Early diagnosis and pharmacoprophylaxis of vibration disease and hands vegeto-sensory polyneuropathy among miners of colliers in Lviv-Volun region

The article covers the particular features of the neuro-muscular system in vibration disease of various types and severity by electroneuromyographical tests at the Department of Occupational Disorders, Regional Center for Occupational Disorders, Samara Medical and Sanitary Unit № 5 of the Kirov Region (State Budgetary Healthcare Institution of the Samara Region). Changes in excitability and functional mobility of the sensorimotor system, development of vegetative-sensory polyneuropathy depending on the vibration disease type, severity, and the length of exposure to vibration at work are found in vibration disease patients.

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Prevalence of comorbid pathology in patients with vibration disease caused by exposure to local vibration

Hygiene and Sanitation ◽

10.47470/0016-9900-2020-99-10-1079-1085 ◽

2020 ◽

Vol 99 (10) ◽

pp. 1079-1085

Author(s):

Marina V. Kuleshova ◽

Vladimir A. Pankov ◽

Natalya V. Slivnitsyna

Keyword(s):

Mastoid Process ◽

Local Vibration ◽

Work Related ◽

Vibration Disease ◽

Clinical Syndromes ◽

Number Of Patients ◽

Health Disorders ◽

Relationship Of ◽

The Relationship ◽

Sensory Polyneuropathy

Introduction. Vibration as a factor of production is one of the leading that influences negatively on workers in various sectors of the economy. In available literature there no adequate information on the comorbid pathology in hand-arm vibration disease (HAVD) patients. The purpose of the study is to analyze the prevalence of somatic pathology in HAVD patients. Material and methods. The analysis of comorbidity of HAVD patients according in-depth medical data is carried out. The degree of relationship between work-related health disorders is assessed. The results are presented by average values, intensive and extensive indices, the relationship of work-related health disorders is confirmed by the calculation of the relative risk. Results. The main syndrome in the clinical picture of HAVD is autonomous-sensory polyneuropathy of the upper extremities, which is recorded in all patients, while some patients have a combination of two or more clinical syndromes of HAVD. A significant prevalence of diseases of the musculoskeletal and circulatory systems, eyes and its adnexa, ear and mastoid process, digestive, genitourinary system, and respiratory systems was revealed. Number of patients who have diseases of endocrine (up to 25.0%, p <0.01), digestive (up to 43.8%, p <0.01), urogenital (up to 37.5%, p <0.01), respiratory (up to 37.5%, p <0.05) and the circulatory (up to 52.9%, p <0.05) systems grows up with an increase of the experience dose of local vibration. Conclusion. The results of the study can serve as the basis for the implementation of measures for primary and secondary prevention of occupational diseases caused by local vibration, aimed at preventing the development of health disorders.

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The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension

Terapevticheskii arkhiv ◽

10.26442/00403660.2021.06.200880 ◽

2021 ◽

Vol 93 (6) ◽

pp. 693-698

Author(s):

Sergei A. Babanov ◽

Rimma A. Baraeva ◽

Leonid A. Strizhakov ◽

Sergei V. Moiseev ◽

Viktor V. Fomin

Keyword(s):

