scholarly journals Alternations in the cardiovascular autonomic regulation and growth factors in autism

2021 ◽  
pp. 551-561
Author(s):  
Ingrid Tonhajzerova ◽  
Igor Ondrejka ◽  
Nikola Ferencova ◽  
Iveta Bujnakova ◽  
Marian Grendar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Growth Factor ◽  
Frequency Band ◽  
Plasma Levels ◽  
Autism Spectrum ◽  
Autonomic Regulation ◽  
Autistic Children ◽  
Rr Intervals ◽  
Cardiovascular Autonomic Regulation

Autism spectrum disorder (ASD) represents a serious neurodevelopmental disorder associated with autonomic nervous system dysregulation. The aim was to study complex cardiovascular autonomic regulation using heart rate variability (HRV) and systolic blood pressure variability (SBPV) linear/non-linear analysis at rest and during orthostasis, and to assess plasma levels of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) in autistic children. Twenty-five ASD boys and 25 age and gender-matched children at the age 7 15 years were examined. After venous blood taking, continuous ECG and blood pressure biosignals were recorded at rest and during orthostasis. Evaluated parameters: RR intervals, high- and low-frequency band of HRV spectral analysis (HF-HRV, LF-HRV), symbolic dynamics parameters 0V %, 1V %, 2LV %, 2UV %, low- and high-frequency band of SBPV (LF-SBPV, HF-SBPV), systolic, diastolic, mean blood pressure, EGF, VEGF plasma levels. RR intervals were significantly shortened and the HF-HRV, LF-SBPV, HF-SBPV parameters were significantly lower at rest, the HF-HRV and LF-SBPV remained lower during orthostasis in autistic children compared to controls (p0.05). EGF plasma levels were significantly lower in ASD compared to controls (p=0.046). No significant differences were found in remaining parameters. Our study revealed tachycardia, cardiovagal underactivity, and blunted sympathetic vasomotor regulation at rest and during orthostasis in autistic children. Additionally, complex heart rate dynamics are similar in autistic children than controls. Furthermore, EGF was reduced in autistic children without significant correlations with any autonomic parameters. We suggest that the abnormal complex cardiovascular reflex control could contribute to understanding the pathway linking autonomic features and autism.

The Involvement of Platelets and the Coronary Vasculature in Collagen-Induced Sudden Death in Rabbits

1985 ◽  
Vol 53 (01) ◽  
pp. 070-074 ◽  
Author(s):  
G Mallarkey ◽  
G M Smith
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Platelet Count ◽  
Sudden Death ◽  
Myocardial Ischaemia ◽  
Plasma Levels ◽  
Sodium Citrate ◽  
Plasma Samples ◽  
Calcium Entry Blockers

SummaryThe mechanism of collagen-induced sudden death in rabbits was studied by measuring blood pressure (BP), heart rate, ECG, the continuous platelet count and the plasma levels of thromboxane B2 (TxB2) and 6-keto prostaglandin Fia (6-keto PGF1α). Death was preceded by myocardial ischaemia and a sharp fall in BP which occurred before any fall in platelet count was observed. The calcium entry blockers (CEBs), verapamil, nifedipine and PY 108-068 protected the rabbits from sudden death without any significant effect on the decrease in the platelet count or increase in plasma TxB2 levels. 6-keto PGF1α could not be detected in any plasma samples. Indomethacin and tri-sodium citrate also protected the rabbits but significantly reduced the fall in platelet count and plasma TxB2. In vitro studies on isolated aortae indicated that verapamil non-specifically inhibited vasoconstriction induced by KC1, adrenaline and U46619 (a thromboxane agonist). It is concluded that CEBs physiologically antagonize the vasoconstricting actions of platelet-derived substances and that it is coronary vasoconstriction that is primarily the cause of death.

scholarly journals Autonomic impairment and oxidative stress: Relationship in PCOS patients

2020 ◽  
Vol 14 (2) ◽  
pp. 82-88
Author(s):  
Musfika Mostafa ◽  
Sultana Ferdousi ◽  
Shamima Sultana ◽  
Ayesha Akhter
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Heart Rate ◽  
Standard Deviation ◽  
Polycystic Ovary ◽  
Digital Data ◽  
Autonomic Nerve ◽  
Cardiovascular Risks ◽  
Rr Intervals ◽  
And Oxidative Stress

