scholarly journals Intrahepatic cholangiocarcinoma: tumour heterogeneity and its clinical relevance

2022 ◽  
Author(s):  
Mina Komuta
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Clinical Relevance ◽  
Tumour Heterogeneity

scholarly journals Human tumour heterogeneity: Biological basis and clinical relevance

Cytometry ◽  
1995 ◽  
Vol 19 (3) ◽  
pp. 282-282
Author(s):  
David Hedley ◽  
T. Vincent Shankey ◽  
Leon Wheeless
Keyword(s):  
Clinical Relevance ◽  
Human Tumour ◽  
Tumour Heterogeneity ◽  
Biological Basis

scholarly journals Clinical Relevance of Intra-Tumour Heterogeneity

Pathobiology ◽  
2018 ◽  
Vol 85 (1-2) ◽  
pp. 5-6
Author(s):  
Bettina Borisch ◽  
Giorgio Stanta
Keyword(s):  
Clinical Relevance ◽  
Tumour Heterogeneity

scholarly journals NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocyte reprogramming into intrahepatic cholangiocarcinoma

2020 ◽  
Author(s):  
Shikai Hu ◽  
Laura Molina ◽  
Junyan Tao ◽  
Silvia Liu ◽  
Mohammed Hassan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epithelial Cell ◽  
Intrahepatic Cholangiocarcinoma ◽  
Clinical Relevance ◽  
Poor Prognosis ◽  
Tumor Development ◽  
Biliary Epithelial Cell ◽  
Therapeutic Implications ◽  
Cellular Origin ◽  
Downstream Effector

ABSTRACTIntrahepatic cholangiocarcinoma (ICC), a disease of poor prognosis, has increased in incidence. It is challenging to treat due to intra- and inter-tumoral heterogeneity, which in part is attributed to diverse cellular origin. Indeed, co-expression of AKT and NICD in hepatocytes (HCs) yielded ICC, with similarity to proliferative, Notch-activated, and stem cell-like subclasses of clinical ICC. NICD regulated SOX9 and YAP1 during ICC development. Yap1 deletion or TEAD inhibition impaired HC-to-biliary epithelial cell (BEC) reprogramming and ICC proliferation; Sox9 loss repressed tumor growth; and Yap1-Sox9 combined loss abolished ICC development in AKT-NICD model. DNMT1 was discovered as a novel downstream effector of YAP1-TEAD complex that directed HC-to-BEC/ICC fate-switch. DNMT1 loss prevented Notch-dependent HC-to-ICC development, and DNMT1 re-expression restored ICC development following TEAD repression. Coexpression of DNMT1 with AKT was sufficient to induce hepatic tumor development including ICC. Thus, we have identified a novel NOTCH-YAP1/TEAD-DNMT1 axis essential for HC-driven ICC development.SIGNIFICANCEWe evaluated the clinical relevance of hepatocyte-driven ICC model and revealed critical but distinct roles of YAP1 and SOX9 in AKT-NICD-driven hepatocyte-derived ICC. We also identified NOTCH-YAP1/TEAD-DNMT1 axis as a critical driver for hepatocyte-to-ICC reprogramming, which might have biological and therapeutic implications in ICC subsets.

Expression pattern of cancer-associated fibroblast and its clinical relevance in intrahepatic cholangiocarcinoma

2017 ◽  
Vol 65 ◽  
pp. 92-100 ◽  
Author(s):  
Xiao-fang Zhang ◽  
Min Dong ◽  
Yu-hang Pan ◽  
Jian-ning Chen ◽  
Xiang-qi Huang ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Intrahepatic Cholangiocarcinoma ◽  
Clinical Relevance ◽  
Cancer Associated Fibroblast

Selected Abstracts of Recent Research in Stuttering

1999 ◽  
Vol 9 (1) ◽  
pp. 5-6
Author(s):  
Carrie Bain ◽  
Nan Bernstein Ratner
Keyword(s):  
Large Volume ◽  
Clinical Relevance

Due to the large volume of fluency-related publications since the last column, we have chosen to highlight those articles of highest potential clinical relevance.

259: Evaluation and Clinical Relevance of Prognostic Molecular Risk Factors in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 86-86
Author(s):  
Roland Bonfig ◽  
Hubertus Riedmiller ◽  
Burkhardt Kneitz ◽  
Philipp Stroebel
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Clinical Relevance
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