Endothelial Dysfunction ◽

Early Diagnosis ◽

Arterial Hypertension ◽

Inflammatory Cytokines ◽

Endothelial Damage ◽

The State ◽

Cytokine Regulation ◽

Vibration Disease ◽

Willebrand Factor ◽

Cytokine Imbalance

Background. The article presents data on the state of cytokine regulation, indicators of endothelial damage when exposed to industrial vibration (general, local) and in combination with arterial hypertension. Aim. To improve the quality of early diagnosis and prevention of vibration disease in an isolated course and its combination with arterial hypertension based on a study of the cytokine profile, biomarkers of endothelial dysfunction in this pathology. Materials and methods. A comprehensive survey of 84 patients with isolated vibration disease from the effects of local, general, first, second degree and 61 patients with a combined course of vibration disease from the effects of local, general second degree vibration and arterial hypertension, 30 people in the control group without contact with industrial vibration and found healthy by medical examination. The levels of pro-inflammatory (IL-1, IL-8, TNF-) and anti-inflammatory cytokines (IL-4), biomarkers of endothelial damage (EDN-1, TGF-1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor) were determined using the enzyme immunoassay method. Results. The response of the immune system to the effects of industrial vibration is characterized by a cytokine imbalance an increase in the level of pro-inflammatory cytokines (IL-1, IL-8, TNF-) and a decrease in the level of anti-inflammatory cytokine (IL-4). With a combined course of vibratory disease and arterial hypertension, the cytokine imbalance is characterized by an even more significant increase in serum IL-1, IL-8, TNF- and a decrease in serum IL-4 concentration. Endothelial dysfunction with WB from the action of both local and general vibration in combination with hypertension is characterized by a significant increase in serum EDN-1, TGF-1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor. Conclusion. The study of the cytokine profile, biomarkers of damage to the vascular endothelium in this pathology will allow for the early diagnosis of vascular disorders and to optimize preventive measures for workers in vibration-hazardous industries.

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Vibration disease from exposure to general vibration: methodology of diagnosis and place of electroneuromyography

Terapevt (General Physician) ◽

10.33920/med-12-2103-01 ◽

2021 ◽

pp. 7-16

Author(s):

S.A. Babanov

Keyword(s):

The State ◽

Functional Mobility ◽

Sensorimotor System ◽

Vibration Disease ◽

Regional Center ◽

Neuromuscular Apparatus ◽

Degrees Of Severity ◽

Sensory Polyneuropathy

The article describes the features of the state of the neuromuscular apparatus in vibration diseases of various degrees of severity using electroneuromyographic research on the basis of the department of occupational Pathology of the regional center of Occupational Pathology of the Samara Medical and Sanitary Unit No. 5 of the Kirov district. It was found that patients with vibration disease are characterized by changes in the excitability and functional mobility of the sensorimotor system, the formation of vegetative-sensory polyneuropathy, depending on the severity of the vibration disease, the length of work in contact with vibration.

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Comparative assessment of methods of diagnostics of vibration disease and hands vegeto-sensory polyneuropathy in miners

Ukrainian Journal of Occupational Health ◽

10.33573/ujoh2011.03.033 ◽

2011 ◽

Vol 2011 (3) ◽

pp. 33-37

Author(s):

V. V. Mazur ◽

Keyword(s):

Comparative Assessment ◽

Vibration Disease ◽

Sensory Polyneuropathy

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Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS): literature review

Neuromuscular Diseases ◽

10.17650/2222-8721-2020-10-3-27-34 ◽

2020 ◽

Vol 10 (3) ◽

pp. 27-34

Author(s):

E. P. Nuzhnyi ◽

S. N. Illarioshkin

Keyword(s):

Early Diagnosis ◽

Cerebellar Ataxia ◽

Molecular Basis ◽

Autosomal Recessive ◽

Clinical Presentation ◽

Clinical Manifestations ◽

Sensory Neuropathy ◽

Genetic Diagnostics ◽

Phenotypic Spectrum ◽

Sensory Polyneuropathy

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) is a relatively poorly understood autosomal recessive neurodegenerative disease. The molecular basis of CANVAS was discovered only in 2019 and it is associated with the biallelic pentanucleotide AAGGG expansion carriage in the RFC1 gene. With the advent of genetic diagnostics, the understanding of the phenotypic spectrum and variety of clinical manifestations of this disease has expanded, including a combination of cerebellar ataxia and sensory neuropathy, as well as isolated sensory polyneuropathy/ganglionopathy. This review details current information on the etiology, pathogenesis, clinical presentation and diagnosis of CANVAS in order to increase the awareness of practitioners and early diagnosis of this disease.

