scholarly journals Hepatic metastases from hepatoid adenocarcinoma of stomach mimicking hepatocellular carcinoma

2012 ◽  
Vol 18 (4) ◽  
pp. 420 ◽  
Author(s):  
Jae Myeong Jo ◽  
Jin Woong Kim ◽  
Suk Hee Heo ◽  
Sang Soo Shin ◽  
Yong Yeon Jeong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Metastases ◽  
Hepatoid Adenocarcinoma

Aberrant β-catenin activity in hepatoid adenocarcinoma of the stomach

2020 ◽  
Vol 20 ◽  
Author(s):  
Nan Wang ◽  
Rui Kong ◽  
Wei Han ◽  
Jie Lu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pearson Correlation ◽  
Clinicopathological Characteristics ◽  
Cancer Tissue ◽  
Hepatoid Adenocarcinoma ◽  
Tumor Initiating Cells ◽  
Significant Difference ◽  
Diagnostic Confusion ◽  
Hematoxylin And Eosin ◽  
Cancer Tissues

Background: Hepatoid adenocarcinoma of the stomach (HAS) has been recognized as a rare primary gastric tumor characterized by hepatocellular carcinoma-like histology. HAS often causes diagnostic confusion with conventional gastric adenocarcinoma (CGA) due to the difficulty to detect hepatoid differentiation solely based on findings from hematoxylin and eosin (H&E) staining. Hence, HAS should be distinguished from solid-type CGA based on their different biological behaviors. β-catenin is highly expressed in hepatocellular carcinoma (HCC), which is involved in the maintenance of tumor initiating cells, drug resistance, tumor progression, and metastasis. Methods and Results: Given the dearth of HAS cases, systematic examination of the expression of β-catenin in HAS remains under-explored. In this study, 14 cases were subjected to immunostaining with with AFP, β-catenin, glypican3, hepar-1 and CerbB-2. In parallel, the clinicopathological characteristics of these patients were collected. We detected statistically significant difference in the expression of β-catenin (P = 0.000), glypican3 (P = 0.019), and hepar-1 (P = 0.007) between HAS cancer tissues and the adjacent non-cancerous tissues. Furthermore, a significant correlation was observed between the expression of β-catenin in HAS cancer tissue and adjacent tissue (Pearson correlation coefficient: 0.686, P = 0.007). Moreover, in cancer tissues, a significant correlation was observed between the expression of β-catenin and survival time (Spearman correlationcoefficient= - 0.482, P = 0.003). However, we found the expression of β-catenin did not correlate with the degree of tumor differentiation and tumor size, age, gender, serum AFP levels, microinvasion, and metastasis (P > 0.05). Conclusion: Our findings establish β-catenin as a useful marker that can distinguish HAS from CGA and may improve the early diagnosis to guide the appropriate and timely treatment of HAS patients.

scholarly journals Is the Rationale of Anatomical Liver Resection for Hepatocellular Carcinoma Universally Adoptable? A Hypothesis-Driven Review

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 131
Author(s):  
Young-Jen Lin ◽  
Cheng-Maw Ho
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Microenvironment ◽  
Surgical Resection ◽  
Tumor Recurrence ◽  
Hepatic Metastases ◽  
Vascular Supply ◽  
Tumor Ablation ◽  
Supporting Evidence ◽  
En Bloc ◽  
Margin Width

Surgical resection is the first-line curative treatment modality for resectable hepatocellular carcinoma (HCC). Anatomical resection (AR), described as systematic removal of a liver segment confined by tumor-bearing portal tributaries, may improve survival by reducing the risk of tumor recurrence compared with non-AR. In this article, we propose the rationale for AR and its universal adoption by providing supporting evidence from the advanced understanding of a tumor microenvironment and accumulating clinical experiences of locoregional tumor ablation therapeutics. AR may be advantageous because it completely removes the en-bloc by interrupting tumor vascular supply and thus extirpates the spreading of tumor microthrombi, if they ever exist, within the supplying portal vein. However, HCC is a hypervascular tumor that can promote neoangiogenesis in the local tumor microenvironment, which in itself can break through the anatomical boundary within the liver and even retrieve nourishment from extrahepatic vessels, such as inferior phrenic or omental arteries. Additionally, increasing clinical evidence for locoregional tumor ablation therapies, such as radiofrequency ablation, predominantly performed as a non-anatomical approach, suggests comparable outcomes for surgical resection, particularly in small HCC and colorectal, hepatic metastases. Moreover, liver transplantation for HCC, which can be considered as AR of the whole liver followed by implantation of a new graft, is not universally free from post-transplant tumor recurrence. Overall, AR should not be considered the gold standard among all surgical resection methods. Surgical resection is fundamentally reliant on choosing the optimal margin width to achieve en-bloc tumor niche removal while balancing between oncological radicality and the preservation of postoperative liver function. The importance of this is to liberate surgical resilience in hepatocellular carcinoma. The overall success of HCC treatment is determined by the clearance of the theoretical niche. Developing biomolecular-guided navigation device/technologies may provide surgical guidance toward the total removal of microscopic tumor niche to achieve superior oncological outcomes.

