve adequate mydriasis with minimal side effects for retinopathy of prematurity screening remains an urgent challenge. Purpose. To estimate the clinical efficacy of combination mydriatic eye drops Fenicamide in infants born at different gestation terms. Materials and methods. Under observation, there were 75 newborns (150 eyes) and babies aged from 1 day to 3 months (average, 38.2 ± 32.2 days). Patients were distributed into 3 groups depending on gestational age: group 1 consisted of 25 full-term infants; group 2 – of 25 premature babies, and group 3 – of 25 extremely preterm infants. To achieve mydriasis, 1 drop of combination eye drops (5% phenylephrine and 0.8% tropicamide) was instilled. Dynamics of pupil diameter change in each group of patients was registered within 4 hours, and side effects were recorded within 24 hours. The quality of fundus visualization was estimated using a pediatric retinal camera RetCam 3. Results. Maximal pupil dilation (average, 6.5 ± 0.5 mm) was reached to 60 ± 14 min after instillation on average; pupil remained dilated within 1 hour, its diameter became normal in 4 hours. Mydriasis varied from 5.9 mm in extremely premature infants to 7 mm in the full-term newborns (p > 0.05), and allowed a full and high quality examination of the fundus in all patients, including the visualization of peripheral zones of the retina for retinopathy of prematurity screening. It was established that drug side effects were absent in 76% (57) of infants, they were present in 24% (18) of infants, mostly as local reaction. Conclusion. Fenicamide eye drops are an effective mydriatic medication, with a convenient instillation regimen, have minimal side effects, and can be recommended for retinopathy of prematurity screening and monitoring.

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Retinopathy of Prematurity and Bronchopulmonary Dysplasia are Independent Antecedents of Cortical Maturational Abnormalities in Very Preterm Infants

Scientific Reports ◽

10.1038/s41598-019-56298-x ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Julia E. Kline ◽

Venkata Sita Priyanka Illapani ◽

Lili He ◽

Mekibib Altaye ◽

Nehal A. Parikh

Keyword(s):

Surface Area ◽

Bronchopulmonary Dysplasia ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Brain Mri ◽

Full Term ◽

Term Infants ◽

Very Preterm Infants ◽

Equivalent Age ◽

Very Preterm

AbstractVery preterm (VPT) infants are at high-risk for neurodevelopmental impairments, however there are few validated biomarkers at term-equivalent age that accurately measure abnormal brain development and predict future impairments. Our objectives were to quantify and contrast cortical features between full-term and VPT infants at term and to associate two key antecedent risk factors, bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP), with cortical maturational changes in VPT infants. We prospectively enrolled a population-based cohort of 110 VPT infants (gestational age ≤31 weeks) and 51 healthy full-term infants (gestational age 38–42 weeks). Structural brain MRI was performed at term. 94 VPT infants and 46 full-term infants with high-quality T2-weighted MRI were analyzed. As compared to full-term infants, VPT infants exhibited significant global cortical maturational abnormalities, including reduced surface area (−5.9%) and gyrification (−6.7%) and increased curvature (5.9%). In multivariable regression controlled for important covariates, BPD was significantly negatively correlated with lobar and global cortical surface area and ROP was significantly negatively correlated with lobar and global sulcal depth in VPT infants. Our cohort of VPT infants exhibited widespread cortical maturation abnormalities by term-equivalent age that were in part anteceded by two of the most potent neonatal diseases, BPD and ROP.

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