scholarly journals B-cell Complement Dependent Cytotoxic Crossmatch Positivity is an Independent Risk Factor for Long-term Renal Allograft Survival

2011 ◽  
Vol 26 (4) ◽  
pp. 528 ◽  
Author(s):  
Hyeon Seok Hwang ◽  
Hye Eun Yoon ◽  
Bum Soon Choi ◽  
Eun Jee Oh ◽  
Ji Il Kim ◽  
...  
Keyword(s):  
Risk Factor ◽  
B Cell ◽  
Independent Risk Factor ◽  
Renal Allograft ◽  
Allograft Survival

DEFING LONG TERM RENAL ALLOGRAFT SURVIVAL FOLLOWING EARLY CORTICOSTEROID WITHDRAWAL AND RISK FACTOR ASSESSMENT

2010 ◽  
Vol 90 ◽  
pp. 175
Author(s):  
A. R. Shields ◽  
R. R. Alloway ◽  
A. Govil ◽  
M. Cardi ◽  
S. Safdar ◽  
...  
Keyword(s):  
Risk Factor ◽  
Renal Allograft ◽  
Allograft Survival ◽  
Risk Factor Assessment ◽  
Corticosteroid Withdrawal

Pneumonectomy for Treatment of Destroyed Lung: A Retrospective Study of 137 Patients

2016 ◽  
Vol 65 (07) ◽  
pp. 528-534 ◽  
Author(s):  
Yuping Li ◽  
Gening Jiang ◽  
Chang Chen ◽  
Xuefei Hu
Keyword(s):  
Risk Factor ◽  
Postoperative Complications ◽  
Operative Technique ◽  
Independent Risk Factor ◽  
Multivariate Analyses ◽  
Bronchopleural Fistula ◽  
Long Term Outcomes ◽  
Term Survival ◽  
Destroyed Lung

Objectives Whether pneumonectomy is needed for the treatment of destroyed lungs is still controversial and unresolved in the clinic. Pneumonectomy is destructive and is associated with a significant incidence of postoperative complications. The purpose of this study is to analyze the operative techniques, postoperative morbidity, mortality, and long-term outcomes of patients with destroyed lungs who underwent pneumonectomy. Patients and Methods We retrospectively analyzed 137 patients with destroyed lungs who underwent pneumonectomy. The data were queried for the details of operative technique, development of perioperative complications, mortality, and long-term survival. Univariate and multivariate analyses were performed to investigate the risk factors of pneumonectomy among the patients. Results A total of 77 male and 60 female patients were reviewed. The youngest patient was 18 years, and the oldest was 75 years, with a mean age of 40.1 years. Postoperative complications were observed in 25 patients (18.2%). The rate of bronchopleural fistula (BPF) was 5.1% (7/137). Two perioperative deaths (1.5%) were noted. Univariate and multivariate analyses indicated the blood loss (hazard ratio [HR], 5.32; 95% confidence interval [CI], 1.27–18.50; p = 0.021) was the independent risk factor of postoperative complications, and the type of the disease (HR, 4.50; 95% CI, 1.19–9.69; p = 0.034) was the independent risk factor of the BPF, for the patients with destroyed lung after pneumonectomy. Conclusion Pneumonectomy for destroyed lung is a high risk for postoperative complications. Our findings suggested that pneumonectomy in destroyed lung was satisfactory with strict surgical indications, adequate preoperative preparation, and careful operative technique, and the long-term outcomes can be especially satisfactory. Pneumonectomy for destroyed lung is still a treatment option.

scholarly journals A Novel, Blocking, Fc-Silent Anti-CD40 Monoclonal Antibody Prolongs Nonhuman Primate Renal Allograft Survival in the Absence of B Cell Depletion

2015 ◽  
Vol 15 (11) ◽  
pp. 2825-2836 ◽  
Author(s):  
F. Cordoba ◽  
G. Wieczorek ◽  
M. Audet ◽  
L. Roth ◽  
M. A. Schneider ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
B Cell ◽  
Nonhuman Primate ◽  
Renal Allograft ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
Allograft Survival

scholarly journals B Cell Activating Factor, Renal Allograft Antibody-Mediated Rejection, and Long-Term Outcome

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Haiyan Xu ◽  
Xiaozhou He ◽  
Renfang Xu
Keyword(s):  
B Cell ◽  
Renal Allograft ◽  
Delayed Diagnosis ◽  
Clinical Manifestations ◽  
Direct Proof ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Antibody Mediated Rejection ◽  
B Cell Activating Factor

Antibody-mediated rejection (ABMR) of renal allograft lacks typical phenotypes and clinical manifestations, always resulting in delayed diagnosis and treatment. It has been considered to be an elemental factor influencing the improvement of the long-term outcome of renal allograft. The B cell activating factor (BAFF) signal plays a fundamental function in the process of antibody-mediated immune response. Data from recipients and the nonhuman primate ABMR model suggest that the BAFF signal participates in the ABMR of renal allograft, while there are objections. The challenges in the diagnosis of ABMR, different study population, and details of research may explain the discrepancy. Large quantities of dynamic, credible data of BAFF ligands and their association with renal allograft pathological characteristics would constitute a direct proof of the role of BAFF in the progression of renal allograft ABMR.

VKORC1 Haplotypes and Long-Term Renal Allograft Survival

2009 ◽  
Vol 87 (6) ◽  
pp. 942
Author(s):  
Nicolas Pallet ◽  
Marie-Anne Loriot ◽  
Dany Anglicheau ◽  
Christophe Legendre ◽  
Philippe Beaune ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Allograft Survival

Is preterm delivery an independent risk factor for long-term maternal kidney disease?

2016 ◽  
Vol 30 (9) ◽  
pp. 1102-1107 ◽  
Author(s):  
Gali Pariente ◽  
Roy Kessous ◽  
Ruslan Sergienko ◽  
Eyal Sheiner
Keyword(s):  
Risk Factor ◽  
Kidney Disease ◽  
Preterm Delivery ◽  
Independent Risk Factor

Long-Term Improvement of Deceased Donor Renal Allograft Survival Since 1996: A Single Transplant Center Study

2010 ◽  
Vol 89 (6) ◽  
pp. 714-720 ◽  
Author(s):  
Eugenia Sola ◽  
Miguel Gonzalez-Molina ◽  
Mercedes Cabello ◽  
Dolores Burgos ◽  
Jose Ramos ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Deceased Donor ◽  
Allograft Survival ◽  
Transplant Center ◽  
Center Study
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