Background: Polycystic ovary syndrome (PCOS) is one of the most common, heterogeneous endocrine disorder of reproductive aged women. Association of autonomic impairment and elevated oxidative stress may predispose these patients to increased cardiovascular risks. Objective: To evaluate the relationship between cardiac autonomic nerve function (CANF) and oxidative stress in patients with PCOS. Methods: This cross sectional study was conducted in Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from September, 2018 to August, 2019. For this study, 30 newly diagnosed PCOS patients aged 20-35 years were recruited and similar age, body mass index (BMI) 30 apparently healthy, regularly menstruating women were enrolled as control. CANF was assessed by analyzing time domain measures of Heart Rate Variability (HRV). HRV data were recorded by a digital data acquisition device, Powerlab 8/35 (AD instruments, Australia). For evaluation of oxidative stress, plasma catalase and plasma Malondialdehyde (MDA) levels were measured. Statistical analysis was done by unpaired “t” test and Pearson’s correlation test as applicable. Results: In this study, resting pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly higher (p<0.001, p<0.01, p<0.01 respectively) and standard deviation of the RR intervals (SDRR) (p<0.01), mean R-R interval, standard deviation of the difference between successive RR intervals (SDSD), square root of mean squared differences of successive RR intervals (RMSSD), proportion of RR interval with duration >50 ms (pRR50%) were significantly lower (p<0.001) in PCOS than healthy controls. In addition, plasma catalase was significantly lower (p<0.01) and plasma MDA was significantly higher (p<0.001) in PCOS patients compared to controls. On correlation analysis, mean heart rate, SDRR, SDSD, RMSSD and pRR50% showed negative correlation with plasma catalase and plasma MDA (p<0.05) in PCOS patients but these were not significant. Conclusion: The present study reveals that reduced parasympathetic activity in PCOS patients may be related to oxidative stress. J Bangladesh Soc Physiol. 2019, December; 14(2): 82-88

Analysis of Heart Rate and Blood Pressure Variability in the Assessment of Autonomic Regulation in Arterial Hypertension

1996 ◽  
Vol 91 (s1) ◽  
pp. 129-132 ◽  
Author(s):  
Gianfranco Parati ◽  
Alessandra Frattola ◽  
Stefano Omboni ◽  
Giuseppe Mancia ◽  
Marco Di Rienzo
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Arterial Hypertension ◽  
Blood Pressure Variability ◽  
Autonomic Regulation

scholarly journals Angiopoietin-2 is released during anaphylactic hypotension in anesthetized and unanesthetized rats

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242026
Author(s):  
Tao Zhang ◽  
Toshishige Shibamoto ◽  
Mamoru Tanida ◽  
Makoto Taniguchi ◽  
Yuhichi Kuda ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Skeletal Muscle ◽  
Acute Lung Injury ◽  
Growth Factor ◽  
Vascular Permeability ◽  
Plasma Levels ◽  
Blue Dye ◽  
Arterial Blood ◽  
Tnf Α ◽  
Angiopoietin 2

Angiopoietin (Angpt)-2, a permeability-increasing growth factor, is involved in vascular leakage of sepsis and acute lung injury, and could be released from endothelium in response to anaphylaxis-related secretagogues such as histamine and leukotrienes, or cytokines. However, roles of Angpt-2 in the hyperpermeability during systemic anaphylaxis are not known. Thus, we determined plasma levels of Angpt-2 and cytokines and vascular permeability during anaphylactic hypotension in unanesthetized rats. Anaphylaxis was induced by an intravenous injection of ovalbumin antigen. Mean arterial blood pressure (MBP) was measured, and hematocrit (Hct) and plasma levels of Angpt-2 and cytokines were assessed for 24 h after antigen injection. Separately, vascular permeability was measured in various organs using the Evans blue dye method, and Angpt-2 mRNA expression in liver was measured. After antigen injection, MBP decreased to the nadir at 6 min, and returned to baseline at 45 min, and Hct peaked at 20 min and thereafter progressively declined, suggesting that vascular leak and hypotension occurred within 20 min. Plasma Angpt-2 levels began to increase significantly at 1 h after antigen, reaching the peak 2.7-fold baseline at 6 h with a return to baseline at 24 h. Detected cytokines of IL-1α, IL-1β, IL-6, IL-10, and TNF-α peaked 1 or 2 h after antigen. Angpt-2 mRNA increased at 2 h and showed an increasing tendency at 6 h. Vascular permeability in bronchus, trachea, intestines, mesentery and skeletal muscle was increased at 10 min but not at 6 h after antigen. In addition, we confirmed using anesthetized rat anaphylaxis models that plasma Angpt-2 levels increased at 1 h after antigen. In conclusion, plasma Angpt-2 is elevated presumably due to increased cytokines and enhanced gene transcription during anaphylaxis in anesthetized and unanesthetized rats.

