scholarly journals Immune responses of hepatitis B vaccination among very low birth weight infant

2006 ◽  
Vol 49 (8) ◽  
pp. 857 ◽  
Author(s):  
Young-Deuk Kim ◽  
Myung-Ki Han ◽  
Ai-Rhan E. Kim ◽  
Ki-Soo Kim ◽  
Soo-Young Pi
PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92271 ◽  
Author(s):  
Chien-Yi Chen ◽  
Huey-Ling Chen ◽  
Hung-Chieh Chou ◽  
Po-Nien Tsao ◽  
Wu-Shiun Hsieh ◽  
...  

Author(s):  
Katarina Ost ◽  
Natalia V. Oster ◽  
Elizabeth N. Jacobson ◽  
M. Patricia deHart ◽  
Janet A. Englund ◽  
...  

Objective The U.S. Advisory Committee on Immunization Practices (ACIP) recommends that infants born weighing less than 2,000 g receive the hepatitis B (HepB) vaccine at hospital discharge or 30 days of age. This study aimed to assess timely HepB vaccination among low birth weight infants. We hypothesized that many of these vulnerable infants would fail to receive their HepB birth dose on time. Study Design This retrospective cohort study included Washington State infants born weighing less than 2,000 g at an academic medical center between 2008 and 2013. Data were abstracted from electronic health records and linked to vaccine data from the Washington State Immunization Information System. Multivariable logistic regression was used to examine the associations between sociodemographic, clinical, and visit characteristics and HepB vaccination by birth hospitalization discharge or 30 days of age. Results Among 976 study infants, 58.4% received their HepB vaccine by birth hospitalization discharge or 30 days of age. Infants had higher odds of timely HepB vaccination if they were Hispanic (adjusted odds ratio [AOR] = 1.80, 95% confidence interval [CI]: 1.10–2.95) or non-Hispanic black (AOR = 2.28, 95% CI: 1.36–3.80) versus non-Hispanic white or if they were hospitalized 14 days or longer versus less than 14 days (AOR = 2.43, 95% CI: 1.66–3.54). Infants had lower odds of timely HepB vaccination if they were born before 34 weeks versus on or after 34 weeks of gestational age (AOR = 0.41, 95% CI: 0.27–0.63) or if they had an estimated household income less than $50,845 versus 50,845 or greater (AOR = 0.64, 95% CI: 0.48–0.86). Conclusion Many infants born weighing less than 2,000 g did not receive their first HepB birth dose according to ACIP recommendations. Strategies are needed to improve timely HepB vaccination in this high-risk population. Key Points


1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 221A-221A
Author(s):  
Samuel Rodgers ◽  
Gisela Witz ◽  
Mujahid Anwar ◽  
Mark Hiatt ◽  
Thomas Hegyi

PEDIATRICS ◽  
2021 ◽  
pp. e2021054272
Author(s):  
Margaret G. Parker ◽  
Lisa M. Stellwagen ◽  
Lawrence Noble ◽  
Jae H. Kim ◽  
Brenda B. Poindexter ◽  
...  

Author(s):  
Patricia Lengua Hinojosa ◽  
Frank Eifinger ◽  
Michael Wagner ◽  
Jochen Herrmann ◽  
Monika Wolf ◽  
...  

Abstract Background Medical simulation training requires realistic simulators with high fidelity. This prospective multi-center study investigated anatomic precision, physiologic characteristics, and fidelity of four commercially available very low birth weight infant simulators. Methods We measured airway angles and distances in the simulators Premature AirwayPaul (SIMCharacters), Premature Anne (Laerdal Medical), Premie HAL S2209 (Gaumard), and Preterm Baby (Lifecast Body Simulation) using computer tomography and compared these to human cadavers of premature stillbirths. The simulators’ physiologic characteristics were tested, and highly experienced experts rated their physical and functional fidelity. Results The airway angles corresponded to those of the reference cadavers in three simulators. The nasal inlet to glottis distance and the mouth aperture to glottis distance were only accurate in one simulator. All simulators had airway resistances up to 20 times higher and compliances up to 19 times lower than published reference values. Fifty-six highly experienced experts gave three simulators (Premature AirwayPaul: 5.1 ± 1.0, Premature Anne 4.9 ± 1.1, Preterm Baby 5.0 ± 1.0) good overall ratings and one simulator (Premie HAL S2209: 2.8 ± 1.0) an unfavorable rating. Conclusion The simulator physiology deviated significantly from preterm infants’ reference values concerning resistance and compliance, potentially promoting a wrong ventilation technique. Impact Very low birth weight infant simulators showed physiological properties far deviating from corresponding patient reference values. Only ventilation with very high peak pressure achieved tidal volumes in the simulators, as aimed at in very low birth weight infants, potentially promoting a wrong ventilation technique. Compared to very low birth weight infant cadavers, most tested simulators accurately reproduced the anatomic angular relationships, but their airway dimensions were relatively too large for the represented body. The more professional experience the experts had, the lower they rated the very low birth weight infant simulators.


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