scholarly journals Negative association between lipoprotein associated phospholipase A2 activity and baroreflex sensitivity in subjects with high normal blood pressure and a positive family history of hypertension

2021 ◽  
pp. 183-191
Author(s):  
D Čelovská ◽  
K Vlčková ◽  
J Gonsorčík
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Phospholipase A2 ◽  
Spectral Methods ◽  
Baroreflex Sensitivity ◽  
Vascular Inflammation ◽  
Positive Family History ◽  
Normal Blood Pressure ◽  
History Of ◽  
Family History Of Hypertension

The relationship between baroreflex sensitivity (BRS) and inflammatory vascular biomarker Lipoprotein associated phospholipase A2 (Lp-PLA(2)) in subjects with high normal blood pressure (HNBP, prehypertensives) with a positive family history of hypertension (FHH+) and hypertension history free control subjects (FHH-) was evaluated. A total of 24 HNBP participants (age 39.5 ± 2.5 years, 18 male/ 6 female) were studied. 14 HNBP subjects FHH+ were compared to 10 HNBP participants FHH-, being of similar age and body mass index. BRS (ms/mmHg) was determined by the sequence and spectral methods (five-minute non-invasive beat-to-beat recording of blood pressure and RR interval, controlled breathing at a frequency of 0.33 Hz). Venous blood was analyzed for Lp-PLA(2) biomarker of vascular inflammation and atherothrombotic activity. A significant negative correlation between spontaneous BRS obtained by both methods and systolic blood pressure (BP) was present (BRS spect r = –0.54, P<0.001, BRS seq r = –0.59, P<0.001). BRS obtained by sequence and spectral methods were reduced in HNBP FHH+ compared to the group of HNBP FHH- (P = 0.0317 BRS seq, P = 0.0395 BRS spect). Lp-PLA(2) was significantly higher in HNBP FHH+ compared to FHH- controls (P< 0.05). Lp-PLA(2) was negatively correlated with BRS obtained by sequence method (r = -0.798, R2 = 0.636, P< 0.001) in the HNBP FHH+ subjects. These findings demonstrate that reduced baroreflex sensitivity, as a marker of autonomic dysfunction, is associated with vascular inflammation, predominantly in otherwise healthy participants with a positive family history of hypertension who could predispose to increased risk of hypertension. We conclude that our transversal study suggests that a low baroreflex sensitivity could be an early sign of autonomic dysfunction even in the prehypertensive period, and to corroborate these findings, a longitudinal study is needed.

Blood Pressure and Intra-Erythrocyte Sodium during Normal and High Salt Intake in Middle-Aged Men: Relationship to Family History of Hypertension, and Neurogenic and Hormonal Variables

1984 ◽  
Vol 66 (4) ◽  
pp. 427-433 ◽  
Author(s):  
Ottar Gudmundsson ◽  
Hans Herlitz ◽  
Olof Jonsson ◽  
Thomas Hedner ◽  
Ove Andersson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Salt Intake ◽  
Sodium Intake ◽  
Positive Family History ◽  
Sodium Content ◽  
High Salt Intake ◽  
History Of ◽  
Family History Of Hypertension ◽  
Erythrocyte Sodium

1. During 4 weeks 37 normotensive 50-year-old men identified by screening in a random population sample were given 12 g of NaCl daily, in addition to their usual dietary sodium intake. Blood pressure, heart rate, weight, urinary excretion of sodium, potassium and catecholamines, plasma aldosterone and noradrenaline and intra-erythrocyte sodium content were determined on normal and increased salt intake. The subjects were divided into those with a positive family history of hypertension (n = 11) and those without such a history (n = 26). 2. Systolic blood pressure and weight increased significantly irrespective of a positive family history of hypertension. 3. On normal salt intake intra-erythrocyte sodium content was significantly higher in those with a positive family history of hypertension. During high salt intake intra-erythrocyte sodium content decreased significantly in that group and the difference between the hereditary subgroups was no longer significant. 4. In the whole group urinary excretion of noradrenaline, adrenaline and dopamine increased whereas plasma aldosterone decreased during the increased salt intake. 5. Thus, in contrast to some earlier studies performed in young subjects, our results indicate that moderately increased sodium intake acts as a pressor agent in normotensive middle-aged men whether there was a positive family history of hypertension or not. We confirm that men with positive family history of hypertension have an increased intra-erythrocyte sodium content, and that an increase in salt intake seems to increase overall sympathetic activity.

scholarly journals Altered baroreflex sensitivity in young women with a family history of hypertension

2019 ◽  
Vol 121 (3) ◽  
pp. 1011-1017 ◽  
Author(s):  
Evan L. Matthews ◽  
Kelly N. Sebzda ◽  
Megan M. Wenner
Keyword(s):  
Family History ◽  
Young Women ◽  
Baroreflex Sensitivity ◽  
Valsalva Maneuver ◽  
Muscle Sympathetic Nerve Activity ◽  
Positive Family History ◽  
The Future ◽  
History Of ◽  
Family History Of Hypertension ◽  
Important Marker