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Application of ischemic preconditioning in the rehabilitation of miners suffered from the vibration disease

Hygiene and Sanitation ◽

10.47470/0016-9900-2021-100-7-700-703 ◽

2021 ◽

Vol 100 (7) ◽

pp. 700-703

Author(s):

Anastasia V. Yamshchikova ◽

Ilya D. Martynov ◽

Arnold N. Fleishman ◽

Margarita O. Gidayatova

Keyword(s):

Ischemic Preconditioning ◽

Neuroprotective Effect ◽

Upper Extremities ◽

Control Group ◽

Vibration Disease ◽

Study Results ◽

Sensory Responses ◽

Functional Indices ◽

Sensory Polyneuropathy

Introduction. Vibration disease is characterized by the early development of sensory polyneuropathy. Sensitive disorders significantly worsen the quality of life and increase the duration of the unemployable period of miners, which requires the search for new modern methods of correction and rehabilitation. Ischemic preconditioning is a promising direction in the treatment of occupationally caused polyneuropathies. However, its potential neuroprotective effect has not been sufficiently studied. The aim of the study was to evaluate the effectiveness of ischemic preconditioning of the upper extremities for the correction of sensory polyneuropathy manifestations in miners with vibration disease. Material and methods. Seventy-eight persons with a proven diagnosis of vibration disease were examined. According to a specially elaborated technique, the ischemic preconditioning of the upper extremities was performed in 46 patients who were included in the leading group; 32 patients made up the control group. The clinical and electroneuromyographic examination was carried out before the ischemic preconditioning procedure and on the 5th day of the study. Results. The initial clinical and neurophysiological indices in both groups did not differ statistically significant and indicated sensory polyneuropathy. After ischemic preconditioning, the subjects of the leading group showed an improvement in clinical and functional indices (reduction of numbness and paresthesia, improvement of vibration sensitivity, an increase in the sensory conduction velocity of impulse and the amplitudes of sensory responses) of the peripheral nerves of the upper extremities. In contrast, in the control group, there was no statistically significant change in objective indices. Conclusion. Ischemic preconditioning of the upper extremities is effective in the rehabilitation of miners with vibration disease, helps to reduce the manifestations of sensory polyneuropathy, sensitive disorders and normalize neurophysiological indices.

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Analysis of Symptoms of Vibration Disease and Its Early Diagnosis

Sangyo Igaku ◽

10.1539/joh1959.9.3_326_2 ◽

1967 ◽

Vol 9 (3) ◽

pp. 326-327

Author(s):

S. Yamada ◽

S. Takagi

Keyword(s):

Early Diagnosis ◽

Vibration Disease

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Red Flags: Barriers to Listening and Spoken Language in Children with Hearing Loss

Perspectives on Hearing and Hearing Disorders in Childhood ◽

10.1044/hhdc24.1.11 ◽

2014 ◽

Vol 24 (1) ◽

pp. 11-18

Author(s):

Andrea Bell ◽

K. Todd Houston

Keyword(s):

Hearing Loss ◽

Early Diagnosis ◽

Skill Acquisition ◽

Dynamic Process ◽

Spoken Language ◽

Red Flags ◽

Careful Monitoring ◽

Auditory Development ◽

Children With Hearing Loss ◽

Family Centered

To ensure optimal auditory development for the acquisition of spoken language, children with hearing loss require early diagnosis, effective ongoing audiological management, well fit and maintained hearing technology, and appropriate family-centered early intervention. When these elements are in place, children with hearing loss can achieve developmental and communicative outcomes that are comparable to their hearing peers. However, for these outcomes to occur, clinicians—early interventionists, speech-language pathologists, and pediatric audiologists—must participate in a dynamic process that requires careful monitoring of countless variables that could impact the child's skill acquisition. This paper addresses some of these variables or “red flags,” which often are indicators of both minor and major issues that clinicians may encounter when delivering services to young children with hearing loss and their families.

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