scholarly journals Plastics and cardiovascular health: phthalates may disrupt heart rate variability and cardiovascular reactivity

2017 ◽  
Vol 313 (5) ◽  
pp. H1044-H1053 ◽  
Author(s):  
Rafael Jaimes ◽  
Adam Swiercz ◽  
Meredith Sherman ◽  
Narine Muselimyan ◽  
Paul J. Marvar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Medical Device ◽  
Cardiovascular Reactivity ◽  
Medical Devices ◽  
Autonomic Regulation ◽  
Phthalate Exposure ◽  
The Impact ◽  
Ethylhexyl Phthalate

Plastics have revolutionized medical device technology, transformed hematological care, and facilitated modern cardiology procedures. Despite these advances, studies have shown that phthalate chemicals migrate out of plastic products and that these chemicals are bioactive. Recent epidemiological and research studies have suggested that phthalate exposure adversely affects cardiovascular function. Our objective was to assess the safety and biocompatibility of phthalate chemicals and resolve the impact on cardiovascular and autonomic physiology. Adult mice were implanted with radiofrequency transmitters to monitor heart rate variability, blood pressure, and autonomic regulation in response to di-2-ethylhexyl-phthalate (DEHP) exposure. DEHP-treated animals displayed a decrease in heart rate variability (−17% SD of normal beat-to-beat intervals and −36% high-frequency power) and an exaggerated mean arterial pressure response to ganglionic blockade (31.5% via chlorisondamine). In response to a conditioned stressor, DEHP-treated animals displayed enhanced cardiovascular reactivity (−56% SD major axis Poincarè plot) and prolonged blood pressure recovery. Alterations in cardiac gene expression of endothelin-1, angiotensin-converting enzyme, and nitric oxide synthase may partly explain these cardiovascular alterations. This is the first study to show an association between phthalate chemicals that are used in medical devices with alterations in autonomic regulation, heart rate variability, and cardiovascular reactivity. Because changes in autonomic balance often precede clinical manifestations of hypertension, atherosclerosis, and conduction abnormalities, future studies are warranted to assess the downstream impact of plastic chemical exposure on end-organ function in sensitive patient populations. This study also highlights the importance of adopting safer biomaterials, chemicals, and/or surface coatings for use in medical devices.NEW & NOTEWORTHY Phthalates are widely used in the manufacturing of consumer and medical products. In the present study, di-2-ethylhexyl-phthalate exposure was associated with alterations in heart rate variability and cardiovascular reactivity. This highlights the importance of investigating the impact of phthalates on health and identifying suitable alternatives for medical device manufacturing.

scholarly journals Sociopsychological and physiological effects of a robot-assisted therapy for children with autism

2017 ◽  
Vol 14 (5) ◽  
pp. 172988141773689 ◽  
Author(s):  
Jaishankar Bharatharaj ◽  
Loulin Huang ◽  
Ahmed Al-Jumaily ◽  
Rajesh Elara Mohan ◽  
Chris Krägeloh
Keyword(s):  
Blood Pressure ◽  
Autism Spectrum Disorder ◽  
Heart Rate ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Physiological Effects ◽  
Physiological Changes ◽  
Robot Assisted ◽  
Before And After

This article reports our findings from a robot-assisted therapeutic study conducted over 49 days to investigate the sociopsychological and physiological effects in children with autism spectrum disorder using a parrot-inspired robot, KiliRo, that we developed to help in therapeutic settings. We investigated the frequency of participants’ interactions among each other and assessed any changes in interaction using social network analysis. Interactions were assessed through manual observation before and after exposure to the robot. Urinary and salivary tests were performed to obtain protein and α-amylase levels, respectively, to report the physiological changes in participating children with autism spectrum disorder before and after interacting with the robot. This is a pioneering human–robot interaction study to investigate changes in stress levels using salivary samples. Systolic and diastolic blood pressure, heart rate, and arterial oxygen saturation level in blood were also monitored to investigate the physiological changes in participating children before, during, and after interacting with our parrot-inspired robot, KiliRo. The results show that the robot can help increase social interaction among children with autism spectrum disorder and assist in learning tasks. Furthermore, the clinical biochemistry test report using urinary and salivary samples indicates that the stress levels of children with autism reduced notably after interacting with the robot. Nevertheless, blood pressure, heart rate, and oxygen levels in blood did not show positive change in all participants.

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