A positive family history of hypertension (+FH) is a risk factor for the future development of hypertension. Hypertension is associated with reductions in baroreflex sensitivity (BRS). Therefore, we hypothesized that young women with a +FH [ n = 12, 22 ± 1 yr, body mass index (BMI) 21 ± 1 kg/m2, mean arterial pressure (MAP) 79 ± 1 mmHg] would have lower BRS compared with young women without a family history of hypertension (−FH) ( n = 13, 22 ± 1 yr, BMI 21 ± 1 kg/m2, MAP 77 ± 2 mmHg, all P > 0.05 between groups). Continuous measurements of muscle sympathetic nerve activity, blood pressure, and electrocardiogram derived R-R interval were recorded at rest and during a Valsalva maneuver. Both cardiovagal BRS and vascular sympathetic BRS were assessed. Resting cardiovagal BRS was reduced in the +FH women (all sequences: −FH 32.3 ± 3.7 vs. +FH 20.2 ± 2.9 ms/mmHg, P = 0.02). Cardiovagal BRS during phase IV (−FH 16.5 ± 2.7 vs. +FH 7.6 ± 1.3 ms/mmHg, P < 0.01) but not phase II (−FH 5.5 ± 0.9 vs. +FH 5.0 ± 0.8 ms/mmHg, P = 0.67) of the Valsalva maneuver was also lower in the +FH women. Vascular sympathetic BRS at rest (−FH −2.38 ± 0.7 vs. +FH −2.33 ± 0.3 bursts· min−1·mmHg−1, P = 0.58) and during the Valsalva (−FH −0.74 ± 0.23 vs. +FH −0.66 ± 0.18 bursts·15 s−1·mmHg−1, P = 0.79) were not different between groups. These data suggest that healthy young women with a positive family history of hypertension have reduced cardiovagal BRS. This may be one mechanism contributing to the increased incidence of hypertension in this population later in life. NEW & NOTEWORTHY Having a family history of hypertension increases the risk of developing future hypertension. Reductions in baroreflex function have been demonstrated in hypertension and are an important marker for future cardiovascular disease. We show that young women with a family history of hypertension have lower cardiovagal baroreflex sensitivity. This alteration in autonomic function may be one mechanism contributing to the future incidence of hypertension in this patient population.

scholarly journals The Prevalence rate of Hypertension in Rural Population of Bangladesh

2012 ◽  
Vol 18 (1) ◽  
pp. 12-17 ◽  
Author(s):  
MA Rahim ◽  
MM Rahman ◽  
M Rahman ◽  
F Ahmed ◽  
J Chowdhury ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Family History ◽  
Rural Population ◽  
Prevalence Rate ◽  
Positive Family History ◽  
Significant Risk ◽  
Major Health Problem ◽  
History Of ◽  
Family History Of Hypertension

Background: The non-communicable diseases like hypertension, diabetes and asthma are emerging as a major health problem in Bangladesh. Recently, these are given high research priority by the Government of Bangladesh. The prevalence of hypertension is increasing rapidly, but there is no current study on prevalence of hypertension in rural population of Bangladesh. There are some studies conducted on prevalence of hypertension from mid 70's to late 90's. Those studies showed the prevalence of hypertension is increasing significantly in both urban and rural population. In rural population the prevalence of hypertension was in 23.6% 1. After that there is no population based study was conducted on prevalence of hypertension in rural population of Bangladesh. Methods: We measured blood pressure, body weight and height of 532 individuals at and above the age of 20 years (age range 20-70 years) of both sexes accept pregnant and those who were under medication of hypertension. We collected information about smoking, family history of hypertension, status of physical activity, diabetes, annual income etc. Result: The overall prevalence rate of hypertension was 30.64% (male 31.53% and female 29.36%). In the study, the blood pressure was measured in all study subjects. The mean blood pressure was higher in hypertensive participants than that of non hypertensive. The prevalence of hypertension (30.64%) observed in this study was higher than the previous study. In this study showed that with the increasing age more the prevalence of hypertension. The similar funding also observed in recent Indian study. Our study showed that the hypertension prevalence was high among people with high BMI and obesity, positive family history, smoking and less physical activity. Conclusion: The prevalence of hypertension in the rural population was found to be on the increased compare to previous reports of Bangladesh and other Asian studies. Advanced age, obesity, higher incomes, family history of hypertension, smoking and reduced physical activity were proved significant risk factors for hypertension, whereas, sex, occupation, showed no association with hypertension. DOI: http://dx.doi.org/10.3329/jdnmch.v18i1.12225 J. Dhaka National Med. Coll. Hos. 2012; 18 (01): 12-17

Different Haemodynamic Reaction Patterns during Noise Exposure in Normotensive Subjects with and without Heredity for Essential Hypertension

1982 ◽  
Vol 63 (s8) ◽  
pp. 371s-374s ◽  
Author(s):  
L. Andrén ◽  
S. Piros ◽  
L. Hansson ◽  
H. Herlitz ◽  
O. Jonsson
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Noise Exposure ◽  
Blood Pressure Response ◽  
Positive Family History ◽  
Peripheral Resistance ◽  
Sodium Concentration ◽  
History Of ◽  
Family History Of Hypertension ◽  
Normotensive Subjects

1. Stimulation with noise (100 dBA) for 10 min caused a significant increase in diastolic and mean arterial pressure in normotensive subjects with and without a positive family history of hypertension. 2. The blood pressure response in the group with a positive family history of hypertension was due to a significant increase in total peripheral resistance (9%, P < 0.05); no such change was seen in the group without heredity for hypertension. 3. Systolic blood pressure, heart rate, stroke volume and cardiac output did not change significantly during exposure to noise. 4. There was no difference between the groups in mean intracellular sodium concentration measured in erythrocytes.

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