scholarly journals Atypical Presentation of Hepatocellular Carcinoma Mimicking a Gastric Hepatoid Adenocarcinoma

Medicine ◽  
2015 ◽  
Vol 94 (27) ◽  
pp. e1101 ◽  
Author(s):  
Aymeric Becq ◽  
Christian Mateescu ◽  
David Khayat ◽  
Mohamed Bouattour
Keyword(s):  
Hepatocellular Carcinoma ◽  
Atypical Presentation ◽  
Hepatoid Adenocarcinoma

CT features of hepatic metastases from hepatoid adenocarcinoma

2017 ◽  
Vol 42 (10) ◽  
pp. 2402-2409 ◽  
Author(s):  
Min-Yung Chang ◽  
Hye Jin Kim ◽  
Seung Hyun Park ◽  
Hyunki Kim ◽  
Dong Kyu Choi ◽  
...  
Keyword(s):  
Hepatic Metastases ◽  
Hepatoid Adenocarcinoma ◽  
Ct Features

scholarly journals Hepatoid Adenocarcinoma of the Stomach: Current Perspectives and New Developments

2021 ◽  
Vol 11 ◽  
Author(s):  
Ruolan Xia ◽  
Yuwen Zhou ◽  
Yuqing Wang ◽  
Jiaming Yuan ◽  
Xuelei Ma
Keyword(s):  
Gastric Cancer ◽  
Hepatocellular Carcinoma ◽  
Malignant Tumor ◽  
Advanced Disease ◽  
Clinical Manifestations ◽  
Disease Stage ◽  
Hepatoid Adenocarcinoma ◽  
New Developments ◽  
Advanced Disease Stage ◽  
Worse Prognosis

Hepatoid adenocarcinoma of the stomach (HAS) is a rare malignant tumor, accounting for only 0.17–15% of gastric cancers. Patients are often diagnosed at an advanced disease stage, and their symptoms are similar to conventional gastric cancer (CGC) without specific clinical manifestation. Morphologically, HAC has identical morphology and immunophenotype compared to hepatocellular carcinoma (HCC). This is considered to be an underestimation in diagnosis due to its rare incidence, and no consensus is reached regarding therapy. HAS generally presents with more aggressive behavior and worse prognosis than CGC. The present review summarizes the current literature and relevant knowledge to elaborate on the epidemic, potential mechanisms, clinical manifestations, diagnosis, management, and prognosis to help clinicians accurately diagnose and treat this malignant tumor.

Suprahepatic Catheter Placement for Hydrodissection

2018 ◽  
Author(s):  
Alessandro Gasparetto ◽  
John Fritz Angle
Keyword(s):  
Hepatocellular Carcinoma ◽  
Thermal Insulation ◽  
Microwave Ablation ◽  
Fluid Layer ◽  
Hepatic Metastases ◽  
Target Lesion ◽  
Catheter Placement ◽  
Ablation Area

Heat injuries of adjacent organs need to be considered when radiofrequency and microwave ablation procedures of hepatocellular carcinoma or hepatic metastases are performed, especially when the target lesion is in a subcapsular portion of the liver. Hydrodissection can be performed prior to radiofrequency or microwave ablation procedures in which the target lesion is in a subcapsular portion of the liver and adjacent to another structure, particularly the diaphragm. This technique creates a fluid layer thick enough to separate the nearby structures from the target lesion in the liver, providing thermal insulation around the ablation area. Moreover, if fluid (rather than CO2) is used, it improves the sonic window when the target lesion is not visible or only partially visible due to overlapping bowel, lung, or ribs.

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